메뉴 건너뛰기




Volumn 82, Issue 3, 2014, Pages 300-309

Intrathecal immune reset in multiple sclerosis: Exploring a new concept

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES, MONOCLONAL; HUMANS; INJECTIONS, SPINAL; MULTIPLE SCLEROSIS; PROGNOSIS;

EID: 84893971675     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2013.12.015     Document Type: Article
Times cited : (7)

References (156)
  • 1
    • 53049098427 scopus 로고    scopus 로고
    • Compartmentalization of inflammation in the CNS: a major mechanism driving progressive multiple sclerosis
    • Meinl E., Krumbholz M., Derfuss T., Junker A., Hohlfeld R. Compartmentalization of inflammation in the CNS: a major mechanism driving progressive multiple sclerosis. J Neurol Sci 2008, 274:42-44.
    • (2008) J Neurol Sci , vol.274 , pp. 42-44
    • Meinl, E.1    Krumbholz, M.2    Derfuss, T.3    Junker, A.4    Hohlfeld, R.5
  • 2
    • 84868023178 scopus 로고    scopus 로고
    • Setting a research agenda for progressive multiple sclerosis: the international collaborative on progressive MS
    • Fox R.J., Thompson A., Baker D., et al. Setting a research agenda for progressive multiple sclerosis: the international collaborative on progressive MS. Multiple Scler 2012, 18:1534-1540.
    • (2012) Multiple Scler , vol.18 , pp. 1534-1540
    • Fox, R.J.1    Thompson, A.2    Baker, D.3
  • 3
    • 77953335345 scopus 로고    scopus 로고
    • Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes
    • De Stefano N., Giorgio A., Battaglini M., et al. Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes. Neurology 2010, 74:1868-1876.
    • (2010) Neurology , vol.74 , pp. 1868-1876
    • De Stefano, N.1    Giorgio, A.2    Battaglini, M.3
  • 4
    • 0036791829 scopus 로고    scopus 로고
    • Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype
    • Kalkers N.F., Ameziane N., Bot J.C., Minneboo A., Polman C.H., Barkhof F. Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype. Arch Neurol 2002, 59:1572-1576.
    • (2002) Arch Neurol , vol.59 , pp. 1572-1576
    • Kalkers, N.F.1    Ameziane, N.2    Bot, J.C.3    Minneboo, A.4    Polman, C.H.5    Barkhof, F.6
  • 5
    • 84869507357 scopus 로고    scopus 로고
    • Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial
    • Coles A.J., Twyman C.L., Arnold D.L., et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 2012, 380:1829-1839.
    • (2012) Lancet , vol.380 , pp. 1829-1839
    • Coles, A.J.1    Twyman, C.L.2    Arnold, D.L.3
  • 6
    • 1642482932 scopus 로고    scopus 로고
    • Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation
    • Inglese M., Mancardi G.L., Pagani E., et al. Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J Neurol Neurosurg Psychiatry 2004, 75:643-644.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 643-644
    • Inglese, M.1    Mancardi, G.L.2    Pagani, E.3
  • 7
    • 0141816715 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis
    • Nash R.A., Bowen J.D., McSweeney P.A., et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood 2003, 102:2364-2372.
    • (2003) Blood , vol.102 , pp. 2364-2372
    • Nash, R.A.1    Bowen, J.D.2    McSweeney, P.A.3
  • 8
    • 35349012123 scopus 로고    scopus 로고
    • A three-year study of brain atrophy after autologous hematopoietic stem cell transplantation in rapidly evolving secondary progressive multiple sclerosis
    • Rocca M.A., Mondria T., Valsasina P., et al. A three-year study of brain atrophy after autologous hematopoietic stem cell transplantation in rapidly evolving secondary progressive multiple sclerosis. AJNR Am J Neuroradiol 2007, 28:1659-1661.
    • (2007) AJNR Am J Neuroradiol , vol.28 , pp. 1659-1661
    • Rocca, M.A.1    Mondria, T.2    Valsasina, P.3
  • 9
    • 83155173565 scopus 로고    scopus 로고
    • Inflammatory cortical demyelination in early multiple sclerosis
    • Lucchinetti C.F., Popescu B.F., Bunyan R.F., et al. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med 2011, 365:2188-2197.
    • (2011) N Engl J Med , vol.365 , pp. 2188-2197
    • Lucchinetti, C.F.1    Popescu, B.F.2    Bunyan, R.F.3
  • 11
    • 84859100978 scopus 로고    scopus 로고
    • Meningeal and cortical grey matter pathology in multiple sclerosis
    • Popescu B.F., Lucchinetti C.F. Meningeal and cortical grey matter pathology in multiple sclerosis. BMC Neurol 2012, 12:11.
    • (2012) BMC Neurol , vol.12 , pp. 11
    • Popescu, B.F.1    Lucchinetti, C.F.2
  • 12
    • 79955582720 scopus 로고    scopus 로고
    • Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications
    • Stadelmann C. Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications. Curr Opin Neurol 2011, 24:224-229.
    • (2011) Curr Opin Neurol , vol.24 , pp. 224-229
    • Stadelmann, C.1
  • 13
    • 54849442682 scopus 로고    scopus 로고
    • Is progressive multiple sclerosis a gray matter disease?
    • Geurts J.J. Is progressive multiple sclerosis a gray matter disease?. Ann Neurol 2008, 64:230-232.
    • (2008) Ann Neurol , vol.64 , pp. 230-232
    • Geurts, J.J.1
  • 15
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • Peterson J.W., Bo L., Mork S., Chang A., Trapp B.D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001, 50:389-400.
    • (2001) Ann Neurol , vol.50 , pp. 389-400
    • Peterson, J.W.1    Bo, L.2    Mork, S.3    Chang, A.4    Trapp, B.D.5
  • 16
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • Kutzelnigg A., Lucchinetti C.F., Stadelmann C., et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 2005, 128:2705-2712.
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3
  • 17
    • 33847227721 scopus 로고    scopus 로고
    • Widespread demyelination in the cerebellar cortex in multiple sclerosis
    • Kutzelnigg A., Faber-Rod J.C., Bauer J., et al. Widespread demyelination in the cerebellar cortex in multiple sclerosis. Brain Pathol 2007, 17:38-44.
    • (2007) Brain Pathol , vol.17 , pp. 38-44
    • Kutzelnigg, A.1    Faber-Rod, J.C.2    Bauer, J.3
  • 18
    • 34548441088 scopus 로고    scopus 로고
    • Extensive hippocampal demyelination in multiple sclerosis
    • Geurts J.J., Bo L., Roosendaal S.D., et al. Extensive hippocampal demyelination in multiple sclerosis. J Neuropathol Exp Neurol 2007, 66:819-827.
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 819-827
    • Geurts, J.J.1    Bo, L.2    Roosendaal, S.D.3
  • 20
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R., Howell O., Vora A., et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3
  • 21
    • 80052927697 scopus 로고    scopus 로고
    • Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
    • Howell O.W., Reeves C.A., Nicholas R., et al. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 2011, 134:2755-2771.
