-
1
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B., and, Kroemer, G., (2008) Autophagy in the pathogenesis of disease. Cell 132, 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
2
-
-
36249025723
-
Autophagy: Process and function
-
Mizushima, N., (2007) Autophagy: process and function. Genes Dev. 21, 2861-2873.
-
(2007)
Genes Dev.
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
3
-
-
56749170677
-
Autophagic cell death: The story of a misnomer
-
Kroemer, G., and, Levine, B., (2008) Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol. 9, 1004-1010.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 1004-1010
-
-
Kroemer, G.1
Levine, B.2
-
4
-
-
84863397956
-
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy
-
et al
-
Troncoso, R., Vicencio, J. M., Parra, V., Nemchenko, A., Kawashima, Y., et al. (2012) Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc. Res. 93, 320-329.
-
(2012)
Cardiovasc. Res.
, vol.93
, pp. 320-329
-
-
Troncoso, R.1
Vicencio, J.M.2
Parra, V.3
Nemchenko, A.4
Kawashima, Y.5
-
5
-
-
0034803527
-
Insulin-like growth factor 1 (IGF-1): A growth hormone
-
Laron, Z., (2001) Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol. Pathol. 54, 311-316.
-
(2001)
Mol. Pathol.
, vol.54
, pp. 311-316
-
-
Laron, Z.1
-
6
-
-
0025342410
-
Insulin receptor structure and function in normal and pathological conditions
-
Becker, A. B., and, Roth, R. A., (1990) Insulin receptor structure and function in normal and pathological conditions. Annu. Rev. Med. 41, 99-115.
-
(1990)
Annu. Rev. Med.
, vol.41
, pp. 99-115
-
-
Becker, A.B.1
Roth, R.A.2
-
7
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M., and, Sabatini, D. M., (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
8
-
-
69549116880
-
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
-
et al
-
Yang, W. L., Wang, J., Chan, C. H., Lee, S. W., Campos, A. D., et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325, 1134-1138.
-
(2009)
Science
, vol.325
, pp. 1134-1138
-
-
Yang, W.L.1
Wang, J.2
Chan, C.H.3
Lee, S.W.4
Campos, A.D.5
-
9
-
-
0036709020
-
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
-
Pouyssegur, J., Volmat, V., and, Lenormand, P., (2002) Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem. Pharmacol. 64, 755-763.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 755-763
-
-
Pouyssegur, J.1
Volmat, V.2
Lenormand, P.3
-
10
-
-
79958833184
-
The IGF-I/PI3K/Akt and the IGF-I/MAPK/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder
-
et al
-
Fuentes, E. N., Bjornsson, B. T., Valdes, J. A., Einarsdottir, I. E., Lorca, B., et al. (2011) The IGF-I/PI3K/Akt and the IGF-I/MAPK/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder. Am. J. Physiol. 300, R1532-R1542.
-
(2011)
Am. J. Physiol.
, vol.300
-
-
Fuentes, E.N.1
Bjornsson, B.T.2
Valdes, J.A.3
Einarsdottir, I.E.4
Lorca, B.5
-
11
-
-
1542289963
-
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate- dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
-
et al
-
Ibarra, C., Estrada, M., Carrasco, L., Chiong, M., Liberona, J. L., et al. (2004) Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate- dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. J. Biol. Chem. 279, 7554-7565.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7554-7565
-
-
Ibarra, C.1
Estrada, M.2
Carrasco, L.3
Chiong, M.4
Liberona, J.L.5
-
12
-
-
84872832228
-
2+ signalling in cardiac myocytes by perinuclear microdomains of sarcolemmal igf-1 receptors
-
et al
-
2+ signalling in cardiac myocytes by perinuclear microdomains of sarcolemmal igf-1 receptors. Circ. Res. 112, 236-245.
-
(2012)
Circ. Res.
, vol.112
, pp. 236-245
-
-
Ibarra, C.1
Vicencio, J.M.2
Estrada, M.3
Lin, Y.4
Rocco, P.5
-
13
-
-
0032514229
-
Survey of studies examining mammalian cardiomyocyte DNA synthesis
-
Soonpaa, M. H., and, Field, L. J., (1998) Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circ. Res. 83, 15-26.
