Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 25, 2013, Pages 10159-10164

  Liu, C Tony ^a   Hanoian, Philip ^a   French, Jarrod B ^a   Pringle, Thomas H ^b   Hammes Schiffer, Sharon ^c   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Sperling Foundation   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

EVB; Phylogenetic

Indexed keywords

DIHYDROFOLATE REDUCTASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; GENE MUTATION; GENETIC VARIABILITY; HUMAN; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION;

EVB; PHYLOGENETIC;

AMINO ACID SEQUENCE; ANIMALS; ENZYME ACTIVATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; FISHES; HUMANS; MAMMALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHYLOGENY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEA URCHINS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; UROCHORDATA;

ESCHERICHIA COLI; MYA;

EID: 84879301337     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307130110     Document Type: Article

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