    • (2011) Brain , vol.134 , pp. 2755-2771
    • Howell, O.W.1    Reeves, C.A.2    Nicholas, R.3
  • 22
    • 79959696274 scopus 로고    scopus 로고
    • Regionally distinct white matter lesions do not contribute to regional gray matter atrophy in patients with multiple sclerosis
    • Antulov R., Carone D.A., Bruce J., et al. Regionally distinct white matter lesions do not contribute to regional gray matter atrophy in patients with multiple sclerosis. J Neuroimaging 2011, 21:210-218.
    • (2011) J Neuroimaging , vol.21 , pp. 210-218
    • Antulov, R.1    Carone, D.A.2    Bruce, J.3
  • 23
    • 33846093882 scopus 로고    scopus 로고
    • Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    • Bo L., Geurts J.J., van der Valk P., Polman C., Barkhof F. Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol 2007, 64:76-80.
    • (2007) Arch Neurol , vol.64 , pp. 76-80
    • Bo, L.1    Geurts, J.J.2    van der Valk, P.3    Polman, C.4    Barkhof, F.5
  • 24
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch A., Schuchardt J., Bunkowski S., Kuhlmann T., Brück W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 2000, 123(Pt. 6):1174-1183.
    • (2000) Brain , vol.123 , Issue.PART 6 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Brück, W.5
  • 25
    • 84867712909 scopus 로고    scopus 로고
    • Cortical lesion load associates with progression of disability in multiple sclerosis
    • Calabrese M., Poretto V., Favaretto A., et al. Cortical lesion load associates with progression of disability in multiple sclerosis. Brain 2012, 135:2952-2961.
    • (2012) Brain , vol.135 , pp. 2952-2961
    • Calabrese, M.1    Poretto, V.2    Favaretto, A.3
  • 26
    • 54849431592 scopus 로고    scopus 로고
    • Gray matter atrophy is related to long-term disability in multiple sclerosis
    • Fisniku L.K., Chard D.T., Jackson J.S., et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol 2008, 64:247-254.
    • (2008) Ann Neurol , vol.64 , pp. 247-254
    • Fisniku, L.K.1    Chard, D.T.2    Jackson, J.S.3
  • 27
    • 0037426402 scopus 로고    scopus 로고
    • Evidence of early cortical atrophy in MS: relevance to white matter changes and disability
    • De Stefano N., Matthews P.M., Filippi M., et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 2003, 60:1157-1162.
    • (2003) Neurology , vol.60 , pp. 1157-1162
    • De Stefano, N.1    Matthews, P.M.2    Filippi, M.3
  • 28
    • 78650520038 scopus 로고    scopus 로고
    • Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy
    • Giorgio A., De Stefano N. Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy. Neurol Sci 2010, 31:S245-S248.
    • (2010) Neurol Sci , vol.31
    • Giorgio, A.1    De Stefano, N.2
  • 29
    • 67349197281 scopus 로고    scopus 로고
    • CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis
    • Villar L.M., Masterman T., Casanova B., et al. CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis. J Neuroimmunol 2009, 211:101-104.
    • (2009) J Neuroimmunol , vol.211 , pp. 101-104
    • Villar, L.M.1    Masterman, T.2    Casanova, B.3
  • 30
    • 0022656998 scopus 로고
    • Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis
    • Walsh M.J., Tourtellotte W.W. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J Exp Med 1986, 163:41-53.
    • (1986) J Exp Med , vol.163 , pp. 41-53
    • Walsh, M.J.1    Tourtellotte, W.W.2
  • 31
    • 83555179119 scopus 로고    scopus 로고
    • Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time
    • Yu X., Burgoon M., Green M., et al. Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time. J Neuroimmunol 2011, 240-241:129-136.
    • (2011) J Neuroimmunol , pp. 129-136
    • Yu, X.1    Burgoon, M.2    Green, M.3
  • 32
    • 0346121471 scopus 로고    scopus 로고
    • Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients
    • Colombo M., Dono M., Gazzola P., Chiorazzi N., Mancardi G., Ferrarini M. Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients. Eur J Immunol 2003, 33:3433-3438.
    • (2003) Eur J Immunol , vol.33 , pp. 3433-3438
    • Colombo, M.1    Dono, M.2    Gazzola, P.3    Chiorazzi, N.4    Mancardi, G.5    Ferrarini, M.6
  • 33
    • 0042429215 scopus 로고    scopus 로고
    • Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid
    • Owens G.P., Ritchie A.M., Burgoon M.P., Williamson R.A., Corboy J.R., Gilden D.H. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J Immunol 2003, 171:2725-2733.
    • (2003) J Immunol , vol.171 , pp. 2725-2733
    • Owens, G.P.1    Ritchie, A.M.2    Burgoon, M.P.3    Williamson, R.A.4    Corboy, J.R.5    Gilden, D.H.6
  • 35
    • 0031663125 scopus 로고    scopus 로고
    • The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis
    • Reiber H., Ungefehr S., Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Multiple Scler 1998, 4:111-117.
    • (1998) Multiple Scler , vol.4 , pp. 111-117
    • Reiber, H.1    Ungefehr, S.2    Jacobi, C.3
  • 36
    • 0034961389 scopus 로고    scopus 로고
    • Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response
    • Derfuss T., Gurkov R., Then Bergh F., et al. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 2001, 124:1325-1335.
    • (2001) Brain , vol.124 , pp. 1325-1335
    • Derfuss, T.1    Gurkov, R.2    Then Bergh, F.3
  • 37
    • 0023024901 scopus 로고
    • Oligoclonal "fingerprint" of CSF IgG in multiple sclerosis patients is not modified following intrathecal administration of natural beta-interferon
    • Confavreux C., Chapuis-Cellier C., Arnaud P., Robert O., Aimard G., Devic M. Oligoclonal "fingerprint" of CSF IgG in multiple sclerosis patients is not modified following intrathecal administration of natural beta-interferon. J Neurol Neurosurg Psychiatry 1986, 49:1308-1312.
    • (1986) J Neurol Neurosurg Psychiatry , vol.49 , pp. 1308-1312
    • Confavreux, C.1    Chapuis-Cellier, C.2    Arnaud, P.3    Robert, O.4    Aimard, G.5    Devic, M.6
  • 38
    • 0024253837 scopus 로고
    • The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching
    • Tourtellotte W.W., Baumhefner R.W., Syndulko K., et al. The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching. J Neuroimmunol 1988, 20:217-227.
    • (1988) J Neuroimmunol , vol.20 , pp. 217-227
    • Tourtellotte, W.W.1    Baumhefner, R.W.2    Syndulko, K.3
  • 39
    • 0018953704 scopus 로고
    • Prolonged effects of large-dose methylprednisolone infusion in multiple sclerosis
    • Trotter J.L., Garvey W.F. Prolonged effects of large-dose methylprednisolone infusion in multiple sclerosis. Neurology 1980, 30:702-708.
    • (1980) Neurology , vol.30 , pp. 702-708
    • Trotter, J.L.1    Garvey, W.F.2
  • 40
    • 0019209039 scopus 로고
    • Multiple sclerosis de novo CNS IgG synthesis: effect of ACTH and corticosteroids
    • Tourtellotte W.W., Baumhefner R.W., Potvin A.R., et al. Multiple sclerosis de novo CNS IgG synthesis: effect of ACTH and corticosteroids. Neurology 1980, 30:1155-1162.
