CSF-enriched antibodies do not share specificities among MS patients

Multiple Sclerosis

Volumn 4, Issue 3, 1998, Pages 118-123

  Cortese, I ^a,d   Capone, S ^b   Luchetti, S ^a,d   Grimaldi, L M E ^c   Nicosia, A ^b   Cortese, R ^b  

^a Università di Roma   (Italy)

^b IRBM   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

CSF; Multiple sclerosis; Oligoclonal bonds; Phage library

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN ANTIBODY; PEPTIDE LIBRARY;

ADULT; AMINO ACID SEQUENCE; ARTICLE; BLOOD LEVEL; CEREBROSPINAL FLUID; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PHAGE DISPLAY;

EID: 0031661555     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859800400305     Document Type: Article

References (18)

1. Vartdal F, Vandvik B, Norrby E. (1980) Viral and bacterial antibody responses in multiple sclersosis. Ann Neurol 1: 248 - 255.
2. Rostrom B et al. (1981) Viral antibody activity of oligoclonal and polyclonal immunoglobulins synthesized within the central nervous system in multiple sclerosis. Ann Neurol 9: 569 - 574.
3. Cruz M et al. (1987) Immunoblot detection of oligoclonal anti-myelin basic protein IgG antibodies in cerebrospinal fluid in multiple sclerosis. Neurology 37: 1515 - 1519.
4. Cortese R et al. (1994) Epitope discovery with peptide libraries displayed on phage. TIBTECH 12: 262 - 267.
5. Folgori A et al. (1994) A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J 13: 2236 - 2243.
6. Cortese R et al. (1996) Selection of biologically active peptides by phage display of random peptide libraries. Curr Opin Biotechnol 7: 616 - 621.
7. Cortese I et al. (1996) Identification of peptides specific for cerebrospinal fluid antibodies in multiple sclerosis by using phage libraries. Proc Natl Acad Sci USA 93: 11063 - 11067.
8. Cortese I et al. (1997) Identification of peptides binding to IgG in the CSF of multiple sclerosis patients. Multiple Sclerosis in press.
9. Poser CM et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13: 227 - 231.
10. Felici F et al. (1991) Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector. J Mol Biol 222: 301 - 310.
11. Dente L et al. (1994) Monoclonal antibodies that recognise filamentous phage: tools for phage display technology. Gene 148: 7 - 13.
12. Tafi R et al. (1997) Identification of HCV core mimotopes: improved methods for the selection and use of disease-related phage-displayed peptides. Biol Chem 378: 495 - 502.
13. Olssen JE, Link H. (1973) Immunoglobulin abnormalities in multiple sclerosis. Arch Neurol 28: 392 - 399.
14. Hershey LA, Trotter JL. (1980) The use and abuse of the cerebrospinal fluid IgG profile in the adult: a practical evaluation. Ann Neurol 8: 426 - 434
15. Ebers GC. (1985) Oligoclonal banding in MS. Ann NY Acad Sci 436: 206 - 212.
16. Kurtzke JF. (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33: 1444 - 1452.
17. Williams KC, Ulvestad E, Hickey WF. (1994) Immunology of Multiple Sclerosis. Clinical Neuroscience 2: 229 - 245.
18. Storch M, Lassmann H. (1997) Pathology and pathogenesis of demyelinating diseases. Curr Opin Neurol 10: 186 - 192.