Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

Biotechnology Progress

Volumn 27, Issue 6, 2011, Pages 1689-1699

  Davies, Sarah L ^a   O'Callaghan, Peter M ^a   Mcleod, Jane ^a   Pybus, Leon P ^a   Sung, Yun Hee ^b   Rance, James ^c   Wilkinson, Stephen J ^a   Racher, Andrew J ^c   Young, Robert J ^d   James, David C ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b LG Chemical Ltd   (South Korea)

^c LONZA AG   (Switzerland)

^d New Expression Technologies Group   (United Kingdom)

Author keywords

Chinese hamster ovary cells; Mathematical modeling; Recombinant monoclonal antibody

Indexed keywords

ASSEMBLY REACTIONS; CHINESE HAMSTER OVARY CELLS; CHO CELL; CMV PROMOTER; EMPIRICAL MODELING; EXPRESSION VECTORS; FOOT-AND-MOUTH DISEASE VIRUS; GENE TRANSCRIPTIONS; GENE VECTORS; HEAVY CHAIN; INTERMEDIATE LEVEL; LIGHT CHAIN; LINKER SEQUENCE; LOCAL SENSITIVITY ANALYSIS; MATHEMATICAL MODELING; MOLAR EXCESS; OPEN READING FRAME; RECOMBINANT MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; TRANSFECTANTS; TRANSLATION RATES; VECTOR DESIGN;

CELLS; DESIGN; GENES; MONOCLONAL ANTIBODIES; OLIGOMERS; PROTEINS; SENSITIVITY ANALYSIS; STOICHIOMETRY; TRANSCRIPTION; VIRUSES;

VECTORS;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; CHO CELL; CRICETULUS; CULTURE TECHNIQUE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; METABOLISM; OPEN READING FRAME;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN G; OPEN READING FRAMES; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 82955214824     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.692     Document Type: Article

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