Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound

Journal of Controlled Release

Volumn 163, Issue 2, 2012, Pages 154-160

  Schoellhammer, Carl M ^a   Polat, Baris E ^a   Mendenhall, Jonathan ^a   Maa, Ruby ^a   Jones, Brianna ^a   Hart, Douglas P ^a   Langer, Robert ^a   Blankschtein, Daniel ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Cavitation; Diffusion; Permeability; Skin; Transdermal drug delivery; Ultrasound

Indexed keywords

CAVITATIONAL ACTIVITY; DUAL FREQUENCY; IN-VITRO TESTS; LOCALIZED TRANSPORT REGIONS; LOW FREQUENCY; LOW-FREQUENCY ULTRASOUND; PERMEABILIZATION; PORCINE SKIN; SIDE EFFECT; SKIN PERMEABILITY; TRANSDERMAL; TRANSDERMAL DRUG DELIVERY; TRANSDERMAL FLUX; TREATMENT TIME; ULTRASOUND EXPOSURE; ULTRASOUND FREQUENCY; ULTRASOUND INTENSITY; ULTRASOUND TREATMENTS;

ALUMINUM FOIL; CAVITATION; CONTROLLED DRUG DELIVERY; DIFFUSION; EXPERIMENTS; GLUCOSE; MECHANICAL PERMEABILITY; SKIN;

ULTRASONICS;

GLUCOSE; INULIN;

ALUMINUM FOIL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEMALE; HIGH INTENSITY FOCUSED ULTRASOUND; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; SKIN PERMEABILITY; SWINE; TREATMENT DURATION;

ALUMINUM; ANIMALS; FEMALE; GLUCOSE; INULIN; PERMEABILITY; SKIN; SKIN ABSORPTION; SOUND; SWINE;

EID: 84866714104     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.019     Document Type: Article

References (20)

1. M.K. Newman, M. Kill, and G. Frampton Effects of ultrasound alone and combined with hydrocortisone injections by needle or hypo-spray Am. J. Phys. Med. 37 4 Aug. 1958 206 209
2. S. Mitragotri, D.A. Edwards, and R. Langer A mechanistic study of ultrasonically-enhanced transdermal drug delivery J. Pharm. Sci. 84 6 Jun. 1995 697 706
3. B.E. Polat, D. Hart, R. Langer, and D. Blankschtein Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends J. Control. Release 152 3 2011 330 348
4. A. Tezel, A. Sens, J. Tuchscherer, and S. Mitragotri Synergistic effect of low-frequency ultrasound and surfactants on skin permeability J. Pharm. Sci. 91 1 2002 91 100 (Pubitemid 34074469)
5. J. Kushner, D. Kim, P.T.C. So, D. Blankschtein, and R.S. Langer Dual-channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer J. Investig. Dermatol. 127 12 2007 2832 2846 (Pubitemid 350134811)
6. J. Kushner, D. Blankschtein, and R. Langer Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with low-frequency ultrasound and sodium lauryl sulfate J. Pharm. Sci. 97 2 2008 906 918 (Pubitemid 351293890)
7. B.E. Polat, W.M. Deen, R. Langer, and D. Blankschtein A physical mechanism to explain the delivery of chemical penetration enhancers into skin during transdermal sonophoresis - Insight into the observed synergism J. Control. Release 158 2 Mar. 10 2012 250 260
8. B.E. Polat, P.L. Figueroa, D. Blankschtein, and R. Langer Transport Pathways and Enhancement Mechanisms Within Localized and Non-Localized Transport Regions in Skin Treated with Low-Frequency Sonophoresis and Sodium Lauryl Sulfate J. Pharm. Sci. 100 2 2011 512 529
9. M. Ogura, S. Pahwal, and S. Mitragotri Low-frequency sonophoresis: Current status and future prospects Adv. Drug Deliv. Rev. 60 10 2008 1218 1223
10. H.-L. Liu, and C.-M. Hsieh Single-transducer dual-frequency ultrasound generation to enhance acoustic cavitation Ultrason. Sonochem. 16 3 Mar. 2009 431 438
11. H. Hasanzadeh, M. Mokhtari-Dizaji, S.Z. Bathaie, Z.M. Hassan, V. Nilchiani, and H. Goudarzi Enhancement and control of acoustic cavitation yield by low-level dual frequency sonication: A subharmonic analysis Ultrason. Sonochem. 18 1 2011 394 400
12. S. Mitragotri, D. Ray, J. Farrell, H. Tang, B. Yu, J. Kost, D. Blankschtein, and R. Langer Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport J. Pharm. Sci. 89 7 2000 892 900
13. J.E. Seto, B.E. Polat, R.F.V. Lopez, D. Blankschtein, and R. Langer Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin J. Control. Release 145 1 2010 26 32
14. T. Terahara, S. Mitragotri, J. Kost, and R. Langer Dependence of low-frequency sonophoresis on ultrasound parameters; distance of the horn and intensity Int. J. Pharm. 235 2002 35 42 (Pubitemid 34185434)
15. B.E. Polat, J.E. Seto, D. Blankschtein, and R. Langer Application of the Aqueous Porous Pathway Model to Quantify the Effect of Sodium Lauryl Sulfate on Ultrasound-Induced Skin Structural Perturbation J. Pharm. Sci. 100 4 2011 1387 1397
16. J. Kushner, D. Blankschtein, and R. Langer Experimental demonstration of the existence of highly permeable localize transport regions in low-frequency sonophoresis J. Pharm. Sci. 93 11 2004 2733 2745 (Pubitemid 39506624)
17. S. Wu, T. Leong, S. Kentish, and M. Ashokkumar Frequency Effects during Acoustic Cavitation in Surfactant Solutions J. Phys. Chem. B 113 52 2009 16568 16573
18. J. Lee, S. Kentish, and M. Ashokkumar Effect of surfactants on the rate of growth of an air bubble by rectified diffusion J. Phys. Chem. B 109 30 2005 14595 14598 (Pubitemid 41156834)
19. J. Lee, S. Kentish, T. Matula, and M. Ashokkumar Effect of surfactants on inertial cavitation activity in a pulsed acoustic field J. Phys. Chem. B 109 35 2005 16860 16865 (Pubitemid 41367427)
20. I. Lavon, N. Grossman, and J. Kost The nature of ultrasound-SLS synergism during enhanced transdermal transport J. Control. Release 107 3 2005 484 494 (Pubitemid 41398069)