Myocardial dysfunction in sepsis: A large, unsolved puzzle

Critical Care Research and Practice

Volumn 2012, Issue , 2012, Pages

  Fernandes, Constantino Jose ^a   De Assuncao, Murillo Santucci Cesar ^a  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84866240614     PISSN: 20901305     EISSN: 20901313     Source Type: Journal    
DOI: 10.1155/2012/896430     Document Type: Review

References (69)

1. the Centers for Disease Control From, Increase in National Hospital Discharge Survey rates for septicemiaUnited States, 19791987. Journal of the American Medical Association 1990 263 7 937 938
2. Annane D., Aegerter P., Jars-Guincestre M. C., Guidet B., Current epidemiology of septic shock: the CUB-Réa network. American Journal of Respiratory and Critical Care Medicine 2003 168 2 165 172 2-s2.0-0042165861 10.1164/rccm.2201087 (Pubitemid 36920969)
3. Silva E., Pedro M. A., Sogayar A. C., Mohovic T., Silva C. L., Janiszewski M., Cal R. G., de Sousa E. F., Abe T. P., de Andrade J., de Matos J. D., Rezende E., Assunção M., Avezum A., Rocha P. C., de Matos G. F., Bento A. M., Corrêa A. D., Vieira P. C., Knobel E., Brazilian Sepsis Epidemiological Study (BASES study). Critical Care 2004 8 4 R251 R260 2-s2.0-4344716641
4. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., Peterson E., Tomlanovich M., Early goal-directed therapy in the treatment of severe sepsis and septic shock. New England Journal of Medicine 2001 345 19 1368 1377 2-s2.0-0035829842 10.1056/NEJMoa010307
5. Parrillo J. E., The cardiovascular pathophysiology of sepsis. Annual Review of Medicine 1989 40 469 485 2-s2.0-0024405217 (Pubitemid 19145370)
6. Vieillard-Baron A., Caille V., Charron C., Belliard G., Page B., Jardin F., Actual incidence of global left ventricular hypokinesia in adult septic shock. Critical Care Medicine 2008 36 6 1701 1706 2-s2.0-45149125311 10.1097/CCM.0b013e318174db05
7. F. Dhainaut AC J., Laurent I., Myocardial dysfunction in sepsis. Sepsis 2000 4 2 89 97 (Pubitemid 32427965)
8. Wiggers C. J., Myocardial depression in shock. A survey of cardiodynamic studies. American Heart Journal 1947 33 5 633 650 2-s2.0-0000934822
9. Maclean L. D., Spink W. W., Visscher M. B., Weil M. H., Studies on the circulatory changes in the dog produced by endotoxin from gram-negative microorganisms. The Journal of Clinical Investigation 1956 35 11 1191 1198 2-s2.0-0001633299
10. Fernandes Júnior C. J., Akamine N., Knobel E., Myocardial depression in sepsis. Shock 2008 30 supplement 1 14 17 2-s2.0-54049158885 10.1097/SHK.0b013e3181818617
11. Moon V. H., The pathology of secondary shock. The American Journal of Pathology 1948 24 2 235 273
12. Fernandes Júnior C. J., Iervolino M., Neves R. A., Sampaio E. L., Knobel E., Sustovich D. R., The myocardium in sepsis: anatomo-pathologic aspects. Arquivos Brasileiros de Cardiologia 1988 50 3 175 178 2-s2.0-0023980175
13. Fernandes Júnior C. J., Iervolino M., Neves R. A., Sampaio E. L. M., Knobel E., Interstitial myocarditis in sepsis. American Journal of Cardiology 1994 74 9 958 2-s2.0-0027948441 10.1016/0002-9149(94)90597-5 (Pubitemid 24340326)
14. Natanson C., Eichenholz P. W., Danner R. L., Eichacker P. Q., Hoffman W. D., Kuo G. C., Banks S. M., MacVittie T. J., Parrillo J. E., Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. Journal of Experimental Medicine 1989 169 3 823 832 2-s2.0-0024520830 (Pubitemid 19085823)
15. Suffredini A. F., Fromm R. E., Parker M. M., Brenner M., Kovacs J. A., Wesley R. A., Parrillo J. E., The cardiovascular response of normal humans to the administration of endotoxin. New England Journal of Medicine 1989 321 5 280 287 2-s2.0-0024342856 (Pubitemid 19193802)
16. Russell J. A., Jim.Russell@hli.ubc.ca Boyd J., Nakada T., Thair S., Walley K. R., Molecular mechanisms of sepsis. Contributions to Microbiology 2011 17 48 85 10.1159/000324009
17. Akira S., Uematsu S., Takeuchi O., Pathogen recognition and innate immunity. Cell 2006 124 4 783 801 2-s2.0-32944464648 10.1016/j.cell.2006.02.015 (Pubitemid 43261452)
18. Flesch M., Kilter H., Cremers B., Laufs U., Südkamp M., Ortmann M., Müller F. U., Böhm M., Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite. Journal of the American College of Cardiology 1999 33 4 1062 1070 2-s2.0-0033558704 10.1016/S0735-1097(98)00660-3
19. Cain B. S., Meldrum D. R., Dinarello C. A., Meng X., Joo K. S., Banerjee A., Harken A. H., Tumor necrosis factor- α and interleukin-1 β synergistically depress human myocardial function. Critical Care Medicine 1999 27 7 1309 1318 2-s2.0-0032805207 10.1097/00003246-199907000-00018 (Pubitemid 29379369)
20. -1 signaling and protects against contractile dysfunction. American Journal of Physiology 2003 285 2 H597 H606 2-s2.0-0037623904 (Pubitemid 36885890)
21. Avlas O., Fallach R., Shainberg A., Porat E., Hochhauser E., hochhaus@post.tau.ac.il Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility. Antioxidants and Redox Signaling 2011 15 7 1895 1909 10.1089/ars.2010.3728
22. Cunnion R. E., Schaer G. L., Parker M. M., The coronary circulation in human septic shock. Circulation 1986 73 4 637 644 2-s2.0-0022480082 (Pubitemid 16081421)
23. Lefer A. M., Martin J., Origin of myocardial depressant factor in shock. The American Journal of Physiology 1970 218 5 1423 1427 2-s2.0-0014782290
24. McConn R., Greineder J. K., Wasserman F., Clowes G. H. Jr., Is there a humoral factor that depresses ventricular function in sepsis? Circulatory Shock 1979 1, supplement 9 22 2-s2.0-0018368224
25. Kumar A., Thota V., Dee L., Olson J., Uretz E., Parrillo J. E., Tumor necrosis factor α and interleukin 1 β are responsible for in vitro myocardial cell depression induced by human septic shock serum. Journal of Experimental Medicine 1996 183 3 949 958 2-s2.0-0029975877 10.1084/jem.183.3.949 (Pubitemid 26113964)
26. Casey L. C., Balk R. A., Bone R. C., Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Annals of Internal Medicine 1993 119 8 771 778 2-s2.0-0027731546 (Pubitemid 24012641)
27. Billiau A., Vandekerckhove F., Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock. European Journal of Clinical Investigation 1991 21 6 559 573 2-s2.0-0025933270
28. Vincent J. L., Bakker J., Marecaux G., Schandene L., Kahn R. J., Dupont E., Administration of anti-TNF antibody improves left ventricular function in septic shock patients; Results of a pilot study. Chest 1992 101 3 810 815 2-s2.0-0026508075
29. Müller-Werdan U., Schumann H., Loppnow H., Fuchs R., Darmer D., Stadler J., Holtz J., Werdan K., Endotoxin and tumor necrosis factor α exert a similar proinflammatory effect in neonatal rat cardiomyocytes, but have different cardiodepressant profiles. Journal of Molecular and Cellular Cardiology 1998 30 5 1027 1036 10.1006/jmcc.1998.0667 (Pubitemid 28279315)
