Probing the stability-limiting regions of an antibody single-chain variable fragment: A molecular dynamics simulation study

Protein Engineering, Design and Selection

Volumn 24, Issue 9, 2011, Pages 649-657

  Wang, Ting ^a   Duan, Yong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

molecular dynamics; single chain fragment; stability

Indexed keywords

BIOTECHNOLOGICAL APPLICATIONS; ELEVATED TEMPERATURE; HYDROGEN BONDING INTERACTIONS; HYDROPHOBIC AND AROMATIC INTERACTION; MOLECULAR DYNAMICS SIMULATIONS; NATIVE STRUCTURES; SINGLE CHAINS; STRUCTURAL ELEMENTS; VARIABLE FRAGMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR;

DISSOCIATION; HYDROGEN BONDS; MOLECULAR DYNAMICS; PLANTS (BOTANY); THERMODYNAMIC STABILITY;

ANTIBODIES;

SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; TEMPERATURE;

ANIMALS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MOLECULAR DYNAMICS SIMULATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SINGLE-CHAIN ANTIBODIES; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MURINAE;

EID: 80052319253     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr029     Document Type: Article

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