-
(1998)
Circ. Res.
, vol.83
, pp. 15-26
-
-
Soonpaa, M.H.1
Field, L.J.2
-
14
-
-
0035940387
-
In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein
-
et al
-
Mehrhof, F. B., Muller, F. U., Bergmann, M. W., Li, P., Wang, Y., et al. (2001) In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 104, 2088-2094.
-
(2001)
Circulation
, vol.104
, pp. 2088-2094
-
-
Mehrhof, F.B.1
Muller, F.U.2
Bergmann, M.W.3
Li, P.4
Wang, Y.5
-
15
-
-
33746324537
-
Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
-
et al
-
Eisner, V., Criollo, A., Quiroga, C., Olea-Azar, C., Santibanez, J. F., et al. (2006) Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. FEBS Lett. 580, 4495-4500.
-
(2006)
FEBS Lett.
, vol.580
, pp. 4495-4500
-
-
Eisner, V.1
Criollo, A.2
Quiroga, C.3
Olea-Azar, C.4
Santibanez, J.F.5
-
16
-
-
84862908305
-
Cardiomyocyte death: Mechanisms and translational implications
-
et al
-
Chiong, M., Wang, Z. V., Pedrozo, Z., Cao, D. J., Troncoso, R., et al. (2011) Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis. 2, e244.
-
(2011)
Cell Death Dis.
, vol.2
-
-
Chiong, M.1
Wang, Z.V.2
Pedrozo, Z.3
Cao, D.J.4
Troncoso, R.5
-
17
-
-
15944418974
-
IGF-I is a matter of heart
-
Saetrum Opgaard, O., and, Wang, P. H., (2005) IGF-I is a matter of heart. Growth Horm. IGF Res. 15, 89-94.
-
(2005)
Growth Horm. IGF Res.
, vol.15
, pp. 89-94
-
-
Saetrum Opgaard, O.1
Wang, P.H.2
-
18
-
-
33746840153
-
IGF-I mediated survival pathways in normal and malignant cells
-
Kurmasheva, R. T., and, Houghton, P. J., (2006) IGF-I mediated survival pathways in normal and malignant cells. Biochim. Biophys. Acta 1766, 1-22.
-
(2006)
Biochim. Biophys. Acta
, vol.1766
, pp. 1-22
-
-
Kurmasheva, R.T.1
Houghton, P.J.2
-
19
-
-
0343517544
-
Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes
-
et al
-
Foncea, R., Galvez, A., Perez, V., Morales, M. P., Calixto, A., et al. (2000) Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes. Biochem. Biophys. Res. Commun. 273, 736-744.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 736-744
-
-
Foncea, R.1
Galvez, A.2
Perez, V.3
Morales, M.P.4
Calixto, A.5
-
20
-
-
0036349327
-
IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts
-
et al
-
Maggi, D., Biedi, C., Segat, D., Barbero, D., Panetta, D., et al. (2002) IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts. Biochem. Biophys. Res. Commun. 295, 1085-1089.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.295
, pp. 1085-1089
-
-
Maggi, D.1
Biedi, C.2
Segat, D.3
Barbero, D.4
Panetta, D.5
-
21
-
-
38549112056
-
Caveolin-1 down-regulation inhibits insulin-like growth factor-I receptor signal transduction in H9C2 rat cardiomyoblasts
-
Salani, B., Briatore, L., Garibaldi, S., Cordera, R., and, Maggi, D., (2008) Caveolin-1 down-regulation inhibits insulin-like growth factor-I receptor signal transduction in H9C2 rat cardiomyoblasts. Endocrinology 149, 461-465.
-
(2008)
Endocrinology
, vol.149
, pp. 461-465
-
-
Salani, B.1
Briatore, L.2
Garibaldi, S.3
Cordera, R.4
Maggi, D.5
-
22
-
-
77950597958
-
IGF-1, oxidative stress and atheroprotection
-
Higashi, Y., Sukhanov, S., Anwar, A., Shai, S. Y., and, Delafontaine, P., (2010) IGF-1, oxidative stress and atheroprotection. Trends Endocrinol. Metab. 21, 245-254.
