메뉴 건너뛰기




Volumn 3, Issue 5, 2012, Pages 429-445

Transforming growth factor-β superfamily, implications in development and differentiation of stem cells

Author keywords

BMP; differentiation; signaling; stem cells; TGF

Indexed keywords


EID: 84893825375     PISSN: 18685021     EISSN: 1868503X     Source Type: Journal    
DOI: 10.1515/bmc-2012-0015     Document Type: Review
Times cited : (25)

References (162)
  • 1
    • 40849133772 scopus 로고    scopus 로고
    • Role of transforming growth factor-?superfamily signaling pathways in human disease
    • Gordon KJ, Blobe GC. Role of transforming growth factor-?superfamily signaling pathways in human disease. Biochim Biophys Acta 2008; 1782: 197-228.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 197-228
    • Gordon, K.J.1    Blobe, G.C.2
  • 3
    • 34548329486 scopus 로고    scopus 로고
    • Differentiation plasticity regulated by TGF-?family proteins in development and disease
    • Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF-?family proteins in development and disease. Nat Cell Biol 2007; 9: 1000-4.
    • (2007) Nat Cell Biol , vol.9 , pp. 1000-1004
    • Derynck, R.1    Akhurst, R.J.2
  • 4
    • 84857232423 scopus 로고    scopus 로고
    • A portrait of transforming growth factor ?superfamily signalling: Background matters
    • Horbelt D, Denkis A, Knaus P. A portrait of transforming growth factor ?superfamily signalling: Background matters. Int J Biochem Cell Biol 2012; 44: 469-74.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 469-474
    • Horbelt, D.1    Denkis, A.2    Knaus, P.3
  • 5
    • 80054722795 scopus 로고    scopus 로고
    • Common structural traits for cystine knot domain of the TGF ?superfamily of proteins and three-fi ngered ectodomain of their cellular receptors
    • Galat A. Common structural traits for cystine knot domain of the TGF ?superfamily of proteins and three-fi ngered ectodomain of their cellular receptors. Cell Mol Life Sci 2011; 68: 3437-51.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3437-3451
    • Galat, A.1
  • 6
    • 0009518290 scopus 로고
    • Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors
    • Anzano MA, Roberts AB, Smith JM, Sporn MB, De Larco JE. Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors. Proc Natl Acad Sci USA 1983; 80: 6264-8.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 6264-6268
    • Anzano, M.A.1    Roberts, A.B.2    Smith, J.M.3    Sporn, M.B.4    De Larco, J.E.5
  • 7
    • 0037407769 scopus 로고    scopus 로고
    • Genealogy, expression, and cellular function of transforming growth factor
    • Govinden R, Bhoola KD. Genealogy, expression, and cellular function of transforming growth factor-? Pharmacol Ther 2003; 98: 257-65
    • (2003) Pharmacol Ther , vol.98 , pp. 257-265
    • Govinden, R.1    Bhoola, K.D.2
  • 9
    • 0028304008 scopus 로고
    • Repression of the transforming growth factor-beta 1 gene by the Wilms tumor suppressor WT1 gene product
    • Dey BR, Sukhatme VP, Roberts AB, Sporn MB, Rauscher FJ 3rd, Kim SJ. Repression of the transforming growth factor-beta 1 gene by the Wilms tumor suppressor WT1 gene product. Mol Endocrinol 1994; 8: 595-602.
    • (1994) Mol Endocrinol , vol.8 , pp. 595-602
    • Dey, B.R.1    Sukhatme, V.P.2    Roberts, A.B.3    Sporn, M.B.4    Rauscher, F.J.5    Kim, S.J.6
  • 10
    • 0025010875 scopus 로고
    • Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription
    • Lafyatis R, Lechleider R, Kim SJ, Jakowlew S, Roberts AB, Sporn MB. Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription. J Biol Chem 1990; 265: 19128-36.
    • (1990) J Biol Chem , vol.265 , pp. 19128-19136
    • Lafyatis, R.1    Lechleider, R.2    Kim, S.J.3    Jakowlew, S.4    Roberts, A.B.5    Sporn, M.B.6
  • 11
    • 0026726489 scopus 로고
    • Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter
    • OReilly MA, Geiser AG, Kim SJ, Bruggeman LA, Luu AX, Roberts AB, Sporn MB. Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter. J Biol Chem 1992; 267: 19938-43.
    • (1992) J Biol Chem , vol.267 , pp. 19938-19943
    • Oreilly, M.A.1    Geiser, A.G.2    Kim, S.J.3    Bruggeman, L.A.4    Luu, A.X.5    Roberts, A.B.6    Sporn, M.B.7
  • 12
    • 0031933224 scopus 로고    scopus 로고
    • Molecular and cell biology of TGF-beta
    • Roberts AB. Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 1998; 24: 111-9.
    • (1998) Miner Electrolyte Metab , vol.24 , pp. 111-119
    • Roberts, A.B.1
  • 13
    • 14844302670 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability
    • Rifkin DB. Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability. J Biol Chem 2005; 280: 7409-12.
    • (2005) J Biol Chem , vol.280 , pp. 7409-7412
    • Rifkin, D.B.1
  • 14
    • 0028906190 scopus 로고
    • Processing of transforming growth factor beta 1 precursor by human furin convertase
    • Dubois CM, Laprise MH, Blanchette F, Gentry LE, Leduc R. Processing of transforming growth factor beta 1 precursor by human furin convertase. J Biol Chem 1995; 270: 10618-24.
    • (1995) J Biol Chem , vol.270 , pp. 10618-10624
    • Dubois, C.M.1    Laprise, M.H.2    Blanchette, F.3    Gentry, L.E.4    Leduc, R.5
  • 17
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 2000; 14: 163-76.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 18
    • 0030908028 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta: Structural features and mechanisms of activation
    • Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I, Rifkin DB. Latent transforming growth factor-beta: Structural features and mechanisms of activation. Kidney Int 1997; 51: 1376-82.