    • (1980) Neurology , vol.30 , pp. 1155-1162
    • Tourtellotte, W.W.1    Baumhefner, R.W.2    Potvin, A.R.3
  • 41
    • 0032943375 scopus 로고    scopus 로고
    • Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The multiple sclerosis collaborative research group
    • Rudick R.A., Cookfair D.L., Simonian N.A., et al. Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The multiple sclerosis collaborative research group. J Neuroimmunol 1999, 93:8-14.
    • (1999) J Neuroimmunol , vol.93 , pp. 8-14
    • Rudick, R.A.1    Cookfair, D.L.2    Simonian, N.A.3
  • 43
    • 60549116884 scopus 로고    scopus 로고
    • Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis
    • Stüve O., Leussink V.I., Fröhlich R., et al. Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis. Arch Neurol 2009, 66:259-261.
    • (2009) Arch Neurol , vol.66 , pp. 259-261
    • Stüve, O.1    Leussink, V.I.2    Fröhlich, R.3
  • 44
    • 43149122203 scopus 로고    scopus 로고
    • Rituximab in a patient with multiple sclerosis - effect on B cells, plasma cells and intrathecal IgG synthesis
    • Petereit H.F., Moeller-Hartmann W., Reske D., Rubbert A. Rituximab in a patient with multiple sclerosis - effect on B cells, plasma cells and intrathecal IgG synthesis. Acta Neurol Scand 2008, 117:399-403.
    • (2008) Acta Neurol Scand , vol.117 , pp. 399-403
    • Petereit, H.F.1    Moeller-Hartmann, W.2    Reske, D.3    Rubbert, A.4
  • 45
    • 77953341196 scopus 로고    scopus 로고
    • Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis
    • Piccio L., Naismith R.T., Trinkaus K., et al. Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis. Arch Neurol 2010, 67:707-714.
    • (2010) Arch Neurol , vol.67 , pp. 707-714
    • Piccio, L.1    Naismith, R.T.2    Trinkaus, K.3
  • 46
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • Cross A.H., Stark J.L., Lauber J., Ramsbottom M.J., Lyons J.-A. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 2006, 180:63-70.
    • (2006) J Neuroimmunol , vol.180 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.-A.5
  • 47
    • 84864558396 scopus 로고    scopus 로고
    • Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis
    • p. 145ra106
    • Perry J.S., Han S., Xu Q., et al. Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis. Sci Transl Med 2012, 4. p. 145ra106.
    • (2012) Sci Transl Med , vol.4
    • Perry, J.S.1    Han, S.2    Xu, Q.3
  • 48
    • 41549098712 scopus 로고    scopus 로고
    • Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    • Tintore M., Rovira A., Rio J., et al. Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?. Neurology 2008, 70:1079-1083.
    • (2008) Neurology , vol.70 , pp. 1079-1083
    • Tintore, M.1    Rovira, A.2    Rio, J.3
  • 49
    • 33645010750 scopus 로고    scopus 로고
    • Clinically isolated syndromes: a new oligoclonal band test accurately predicts conversion to MS
    • Masjuan J., Alvarez-Cermeno J.C., Garcia-Barragan N., et al. Clinically isolated syndromes: a new oligoclonal band test accurately predicts conversion to MS. Neurology 2006, 66:576-578.
    • (2006) Neurology , vol.66 , pp. 576-578
    • Masjuan, J.1    Alvarez-Cermeno, J.C.2    Garcia-Barragan, N.3
  • 50
    • 77956343443 scopus 로고    scopus 로고
    • The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands
    • Boscá I., Magraner M.J., Coret F., et al. The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands. J Neuroimmunol 2010, 226:143-146.
    • (2010) J Neuroimmunol , vol.226 , pp. 143-146
    • Boscá, I.1    Magraner, M.J.2    Coret, F.3
  • 51
    • 0022356225 scopus 로고
    • Synthèse intrathécale des anticorps viraux au cours des encéphalits virales
    • Puel J., Gayet C., Averous S., Brochier B. Synthèse intrathécale des anticorps viraux au cours des encéphalits virales. Méd Mal Infect 1982, 10:616-619.
    • (1982) Méd Mal Infect , vol.10 , pp. 616-619
    • Puel, J.1    Gayet, C.2    Averous, S.3    Brochier, B.4
  • 52
    • 85047691237 scopus 로고    scopus 로고
    • Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
    • Villar L.M., Sadaba M.C., Roldan E., et al. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J Clin Invest 2005, 115:187-194.
    • (2005) J Clin Invest , vol.115 , pp. 187-194
    • Villar, L.M.1    Sadaba, M.C.2    Roldan, E.3
  • 53
    • 0002348524 scopus 로고    scopus 로고
    • Acute optic neuritis: combined immunological markers and magnetic resonance imaging predict subsequent development of multiple sclerosis. The optic neuritis study group
    • Tumani H., Tourtellotte W.W., Peter J.B., Felgenhauer K. Acute optic neuritis: combined immunological markers and magnetic resonance imaging predict subsequent development of multiple sclerosis. The optic neuritis study group. J Neurol Sci 1998, 155:44-49.
    • (1998) J Neurol Sci , vol.155 , pp. 44-49
    • Tumani, H.1    Tourtellotte, W.W.2    Peter, J.B.3    Felgenhauer, K.4
  • 54
    • 0035196870 scopus 로고    scopus 로고
    • Oligoclonal band number as a marker for prognosis in multiple sclerosis
    • Avasarala J.R., Cross A.H., Trotter J.L. Oligoclonal band number as a marker for prognosis in multiple sclerosis. Arch Neurol 2001, 58:2044-2045.
    • (2001) Arch Neurol , vol.58 , pp. 2044-2045
    • Avasarala, J.R.1    Cross, A.H.2    Trotter, J.L.3
  • 55
    • 84860436777 scopus 로고    scopus 로고
    • Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual
    • Durante L., Zaaraoui W., Rico A., et al. Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual. Multiple Scler 2012, 18:587-591.
    • (2012) Multiple Scler , vol.18 , pp. 587-591
    • Durante, L.1    Zaaraoui, W.2    Rico, A.3
  • 56
    • 33746301710 scopus 로고    scopus 로고
    • Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis
    • Perini P., Ranzato F., Calabrese M., Battistin L., Gallo P. Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis. J Neurol Neurosurg Psychiatry 2006, 77:953-955.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 953-955
    • Perini, P.1    Ranzato, F.2    Calabrese, M.3    Battistin, L.4    Gallo, P.5
  • 57
    • 0037066132 scopus 로고    scopus 로고
    • Intrathecal IgM synthesis in neurologic diseases: relationship with disability in MS
    • Villar L.M., Masjuan J., Gonzalez-Porque P., et al. Intrathecal IgM synthesis in neurologic diseases: relationship with disability in MS. Neurology 2002, 58:824-826.
    • (2002) Neurology , vol.58 , pp. 824-826
    • Villar, L.M.1    Masjuan, J.2    Gonzalez-Porque, P.3
  • 58
    • 0035803835 scopus 로고    scopus 로고
    • Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis
    • Greve B., Magnusson C.G., Melms A., Weissert R. Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis. J Neuroimmunol 2001, 121:120-125.
