Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis

Journal of Neuroimmunology

Volumn 121, Issue 1-2, 2001, Pages 120-125

  Greve, B ^a   Magnusson, C G M ^b   Melms, A ^a   Weissert, R ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

B cells; Demyelinating disease; IgE; Isotypes; Multiple sclerosis

Indexed keywords

IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4;

ADULT; ARTICLE; BLOOD ANALYSIS; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID EXAMINATION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOGLOBULIN PRODUCTION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MALE; MULTIPLE SCLEROSIS; TH1 CELLS; TH2 CELLS;

EID: 0035803835     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00436-2     Document Type: Article

References (43)

1. Functional diversity of helper T lymphocytes
2. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1 alpha and IP-10 are expressed in demyelinating brain lesions
3. Standardization and stability of immunoglobulin E (IgE)
4. Formulas for the quantitation of intrathecal IgG production
5. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation
6. Relationships between abnormal IgG index, oligoclonal bands, acute phase reactants and some clinical data in multiple sclerosis
7. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
8. Immunochemical estimation of IgG and albumin in cerebrospinal fluid
9. A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice
10. Cytokine production and surface marker expression in acute and stable multiple sclerosis: Altered IL-12 production and augmented signalling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosis
11. Immunoglobulin isotype production by cycling human B lymphocytes in response to recombinant cytokines and anti-IgM
12. Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses
13. Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2
14. IgE and IgG subclass regulation by IL-4 and IFN-gamma in human helminth infections. Assessment by B cell precursor frequencies
15. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
16. Intrathecal synthesis of IgG subclasses in multiple sclerosis and in acquired immunodeficiency syndrome (AIDS)
17. Identification of IgG subclasses' oligoclonal bands in multiple sclerosis CSF
18. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: A study of 113 cases
19. Interleukin 4 induces synthesis of IgE and IgG4 in human B cells
20. An automated particle-counting immunoassay (PACIA) for serum IgE
21. Monoclonal antibodies against human IgE. Identification of a determinant restricted to IgE of the lambda light-chain type
22. Quantitation of IgG subclasses in cerebrospinal fluid of patients with multiple sclerosis
23. Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins
24. T lymphocyte differentiation in the periphery
25. Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis
26. Systemic levels of cytokines and GAD-specific autoantibodies isotypes in Chinese IDDM patients
27. An improved formula for the judgement of intrathecally produced IgG in the presence of blood brain barrier damage
28. Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis
29. Immunoglobulin abnormalities in multiple sclerosis. Relation to clinical parameters: Disability, duration and age of onset
30. IgG subgroups in cerebrospinal fluid in multiple sclerosis
31. Monoclonal antibody-based solid-phase immunoenzymometric assays for quantifying human immunoglobulin G and its subclasses in serum
32. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
33. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
34. Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis
35. The course of multiple sclerosis cases with extremely high gamma-globulin values in the cerebrospinal fluid
36. IgE in the cerebrospinal fluid
37. IgG subclass distribution of antibody responses to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patients
38. Relation between benign course of multiple sclerosis and low-grade humoral immune response in cerebrospinal fluid
39. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
40. Biologic variation of human immunoglobulin concentration: I. Sex-age specific effects on serum levels of IgG, IgA, IgM and IgD
41. Axonal pathology in multiple sclerosis: Relationship to neurologic disability
42. IgG subclasses in Lyme borreliosis: A study of specific IgG subclass distribution in an interferon-gamma-predominated disease
43. Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease