Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain

Biotechnology Progress

Volumn 30, Issue 1, 2014, Pages 188-197

  Pybus, Leon P ^a   James, David C ^a   Dean, Greg ^b   Slidel, Tim ^b   Hardman, Colin ^b   Smith, Andrew ^b   Daramola, Olalekan ^b   Field, Ray ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b MEDIMMUNE   (United States)

Author keywords

Bioinformatics; Chinese hamster; Difficult to express proteins; Ovary cells; Recombinant monoclonal antibodies

Indexed keywords

CHINESE HAMSTER OVARY CELLS; CHINESE HAMSTERS; COMPLEMENTARITY-DETERMINING REGION 3; INTERVENTION STRATEGY; OVARY CELLS; PROTEIN CODING SEQUENCES; RECOMBINANT MONOCLONAL ANTIBODY; ROOT MEAN SQUARE ERRORS;

BIOINFORMATICS; FORECASTING; MEAN SQUARE ERROR; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

RECOMBINANT PROTEINS;

CRICETULUS GRISEUS;

IMMUNOGLOBULIN LIGHT CHAIN; MESSENGER RNA; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOINFORMATICS; BIOLOGY; BIOTECHNOLOGY; CHEMICAL PHENOMENA; CHEMISTRY; CHINESE HAMSTER; CHO CELL LINE; COMPLEMENTARITY DETERMINING REGION; CRICETULUS; DIFFICULT-TO-EXPRESS PROTEINS; GENETICS; HAMSTER; METABOLISM; METHODOLOGY; OVARY CELLS; RECOMBINANT MONOCLONAL ANTIBODIES; SEQUENCE ANALYSIS;

BIOINFORMATICS; CHINESE HAMSTER; DIFFICULT-TO-EXPRESS PROTEINS; OVARY CELLS; RECOMBINANT MONOCLONAL ANTIBODIES;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CHO CELLS; COMPLEMENTARITY DETERMINING REGIONS; COMPUTATIONAL BIOLOGY; CRICETINAE; CRICETULUS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN LIGHT CHAINS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS, PROTEIN;

EID: 84893787367     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1839     Document Type: Article

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