The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/β-catenin signaling pathways

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 9136-9145

  Guo, Wen ^a,c   Flanagan, John ^a,b   Jasuja, Ravi ^a   Kirkland, James ^a   Jiang, Lan ^a   Bhasin, Shalender ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL CULTURE; FATTY ACIDS;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUES; BONE MARROWS; CATENIN; CATENIN SIGNALING; CELLULAR LIPIDS; HUMAN BONE MARROWS; HUMAN MESENCHYMAL STEM CELLS; INHIBITORY EFFECTS; LIPID ACCUMULATIONS; MESENCHYMAL STEM CELLS; MYOSTATIN; NUCLEAR TRANSLOCATIONS; OVEREXPRESSION; PATHWAY GENES; PREADIPOCYTES; PROGENITOR CELLS; RNAI SILENCING; SMAD SIGNALS; UNDERLYING MECHANISMS;

DIFFERENTIATION (CALCULUS);

BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; FATTY ACID; LEPTIN; MYOSTATIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; WNT PROTEIN; DIFFERENTIATION ANTIGEN; SMAD3 PROTEIN, HUMAN; T CELL FACTOR 4; T CELL FACTOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADIPOGENESIS; ADIPOSE TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; GENE SILENCING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LIPID STORAGE; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; ACTIVE TRANSPORT; ADIPOCYTE; ADULT; BIOSYNTHESIS; BONE MARROW CELL; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; GENETICS; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADIPOCYTES; ADIPOGENESIS; ADULT; ANTIGENS, DIFFERENTIATION; BETA CATENIN; BONE MARROW CELLS; CELL NUCLEUS; CELLS, CULTURED; DOWN-REGULATION; HUMANS; MALE; MESENCHYMAL STEM CELLS; PHOSPHORYLATION; PPAR GAMMA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TCF TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS;

EID: 44049094434     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708968200     Document Type: Article

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