Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients

Journal of Immunology

Volumn 164, Issue 5, 2000, Pages 2782-2789

  Colombo, Monica ^a,b   Dono, Mariella ^a   Gazzola, Paola ^c   Roncella, Silvio ^a,d   Valetto, Angelo ^e   Chiorazzi, Nicholas ^e   Mancardi, Giovanni L ^c   Ferrarini, Manlio ^a,c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; UNINDEXED SEQUENCE;

EID: 0034163331     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.5.2782     Document Type: Article

References (49)

1. Hafler, D., and H. L. Weiner. 1995. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144:75.
2. Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299.
3. Wekerle, H., K. Kojma, J. Lannes-Vieira, H. Lassman, and C. Linngton. 1994. Animal models. Ann. Neurol. 36:S47.
4. Olsson, T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:245.
5. Wekerle, H. 1999. Remembering MOG: autoantibody mediated demyelination in multiple sclerosis? Nat. Med. 5:153.
6. Storch, M. K., A. Stefferl, U. Brehm, R. Weissert, E. Wallstrom, and M. Kerschensteiner. 1998. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 8:681.
7. Genain, C. P., M. H. Nguyen, N. L. Letvin, R. Pearl, R. L. Davis, M. Adelman, and M. B. Lees. 1995. Antibody facilitation of multiple sclerosis-like lesions in a non human primate. J. Clin. Invest. 96:2966.
8. Litzenburger, T., R. Fässler, J. Bauer, H. Lassmann, C. Linington, H. Wekerle, and A. Iglesias. 1998. B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J. Exp. Med 188: 169.
9. Genain, C. P., B. Cannella, S. L. Hauser, and C. S. Raine. 1999. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:170.
10. Andersson, M., J. Alvarez-Cermeno, G. Bernardi, I. Cogato, P. Fredman, and J. Frederiksen. 1994. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J. Neurol. Neurosurg. Psychiatry 57:897.
11. Link, H., and G. Tibbling. 1977. Principles of albumin and IgG analyses in neurological disorders. Scand. J. Clin. Lab. Invest. 37:397.
12. McLean, B. N., R. W. Luxton, and E. J. Thompson. 1990. A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the log IgG-index: a comparison and diagnostic applications. Brain 113:1269.
13. Tourtellotte, W. W., R. W. Baumhefner, K. Syndulko, P. Shapshak, M. Osborne, G. Rubinshtein, and L. Newton. 1988. The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis: and still marching. J. Neuroimmunol. 20:217.
14. Olsson, T., S. Baig, B. Hojeberg, and H. Link. 1990. Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. Ann. Neurol. 27:132.
15. Baig, S., T. Olsson, J. Yu-Ping, B. Hojeberg, M. Cruz, and H. Link. 1991. Multiple sclerosis: cells secreting antibodies against myelin-associated. Scand. J. Immunol. 33:73.
16. Sun, J.B., H. Link, T. Olsson, B. G. Xiao, G. Andersson, H. P. Ekre, C. Linington, and P. Diener. 1991. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 146:1490.
17. Svenningsson, A., O. Andersen, M. Edsbagge, and S. Stemme. 1995. Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid. J. Neuroimmunol. 63:39.
18. Oreja-Guevara, C., E. Sindern, M. Raulf-Heimsoth, and J. P. Malin. 1998. Analysis of lymphocyte subpopulations in cerebrospinal fluid and peripheral blood with multiple sclerosis and inflammatory diseases of the nervous system. Acta Neurol. Scand. 98:310.
19. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
20. Matsumoto, M., S. F. Lo, C. J. Carruthers, J. Min, S. Mariathasan, G. Huang, and D. R. Plas. 1996. Affinity maturation without germinal centres in lymphotoxin-α-dencient mice. Nature 382:462.
21. Chu, Y. W., E. Marin, R. Fuleihan, N. Ramesh, F. S. Rosen, R. S. Geha, and R. A. Insel. 1995. Somatic mutation of human immunoglobulin V genes in the X-linked hyperlgM. J. Clin. Invest. 95:1389.
22. Kelsoe, G. 1999. V(D)J hypermutation and receptor revision: coloring outside the lines. Curr. Opin. Immunol. 11:70.
23. Fais, F., F. Ghiotto, S. Hashimoto, B. Sellars, A. Valette, S. L. Allen, and P. Schulman. 1998. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J. Clin. Invest. 102:1515.
24. + chronic lymphocytic leukemia B cells. J. Exp. Med. 181:1507.
