Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 22, 2008, Pages 9729-9740

  La Regina, Giuseppe ^a   Silvestri, Romano ^a   Gatti, Valerio ^a   Lavecchia, Antonio ^b   Novellino, Ettore ^b   Befani, Olivia ^a   Turini, Paola ^a   Agostinelli, Enzo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Amine oxidase; Indole; Molecular dynamics; Molecular modeling; Monoamine oxidase type A; Monoamine oxidase type B; Structure activity relationships

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; N METHYL N (3 PHENYLPROPYL) 1H INDOLE 2 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATTLE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR STABILITY; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 84954358613     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.072     Document Type: Article

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