    • (1997) Kidney Int , vol.51 , pp. 1376-1382
    • Munger, J.S.1    Harpel, J.G.2    Gleizes, P.E.3    Mazzieri, R.4    Nunes, I.5    Rifkin, D.B.6
  • 19
    • 0015155737 scopus 로고
    • Bone morphogenetic protein
    • Urist MR, Strates BS. Bone morphogenetic protein. J Dent Res 1971; 50: 1392-406.
    • (1971) J Dent Res , vol.50 , pp. 1392-1406
    • Urist, M.R.1    Strates, B.S.2
  • 20
    • 54549116504 scopus 로고    scopus 로고
    • In: Derynck R, Miyazono K, editors. The TGF-beta family. New York: Cold Spring Harbor Laboratory Press
    • Katagiri T, Suda T, Miyazono K. The bone morphogenetic proteins in the TGF-B family. In: Derynck R, Miyazono K, editors. The TGF-beta family. New York: Cold Spring Harbor Laboratory Press, 2008: 121-49.
    • (2008) The Bone Morphogenetic Proteins in the TGF-B Family , pp. 121-149
    • Katagiri, T.1    Suda, T.2    Miyazono, K.3
  • 21
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and signal transduction
    • Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. J Biochem 2010; 147: 35-51.
    • (2010) J Biochem , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 22
    • 0033829535 scopus 로고    scopus 로고
    • Molecular architecture and biorecognition processes of the cystine knot protein superfamily: Part I. The glycoprotein hormones
    • Hearn MT, Gomme PT. Molecular architecture and biorecognition processes of the cystine knot protein superfamily: Part I. The glycoprotein hormones. J Mol Recognit 2000; 13: 223-78.
    • (2000) J Mol Recognit , vol.13 , pp. 223-278
    • Hearn, M.T.1    Gomme, P.T.2
  • 23
    • 67649216557 scopus 로고    scopus 로고
    • BMP modulators regulate the function of BMP during body patterning and disease progression
    • Yanagita M. BMP modulators regulate the function of BMP during body patterning and disease progression. Biofactors 2009; 35: 113-9.
    • (2009) Biofactors , vol.35 , pp. 113-119
    • Yanagita, M.1
  • 24
    • 77954527232 scopus 로고    scopus 로고
    • Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists
    • Rider CC, Mulloy B. Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists. Biochem J 2010; 429: 1-12.
    • (2010) Biochem J , vol.429 , pp. 1-12
    • Rider, C.C.1    Mulloy, B.2
  • 28
    • 33750577229 scopus 로고    scopus 로고
    • Comparative integromics on BMP/GDF family
    • Katoh Y, Katoh M. Comparative integromics on BMP/GDF family. Int J Mol Med 2006; 17: 951-5.
    • (2006) Int J Mol Med , vol.17 , pp. 951-955
    • Katoh, Y.1    Katoh, M.2
  • 31
    • 67650717476 scopus 로고    scopus 로고
    • The biology of activin: Recent advances in structure, regulation and function
    • Xia Y, Schneyer AL. The biology of activin: Recent advances in structure, regulation and function. J Endocrinol 2009; 202: 1-12.
    • (2009) J Endocrinol , vol.202 , pp. 1-12
    • Xia, Y.1    Schneyer, A.L.2
  • 32
    • 33747743119 scopus 로고    scopus 로고
    • The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding
    • Lin SJ, Lerch TF, Cook RW, Jardetzky TS, Woodruff TK. The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Reproduction 2006; 132: 179-90.
    • (2006) Reproduction , vol.132 , pp. 179-190
    • Lin, S.J.1    Lerch, T.F.2    Cook, R.W.3    Jardetzky, T.S.4    Woodruff, T.K.5
  • 33
    • 77949328305 scopus 로고    scopus 로고
    • Inhibins: From reproductive hormones to tumor suppressors
    • Stenvers KL, Findlay JK. Inhibins: From reproductive hormones to tumor suppressors. Trends Endocrinol Metab 2010; 21: 174-80.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 174-180
    • Stenvers, K.L.1    Findlay, J.K.2
  • 35
    • 84862758806 scopus 로고    scopus 로고
    • Oligomeric interactions of TGF-?and BMP receptors
    • Ehrlich M, Gutman O, Knaus P, Henis YI. Oligomeric interactions of TGF-?and BMP receptors. FEBS Lett 2012; 586: 1885-96.
    • (2012) FEBS Lett , vol.586 , pp. 1885-1896
    • Ehrlich, M.1    Gutman, O.2    Knaus, P.3    Henis, Y.I.4
  • 36
    • 79958768845 scopus 로고    scopus 로고
    • Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling
    • Ehrlich M, Horbelt D, Marom B, Knaus P, Henis YI. Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling. Cell Signal 2011; 23: 1424-32.
    • (2011) Cell Signal , vol.23 , pp. 1424-1432
    • Ehrlich, M.1    Horbelt, D.2    Marom, B.3    Knaus, P.4    Henis, Y.I.5
  • 37
    • 70349273685 scopus 로고    scopus 로고
    • The emerging role of TGF-beta superfamily coreceptors in cancer
    • Bernabeu C, Lopez-Novoa JM, Quintanilla M. The emerging role of TGF-beta superfamily coreceptors in cancer. Biochim Biophys Acta 2009; 1792: 954-73.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 954-973
    • Bernabeu, C.1    Lopez-Novoa, J.M.2    Quintanilla, M.3
  • 38
    • 0029959774 scopus 로고    scopus 로고
    • Phosphorylation of Ser165 in TGF-beta type i receptor modulates TGF-beta1-induced cellular responses
    • Souchelnytskyi S, ten Dijke P, Miyazono K, Heldin CH. Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses. EMBO J 1996; 15: 6231-40.