30. Abraham E., Wunderink R., Silverman H., Perl T. M., Nasraway S., Levy H., Bone R., Wenzel R. P., Balk R., Allred R., Pennington J. E., Wherry J. C., Efficacy and safety of monoclonal antibody to human tumor necrosis factor α in patients with sepsis syndrome: a randomized, controlled, double-blind, multicenter clinical trial. Journal of the American Medical Association 1995 273 12 934 941 10.1001/jama.273.12.934
31. -1 in the pathogenesis of heart disease. Archivum Immunologiae et Therapiae Experimentalis 2009 57 3 165 176 2-s2.0-70349488694 10.1007/s00005-009-0024-y
32. Muller-Werdan U., Buerke M., Ebelt H., Heinroth K. M., Herklotz A., Loppnow H., Ru M., Schlegel F., Schlitt A., Schmidt H. B., S-dsoffker G., Werdan K., Septic cardiomyopathya not yet discovered cardiomyopathy? Experimental and Clinical Cardiology 2006 11 3 226 236 2-s2.0-33749586506 (Pubitemid 44540867)
33. Finkel M. S., Oddis C. V., Jacob T. D., Watkins S. C., Hattler B. G., Simmons R. L., Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992 257 5068 387 389 2-s2.0-0026735208
34. Niederbichler A. D., Hoesel L. M., Westfall M. V., Gao H., Ipaktchi K. R., Sun L., Zetoune F. S., Su G. L., Arbabi S., Sarma J. V., Wang S. C., Hemmila M. R., Ward P. A., An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. Journal of Experimental Medicine 2006 203 1 53 61 2-s2.0-31344464342 10.1084/jem.20051207 (Pubitemid 43139645)
35. Schulz R., Rassaf T., Massion P. B., Kelm M., Balligand J. L., Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacology and Therapeutics 2005 108 3 225 256 2-s2.0-28044467552 10.1016/j.pharmthera.2005.04.005 (Pubitemid 41691866)
36. Ziolo M. T., Bers D. M., The real estate of NOS signaling location, location, location. Circulation Research 2003 92 12 1279 1281 2-s2.0-0037786972 10.1161/01.RES.0000080783.34092.AF (Pubitemid 36773467)
37. Ichinose F., Buys E. S., Neilan T. G., Furutani E. M., Morgan J. G., Jassal D. S., Graveline A. R., Searles R. J., Lim C. C., Kaneki M., Picard M. H., Scherrer-Crosbie M., Janssens S., Liao R., Bloch K. D., Cardiomyocyte- specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circulation Research 2007 100 1 130 139 2-s2.0-33846116583 10.1161/01.RES.0000253888.09574.7a (Pubitemid 46066781)
38. Bougaki M., Searles R. J., Kida K., Yu J., Buys E. S., Ichinose F., NOS3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis. Shock 2010 34 3 281 290 2-s2.0-77955970985 10.1097/SHK.0b013e3181cdc327
39. Dawson D., Lygate C. A., Zhang M. H., Hulbert K., Neubauer S., Casadei B., nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction. Circulation 2005 112 24 3729 3737 2-s2.0-33644875411 10.1161/CIRCULATIONAHA.105.539437 (Pubitemid 43739513)
40. Rassaf T., Poll L. W., Brouzos P., Lauer T., Totzeck M., Kleinbongard P., Gharini P., Andersen K., Schulz R., Heusch G., Mödder U., Kelm M., Positive effects of nitric oxide on left ventricular function in humans. European Heart Journal 2006 27 14 1699 1705 2-s2.0-33745778223 10.1093/eurheartj/ehl096 (Pubitemid 44025358)
41. Ullrich R., Scherrer-Crosbie M., Bloch K. D., Ichinose F., Nakajima H., Picard M. H., Zapol W. M., Quezado Z. M. N., Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation 2000 102 12 1440 1446 2-s2.0-0034687080