    • (2001) J Neuroimmunol , vol.121 , pp. 120-125
    • Greve, B.1    Magnusson, C.G.2    Melms, A.3    Weissert, R.4
  • 59
    • 33749830743 scopus 로고    scopus 로고
    • Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis
    • Rinker J.R., Trinkaus K., Cross A.H. Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis. Neurology 2006, 67:1288-1290.
    • (2006) Neurology , vol.67 , pp. 1288-1290
    • Rinker, J.R.1    Trinkaus, K.2    Cross, A.H.3
  • 60
    • 0037310781 scopus 로고    scopus 로고
    • Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
    • Villar L.M., Masjuan J., González-Porqué P., et al. Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis. Ann Neurol 2003, 53:222-226.
    • (2003) Ann Neurol , vol.53 , pp. 222-226
    • Villar, L.M.1    Masjuan, J.2    González-Porqué, P.3
  • 61
  • 62
    • 77955033531 scopus 로고    scopus 로고
    • Response to interferon in multiple sclerosis is related to lipid-specific oligoclonal IgM bands
    • Bosca I., Villar L.M., Coret F., et al. Response to interferon in multiple sclerosis is related to lipid-specific oligoclonal IgM bands. Multiple Scler (Houndmills, Basingstoke, England) 2010, 16:810-815.
    • (2010) Multiple Scler (Houndmills, Basingstoke, England) , vol.16 , pp. 810-815
    • Bosca, I.1    Villar, L.M.2    Coret, F.3
  • 63
    • 59249107126 scopus 로고    scopus 로고
    • Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis
    • Thangarajh M., Gomez-Rial J., Hedstrom A.K., et al. Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis. Multiple Scler 2008, 14:1208-1213.
    • (2008) Multiple Scler , vol.14 , pp. 1208-1213
    • Thangarajh, M.1    Gomez-Rial, J.2    Hedstrom, A.K.3
  • 64
    • 84860838574 scopus 로고    scopus 로고
    • Neuronal antigens recognized by cerebrospinal fluid IgM in multiple sclerosis
    • Beltrán E., Hernández A., Lafuente E.M., et al. Neuronal antigens recognized by cerebrospinal fluid IgM in multiple sclerosis. J Neuroimmunol 2012, 247:63-69.
    • (2012) J Neuroimmunol , vol.247 , pp. 63-69
    • Beltrán, E.1    Hernández, A.2    Lafuente, E.M.3
  • 65
    • 84857060090 scopus 로고    scopus 로고
    • Brain atrophy and lesion load are related to CSF lipid-specific IgM oligoclonal bands in clinically isolated syndromes
    • Magraner M.J., Bosca I., Simó-Castelló M., et al. Brain atrophy and lesion load are related to CSF lipid-specific IgM oligoclonal bands in clinically isolated syndromes. Neuroradiology 2012, 54:5-12.
    • (2012) Neuroradiology , vol.54 , pp. 5-12
    • Magraner, M.J.1    Bosca, I.2    Simó-Castelló, M.3
  • 67
    • 0024420910 scopus 로고
    • Intrathecal synthesis of IgG, IgA, IgM and IgD in untreated multiple sclerosis and controls
    • Lolli F., Halawa I., Link H. Intrathecal synthesis of IgG, IgA, IgM and IgD in untreated multiple sclerosis and controls. Acta Neurol Scand 1989, 80:238-247.
    • (1989) Acta Neurol Scand , vol.80 , pp. 238-247
    • Lolli, F.1    Halawa, I.2    Link, H.3
  • 68
    • 0842265938 scopus 로고    scopus 로고
    • Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis
    • Goffette S., Schluep M., Henry H., Duprez T., Sindic C.J. Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis. J Neurol Neurosurg Psychiatry 2004, 75:308-310.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 308-310
    • Goffette, S.1    Schluep, M.2    Henry, H.3    Duprez, T.4    Sindic, C.J.5
  • 69
    • 0042809490 scopus 로고    scopus 로고
    • Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis
    • Qin Y., Duquette P., Zhang Y., et al. Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Lab Invest 2003, 83:1081-1088.
    • (2003) Lab Invest , vol.83 , pp. 1081-1088
    • Qin, Y.1    Duquette, P.2    Zhang, Y.3
  • 70
    • 33846846443 scopus 로고    scopus 로고
    • Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection
    • Harp C., Lee J., Lambracht-Washington D., et al. Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. J Neuroimmunol 2007, 183:189-199.
    • (2007) J Neuroimmunol , vol.183 , pp. 189-199
    • Harp, C.1    Lee, J.2    Lambracht-Washington, D.3
  • 71
    • 61449241679 scopus 로고    scopus 로고
    • The prognostic significance of cerebrospinal fluid in multiple sclerosis
    • Siritho S., Freedman M.S. The prognostic significance of cerebrospinal fluid in multiple sclerosis. J Neurol Sci 2009, 279:21-25.
    • (2009) J Neurol Sci , vol.279 , pp. 21-25
    • Siritho, S.1    Freedman, M.S.2
  • 72
  • 73
    • 84867915470 scopus 로고    scopus 로고
    • Oligoclonal bands in multiple sclerosis patients: worse prognosis?
    • Rojas J.I., Tizio S., Patrucco L., Cristiano E. Oligoclonal bands in multiple sclerosis patients: worse prognosis?. Neurol Res 2012, 34:889-892.
    • (2012) Neurol Res , vol.34 , pp. 889-892
    • Rojas, J.I.1    Tizio, S.2    Patrucco, L.3    Cristiano, E.4
  • 74
    • 84863196420 scopus 로고    scopus 로고
    • The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude
    • Lechner-Scott J., Spencer B., de Malmanche T., et al. The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude. Multiple Scler 2012, 18:974-982.
    • (2012) Multiple Scler , vol.18 , pp. 974-982
    • Lechner-Scott, J.1    Spencer, B.2    de Malmanche, T.3
  • 75
    • 33646105852 scopus 로고    scopus 로고
    • Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-beta
    • Annunziata P., Giorgio A., De Santi L., et al. Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-beta. J Neurol Sci 2006, 244:97-102.
    • (2006) J Neurol Sci , vol.244 , pp. 97-102
    • Annunziata, P.1    Giorgio, A.2    De Santi, L.3
  • 77
    • 84861556651 scopus 로고    scopus 로고
    • Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis
    • Elliott C., Lindner M., Arthur A., et al. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 2012, 135:1819-1833.
    • (2012) Brain , vol.135 , pp. 1819-1833
    • Elliott, C.1    Lindner, M.2    Arthur, A.3
  • 78
    • 39049163500 scopus 로고    scopus 로고
    • Homogeneity of active demyelinating lesions in established multiple sclerosis
    • Breij E.C.W., Brink B.P., Veerhuis R., et al. Homogeneity of active demyelinating lesions in established multiple sclerosis. Ann Neurol 2008, 63:16-25.
    • (2008) Ann Neurol , vol.63 , pp. 16-25
    • Breij, E.C.W.1    Brink, B.P.2    Veerhuis, R.3
  • 79
    • 24344433564 scopus 로고    scopus 로고
    • Clonal expansion of IgA-positive plasma cells and axon-reactive antibodies in MS lesions
    • Zhang Y., Da R.-R., Hilgenberg L.G., et al. Clonal expansion of IgA-positive plasma cells and axon-reactive antibodies in MS lesions. J Neuroimmunol 2005, 167:120-130.