    • (1996) EMBO J , vol.15 , pp. 6231-6240
    • Souchelnytskyi, S.1    Ten Dijke, P.2    Miyazono, K.3    Heldin, C.H.4
  • 39
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the type i TGF beta receptor in complex with FKBP12
    • Huse M, Chen YG, Massagu é J, Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell 1999; 96: 425-36.
    • (1999) Cell , vol.96 , pp. 425-436
    • Huse, M.1    Chen, Y.G.2    Massagué, J.3    Kuriyan, J.4
  • 40
    • 0034796457 scopus 로고    scopus 로고
    • The TGF beta receptor activation process: An inhibitor-To substratebinding switch
    • Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagu é J. The TGF beta receptor activation process: An inhibitor-To substratebinding switch. Mol Cell 2001; 8: 671-82.
    • (2001) Mol Cell , vol.8 , pp. 671-682
    • Huse, M.1    Muir, T.W.2    Xu, L.3    Chen, Y.G.4    Kuriyan, J.5    Massagué, J.6
  • 41
    • 68549123472 scopus 로고    scopus 로고
    • New regulatory mechanisms of TGF-beta receptor function
    • Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol 2009; 19: 385-94.
    • (2009) Trends Cell Biol , vol.19 , pp. 385-394
    • Kang, J.S.1    Liu, C.2    Derynck, R.3
  • 42
    • 1642539976 scopus 로고    scopus 로고
    • GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type i receptor
    • Shi W, Sun C, He B, Xiong W, Shi X, Yao D, Cao X. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. J Cell Biol 2004; 164: 291-300.
    • (2004) J Cell Biol , vol.164 , pp. 291-300
    • Shi, W.1    Sun, C.2    He, B.3    Xiong, W.4    Shi, X.5    Yao, D.6    Cao, X.7
  • 43
    • 33751320113 scopus 로고    scopus 로고
    • Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction
    • Satow R, Kurisaki A, Chan T-C, Hamazaki TS, Asashima M. Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. Dev Cell 2006; 11: 763-74.
    • (2006) Dev Cell , vol.11 , pp. 763-774
    • Satow, R.1    Kurisaki, A.2    Chan, T.-C.3    Hamazaki, T.S.4    Asashima, M.5
  • 44
    • 70849129868 scopus 로고    scopus 로고
    • SUMOylation and deSUMOylation at a glance
    • Wang Y, Dasso M. SUMOylation and deSUMOylation at a glance. J Cell Sci 2009; 122: 4249-52.
    • (2009) J Cell Sci , vol.122 , pp. 4249-4252
    • Wang, Y.1    Dasso, M.2
  • 45
    • 44649163272 scopus 로고    scopus 로고
    • The type i TGFbeta receptor is covalently modifi ed and regulated by sumoylation
    • Kang JS, Saunier EF, Akhurst RJ, Derynck R. The type I TGFbeta receptor is covalently modifi ed and regulated by sumoylation. Nat Cell Biol 2008; 10: 654-64.
    • (2008) Nat Cell Biol , vol.10 , pp. 654-664
    • Kang, J.S.1    Saunier, E.F.2    Akhurst, R.J.3    Derynck, R.4
  • 46
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
    • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 2003; 5: 410-21.
    • (2003) Nat Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 47
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF b receptor for degradation
    • Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF b receptor for degradation. Mol Cell 2000; 6: 1365-75.
    • (2000) Mol Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 48
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-b type i receptor through Smad7 and induces receptor degradation
    • Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K. Smurf1 interacts with transforming growth factor-b type I receptor through Smad7 and induces receptor degradation. J Biol Chem 2001; 276: 12477-80.
    • (2001) J Biol Chem , vol.276 , pp. 12477-12480
    • Ebisawa, T.1    Fukuchi, M.2    Murakami, G.3    Chiba, T.4    Tanaka, K.5    Imamura, T.6    Miyazono, K.7
  • 49
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-beta superfamily
    • Chang H, Brown CW, Matzuk MM. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 2002; 23: 787-823.
    • (2002) Endocr Rev , vol.23 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 50
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massagu é J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 51
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    • Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998; 95: 779-91.
    • (1998) Cell , vol.95 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 53
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-Associated Mad homologues synergize as effectors of the TGF-beta response
    • Zhang Y, Feng X, We R, Derynck R. Receptor-Associated Mad homologues synergize as effectors of the TGF-beta response. Nature 1996; 383: 168-72.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.2    We, R.3    Derynck, R.4
  • 54
    • 33847716712 scopus 로고    scopus 로고
    • Negative regulation of TGF-beta receptor/ Smad signal transduction
    • Itoh S, ten Dijke P. Negative regulation of TGF-beta receptor/ Smad signal transduction. Curr Opin Cell Biol 2007; 19: 176-84.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 176-184
    • Itoh, S.1    Ten Dijke, P.2
  • 55
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-B signaling
    • Massague J, Chen YG. Controlling TGF-B signaling. Genes Dev 2000; 14: 627-44.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 56
    • 21344455768 scopus 로고    scopus 로고
    • BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling crosstalk
    • Miyazono K, Maeda S, Imamura T. BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling crosstalk. Cytokine Growth Factor Rev 2005; 16: 251-63.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 251-263
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 58
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-beta signaling
    • Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009; 19: 128-39.
    • (2009) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 59
    • 0026612306 scopus 로고
    • Activation of p21ras by transforming growth factor beta in epithelial cells
    • Mulder KM, Morris SL. Activation of p21ras by transforming growth factor beta in epithelial cells. J Biol Chem 1992; 267: 5029-31.
    • (1992) J Biol Chem , vol.267 , pp. 5029-5031
    • Mulder, K.M.1    Morris, S.L.2
  • 62
    • 52049111663 scopus 로고    scopus 로고
    • TRAF6 mediates Smad-independent activation of JNK and p38 by TGF
    • Yamashita M, Fatyo K, Jin C, Wang X, Liu Z, Zhang YE. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-? Mol Cell 2008; 31: 918-24.
    • (2008) Mol Cell , vol.31 , pp. 918-924
    • Yamashita, M.1    Fatyo, K.2    Jin, C.3    Wang, X.4    Liu, Z.5    Zhang, Y.E.6
  • 63
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelialmesenchymal transitions during embryogenesis and cancer progression
    • Moustakas A, Heldin CH. Signaling networks guiding epithelialmesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 2007; 98: 1512-20.
    • (2007) Cancer Sci , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 64
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-72.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 65
    • 83755183459 scopus 로고    scopus 로고
    • Regulation of myosin light chain function by BMP signaling controls actin cytoskeleton remodeling
    • Konstantinidis G, Moustakas A, Stournaras C. Regulation of myosin light chain function by BMP signaling controls actin cytoskeleton remodeling. Cell Physiol Biochem 2011; 28: 1031-44.
    • (2011) Cell Physiol Biochem , vol.28 , pp. 1031-1044
    • Konstantinidis, G.1    Moustakas, A.2    Stournaras, C.3
  • 66
    • 59349086946 scopus 로고    scopus 로고
    • Bmp2 induction of actin cytoskeleton reorganization and cell migration requires pi3-kinase and cdc42 activity
    • Gamell C, Osses N, Bartrons R, Ruckle T, Camps M, Rosa JL, Ventura F: Bmp2 induction of actin cytoskeleton reorganization and cell migration requires pi3-kinase and cdc42 activity. J Cell Sci 2008; 121: 3960-70.
    • (2008) J Cell Sci , vol.121 , pp. 3960-3970
    • Gamell, C.1    Osses, N.2    Bartrons, R.3    Ruckle, T.4    Camps, M.5    Rosa, J.L.6    Ventura, F.7
  • 67
    • 28544450380 scopus 로고    scopus 로고
    • Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-Activated kinase-2
    • Wilkes MC, Mitchell H, Penheiter SG, Dor é JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB. Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-Activated kinase-2. Cancer Res 2005; 65: 10431-40.
    • (2005) Cancer Res , vol.65 , pp. 10431-10440
    • Wilkes, M.C.1    Mitchell, H.2    Penheiter, S.G.3    Doré, J.J.4    Suzuki, K.5    Edens, M.6    Sharma, D.K.7    Pagano, R.E.8    Leof, E.B.9
  • 68
    • 15444372825 scopus 로고    scopus 로고
    • Type i transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase
    • Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 2005; 280: 10870-6.
    • (2005) J Biol Chem , vol.280 , pp. 10870-10876
    • Yi, J.Y.1    Shin, I.2    Arteaga, C.L.3
  • 69
    • 0032532206 scopus 로고    scopus 로고
    • Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Chen RH, Su YH, Chuang RL, Chang TY. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene 1998; 17: 1959-68.
    • (1998) Oncogene , vol.17 , pp. 1959-1968
    • Chen, R.H.1    Su, Y.H.2    Chuang, R.L.3    Chang, T.Y.4
  • 70
    • 30444434212 scopus 로고    scopus 로고
    • Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
    • Song K, Wang H, Krebs TL, Danielpour D. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J 2006; 25: 58-69.
    • (2006) EMBO J , vol.25 , pp. 58-69
    • Song, K.1    Wang, H.2    Krebs, T.L.3    Danielpour, D.4
  • 71
    • 16244400050 scopus 로고    scopus 로고
    • TGFb/ activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
    • James D, Levine AJ, Besser D, Hemmati-Brivanlou A. TGFb/ activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005; 132: 1273-82.
    • (2005) Development , vol.132 , pp. 1273-1282
    • James, D.1    Levine, A.J.2    Besser, D.3    Hemmati-Brivanlou, A.4
  • 72
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: Of mice and men
    • Smith AG. Embryo-derived stem cells: Of mice and men. Annu Rev Cell Dev Biol 2001; 17: 435-62.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 73
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans M, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154-6.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.1    Kaufman, M.H.2
  • 75
    • 15544383394 scopus 로고    scopus 로고
    • Embryonic stem cells: Prospects for developmental biology and cell therapy
    • Wobus AM, Boheler KR. Embryonic stem cells: Prospects for developmental biology and cell therapy. Physiol Rev 2005; 85: 635-78.
    • (2005) Physiol Rev , vol.85 , pp. 635-678
    • Wobus, A.M.1    Boheler, K.R.2
  • 76
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development. Cell 2008; 132: 661-80.
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 77
    • 34047162942 scopus 로고    scopus 로고
    • TGF ?in the differentiation of embryonic stem cells
    • Puc é at M. TGF ?in the differentiation of embryonic stem cells. Cardiovasc Res 2007; 74: 256-61.
    • (2007) Cardiovasc Res , vol.74 , pp. 256-261
    • Pucéat, M.1
  • 79
    • 58149239733 scopus 로고    scopus 로고
    • Roles of TGF-?family signaling in stem cell renewal and differentiation
    • Watabe T, Miyazono K. Roles of TGF-?family signaling in stem cell renewal and differentiation. Cell Res 2009; 19: 103-15.
    • (2009) Cell Res , vol.19 , pp. 103-115
    • Watabe, T.1    Miyazono, K.2
  • 80
    • 17044365440 scopus 로고    scopus 로고
    • Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
    • Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 2005; 121: 87-99.
    • (2005) Cell , vol.121 , pp. 87-99
    • Dupont, S.1    Zacchigna, L.2    Cordenonsi, M.3    Soligo, S.4    Adorno, M.5    Rugge, M.6    Piccolo, S.7
  • 81
    • 27644504639 scopus 로고    scopus 로고
    • Characterization of mesendoderm: A diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture
    • Tada S, Era T, Furusawa C, Sakurai H, Nishikawa S, Kinoshita M, Nakao K, Chiba T, Nishikawa S. Characterization of mesendoderm: A diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 2005; 132: 4363-74.
    • (2005) Development , vol.132 , pp. 4363-4374
    • Tada, S.1    Era, T.2    Furusawa, C.3    Sakurai, H.4    Nishikawa, S.5    Kinoshita, M.6    Nakao, K.7    Chiba, T.8    Nishikawa, S.9
  • 82
    • 3042733135 scopus 로고    scopus 로고
    • A hierarchical order of factors in the generation of FLK1-And SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells
    • Park C, Afrikanova I, Chung YS, Zhang WJ, Arentson E, Fong Gh G, Rosendahl A, Choi K. A hierarchical order of factors in the generation of FLK1-And SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development 2004; 131: 2749-62.
    • (2004) Development , vol.131 , pp. 2749-2762
    • Park, C.1    Afrikanova, I.2    Chung, Y.S.3    Zhang, W.J.4    Arentson, E.5    Fong Gh, G.6    Rosendahl, A.7    Choi, K.8
  • 83
    • 49749152786 scopus 로고    scopus 로고
    • Patterning of mouse embryonic stem cellderived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity
    • Willems E, Leyns L. Patterning of mouse embryonic stem cellderived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity. Differentiation 2008; 76: 745-59.
    • (2008) Differentiation , vol.76 , pp. 745-759
    • Willems, E.1    Leyns, L.2
  • 84
    • 77953482266 scopus 로고    scopus 로고
    • Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/activin/nodal signaling using SB-431542
    • Mahmood A, Harkness L, Schroder HD, Abdallah BM, Kassem M. Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/activin/nodal signaling using SB-431542. J Bone Miner Res 2010; 25: 1216-33.
    • (2010) J Bone Miner Res , vol.25 , pp. 1216-1233
    • Mahmood, A.1    Harkness, L.2    Schroder, H.D.3    Abdallah, B.M.4    Kassem, M.5
  • 85
    • 0029831878 scopus 로고    scopus 로고
    • Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps
    • Sasai Y, Lu B, Piccolo S, De Robertis EM. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J 1996; 15: 4547-55.
    • (1996) EMBO J , vol.15 , pp. 4547-4555
    • Sasai, Y.1    Lu, B.2    Piccolo, S.3    De Robertis, E.M.4
  • 90
    • 0031833476 scopus 로고    scopus 로고
    • Progressive lineage analysis by cell sorting and culture identities FLK1+ VE-cadherin+ cells at a diverging point of endothelial and hematopoietic lineages
    • Nishikawa ST, Nishikawa S, Hirashima M. Progressive lineage analysis by cell sorting and culture identities FLK1+ VE-cadherin+ cells at a diverging point of endothelial and hematopoietic lineages. Development 1998; 125: 1747-57.
    • (1998) Development , vol.125 , pp. 1747-1757
    • Nishikawa, S.T.1    Nishikawa, S.2    Hirashima, M.3
  • 92
    • 0037871588 scopus 로고    scopus 로고
    • Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
    • Chadwick K, Wang L, Li L, Menendez P, Murdoch B, Rouleau A, Bhatia M. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 2003; 102: 906-15.
    • (2003) Blood , vol.102 , pp. 906-915
    • Chadwick, K.1    Wang, L.2    Li, L.3    Menendez, P.4    Murdoch, B.5    Rouleau, A.6    Bhatia, M.7
  • 93
    • 33645071578 scopus 로고    scopus 로고
    • TGF ?inhibition of yolk-sac-like differentiation of human embryonic stem-cellderived embryoid bodies illustrates differences between early mouse and human development
    • Poon E, Clermont F, Firpo MT, Akhurst RJ. TGF ?inhibition of yolk-sac-like differentiation of human embryonic stem-cellderived embryoid bodies illustrates differences between early mouse and human development. J Cell Sci 2006; 119: 759-68.
    • (2006) J Cell Sci , vol.119 , pp. 759-768
    • Poon, E.1    Clermont, F.2    Firpo, M.T.3    Akhurst, R.J.4
  • 97
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • Ying QL, Stavridis M, Griffi ths D, Li M, Smith A. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 2003; 21: 183-6.
    • (2003) Nat Biotechnol , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 98
    • 10944266135 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic proteins in early embryonic development
    • Yamamoto Y, Oelgeschläger M. Regulation of bone morphogenetic proteins in early embryonic development. Naturwissenschaften 2004; 91: 519-34.
    • (2004) Naturwissenschaften , vol.91 , pp. 519-534
    • Yamamoto, Y.1    Oelgeschläger, M.2
  • 101
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • Dreesen O, Brivanlou AH. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 2007; 3: 7-17
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 104
    • 0347989458 scopus 로고    scopus 로고
    • Cellular and molecular regulation of muscle regeneration
    • Charg é SB, Rudnicki MA. Cellular and molecular regulation of muscle regeneration. Physiol Rev 2004; 84: 209-38.
    • (2004) Physiol Rev , vol.84 , pp. 209-238
    • Chargé, S.B.1    Rudnicki, M.A.2
  • 105
    • 0142026448 scopus 로고    scopus 로고
    • Controlling mesenchymal stem cell differentiation by TGFBeta family members
    • Roelen BA, Dijke P. Controlling mesenchymal stem cell differentiation by TGFBeta family members. Orthop Sci 2003; 8: 740-8.
    • (2003) Orthop Sci , vol.8 , pp. 740-748
    • Roelen, B.A.1    Dijke, P.2
  • 106
    • 0035890328 scopus 로고    scopus 로고
    • TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    • Liu D, Black BL, Derynck R. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 2001; 15: 2950-66.
    • (2001) Genes Dev , vol.15 , pp. 2950-2966
    • Liu, D.1    Black, B.L.2    Derynck, R.3
  • 107
    • 28844509240 scopus 로고    scopus 로고
    • Myostatin: A modulator of skeletalmuscle stem cells
    • Walsh FS, Celeste AJ. Myostatin: A modulator of skeletalmuscle stem cells. Biochem Soc Trans 2005; 33: 1513-7.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1513-1517
    • Walsh, F.S.1    Celeste, A.J.2
  • 108
    • 0037147210 scopus 로고    scopus 로고
    • Myostatin inhibits myoblast differentiation by down-regulating MyoD expression
    • Langley B, Thomas M, Bishop A, Sharma M, Gilmour S, Kambadur R. Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. J Biol Chem 2002; 277: 49831-40.
    • (2002) J Biol Chem , vol.277 , pp. 49831-49840
    • Langley, B.1    Thomas, M.2    Bishop, A.3    Sharma, M.4    Gilmour, S.5    Kambadur, R.6
  • 110
    • 77951473740 scopus 로고    scopus 로고
    • Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration
    • Clever JL, Sakai Y, Wang RA, Schneider DB. Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration. Am J Physiol Cell Physiol 2010; 298: C1087-99.
    • (2010) Am J Physiol Cell Physiol , vol.298 , pp. C1087-C1099
    • Clever, J.L.1    Sakai, Y.2    Wang, R.A.3    Schneider, D.B.4
  • 111
    • 84859429257 scopus 로고    scopus 로고
    • BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system
    • Ruschke K, Hiepen C, Becker J, Knaus P. BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system. Cell Tissue Res 2012; 347: 521-44.
    • (2012) Cell Tissue Res , vol.347 , pp. 521-544
    • Ruschke, K.1    Hiepen, C.2    Becker, J.3    Knaus, P.4
  • 112
    • 70449640613 scopus 로고    scopus 로고
    • TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: Modulation and integration of signaling pathways through receptor-Smads
    • van der Kraan PM, Blaney Davidson EN, Blom A, van den Berg WB. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: Modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage 2009; 17: 1539-45.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1539-1545
    • Van Der Kraan, P.M.1    Blaney Davidson, E.N.2    Blom, A.3    Van Den Berg, W.B.4
  • 113
    • 0027209267 scopus 로고
    • TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: Regulation of gene expression for cartilage matrix proteins and metalloproteases
    • Ballock RT, Heydemann A, Wakefield LM, Flanders KC, Roberts AB, Sporn MB. TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: Regulation of gene expression for cartilage matrix proteins and metalloproteases. Dev Biol 1993; 158: 414-29.
    • (1993) Dev Biol , vol.158 , pp. 414-429
    • Ballock, R.T.1    Heydemann, A.2    Wakefield, L.M.3    Flanders, K.C.4    Roberts, A.B.5    Sporn, M.B.6
  • 114
    • 43949115205 scopus 로고    scopus 로고
    • Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells
    • Mueller MB, Tuan RS. Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum 2008; 58: 1377-88.
    • (2008) Arthritis Rheum , vol.58 , pp. 1377-1388
    • Mueller, M.B.1    Tuan, R.S.2
  • 115
    • 0142103359 scopus 로고    scopus 로고
    • Transforming growth factorbeta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-Activated protein kinase and Wnt signaling cross-Talk
    • Tuli R, Tuli S, Nandi S, Huang X, Manner PA, Hozack WJ, Danielson KG, Hall DJ, Tuan RS. Transforming growth factorbeta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-Activated protein kinase and Wnt signaling cross-Talk. J Biol Chem 2003; 278: 41227-36.
    • (2003) J Biol Chem , vol.278 , pp. 41227-41236
    • Tuli, R.1    Tuli, S.2    Nandi, S.3    Huang, X.4    Manner, P.A.5    Hozack, W.J.6    Danielson, K.G.7    Hall, D.J.8    Tuan, R.S.9
  • 117
    • 53649092506 scopus 로고    scopus 로고
    • Mesenchymal stem cells and their cell surface receptors
    • Docheva D, Haasters F, Schieker M. Mesenchymal stem cells and their cell surface receptors. Curr Rheumatol Rev 2008; 4: 155-60.
    • (2008) Curr Rheumatol Rev , vol.4 , pp. 155-160
    • Docheva, D.1    Haasters, F.2    Schieker, M.3
  • 118
    • 0035882056 scopus 로고    scopus 로고
    • Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components
    • Barry F, Boynton RE, Liu B, Murphy JM. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components. Exp Cell Res 2001; 268: 189-200.
    • (2001) Exp Cell Res , vol.268 , pp. 189-200
    • Barry, F.1    Boynton, R.E.2    Liu, B.3    Murphy, J.M.4
  • 120
    • 18844447203 scopus 로고    scopus 로고
    • Comparison of effect of BMP-2-4, and-6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma
    • Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ. Comparison of effect of BMP-2,-4, and-6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res 2005; 320: 269-76.
    • (2005) Cell Tissue Res , vol.320 , pp. 269-276
    • Sekiya, I.1    Larson, B.L.2    Vuoristo, J.T.3    Reger, R.L.4    Prockop, D.J.5
  • 122
    • 50949105736 scopus 로고    scopus 로고
    • Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells
    • Miljkovic ND, Cooper GM, Marra KG. Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells. Osteoarthritis Cartilage 2008; 16: 1121-30.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1121-1130
    • Miljkovic, N.D.1    Cooper, G.M.2    Marra, K.G.3
  • 123
    • 79959863141 scopus 로고    scopus 로고
    • BMP7 induces the differentiation of bone marrow-derived mesenchymal cells into chondrocytes
    • Bai X, Li G, Zhao C, Duan H, Qu F. BMP7 induces the differentiation of bone marrow-derived mesenchymal cells into chondrocytes. Med Biol Eng Comput 2011; 49: 687-92
    • (2011) Med Biol Eng Comput , vol.49 , pp. 687-692
    • Bai, X.1    Li, G.2    Zhao, C.3    Duan, H.4    Qu, F.5
  • 125
    • 0024322576 scopus 로고
    • In vivo stimulation of bone formation by transforming growth factor-beta
    • Noda M, Camilliere JJ. In vivo stimulation of bone formation by transforming growth factor-beta. Endocrinology 1989; 124: 2991-4.