-
(2010)
Trends Endocrinol. Metab.
, vol.21
, pp. 245-254
-
-
Higashi, Y.1
Sukhanov, S.2
Anwar, A.3
Shai, S.Y.4
Delafontaine, P.5
-
23
-
-
33747863220
-
Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells
-
Jia, G., Cheng, G., Gangahar, D. M., and, Agrawal, D. K., (2006) Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol. Cell Biol. 84, 448-454.
-
(2006)
Immunol. Cell Biol.
, vol.84
, pp. 448-454
-
-
Jia, G.1
Cheng, G.2
Gangahar, D.M.3
Agrawal, D.K.4
-
24
-
-
84875892111
-
Autophagy as a stress-response and quality-control mechanism: Implications for cell injury and human disease
-
Murrow, L., and, Debnath, J., (2012) Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu. Rev. Pathol. 8, 105-137.
-
(2012)
Annu. Rev. Pathol.
, vol.8
, pp. 105-137
-
-
Murrow, L.1
Debnath, J.2
-
25
-
-
80052801111
-
Autophagy as a therapeutic target in cardiovascular disease
-
Nemchenko, A., Chiong, M., Turer, A., Lavandero, S., and, Hill, J. A., (2011) Autophagy as a therapeutic target in cardiovascular disease. J. Mol. Cell Cardiol. 51, 584-593.
-
(2011)
J. Mol. Cell Cardiol.
, vol.51
, pp. 584-593
-
-
Nemchenko, A.1
Chiong, M.2
Turer, A.3
Lavandero, S.4
Hill, J.A.5
-
26
-
-
79955052480
-
Tuning flux: Autophagy as a target of heart disease therapy
-
Xie, M., Morales, C. R., Lavandero, S., and, Hill, J. A., (2011) Tuning flux: autophagy as a target of heart disease therapy. Curr. Opin. Cardiol. 26, 216-222.
-
(2011)
Curr. Opin. Cardiol.
, vol.26
, pp. 216-222
-
-
Xie, M.1
Morales, C.R.2
Lavandero, S.3
Hill, J.A.4
-
27
-
-
34249714158
-
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
-
et al
-
Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 13, 619-624.
-
(2007)
Nat. Med.
, vol.13
, pp. 619-624
-
-
Nakai, A.1
Yamaguchi, O.2
Takeda, T.3
Higuchi, Y.4
Hikoso, S.5
-
28
-
-
77955342581
-
Inhibition of autophagy in the heart induces age-related cardiomyopathy
-
et al
-
Taneike, M., Yamaguchi, O., Nakai, A., Hikoso, S., Takeda, T., et al. (2010) Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy 6, 600-606.
-
(2010)
Autophagy
, vol.6
, pp. 600-606
-
-
Taneike, M.1
Yamaguchi, O.2
Nakai, A.3
Hikoso, S.4
Takeda, T.5
-
29
-
-
63349109161
-
Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy
-
et al
-
Maron, B. J., Roberts, W. C., Arad, M., Haas, T. S., Spirito, P., et al. (2009) Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy. JAMA 301, 1253-1259.
-
(2009)
JAMA
, vol.301
, pp. 1253-1259
-
-
Maron, B.J.1
Roberts, W.C.2
Arad, M.3
Haas, T.S.4
Spirito, P.5
-
30
-
-
65649120436
-
Functional significance and morphological characterization of starvation-induced autophagy in the adult heart
-
et al
-
Kanamori, H., Takemura, G., Maruyama, R., Goto, K., Tsujimoto, A., et al. (2009) Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. Am. J. Pathol. 174, 1705-1714.
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 1705-1714
-
-
Kanamori, H.1
Takemura, G.2
Maruyama, R.3
Goto, K.4
Tsujimoto, A.5
-
31
-
-
34147168105
-
Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
-
et al
-
Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., et al. (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 100, 914-922.
-
(2007)
Circ. Res.
