Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum

Pharmaceutical Research

Volumn 30, Issue 4, 2013, Pages 1099-1109

  Andrews, Samantha N ^a   Jeong, Eunhye ^b   Prausnitz, Mark R ^a,b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Georgia Institute of Technology   (United States)

Author keywords

insulin; microdermabrasion; skin; stratum corneum; transdermal drug delivery; viable epidermis

Indexed keywords

BOVINE SERUM ALBUMIN; INFLUENZA VACCINE; INSULIN; SULFORHODAMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; EPIDERMIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MICRODERMABRASION; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; SKIN ABRASION; SKIN PERMEABILITY; SKIN SURFACE; STRATUM CORNEUM; SWINE; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; DERMABRASION; EPIDERMIS; HUMANS; INFLUENZA VACCINES; INSULIN; RHODAMINES; SERUM ALBUMIN, BOVINE; SKIN ABSORPTION; SWINE;

EID: 84876479660     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0946-7     Document Type: Article

References (38)

1. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008;26:1261-8.
2. Bolognia J, Jorizzo J, Schaffer J. Dermatology. Philadelphia: Saunders; 2012.
3. Kirschner N, Houdek P, Fromm M, Moll I, Brandner JM. Tight junctions form a barrier in human epidermis. Eur J Cell Biol. 2010;89:839-42.
4. Karande P, Jain A, Ergun K, Kispersky V, Mitragotri S. Design principles of chemical penetration enhancers for transdermal drug delivery. Proc Natl Acad Sci USA. 2005;102:4688-93.
5. Smithand E, Maibach H. Percutaneous penetration enhancers. Boca Raton, FL: CRC Press; 2005.
6. Karande P, Jain A, Mitragotri S. Discovery of transdermal penetration enhancers by high-throughput screening. Nat Biotechnol. 2004;22:192-7.
7. Kim YC, Ludovice PJ, Prausnitz MR. Transdermal delivery enhanced by magainin pore-forming peptide. J Control Release. 2007;122:375-83.
8. Polat BE, Hart D, Langer R, Blankschtein D. Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends. J Control Release. 2011;152:330-48.
9. Arora A, Prausnitz MR, Mitragotri S. Micro-scale devices for transdermal drug delivery. Int J Pharm. 2008;364:227-36.
10. Fujimoto T, Shirakami K, Tojo K. Effect of microdermabrasion on barrier capacity of stratum corneum. Chem Pharm Bull. 2005;53:1014-6.
11. Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C, et al. Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling. J Am Acad Dermatol. 2006;54:405-10.
12. Lew BL, Cho Y, Lee MH. Effect of serial microdermabrasion on the ceramide level in the stratum corneum. Dermatol Surg. 2006;32:376-9.
13. Bhallaand M, Thami G. Microdermabrasion: reappraisal and brief review of literature. Dermatol Surg. 2006;32:809-14.
14. Freedman BM, Rueda-Pedraza E, Earley RV. Clinical and histologic changes determine optimal treatment regimens for microdermabrasion. J Dermatol Treat. 2002;13:193-200.
15. Andrews SN, Lee JW, Choi SO, Prausnitz MR. Transdermal insulin delivery using microdermabrasion. Pharm Res. 2011;28:2110-8.
16. Fang JY, Lee WR, Shen SC, Fang YP, Hu CH. Enhancement of topical 5-aminolaevulinic acid delivery by erbium: YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation. Br J Dermatol. 2004;151:132-40.
17. Lee WR, Shen SC, Wang KH, Hu CH, Fang JY. Lasers and microdermabrasion enhance and control topical delivery of vitamin C. J Invest Dermatol. 2003;121:1118-25.