25. Dono, M., S. Hashimoto, F. Fais, V. Trejo, S. L. Allen, S. M. Lichtman, and P. Schulman. 1996. Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification. Blood 87:1586.
26. Tomlinson, I. M., S. C. Williams, S. J. Corbett, J. B. L. Cox, and G. Winter. 1996. V base sequence directory. MRC Centre for Protein Engineering, Cambridge, UK.
27. Klein, U., R. Kuppers, and K. Rajewsky. 1994. Variable region gene analysis of B cell subsets derived from a 4-year-old. J. Exp. Med. 180:1383.
28. Schroder, A. E., A. Greiner, C. Seyfert, and C. Berek. 1996. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 93:221.
29. Lee, S. K., S. L. J. Bridges, P. M. Kirkham, W. J. Koopman, and H. W. J. Schroeder. 1994. Evidence of antigen receptor-influenced oligoclonal B lymphocyte expansion in the synovium of a patient with longstanding rheumatoid arthritis. J. Clin. Invest. 93:361.
30. Kim, H. J., V. Krenn, G. Steinhauser, and C. Berek. 1999. Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis. J. Immunol. 162:3053.
31. Randen, I., D. Brown, K. M. Thompson, N. Hughes-Jones, Pascual V., K. Victor, and J. D. Capra. 1992. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J. Immunol. 148:3296.
32. Kaplan, S., K. Hyman, R. Brooks, M. Wakai, S. Hashimoto, R. Furie, and N. Chiorazzi. 1993. Monoclonal IgM, IgG, and IgA human rheumatoid factors produced by synovial tissue-derived. EBV-transformed B cell lines. Clin. Immunol. Immunophathol. 66:18.
33. Patki, V., J. Monteiro, P. K. Gregersen, and N. Chiorazzi. 1997. Evidence for B cell oligoclonality in the blood and joints of patients with rheumatoid arthritis. Ann. NY Acad. Sci. 815:472.
34. Kuppers, R., M. Zhao, M. L. Hansmann, and K. Rajewsky. 1993. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological section. EMBO J. 12:4955.
35. Pascual, V., Y. J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180:329.
36. Shlomchik, M. J., A. H. Aucoin, D. S. Pisetsky, and M. G. Weigert. 1987. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl. Acad. Sci. USA 84:9150.
37. Chang B., and P. Casali. 1994. The CDRI sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol. Today 15:367.
38. H rearrangements. Immunol. Rev. 162:161.
39. Bahler, D. W., and S. H. Swerdlow. 1998. Clonal salivary gland infiltrates associated with myoepithelial sialadenitis. Blood 91:1864.
40. Stott, D. I., F. Hiepe, M. Hummel, G. Steinhauser, and C. Berek. 1998. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjogren's syndrome. J. Clin. Invest. 102:938.
41. Knopf, P. M., C. J. Harling-Berg, H. F. Cserr, D. Basu, E. J. Sirulnick, S. C. Nolan, and J. T. Park. 1998. Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells. J. Immunol. 161:692.
42. Harling-Berg, C., P. M. Knopf, J. Merriam, and H. F. Cserr. 1989. Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat cerebrospinal fluid. J. Neuroimmunol. 25:185.
43. Wolf, S. D., B. N. Dittel, F. Hardardottir, and C. A. J. Janeway. 1996. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient-mice, J. Exp. Med. 184:2271.
44. Owens, G. P., H. Kraus, M. P. Burgoon, T. Smith-Jensen, M. E. Devlin, and D. H. Gilden. 1998. Restricted use of VH4 germline segments in an acute multiple sclerosis brain. Ann. Neurol. 43:236.
45. Baranzini, S. E., M. C. Jeong, C. Butunoi, R. S. Murray, C. C. Bernard, and J. R. Oksenberg. 1999. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J. Immunol. 163:5133.
46. Qin, Y., P. Duquette, Y. Zhang, P. Talbot, R. Poole, and J. Antel. 1998. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J. Clin. Invest. 102:1045.
47. Hochwald, G. M., A. Van Driel, M. E. Robinson, and G. J. Thorbecke. 1988. Immune response in draining lymph nodes and spleen after intraventricular injection of antigen. Int. J. Neurosci. 39:299.
48. Widner, H., G. Moller, and B. B. Johansson. 1988. Immune response in deep cervical lymph nodes and spleen in the mouse after antigen deposition. Scand. J. Immunol. 28:563.
49. Cserr, H. F., and P. M. Knopf. 1992. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol. Today 13:507.