, vol.100
, pp. 914-922
-
-
Matsui, Y.1
Takagi, H.2
Qu, X.3
Abdellatif, M.4
Sakoda, H.5
-
32
-
-
79952775153
-
HDAC inhibitors attenuate cardiac hypertrophy by suppressing maladaptive autophagy
-
et al
-
Cao, D. L., Wang, Z. V., Battiprolu, P. K., Jiang, N., Morales, C., et al. (2011) HDAC inhibitors attenuate cardiac hypertrophy by suppressing maladaptive autophagy. Proc. Natl. Acad. Sci. USA 108, 4123-4128.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 4123-4128
-
-
Cao, D.L.1
Wang, Z.V.2
Battiprolu, P.K.3
Jiang, N.4
Morales, C.5
-
33
-
-
77950576949
-
Autophagy in hypertensive heart disease
-
Wang, Z. V., Rothermel, B. A., and, Hill, J. A., (2010) Autophagy in hypertensive heart disease. J. Biol. Chem. 285, 8509-8514.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8509-8514
-
-
Wang, Z.V.1
Rothermel, B.A.2
Hill, J.A.3
-
34
-
-
35848961242
-
Myocyte autophagy in heart disease: Friend or foe?
-
Rothermel, B. A., and, Hill, J. A., (2007) Myocyte autophagy in heart disease: friend or foe? Autophagy 3, 632-634.
-
(2007)
Autophagy
, vol.3
, pp. 632-634
-
-
Rothermel, B.A.1
Hill, J.A.2
-
35
-
-
34447133404
-
Cardiac autophagy is a maladaptive response to hemodynamic stress
-
et al
-
Zhu, H., Tannous, P., Johnstone, J. L., Kong, Y., Shelton, J. M., et al. (2007) Cardiac autophagy is a maladaptive response to hemodynamic stress. J. Clin. Invest. 117, 1782-1793.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1782-1793
-
-
Zhu, H.1
Tannous, P.2
Johnstone, J.L.3
Kong, Y.4
Shelton, J.M.5
-
36
-
-
77958611244
-
Long-term IGF-I exposure decreases autophagy and cell viability
-
et al
-
Bitto, A., Lerner, C., Torres, C., Roell, M., Malaguti, M., et al. (2010) Long-term IGF-I exposure decreases autophagy and cell viability. PLoS One 5, e12592.
-
(2010)
PLoS One
, vol.5
-
-
Bitto, A.1
Lerner, C.2
Torres, C.3
Roell, M.4
Malaguti, M.5
-
37
-
-
8844239959
-
Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis
-
Gu, Y., Wang, C., and, Cohen, A., (2004) Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis. FEBS Lett. 577, 357-360.
-
(2004)
FEBS Lett.
, vol.577
, pp. 357-360
-
-
Gu, Y.1
Wang, C.2
Cohen, A.3
-
38
-
-
57649112017
-
IGF-I, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway
-
Sobolewska, A., Gajewska, M., Zarzynska, J., Gajkowska, B., and, Motyl, T., (2009) IGF-I, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway. Eur. J. Cell Biol. 88, 117-130.
-
(2009)
Eur. J. Cell Biol.
, vol.88
, pp. 117-130
-
-
Sobolewska, A.1
Gajewska, M.2
Zarzynska, J.3
Gajkowska, B.4
Motyl, T.5
-
39
-
-
0346753579
-
Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2
-
Aki, T., Yamaguchi, K., Fujimiya, T., and, Mizukami, Y., (2003) Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 22, 8529-8535.
-
(2003)
Oncogene
, vol.22
, pp. 8529-8535
-
-
Aki, T.1
Yamaguchi, K.2
Fujimiya, T.3
Mizukami, Y.4
-
40
-
-
67749111834
-
Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to-lysosome fusion and degradation
-
Bains, M., Florez-McClure, M. L., and, Heidenreich, K. A., (2009) Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to-lysosome fusion and degradation. J. Biol. Chem. 284, 20398-20407.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20398-20407
-
-
Bains, M.1
Florez-Mcclure, M.L.2
Heidenreich, K.A.3
-
43
-
-
73849101809
-
Key factors in mTOR regulation
-
Bai, X., and, Jiang, Y., (2010) Key factors in mTOR regulation. Cell Mol. Life Sci. 67, 239-253.
