Antigen-dependent intrathecal antibody synthesis in the normal rat brain: Tissue entry and local retention of antigen-specific B cells

Journal of Immunology

Volumn 161, Issue 2, 1998, Pages 692-701

  Knopf, Paul M ^a   Harling Berg, Christine J ^a   Cserr, Helen F ^a   Basu, Devraj ^a   Sirulnick, Erik J ^a   Nolan, Scott C ^a   Park, Joel T ^a   Keir, Geoffrey ^b   Thompson, Edward J ^b   Hickey, William F ^c  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN G; OVALBUMIN; SERUM ALBUMIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BRAIN TISSUE; CAUDATE NUCLEUS; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; IMMUNIZATION; ISOELECTRIC FOCUSING; MALE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; ANTIGENS; B-LYMPHOCYTE SUBSETS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; EPITOPES, B-LYMPHOCYTE; FREUND'S ADJUVANT; HUMANS; IMMUNE SERA; IMMUNIZATION SCHEDULE; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MALE; OVALBUMIN; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN;

EID: 0032528513     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Pantitch H. S., F. J. Vriesendorp and P. S. Fishman. 1991. Neurologic Diseases. In Basic and Clinical Immunology, 7th Ed. D. P. Stites and A. I. Terr, eds. Appleton & Lange, Norwalk, CT, p. 552.
2. Cserr, H. F., and P. M. Knopf. 1992. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol. Today 13:507.
3. Cserr, H. F., and P. M. Knopf. 1997. Cervical lymphatics, the blood-brain barrier, and immunoreactivity of the brain. In Immunology of the Nervous System. R. W. Keane and W. F. Hickey, eds. Oxford University Press, NY, p. 134.
4. Harling-Berg, C. J., P. M. Knopf, J. Merriam, and H. F. Cserr. 1989. Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat CSF. J. Neuroimmunol. 25:185.
5. Cserr, H. F., and B. J. Berman. 1978. Iodide and thiocyanate efflux from brain following injection into rat caudate nucleus. Am. J. Physiol. 235:F331.
6. Cserr, H. F., M. DePasquale, C. J. Harling-Berg, J. T. Park, and P. M. Knopf. 1992. Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability. J. Neuroimmunol. 41:195.
7. Woo, A. H., H. F. Cserr, and P. M. Knopf. 1993. Analysis of IgA in CSF of patients with neuroinflammatory disease. J. Neuroimmunol. 44:129.
8. Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28:254.
9. Wekerle, H., H. Linington, H. Lassmann, and R. Meyermann. 1986. Cellular immune reactivity within the CNS. Trends Neurosci. 9:271.
10. 1 integrin. Nature 356:63.
11. 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57.
12. Pullen, R. G. L., M. DePasquale, and H. F. Cserr. 1987. Bulk flow of cerebrospinal fluid into brain in response to acute hyperosmolarity. Am. J. Physiol. 253: F538.
13. Leibowitz, S., and R. A. C. Hughes. 1983. Immunology of the Nervous System. Edward Arnold Ltd., London, 304 pp.
14. Keir, G., R. W. Luxton, and E. J. Thompson. 1990. Isoelectric focusing of cerebrospinal fluid immunoglobulin G: an annotated update. Ann. Clin. Biochem. 27:436.
15. Hickey, W. F., K. Vass, and H. Lassmann. 1992. Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras. J. Neuropathol. Exp. Neurol. 51:246.
16. Thompson, E. J. 1995. Cerebrospinal fluid. J. Neurol. Neurosurg. Psychiatry 59:349.
17. Hay, J. B., M. J. Murphy, B. Morris, and M. C. Bessis. 1972. Quantitative studies of the proliferation and differentiation of antibody-forming cells in the lymph. Am. J. Pathol. 66:1.
18. Flaris, N. A., T. L. Densmore, M. C. Molleston, and W. F. Hickey. 1993. Characterization of microglia and macrophages in the central nervous system of rats. Glia 7:34.
19. Gordon, L. B., S. C. Nolan, H. F. Cserr, P. M. Knopf, and C. J. Harling-Berg. 1997. Growth of P511 mastocytoma cells in BALB/c mouse brain elicits CTL response without tumor elimination. J. Immunol. 159:2399.
20. Linnington, C., and H. Lassmann. 1987. Antibody response in clinical relapsing experimental autoimmune encephalomyelitis: correlation of serum demyelinating activity with antibody titer to myelin/oligodendrocyte glycoprotein (MOG). J. Neuroimmunol. 17:61.
21. Linnington, C., M. Bradl, and H. Lassmann. 1988. Augmentation of demyelmation in rat acute experimental autoimmune encephalomyelitis by circulating mouse monoclonal antibodies directed against myelin-oligodendrocyte glycoprotein. Am. J. Pathol. 130:443.
22. Cserr, H. F., D. N. Cooper, P. K. Suri, and C. S. Patlak. 1981. Efflux of radiolabelled polyethylene glycols and albumin from rat brain. Am. J. Physiol. 240: F319.
23. Hochwald, G. M., A. Van Driel, M. E. Robinson, and G. J. Thorbecke. 1988. Immune response in draining lymph nodes and spleen after intraventricular injection of antigen. Int. J. Neurosci. 39:299.
24. Widner, H., G. Möller, and B. B. Johansson. 1988. Immune response in deep cervical lymph nodes and spleen in the mouse after antigen deposition in different intracerebral sites. Scand. J. Immunol. 28:563.
25. Kida, S., R. O. Weller, E.-T. Zhang, M. J. Phillips, and F. Iannotti. 1995. Anatomical pathways for lymphatic drainage of the brain and their pathological significance. Neuropathol. Appl. Neurobiol. 21:181.
26. Knopf, P. M., H. F. Cserr, S. C. Nolan, T.-Y. Wu, and C. J. Harling-Berg. 1995. Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain. Neuropathol. Appl. Neurobiol. 21:175.
27. Bradbury, M. W. B., H. F. Cserr, and R. J. Westrop. 1981. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. Am. J. Physiol. 140:F329.
28. Kostulas, V. K., and H. Link. 1983. Agarose isoelectric focusing of unconcentrated CSF and radioimmunofixation for detection of oligoclonal bands in patients with multiple sclerosis and other neurological diseases. J. Neurol. Sci. 54:117.
29. Vartdal, F., B. Vandvik, T. E. Michaelsen, K. Loe, and E. Norrby. 1982. Neurosyphilis: intrathecal synthesis of oligoclonal antibodies to Treponema pallidum. Ann. Neurol 11:35.
30. Hickey, W. F., H. Lassmann, and A. H. Cross. 1997. Lymphocyte entry and the initiation of inflammation in the central nervous system. In Immunology of the Nervous System. R. W. Keane and W. F. Hickey, eds. Oxford University Press, New York, p. 200.
31. Wolf, S. D., B. N. Dittel, F. Hardardottir, and C. A. Janeway, Jr. 1996. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J. Exp. Med. 184:2271.
32. Klein, M. A., R. Frigg, E. Flechsig, A. J. Raeber, U. Kalinke, H. Bluethmann, F. Bootz, M. Suter, R. M. Zinkernagel, and A. Aguzzi. 1997. A crucial role for B cells in neuroinvasive scrapie. Nature 390:687.