42. Balligand J. L., Ungureanu D., Kelly R. A., Kobzik L., Pimental D., Michel T., Smith T. W., Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. Journal of Clinical Investigation 1993 91 5 2314 2319 2-s2.0-0027225229 (Pubitemid 23141511)
43. Pacher P., Beckman J. S., Liaudet L., Nitric oxide and peroxynitrite in health and disease. Physiological Reviews 2007 87 1 315 424 2-s2.0-33846863589 10.1152/physrev.00029.2006 (Pubitemid 46217686)
44. Sharma A. C., Motew S. J., Farias S., Alden K. J., Bosmann H. B., Law W. R., Ferguson J. L., Sepsis alters myocardial and plasma concentrations of endothelin and nitric oxide in rats. Journal of Molecular and Cellular Cardiology 1997 29 5 1469 1477 2-s2.0-0031149785 10.1006/jmcc.1997.0386 (Pubitemid 27259659)
45. Chopra M., Sharma A. C., Distinct cardiodynamic and molecular characteristics during early and late stages of sepsis-induced myocardial dysfunction. Life Sciences 2007 81 4 306 316 2-s2.0-34447106947 10.1016/j.lfs.2007.05.021 (Pubitemid 47030576)
46. Galley H. F., h.f.galley@abdn.ac.uk Oxidative stress and mitochondrial dysfunction in sepsis. British Journal of Anaesthesia 2011 107 1 57 64 10.1093/bja/aer093
47. Lorigados C. B., Soriano F. G., Szabo C., Pathomechanisms of myocardial dysfunction in sepsis. Endocrine, Metabolic and Immune Disorders 2010 10 3 274 284 2-s2.0-78649299966
48. Peng T., Lu X., Feng Q., qfeng@uwo.ca NADH oxidase signaling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB Journal 2005 19 2 293 295 10.1096/fj.04-2289fje (Pubitemid 40189286)
49. Schmidt H., Müller-Werdan U., Hoffmann T., Francis D. P., Piepoli M. F., Rauchhaus M., Prondzinsky R., Loppnow H., Buerke M., Hoyer D., Werdan K., Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups. Critical Care Medicine 2005 33 9 1994 2002 2-s2.0-24944441887 10.1097/01.CCM.0000178181.91250.99 (Pubitemid 41306521)
50. Hahn P. Y., Wang P., Tait S. M., Ba Z. F., Reich S. S., Chaudry I. H., Sustained elevation in circulating catecholamine levels during polymicrobial sepsis. Shock 1995 4 4 269 273 2-s2.0-0029382098
51. Wu L. L., Yang S. L., Yang R. C., Hsu H. K., Hsu C., Dong L. W., Liu M. S., G protein and adenylate cyclase complex-mediated signal transduction in the rat heart during sepsis. Shock 2003 19 6 533 537 2-s2.0-1542647136
52. Zorn-Pauly K., Pelzmann B., Lang P., Mächler H., Schmidt H., Ebelt H., Werdan K., Koidl B., Müller-Werdan U., Endotoxin impairs the human pacemaker current IF. Shock 2007 28 6 655 661 2-s2.0-36248973543 10.1097/shk.0b013e31812386bf (Pubitemid 350135469)
53. Liu S., Schreur K. D., G protein-mediated suppression of L-type Ca2+ current by interleukin- 1 β in cultured rat ventricular myocytes. American Journal of Physiology 1995 268 2 C339 C349 2-s2.0-0028940807
54. Zhong J., Hwang T. C., Adams H. R., Rubin L. J., Reduced L-type calcium current in ventricular myocytes from endotoxemic guinea pigs. American Journal of Physiology 1997 273 5 H2312 H2324 2-s2.0-0030682165
55. Wu L. L., Ji Y., Dong L. W., Liu M. S., Calcium uptake by sarcoplasmic reticulum is impaired during the hypodynamic phase of sepsis in the rat heart. Shock 2001 15 1 49 55 2-s2.0-0035234205 (Pubitemid 33598160)
56. Tavernier B., Garrigue D., Boulle C., Vallet B., Adnet P., Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits. Cardiovascular Research 1998 38 2 472 479 2-s2.0-0032076172 10.1016/S0008-6363(98)00028-5 (Pubitemid 28294165)
57. Fernandes Júnior C. J., Akamine N., Knobel E., Cardiac troponin: a new serum marker of myocardial injury in sepsis. Intensive Care Medicine 1999 25 10 1165 1168 2-s2.0-0032740845 10.1007/s001340051030 (Pubitemid 29525077)
58. Piper H. M., Schwartz P., Spahr R., Early enzyme release from myocardial cells is not due to irreversible cell damage. Journal of Molecular and Cellular Cardiology 1984 16 4 385 388 2-s2.0-0021624613 (Pubitemid 15040769)
59. Ver Elst K. M., Spapen H. D., Nguyen D. N., Garbar C., Huyghens L. P., Gorus F. K., Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clinical Chemistry 2000 46 5 650 657 2-s2.0-0034078373 (Pubitemid 30318420)
60. Turner A., Tsamitros M., Bellomo R., Myocardial cell injury in septic shock. Critical Care Medicine 1999 27 9 1775 1780 2-s2.0-0032871721 10.1097/00003246-199909000-00012 (Pubitemid 29455103)
61. Mehta N. J., Khan I. A., Gupta V., Jani K., Gowda R. M., Smith P. R., Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock. International Journal of Cardiology 2004 95 1 13 17 2-s2.0-2442639944 10.1016/j.ijcard.2003.02.005 (Pubitemid 38670466)
62. Rivers E. P., McCord J., Otero R., Jacobsen G., Loomba M., Clinical utility of B-type natriuretic peptide in early severe sepsis and septic shock. Journal of Intensive Care Medicine 2007 22 6 363 373 2-s2.0-36249007981 10.1177/0885066607307523 (Pubitemid 350132177)
63. Kandil E., Burack J., Sawas A., Bibawy H., Schwartzman A., Zenilman M. E., Bluth M. H., B-type natriuretic peptide: a biomarker for the diagnosis and risk stratification of patients with septic shock. Archives of Surgery 2008 143 3 242 246 2-s2.0-41149145193 10.1001/archsurg.2007.69 (Pubitemid 351439272)
64. Turner K. L., klturner@tmhs.org Moore L. J., Todd S. R., Sucher J. F., Jones S. A., McKinley B. A., Valdivia A., Sailors R. M., Moore F. A., Identification of cardiac dysfunction in sepsis with B-type natriuretic peptide. Journal of the American College of Surgeons 2011 213 1 139 146 10.1016/j.jamcollsurg.2011.03.027
65. Perman S. M., Chang A. M., AnnaMarie.Chang@uphs.upenn.edu Hollander J. E., Gaieski D. F., Trzeciak S., Birkhahn R., Otero R., Osborn T. M., Moretti E., Bryant Nguyen H., Gunnerson K. J., Milzman D., Goyal M., Cairns C. B., Ngo L., Rivers E. P., Shapiro N. I., Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Academic Emergency Medicine 2011 18 2 219 222 10.1111/j.1553-2712.2010.00968.x
66. Bouhemad B., Nicolas-Robin A., Arbelot C., Arthaud M., Féger F., Rouby J. J., Acute left ventricular dilatation and shock-induced myocardial dysfunction. Critical Care Medicine 2009 37 2 441 447 2-s2.0-67650447964 10.1097/CCM.0b013e318194ac44
67. Morelli A., De Castro S., Teboul J. L., Singer M., Rocco M., Conti G., De Luca L., Di Angelantonio E., Orecchioni A., Pandian N. G., Pietropaoli P., Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Medicine 2005 31 5 638 644 2-s2.0-21044443575 10.1007/s00134-005-2619-z (Pubitemid 40684980)
68. Barraud D., Faivre V., Damy T., Welschbillig S., Gayat E., Heymes C., Payen D., Shah A. M., Mebazaa A., Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. Critical Care Medicine 2007 35 5 1376 1382 2-s2.0-34247341002 10.1097/01.CCM.0000261889.18102.84 (Pubitemid 46642669)
69. Rezende E., Assuncao M., Leão G., Silva M., Is it possible to use levosimedan to treat cardiovascular dysfunction in septic patients? Critical Care 2003 7 supplement 3 P37