-
(2010)
Cell Mol. Life Sci.
, vol.67
, pp. 239-253
-
-
Bai, X.1
Jiang, Y.2
-
44
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante, M., and, Sabatini, D. M., (2012) mTOR signaling in growth control and disease. Cell 149, 274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
45
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
et al
-
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M. A., et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
-
46
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
et al
-
Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177-189.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
-
47
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
et al
-
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., et al. (2007) PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol. Cell 25, 903-915.
-
(2007)
Mol. Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
-
48
-
-
79960470913
-
MTOR complex 2 signaling and functions
-
Oh, W. J., and, Jacinto, E., (2011) mTOR complex 2 signaling and functions. Cell Cycle 10, 2305-2316.
-
(2011)
Cell Cycle
, vol.10
, pp. 2305-2316
-
-
Oh, W.J.1
Jacinto, E.2
-
49
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Li, Y., Zhu, T., Wu, J., and, Guan, K. L., (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
50
-
-
77954310492
-
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
-
Feng, Z., and, Levine, A. J., (2010) The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol. 20, 427-434.
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 427-434
-
-
Feng, Z.1
Levine, A.J.2
-
51
-
-
66449083078
-
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
-
et al
-
Ganley, I. G., Lam du, H., Wang, J., Ding, X., Chen, S., et al. (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem. 284, 12297-12305.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam Du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
-
52
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
et al
-
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., et al. (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
-
53
-
-
77950501014
-
MTOR regulation of autophagy
-
Jung, C. H., Ro, S. H., Cao, J., Otto, N. M., and, Kim, D. H., (2010) mTOR regulation of autophagy. FEBS Lett. 584, 1287-1295.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1287-1295
-
-
Jung, C.H.1
Ro, S.H.2
Cao, J.3
Otto, N.M.4
Kim, D.H.5
-
54
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
et al
-
Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., et al. (2012) A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 31, 1095-1108.
-
(2012)
EMBO J.
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
Zoncu, R.2
Medina, D.L.3
Vetrini, F.4
Erdin, S.5
-
55
-
-
33845924783
-
AMP-activated protein kinase and the regulation of autophagic proteolysis
-
et al
-
Meley, D., Bauvy, C., Houben-Weerts, J. H., Dubbelhuis, P. F., Helmond, M. T., et al. (2006) AMP-activated protein kinase and the regulation of autophagic proteolysis. J. Biol. Chem. 281, 34870-34879.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 34870-34879
-
-
Meley, D.1
Bauvy, C.2
Houben-Weerts, J.H.3
Dubbelhuis, P.F.4
Helmond, M.T.5
-
56
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova, M. M., and, Shaw, R. J., (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell Biol. 13, 1016-1023.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
57
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., Zhu, T., and, Guan, K. L., (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
58
-
-
63849149937
-
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
-
Shaw, R. J., (2009) LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol. (Oxf) 196, 65-80.
-
(2009)
Acta Physiol. (Oxf)
, vol.196
, pp. 65-80
-
-
Shaw, R.J.1
-
59
-
-
67650914230
-
AMPK in health and disease
-
Steinberg, G. R., and, Kemp, B. E., (2009) AMPK in health and disease. Physiol. Rev. 89, 1025-1078.
-
(2009)
Physiol. Rev.
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
60
-
-
79951807242
-
AMPK and autophagy get connected
-
Hardie, D. G., (2011) AMPK and autophagy get connected. EMBO J. 30, 634-635.
-
(2011)
EMBO J.
, vol.30
, pp. 634-635
-
-
Hardie, D.G.1
-
61
-
-
78149476877
-
The association of AMPK with ULK1 regulates autophagy
-
Lee, J. W., Park, S., Takahashi, Y., and, Wang, H. G., (2010) The association of AMPK with ULK1 regulates autophagy. PLoS One 5, e15394.