18. Lee WR, Tsai RY, Fang CL, Liu CJ, Hu CH, Fang JY. Microdermabrasion as a novel tool to enhance drug delivery via the skin: An animal study. Dermatol Surg. 2006;32:1013-22.
19. Andrews SN, Zarnitsyn V, Bondy B, Prausnitz MR. Optimization of microdermabrasion for controlled removal of stratum corneum. Int J Pharm. 2011;407:95-104.
20. Koutsonanos DG, Martin MD, Zarnitsyn VG, Sullivan SP, Compans RW, Prausnitz MR, et al. Transdermal influenza immunization with vaccine-coated microneedle arrays. PLoS One. 2009;4:e4773.
21. Jacques SL, McAuliffe DJ, Blank IH, Parrish JA. Controlled removal of human stratum-corneum by pulsed laser. J Invest Dermatol. 1987;88:88-93.
22. Sintov AC, Krymberk I, Daniel D, Hannan T, Sohn Z, Levin G. Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs. J Control Release. 2003;89:311-20.
23. Badkar AV, Smith AM, Eppstein JA, Banga AK. Transdermal delivery of interferon alpha-2B using microporation and iontophoresis in hairless rats. Pharm Res. 2007;24:1389-95.
24. Lee JW, Gadiraju P, Park JH, Allen MG, Prausnitz MR. Microsecond thermal ablation of skin for transdermal drug delivery. J Control Release. 2011;154:58-68.
25. Bachhav YG, Heinrich A, Kalia YN. Using laser microporation to improve transdermal delivery of diclofenac: increasing bioavailability and the range of therapeutic applications. Eur J Pharm Biopharm. 2011;78:408-14.
26. Bachhav YG, Summer S, Heinrich A, Bragagna T, Bohler C, Kalia YN. Effect of controlled laser microporation on drug transport kinetics into and across the skin. J Control Release. 2010;146:31-6.
27. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliver Rev. 2012;64:1547-68.
28. Crichton ML, Ansaldo A, Chen XF, Prow TW, Fernando GJP, Kendall MAF. The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine. Biomaterials. 2010;31:4562-72.
29. Fernando GJP, Chen XF, Prow TW, Crichton ML, Fairmaid EJ, Roberts MS, et al. Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model. PLoS One. 2010;5:e10266.
30. Andrews SN, Lee JW, Prausnitz MR. Recovery of skin barrier after stratum corneum removal by microdermabrasion. AAPS PharmSciTech. 2011;12:1393-400.
31. Gill HS, Denson DD, Burris BA, Prausnitz MR. Effect of microneedle design on pain in human volunteers. Clin J Pain. 2008;24:585-94.
32. Pettisand RJ, Harvey AJ. Microneedle delivery: clinical studies and emerging medical applications. Ther Deliv. 2012;3:357-71.
33. Hoesly FJ, Borovicka J, Gordon J, Nardone B, Holbrook JS, Pace N, et al. Safety of a novel microneedle device applied to facial skin: a subject- and rater-blinded, sham-controlled, randomized trial. Arch Dermatol. 2012;148:711-17.
34. Levin G, Gershonowitz A, Sacks H, Stern M, Sherman A, Rudaev S, et al. Transdermal delivery of human growth hormone through RF-microchannels. Pharm Res. 2005;22:550-5.
35. Bissett, D. Ch 3: anatomy and biochemistry of skin. In: Kydonieus AF, Berner B, editors. Transdermal delivery of drugs, vol. I. Boca Raton, FL: CRC Press, Inc.; 1987. p. 160.
36. Khalil E, Kretsos K, Kasting GB. Glucose partition coefficient and diffusivity in the lower skin layers. Pharm Res. 2006;23:1227-34.
37. Tojo K, Chiang CC, Chien YW. Drug permeation across the skin - effect of penetrant hydrophilicity. J Pharm Sci. 1987;76:123-6.
38. Kretsos K, Miller MA, Zamora-Estrada G, Kasting GB. Partitioning, diffusivity and clearance of skin permeants in mammalian dermis. Int J Pharm. 2008;346:64-79.