    • (2005) J Neuroimmunol , vol.167 , pp. 120-130
    • Zhang, Y.1    Da, R.-R.2    Hilgenberg, L.G.3
  • 80
    • 84860840104 scopus 로고    scopus 로고
    • Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions
    • Sadaba M.C., Tzartos J., Paino C., et al. Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions. J Neuroimmunol 2012, 247:86-94.
    • (2012) J Neuroimmunol , vol.247 , pp. 86-94
    • Sadaba, M.C.1    Tzartos, J.2    Paino, C.3
  • 81
    • 33847180757 scopus 로고    scopus 로고
    • Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis
    • Zhou D., Srivastava R., Nessler S., et al. Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proc Natl Acad Sci USA 2006, 103:19057-19062.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19057-19062
    • Zhou, D.1    Srivastava, R.2    Nessler, S.3
  • 82
    • 50549098924 scopus 로고    scopus 로고
    • Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies
    • von Budingen H.C., Harrer M.D., Kuenzle S., Meier M., Goebels N. Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. Eur J Immunol 2008, 38:2014-2023.
    • (2008) Eur J Immunol , vol.38 , pp. 2014-2023
    • von Budingen, H.C.1    Harrer, M.D.2    Kuenzle, S.3    Meier, M.4    Goebels, N.5
  • 83
    • 21244477130 scopus 로고    scopus 로고
    • Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis
    • Zhang Y., Da R.-R., Guo W., et al. Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis. J Clin Immunol 2005, 25:254-264.
    • (2005) J Clin Immunol , vol.25 , pp. 254-264
    • Zhang, Y.1    Da, R.-R.2    Guo, W.3
  • 84
    • 84871006600 scopus 로고    scopus 로고
    • Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis
    • Pandey S., Alcaro M.C., Scrima M., et al. Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. J Med Chem 2012, 55:10437-10447.
    • (2012) J Med Chem , vol.55 , pp. 10437-10447
    • Pandey, S.1    Alcaro, M.C.2    Scrima, M.3
  • 85
    • 0023552803 scopus 로고
    • Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)
    • Linington C., Lassmann H. Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG). J Neuroimmunol 1987, 17:61-69.
    • (1987) J Neuroimmunol , vol.17 , pp. 61-69
    • Linington, C.1    Lassmann, H.2
  • 86
    • 1042267969 scopus 로고    scopus 로고
    • Antibody-mediated CNS demyelination II. Focal spinal cord lesions induced by implantation of an IgM antisulfatide-secreting hybridoma
    • Rosenbluth J., Schiff R., Liang W.-L., Dou W. Antibody-mediated CNS demyelination II. Focal spinal cord lesions induced by implantation of an IgM antisulfatide-secreting hybridoma. J Neurocytol 2003, 32:265-276.
    • (2003) J Neurocytol , vol.32 , pp. 265-276
    • Rosenbluth, J.1    Schiff, R.2    Liang, W.-L.3    Dou, W.4
  • 87
    • 0016684155 scopus 로고
    • The significance of perivascular infiltrations in multiple sclerosis
    • Guseo A., Jellinger K. The significance of perivascular infiltrations in multiple sclerosis. J Neurol 1975, 211:51-60.
    • (1975) J Neurol , vol.211 , pp. 51-60
    • Guseo, A.1    Jellinger, K.2
  • 88
    • 0014017031 scopus 로고
    • Effect of experimental allergic encephalomyelitis gamma-globulin upon the electrical activity of the brain
    • Jankoovic B., Rakic I., Janjic M., Ivanus J., Mitrovic K. Effect of experimental allergic encephalomyelitis gamma-globulin upon the electrical activity of the brain. Experientia 1966, 22:459-460.
    • (1966) Experientia , vol.22 , pp. 459-460
    • Jankoovic, B.1    Rakic, I.2    Janjic, M.3    Ivanus, J.4    Mitrovic, K.5
  • 89
    • 0000820383 scopus 로고
    • Functional studies of cultured brain tissues as related to "Demyelinative Disorders"
    • Bornstein M.B., Crain S.M. Functional studies of cultured brain tissues as related to "Demyelinative Disorders". Science 1965, 148:1242-1244.
    • (1965) Science , vol.148 , pp. 1242-1244
    • Bornstein, M.B.1    Crain, S.M.2
  • 90
    • 0024213340 scopus 로고
    • Quantitation of IgG subclasses in cerebrospinal fluid of patients with multiple sclerosis
    • Mehta P.D. Quantitation of IgG subclasses in cerebrospinal fluid of patients with multiple sclerosis. Ann N Y Acad Sci 1988, 540:261-263.
    • (1988) Ann N Y Acad Sci , vol.540 , pp. 261-263
    • Mehta, P.D.1
  • 91
    • 71049141624 scopus 로고    scopus 로고
    • Features of intrathecal immunoglobulins in patients with multiple sclerosis
    • Di Pauli F., Gredler V., Kuenz B., et al. Features of intrathecal immunoglobulins in patients with multiple sclerosis. J Neurol Sci 2010, 288:147-150.
    • (2010) J Neurol Sci , vol.288 , pp. 147-150
    • Di Pauli, F.1    Gredler, V.2    Kuenz, B.3
  • 92
    • 47549089843 scopus 로고    scopus 로고
    • CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome
    • Bennett J.L., Haubold K., Ritchie A.M., et al. CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome. J Neuroimmunol 2008, 199:126-132.
    • (2008) J Neuroimmunol , vol.199 , pp. 126-132
    • Bennett, J.L.1    Haubold, K.2    Ritchie, A.M.3
  • 93
    • 0034163331 scopus 로고    scopus 로고
    • Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients
    • Colombo M., Dono M., Gazzola P., et al. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J Immunol 2000, 164:2782-2789.
    • (2000) J Immunol , vol.164 , pp. 2782-2789
    • Colombo, M.1    Dono, M.2    Gazzola, P.3
  • 94
    • 84870498631 scopus 로고    scopus 로고
    • B cell exchange across the blood-brain barrier in multiple sclerosis
    • von Budingen H.C., Kuo T.C., Sirota M., et al. B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest 2012, 122:4533-4543.
    • (2012) J Clin Invest , vol.122 , pp. 4533-4543
    • von Budingen, H.C.1    Kuo, T.C.2    Sirota, M.3
  • 95
    • 33744802197 scopus 로고    scopus 로고
    • B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation
    • Meinl E., Krumbholz M., Hohlfeld R. B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation. Ann Neurol 2006, 59:880-892.
    • (2006) Ann Neurol , vol.59 , pp. 880-892
    • Meinl, E.1    Krumbholz, M.2    Hohlfeld, R.3
  • 96
    • 78650978163 scopus 로고    scopus 로고
    • Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases
    • Franciotta D., Di Stefano A.L., Jarius S., et al. Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases. J Neuroimmunol 2011, 230:160-163.
    • (2011) J Neuroimmunol , vol.230 , pp. 160-163
    • Franciotta, D.1    Di Stefano, A.L.2    Jarius, S.3
  • 97
    • 20244384231 scopus 로고    scopus 로고
    • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    • Krumbholz M., Theil D., Derfuss T., et al. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 2005, 201:195-200.