-
(2010)
PLoS One
, vol.5
-
-
Lee, J.W.1
Park, S.2
Takahashi, Y.3
Wang, H.G.4
-
62
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
et al
-
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
-
63
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
et al
-
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., et al. (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331, 456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
-
64
-
-
42749094854
-
Insulin signaling pathways and cardiac growth
-
DeBosch, B. J., and, Muslin, A. J., (2008) Insulin signaling pathways and cardiac growth. J. Mol. Cell Cardiol. 44, 855-864.
-
(2008)
J. Mol. Cell Cardiol.
, vol.44
, pp. 855-864
-
-
Debosch, B.J.1
Muslin, A.J.2
-
65
-
-
83455238338
-
Optimization of cardiac metabolism in heart failure
-
Nagoshi, T., Yoshimura, M., Rosano, G. M., Lopaschuk, G. D., and, Mochizuki, S., (2011) Optimization of cardiac metabolism in heart failure. Curr. Pharm. Des. 17, 3846-3853.
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 3846-3853
-
-
Nagoshi, T.1
Yoshimura, M.2
Rosano, G.M.3
Lopaschuk, G.D.4
Mochizuki, S.5
-
66
-
-
79953742344
-
Akt2: A critical regulator of cardiomyocyte survival and metabolism
-
Muslin, A. J., (2011) Akt2: a critical regulator of cardiomyocyte survival and metabolism. Pediatr. Cardiol. 32, 317-322.
-
(2011)
Pediatr. Cardiol.
, vol.32
, pp. 317-322
-
-
Muslin, A.J.1
-
67
-
-
0030693249
-
Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting
-
et al
-
Bailyes, E. M., Nave, B. T., Soos, M. A., Orr, S. R., Hayward, A. C., et al. (1997) Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem. J. 327, 209-215.
-
(1997)
Biochem. J.
, vol.327
, pp. 209-215
-
-
Bailyes, E.M.1
Nave, B.T.2
Soos, M.A.3
Orr, S.R.4
Hayward, A.C.5
-
68
-
-
33748744723
-
Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor i receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
-
et al
-
Slaaby, R., Schaffer, L., Lautrup-Larsen, I., Andersen, A. S., Shaw, A. C., et al. (2006) Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J. Biol. Chem. 281, 25869-25874.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25869-25874
-
-
Slaaby, R.1
Schaffer, L.2
Lautrup-Larsen, I.3
Andersen, A.S.4
Shaw, A.C.5
-
69
-
-
0027502045
-
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
-
Soos, M. A., Field, C. E., and, Siddle, K., (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290, 419-426.
-
(1993)
Biochem. J.
, vol.290
, pp. 419-426
-
-
Soos, M.A.1
Field, C.E.2
Siddle, K.3
-
70
-
-
84857595431
-
Heart smart insulin-like growth factor 1
-
Marsh, S. A., and, Davidoff, A. J., (2012) Heart smart insulin-like growth factor 1. Hypertension 59, 550-551.
-
(2012)
Hypertension
, vol.59
, pp. 550-551
-
-
Marsh, S.A.1
Davidoff, A.J.2
-
71
-
-
84868454231
-
Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling
-
et al
-
Tang, M. S., Redfors, B., Lindbom, M., Svensson, J., Ramunddal, T., et al. (2012) Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling. Growth Horm. IGF Res. 22, 206-211.
-
(2012)
Growth Horm. IGF Res.
, vol.22
, pp. 206-211
-
-
Tang, M.S.1
Redfors, B.2
Lindbom, M.3
Svensson, J.4
Ramunddal, T.5
-
72
-
-
84863115697
-
Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: Role of insulin signaling and mitochondrial function
-
et al
-
Zhang, Y., Yuan, M., Bradley, K. M., Dong, F., Anversa, P., et al. (2012) Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function. Hypertension 59, 680-693.
-
(2012)
Hypertension
, vol.59
, pp. 680-693
-
-
Zhang, Y.1
Yuan, M.2
Bradley, K.M.3
Dong, F.4
Anversa, P.5
|