    • (1989) Endocrinology , vol.124 , pp. 2991-2994
    • Noda, M.1    Camilliere, J.J.2
  • 126
    • 0025340885 scopus 로고
    • Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur
    • Joyce ME, Roberts AB, Sporn MB, Bolander ME. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 1990; 110: 2195-207.
    • (1990) J Cell Biol , vol.110 , pp. 2195-2207
    • Joyce, M.E.1    Roberts, A.B.2    Sporn, M.B.3    Bolander, M.E.4
  • 127
    • 0029671373 scopus 로고    scopus 로고
    • Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
    • Erlebacher A, Derynck R. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol 1996; 132: 195-210.
    • (1996) J Cell Biol , vol.132 , pp. 195-210
    • Erlebacher, A.1    Derynck, R.2
  • 128
    • 0035341209 scopus 로고    scopus 로고
    • TGF-betainduced repression of CBFA1 by Smad3 decreases CBFA1 and osteocalcin expression and inhibits osteoblast differentiation
    • Alliston T, Choy L, Ducy P, Karsenty G, Derynck R. TGF-betainduced repression of CBFA1 by Smad3 decreases CBFA1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 2001; 20: 2254-72.
    • (2001) EMBO J , vol.20 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4    Derynck, R.5
  • 129
    • 79954520847 scopus 로고    scopus 로고
    • TGF-beta regulates beta-catenin signaling and osteoblast differentiation in human mesenchymal stem cells
    • Zhou S. TGF-beta regulates beta-catenin signaling and osteoblast differentiation in human mesenchymal stem cells. J Cell Biochem 2011; 112: 1651-60.
    • (2011) J Cell Biochem , vol.112 , pp. 1651-1660
    • Zhou, S.1
  • 130
    • 77955281178 scopus 로고    scopus 로고
    • Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability
    • Huang Z, Ren PG, Ma T, Smith RL, Goodman SB. Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability. Cytokine 2010; 51: 305-10.
    • (2010) Cytokine , vol.51 , pp. 305-310
    • Huang, Z.1    Ren, P.G.2    Ma, T.3    Smith, R.L.4    Goodman, S.B.5
  • 131
    • 0037102589 scopus 로고    scopus 로고
    • Overview of bone morphogenetic proteins
    • Wozney JM. Overview of bone morphogenetic proteins. Spine 2002; 27: S2-8.
    • (2002) Spine , vol.27 , pp. S2-8
    • Wozney, J.M.1
  • 132
  • 133
    • 84863040008 scopus 로고    scopus 로고
    • TGF-?and BMP signaling in osteoblast differentiation and bone formation
    • Chen G, Deng C, Li YP. TGF-?and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci 2012; 8: 272-88.
    • (2012) Int J Biol Sci , vol.8 , pp. 272-288
    • Chen, G.1    Deng, C.2    Li, Y.P.3
  • 135
    • 1442313955 scopus 로고    scopus 로고
    • Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells
    • Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K. Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J 2004; 23: 552-63.
    • (2004) EMBO J , vol.23 , pp. 552-563
    • Maeda, S.1    Hayashi, M.2    Komiya, S.3    Imamura, T.4    Miyazono, K.5
  • 136
    • 33750494938 scopus 로고    scopus 로고
    • Up-regulation of bone morphogenetic protein receptor IB by growth factors enhances BMP-2-induced human bone cell functions
    • Singhatanadgit W, Salih V, Olsen I. Up-regulation of bone morphogenetic protein receptor IB by growth factors enhances BMP-2-induced human bone cell functions. J Cell Physiol 2006; 209: 912-22.
    • (2006) J Cell Physiol , vol.209 , pp. 912-922
    • Singhatanadgit, W.1    Salih, V.2    Olsen, I.3
  • 137
    • 70449518159 scopus 로고    scopus 로고
    • Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: A pilot study
    • Yoshikawa H, Yoshioka K, Nakase T, Itoh K. Stimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: A pilot study. Clin Orthop Relat Res 2009; 467: 3087-95.
    • (2009) Clin Orthop Relat Res , vol.467 , pp. 3087-3095
    • Yoshikawa, H.1    Yoshioka, K.2    Nakase, T.3    Itoh, K.4
  • 138
    • 23744496757 scopus 로고    scopus 로고
    • Adipose development: From stem cell to adipocyte
    • Otto TC, Lane MD. Adipose development: From stem cell to adipocyte. Crit Rev Biochem Mol Biol 2005; 40: 229-42.
    • (2005) Crit Rev Biochem Mol Biol , vol.40 , pp. 229-242
    • Otto, T.C.1    Lane, M.D.2
  • 140
    • 84857238792 scopus 로고    scopus 로고
    • The transforming growth factor-beta/bone morphogenetic protein signalling pathway in adipogenesis
    • Margoni A, Fotis L, Papavassiliou AG. The transforming growth factor-beta/bone morphogenetic protein signalling pathway in adipogenesis. Int J Biochem Cell Biol 2012; 44: 475-9.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 475-479
    • Margoni, A.1    Fotis, L.2    Papavassiliou, A.G.3
  • 141
    • 79958242398 scopus 로고    scopus 로고
    • Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure
    • Zamani N, Brown CW. Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. Endocr Rev 2011; 32: 387-403.
    • (2011) Endocr Rev , vol.32 , pp. 387-403
    • Zamani, N.1    Brown, C.W.2
  • 142
    • 0034194304 scopus 로고    scopus 로고
    • Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation
    • Choy L, Skillington J, Derynck R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 2000; 49: 667-82.