    • (2005) J Exp Med , vol.201 , pp. 195-200
    • Krumbholz, M.1    Theil, D.2    Derfuss, T.3
  • 98
    • 77957766615 scopus 로고    scopus 로고
    • The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)
    • Brettschneider J., Czerwoniak A., Senel M., et al. The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS). PloS One 2010, 5:e11986.
    • (2010) PloS One , vol.5
    • Brettschneider, J.1    Czerwoniak, A.2    Senel, M.3
  • 99
    • 75649132169 scopus 로고    scopus 로고
    • The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis
    • Rupprecht T.A., Plate A., Adam M., et al. The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis. J Neuroinflamm 2009, 6:42.
    • (2009) J Neuroinflamm , vol.6 , pp. 42
    • Rupprecht, T.A.1    Plate, A.2    Adam, M.3
  • 100
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini B., Rosicarelli B., Magliozzi R., Stigliano E., Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol (Zurich, Switzerland) 2004, 14:164-174.
    • (2004) Brain Pathol (Zurich, Switzerland) , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 101
    • 3342884206 scopus 로고    scopus 로고
    • Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    • Corcione A., Casazza S., Ferretti E., et al. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc Natl Acad Sci USA 2004, 101:11064-11069.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11064-11069
    • Corcione, A.1    Casazza, S.2    Ferretti, E.3
  • 103
    • 73349109797 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS
    • Sellebjerg F., Bornsen L., Khademi M., et al. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology 2009, 73:2003-2010.
    • (2009) Neurology , vol.73 , pp. 2003-2010
    • Sellebjerg, F.1    Bornsen, L.2    Khademi, M.3
  • 104
    • 66549130329 scopus 로고    scopus 로고
    • The relation between inflammation and neurodegeneration in multiple sclerosis brains
    • Frischer J.M., Bramow S., Dal-Bianco A., et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009, 132:1175-1189.
    • (2009) Brain , vol.132 , pp. 1175-1189
    • Frischer, J.M.1    Bramow, S.2    Dal-Bianco, A.3
  • 105
    • 84867707040 scopus 로고    scopus 로고
    • Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis
    • Choi S.R., Howell O.W., Carassiti D., et al. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain 2012, 135:2925-2937.
    • (2012) Brain , vol.135 , pp. 2925-2937
    • Choi, S.R.1    Howell, O.W.2    Carassiti, D.3
  • 106
    • 78249280011 scopus 로고    scopus 로고
    • A gradient of neuronal loss and meningeal inflammation in multiple sclerosis
    • Magliozzi R., Howell O.W., Reeves C., et al. A gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol 2010, 68:477-493.
    • (2010) Ann Neurol , vol.68 , pp. 477-493
    • Magliozzi, R.1    Howell, O.W.2    Reeves, C.3
  • 107
    • 84885334498 scopus 로고    scopus 로고
    • Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature
    • Chaitanya G.V., Omura S., Sato F., et al. Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature. J Neuroinflamm 2013, 10:125.
    • (2013) J Neuroinflamm , vol.10 , pp. 125
    • Chaitanya, G.V.1    Omura, S.2    Sato, F.3
  • 108
    • 35648948324 scopus 로고    scopus 로고
    • Multiple sclerosis: T-cell receptor expression in distinct brain regions
    • Junker A., Ivanidze J., Malotka J., et al. Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 2007, 130:2789-2799.
    • (2007) Brain , vol.130 , pp. 2789-2799
    • Junker, A.1    Ivanidze, J.2    Malotka, J.3
  • 109
    • 1442354894 scopus 로고    scopus 로고
    • Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood
    • Skulina C., Schmidt S., Dornmair K., et al. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci USA 2004, 101:2428-2433.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2428-2433
    • Skulina, C.1    Schmidt, S.2    Dornmair, K.3
  • 110
    • 79551695835 scopus 로고    scopus 로고
    • Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis
    • Lovato L., Willis S.N., Rodig S.J., et al. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain 2011, 134:534-541.
    • (2011) Brain , vol.134 , pp. 534-541
    • Lovato, L.1    Willis, S.N.2    Rodig, S.J.3
  • 111
    • 0032528513 scopus 로고    scopus 로고
    • Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells
    • Knopf P.M., Harling-Berg C.J., Cserr H.F., et al. Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells. Journal Immunol (Baltimore, Md.: 1950) 1998, 161:692-701.
    • (1998) Journal Immunol (Baltimore, Md.: 1950) , vol.161 , pp. 692-701
    • Knopf, P.M.1    Harling-Berg, C.J.2    Cserr, H.F.3
  • 112
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • McMahon E.J., Bailey S.L., Castenada C.V., Waldner H., Miller S.D. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 2005, 11:335-339.
    • (2005) Nat Med , vol.11 , pp. 335-339
    • McMahon, E.J.1    Bailey, S.L.2    Castenada, C.V.3    Waldner, H.4    Miller, S.D.5
  • 113
    • 84860147831 scopus 로고    scopus 로고
    • Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
    • Lisak R.P., Benjamins J.A., Nedelkoska L., et al. Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro. J Neuroimmunol 2012, 246:85-95.
    • (2012) J Neuroimmunol , vol.246 , pp. 85-95
    • Lisak, R.P.1    Benjamins, J.A.2    Nedelkoska, L.3
  • 114
    • 79960996832 scopus 로고    scopus 로고
    • Poly(I:C) promotes TNFalpha/TNFR1-dependent oligodendrocyte death in mixed glial cultures
    • Steelman A.J., Li J. Poly(I:C) promotes TNFalpha/TNFR1-dependent oligodendrocyte death in mixed glial cultures. J Neuroinflamm 2011, 8:89.
    • (2011) J Neuroinflamm , vol.8 , pp. 89
    • Steelman, A.J.1    Li, J.2
  • 115
    • 2642513275 scopus 로고    scopus 로고
    • Cytokine-induced cell death in human oligodendroglial cell lines: I. Synergistic effects of IFNg and TNFa on apoptosis
    • Butinx M., Moreels M., Vandenabeele F., et al. Cytokine-induced cell death in human oligodendroglial cell lines: I. Synergistic effects of IFNg and TNFa on apoptosis. J Neurosci Res 2004, 76:834-845.
    • (2004) J Neurosci Res , vol.76 , pp. 834-845
    • Butinx, M.1    Moreels, M.2    Vandenabeele, F.3
  • 116
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • Aloisi F., Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006, 6:205-217.
    • (2006) Nat Rev Immunol , vol.6 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 117
    • 84878372569 scopus 로고    scopus 로고
    • Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response
    • Kuerten S., Schickel A., Kerkloh C., et al. Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response. Acta Neuropathol 2012, 124:861-873.
    • (2012) Acta Neuropathol , vol.124 , pp. 861-873
    • Kuerten, S.1    Schickel, A.2    Kerkloh, C.3
  • 118
    • 84893972478 scopus 로고
    • Immunosuppressive therapy of multiple sclerosis: I. Further studies with X-irradiation of central nervous system
    • Tourtellotte W.W., Murthy K., Brandes D., Jurkowitz J., Fleming J.O. Immunosuppressive therapy of multiple sclerosis: I. Further studies with X-irradiation of central nervous system. Neurology 1975, 25:362-363.
