Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation, stability, and delivery

Pharmaceutical Research

Volumn 29, Issue 6, 2012, Pages 1618-1626

  Peters, Elaine E ^a   Ameri, Mahmoud ^a   Wang, Xiaomei ^b   Maa, Yuh Fun ^c   Daddona, Peter E ^a  

^a Zosano Pharma Inc   (United States)

^b MAP Pharmaceuticals   (United States)

^c GENENTECH INC   (United States)

Author keywords

EPO; erythropoietin alfa; pharmacokinetics; stability; transdermal microneedle patch

Indexed keywords

RECOMBINANT ERYTHROPOIETIN; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CONTACT ANGLE; DOSE RESPONSE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG POTENCY; DRUG STABILITY; FLOW KINETICS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MICRONEEDLE TRANSDERMAL DELIVERY SYSTEM; NEEDLE; NONHUMAN; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; TRANSDERMAL PATCH; VISCOMETRY;

ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COATED MATERIALS, BIOCOMPATIBLE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EQUIPMENT DESIGN; ERYTHROPOIETIN; FEASIBILITY STUDIES; HEMATINICS; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MINIATURIZATION; NEEDLES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RHEOLOGY; SKIN; SKIN ABSORPTION; TECHNOLOGY, PHARMACEUTICAL; TITANIUM; VISCOSITY;

EID: 84862816721     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0674-z     Document Type: Article

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