    • (2000) J Cell Biol , vol.49 , pp. 667-682
    • Choy, L.1    Skillington, J.2    Derynck, R.3
  • 145
    • 0034705835 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone)
    • Sottile V, Seuwen K. Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone). FEBS Lett 2000; 475: 201-4.
    • (2000) FEBS Lett , vol.475 , pp. 201-204
    • Sottile, V.1    Seuwen, K.2
  • 146
    • 0037323398 scopus 로고    scopus 로고
    • Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-Activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis
    • Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, Nokubi T, Yoneda T. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-Activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell 2003; 14: 545-55.
    • (2003) Mol Biol Cell , vol.14 , pp. 545-555
    • Hata, K.1    Nishimura, R.2    Ikeda, F.3    Yamashita, K.4    Matsubara, T.5    Nokubi, T.6    Yoneda, T.7
  • 148
    • 33745727603 scopus 로고    scopus 로고
    • Effect of bone morphogenetic protein-4 (BMP-4) on adipocyte differentiation from mouse embryonic stem cells
    • Taha MF, Valojerdi MR, Mowla SJ. Effect of bone morphogenetic protein-4 (BMP-4) on adipocyte differentiation from mouse embryonic stem cells. Anat Histol Embryol 2006; 35: 271-8.
    • (2006) Anat Histol Embryol , vol.35 , pp. 271-278
    • Taha, M.F.1    Valojerdi, M.R.2    Mowla, S.J.3
  • 149
    • 77951213502 scopus 로고    scopus 로고
    • BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway
    • Stewart A, Guan H, Yang K. BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway. J Cell Physiol 2011; 223: 658-66.
    • (2011) J Cell Physiol , vol.223 , pp. 658-666
    • Stewart, A.1    Guan, H.2    Yang, K.3
  • 151
    • 0141864365 scopus 로고    scopus 로고
    • Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis
    • Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol 2003; 23: 7230-42.
    • (2003) Mol Cell Biol , vol.23 , pp. 7230-7242
    • Rebbapragada, A.1    Benchabane, H.2    Wrana, J.L.3    Celeste, A.J.4    Attisano, L.5
  • 152
    • 33750345334 scopus 로고    scopus 로고
    • Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects
    • Feldman BJ, Streeper RS, Farese Jr. RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci USA 2006; 103: 15675-80.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15675-15680
    • Feldman, B.J.1    Streeper, R.S.2    Farese, R.V.3    Yamamoto, K.R.4
  • 153
    • 44049094434 scopus 로고    scopus 로고
    • The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways
    • Guo W, Flanagan J, Jasuja R, Kirkland J, Jiang L, Bhasin S. The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways. J Biol Chem 2008; 283: 9136-45.
    • (2008) J Biol Chem , vol.283 , pp. 9136-9145
    • Guo, W.1    Flanagan, J.2    Jasuja, R.3    Kirkland, J.4    Jiang, L.5    Bhasin, S.6
  • 154
    • 84860729957 scopus 로고    scopus 로고
    • Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex
    • Hino J, Miyazawa T, Miyazato M, Kangawa K. Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex. Int J Obes (Lond) 2012; 36: 725-34.
    • (2012) Int J Obes (Lond) , vol.36 , pp. 725-734
    • Hino, J.1    Miyazawa, T.2    Miyazato, M.3    Kangawa, K.4
  • 155
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 157
    • 63449110274 scopus 로고    scopus 로고
    • Transforming growth factor beta-induced endothelial-To-mesenchymal transition: A switch to cardiac fibrosis ?
    • Goumans MJ, van Zonneveld AJ, ten Dijke P. Transforming growth factor beta-induced endothelial-To-mesenchymal transition: A switch to cardiac fibrosis ? Trends Cardiovasc Med 2008; 18: 293-8.
    • (2008) Trends Cardiovasc Med , vol.18 , pp. 293-298
    • Goumans, M.J.1    Van Zonneveld, A.J.2    Ten Dijke, P.3
  • 158
    • 73349088160 scopus 로고    scopus 로고
    • Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis
    • Kuhn NZ, Tuan RS. Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis. J Cell Physiol 2010; 222: 268-77.
    • (2010) J Cell Physiol , vol.222 , pp. 268-277
    • Kuhn, N.Z.1    Tuan, R.S.2
  • 159
    • 79960912980 scopus 로고    scopus 로고
    • Control of microRNA biogenesis and transcription by cell signaling pathways
    • Saj A, Lai EC. Control of microRNA biogenesis and transcription by cell signaling pathways. Curr Opin Genet Dev 2011; 21: 504-10.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 504-510
    • Saj, A.1    Lai, E.C.2
  • 160
    • 79956287890 scopus 로고    scopus 로고
    • The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells
    • Guo L, Zhao RC, Wu Y. The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol 2011; 39: 608-16.
    • (2011) Exp Hematol , vol.39 , pp. 608-616
    • Guo, L.1    Zhao, R.C.2    Wu, Y.3
  • 161
    • 78650223089 scopus 로고    scopus 로고
    • MicroRNAs in embryonic stem cell function and fate
    • Tiscornia G, Izpisúa Belmonte JC. MicroRNAs in embryonic stem cell function and fate. Genes Dev 2010; 24: 2732-41.
    • (2010) Genes Dev , vol.24 , pp. 2732-2741
    • Tiscornia, G.1    Izpisúa, B.J.C.2
  • 162
    • 33646035242 scopus 로고    scopus 로고
    • Activin receptor-like kinases: Structure, function and clinical implications
    • Graham H, Peng C. Activin receptor-like kinases: Structure, function and clinical implications. Endocr Metab Immune Disord Drug Targets 2006; 6: 45-58.
    • (2006) Endocr Metab Immune Disord Drug Targets , vol.6 , pp. 45-58
    • Graham, H.1    Peng, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.