    • (1975) Neurology , vol.25 , pp. 362-363
    • Tourtellotte, W.W.1    Murthy, K.2    Brandes, D.3    Jurkowitz, J.4    Fleming, J.O.5
  • 119
    • 84893953162 scopus 로고
    • Modulation of de novo CNS IgG synthesis with preservation of oligoclonal IgG in multiple sclerosis
    • Baumhefner R.W., Booe M.M., Tourtellotte W.W. Modulation of de novo CNS IgG synthesis with preservation of oligoclonal IgG in multiple sclerosis. Neurology 1979, 29:549.
    • (1979) Neurology , vol.29 , pp. 549
    • Baumhefner, R.W.1    Booe, M.M.2    Tourtellotte, W.W.3
  • 120
    • 0018176231 scopus 로고
    • Modifications of the cerebrospinal fluid IgG concentrations in patients with multiple sclerosis treated with intrathecal steroids
    • Massaro A.R. Modifications of the cerebrospinal fluid IgG concentrations in patients with multiple sclerosis treated with intrathecal steroids. J Neurol 1978, 219:221-226.
    • (1978) J Neurol , vol.219 , pp. 221-226
    • Massaro, A.R.1
  • 121
  • 122
    • 0034576841 scopus 로고    scopus 로고
    • Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring
    • Openshaw H., Lund B.T., Kashyap A., et al. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring. Biol Blood Marrow Transplant 2000, 6:563-575.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 563-575
    • Openshaw, H.1    Lund, B.T.2    Kashyap, A.3
  • 123
    • 18544374335 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study
    • Fassas A., Passweg J.R., Anagnostopoulos A., et al. Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study. J Neurol 2002, 249:1088-1097.
    • (2002) J Neurol , vol.249 , pp. 1088-1097
    • Fassas, A.1    Passweg, J.R.2    Anagnostopoulos, A.3
  • 124
    • 29644432533 scopus 로고    scopus 로고
    • Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis
    • Samijn J.P., te Boekhorst P.A., Mondria T., et al. Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis. J Neurol Neurosurg Psychiatry 2006, 77:46-50.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 46-50
    • Samijn, J.P.1    te Boekhorst, P.A.2    Mondria, T.3
  • 125
    • 77953635372 scopus 로고    scopus 로고
    • Neuroinflammation and demyelination in multiple sclerosis after allogeneic hematopoietic stem cell transplantation
    • Lu J.-Q., Joseph J.T., Nash R.A., et al. Neuroinflammation and demyelination in multiple sclerosis after allogeneic hematopoietic stem cell transplantation. Arch Neurol 2010, 67:716-722.
    • (2010) Arch Neurol , vol.67 , pp. 716-722
    • Lu, J.-Q.1    Joseph, J.T.2    Nash, R.A.3
  • 126
    • 34249749383 scopus 로고    scopus 로고
    • Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis
    • Metz I., Lucchinetti C.F., Openshaw H., et al. Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis. Brain 2007, 130:1254-1262.
    • (2007) Brain , vol.130 , pp. 1254-1262
    • Metz, I.1    Lucchinetti, C.F.2    Openshaw, H.3
  • 127
    • 58449095241 scopus 로고    scopus 로고
    • JContinued disease activity in a patient with multiple sclerosis after allogeneic hematopoietic cell transplantation
    • Lu S.J. JContinued disease activity in a patient with multiple sclerosis after allogeneic hematopoietic cell transplantation. Arch Neurol 2009, 66:116-120.
    • (2009) Arch Neurol , vol.66 , pp. 116-120
    • Lu, S.J.1
  • 128
    • 0035942351 scopus 로고    scopus 로고
    • MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS
    • Saiz A., Carreras E., Berenguer J., et al. MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS. Neurology 2001, 56:1084-1089.
    • (2001) Neurology , vol.56 , pp. 1084-1089
    • Saiz, A.1    Carreras, E.2    Berenguer, J.3
  • 130
    • 33646347610 scopus 로고    scopus 로고
    • Immune surveillance in multiple sclerosis patients treated with natalizumab
    • Stüve O., Marra C.M., Jerome K.R., et al. Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann Neurol 2006, 59:743-747.
    • (2006) Ann Neurol , vol.59 , pp. 743-747
    • Stüve, O.1    Marra, C.M.2    Jerome, K.R.3
  • 131
    • 61449227381 scopus 로고    scopus 로고
    • Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab
    • Martin M., Cravens P.D., Winger R., et al. Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. Arch Neurol 2008, 65:1596-1603.
    • (2008) Arch Neurol , vol.65 , pp. 1596-1603
    • Martin, M.1    Cravens, P.D.2    Winger, R.3
  • 132
    • 84881078675 scopus 로고    scopus 로고
    • Cerebrospinal fluid parameters of B cell-related activity in patients with active disease during natalizumab therapy
    • Harrer A., Tumani H., Niendorf S., et al. Cerebrospinal fluid parameters of B cell-related activity in patients with active disease during natalizumab therapy. Multiple Scler 2013, 19:1209-1212.
    • (2013) Multiple Scler , vol.19 , pp. 1209-1212
    • Harrer, A.1    Tumani, H.2    Niendorf, S.3
  • 133
    • 79954611536 scopus 로고    scopus 로고
    • Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS
    • Kowarik M.C., Pellkofer H.L., Cepok S., et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. Neurology 2011, 76:1214-1221.
    • (2011) Neurology , vol.76 , pp. 1214-1221
    • Kowarik, M.C.1    Pellkofer, H.L.2    Cepok, S.3
  • 134
    • 13444274684 scopus 로고    scopus 로고
    • Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis
    • Monson N.L., Cravens P.D., Frohman E.M., Hawker K., Racke M.K. Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis. Arch Neurol 2005, 62:258-264.
    • (2005) Arch Neurol , vol.62 , pp. 258-264
    • Monson, N.L.1    Cravens, P.D.2    Frohman, E.M.3    Hawker, K.4    Racke, M.K.5
  • 135
    • 0034861959 scopus 로고    scopus 로고
    • Complement activation in circulation and central nervous system after rituximab (anti-CD20) treatment of B-cell lymphoma
    • Harjunpaa A., Wiklund T., Collan J., et al. Complement activation in circulation and central nervous system after rituximab (anti-CD20) treatment of B-cell lymphoma. Leuk Lymphoma 2001, 42:731-738.
    • (2001) Leuk Lymphoma , vol.42 , pp. 731-738
    • Harjunpaa, A.1    Wiklund, T.2    Collan, J.3
  • 136
    • 26444598492 scopus 로고    scopus 로고
    • Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis
    • Stüve O., Cepok S., Elias B., et al. Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis. Arch Neurol 2005, 62:1620-1623.
    • (2005) Arch Neurol , vol.62 , pp. 1620-1623
    • Stüve, O.1    Cepok, S.2    Elias, B.3
  • 137
    • 70449418132 scopus 로고    scopus 로고
    • Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial
    • Hawker K., O'Connor P., Freedman M.S., et al. Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol 2009, 66:460-471.
    • (2009) Ann Neurol , vol.66 , pp. 460-471
    • Hawker, K.1    O'Connor, P.2    Freedman, M.S.3
  • 138
    • 34248173334 scopus 로고    scopus 로고
    • Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma
    • Rubenstein J.L., Fridlyand J., Abrey L., et al. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol 2007, 25:1350-1356.
    • (2007) J Clin Oncol , vol.25 , pp. 1350-1356
    • Rubenstein, J.L.1    Fridlyand, J.2    Abrey, L.3
  • 139
    • 47049126989 scopus 로고    scopus 로고
    • B cell survival in intragraft tertiary lymphoid organs after rituximab therapy
    • Thaunat O., Patey N., Gautreau C., et al. B cell survival in intragraft tertiary lymphoid organs after rituximab therapy. Transplantation 2008, 85:1648-1653.
    • (2008) Transplantation , vol.85 , pp. 1648-1653
    • Thaunat, O.1    Patey, N.2    Gautreau, C.3
  • 140
    • 39549100140 scopus 로고    scopus 로고
    • Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results
    • Kavanaugh A., Rosengren S., Lee S.J., et al. Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results. Ann Rheum Dis 2008, 67:402-408.
    • (2008) Ann Rheum Dis , vol.67 , pp. 402-408
    • Kavanaugh, A.1    Rosengren, S.2    Lee, S.J.3
  • 141
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards J.C., Szczepanski L., Szechinski J., et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004, 350:2572-2581.
    • (2004) N Engl J Med , vol.350 , pp. 2572-2581
    • Edwards, J.C.1    Szczepanski, L.2    Szechinski, J.3
  • 142
    • 40449141768 scopus 로고    scopus 로고
    • Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice
    • DiLillo D.J., Hamaguchi Y., Ueda Y., et al. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. J Immunol 2008, 180:361-371.
    • (2008) J Immunol , vol.180 , pp. 361-371
    • DiLillo, D.J.1    Hamaguchi, Y.2    Ueda, Y.3
  • 143
    • 34249719509 scopus 로고    scopus 로고
    • T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue
    • Withers D.R., Fiorini C., Fischer R.T., Ettinger R., Lipsky P.E., Grammer A.C. T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue. Blood 2007, 109:4856-4864.
    • (2007) Blood , vol.109 , pp. 4856-4864
    • Withers, D.R.1    Fiorini, C.2    Fischer, R.T.3    Ettinger, R.4    Lipsky, P.E.5    Grammer, A.C.6
  • 146
    • 84859333953 scopus 로고    scopus 로고
    • Long-term decrease in VLA-4 expression and functional impairment of dendritic cells during natalizumab therapy in patients with multiple sclerosis
    • de Andres C., Teijeiro R., Alonso B., et al. Long-term decrease in VLA-4 expression and functional impairment of dendritic cells during natalizumab therapy in patients with multiple sclerosis. PLoS One 2012, 7:e34103.
    • (2012) PLoS One , vol.7
    • de Andres, C.1    Teijeiro, R.2    Alonso, B.3
  • 147
    • 7044260446 scopus 로고    scopus 로고
    • Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases)
    • Storek J., Zhao Z., Lin E., et al. Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases). Clin Immunol 2004, 113:285-298.
    • (2004) Clin Immunol , vol.113 , pp. 285-298
    • Storek, J.1    Zhao, Z.2    Lin, E.3
  • 148
    • 84871296610 scopus 로고    scopus 로고
    • Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?
    • Gomez A.M., Willcox N., Molenaar P.C., et al. Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?. Ann N Y Acad Sci 2012, 1274:48-59.
    • (2012) Ann N Y Acad Sci , vol.1274 , pp. 48-59
    • Gomez, A.M.1    Willcox, N.2    Molenaar, P.C.3
  • 149
    • 84880698403 scopus 로고    scopus 로고
    • Central nervous system involvement with multiple myeloma: long term survival can be achieved with radiation, intrathecal chemotherapy, and immunomodulatory agents
    • Chen C.I., Masih-Khan E., Jiang H., et al. Central nervous system involvement with multiple myeloma: long term survival can be achieved with radiation, intrathecal chemotherapy, and immunomodulatory agents. Br J Haematol 2013, 162:483-488.
    • (2013) Br J Haematol , vol.162 , pp. 483-488
    • Chen, C.I.1    Masih-Khan, E.2    Jiang, H.3
  • 150
    • 79251570884 scopus 로고    scopus 로고
    • Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
    • de Weers M., Tai Y.T., van der Veer M.S., et al. Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J Immunol 2011, 186:1840-1848.
    • (2011) J Immunol , vol.186 , pp. 1840-1848
    • de Weers, M.1    Tai, Y.T.2    van der Veer, M.S.3
  • 151
    • 80053646308 scopus 로고    scopus 로고
    • Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma
    • Atanackovic D., Panse J., Hildebrandt Y., et al. Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma. Haematologica 2011, 96:1512-1520.
    • (2011) Haematologica , vol.96 , pp. 1512-1520
    • Atanackovic, D.1    Panse, J.2    Hildebrandt, Y.3
  • 152
    • 37049017404 scopus 로고    scopus 로고
    • Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade
    • Lin W.Y., Gong Q., Seshasayee D., et al. Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade. Blood 2007, 110:3959-3967.
    • (2007) Blood , vol.110 , pp. 3959-3967
    • Lin, W.Y.1    Gong, Q.2    Seshasayee, D.3
  • 153
    • 84869745566 scopus 로고    scopus 로고
    • Pathogenic long-lived plasma cells and their survival niches in autoimmunity, malignancy, and allergy
    • Winter O., Dame C., Jundt F., Hiepe F. Pathogenic long-lived plasma cells and their survival niches in autoimmunity, malignancy, and allergy. J Immunol 2012, 189:5105-5111.
    • (2012) J Immunol , vol.189 , pp. 5105-5111
    • Winter, O.1    Dame, C.2    Jundt, F.3    Hiepe, F.4
  • 154
    • 77956422651 scopus 로고    scopus 로고
    • FLT-3 expression and function on microglia in multiple sclerosis
    • DeBoy C.A., Rus H., Tegla C., et al. FLT-3 expression and function on microglia in multiple sclerosis. Exp Mol Pathol 2010, 89:109-116.
    • (2010) Exp Mol Pathol , vol.89 , pp. 109-116
    • DeBoy, C.A.1    Rus, H.2    Tegla, C.3
  • 155
    • 28044445893 scopus 로고    scopus 로고
    • Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease
    • Whartenby K.A., Calabresi P.A., McCadden E., et al. Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease. Proc Natl Acad Sci USA 2005, 102:16741-16746.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16741-16746
    • Whartenby, K.A.1    Calabresi, P.A.2    McCadden, E.3
  • 156
    • 84858146335 scopus 로고    scopus 로고
    • Fatal PML associated with efalizumab therapy: insights into integrin alphaLbeta2 in JC virus control
    • discussion 465
    • Schwab N., Ulzheimer J.C., Fox R.J., et al. Fatal PML associated with efalizumab therapy: insights into integrin alphaLbeta2 in JC virus control. Neurology 2012, 78:458-467. discussion 465.
    • (2012) Neurology , vol.78 , pp. 458-467
    • Schwab, N.1    Ulzheimer, J.C.2    Fox, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.