Artificial neural network analysis of data from multiple in vitro assays for prediction of skin sensitization potency of chemicals

Toxicology in Vitro

Volumn 27, Issue 4, 2013, Pages 1233-1246

  Hirota, Morihiko ^a   Kouzuki, Hirokazu ^a   Ashikaga, Takao ^a   Sono, Sakiko ^a   Tsujita, Kyoko ^a   Sasa, Hitoshi ^a   Aiba, Setsuya ^b  

^a SHISEIDO RESEARCH CENTER   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Artificial neural network; Cell surface thiols; H CLAT; Risk assessment; SH test; Skin sensitization

Indexed keywords

CD86 ANTIGEN; CHEMICAL COMPOUND; HAPTEN; INTERCELLULAR ADHESION MOLECULE 1; THIOL;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ANTIGEN EXPRESSION; ARTICLE; ARTIFICIAL NEURAL NETWORK; CELL ASSAY; CELL SURFACE; CELL VIABILITY; CHEMICAL MODIFICATION; CHEMICAL PARAMETERS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DATA ANALYSIS; HUMAN; HUMAN CELL; HUMAN CELL LINE ACTIVATION TEST; IN VITRO STUDY; INTERMETHOD COMPARISON; LOCAL LYMPH NODE ASSAY; PREDICTION; RISK ASSESSMENT; SH TEST; SKIN SENSITIZATION;

ALLERGENS; ANIMALS; BIOLOGICAL ASSAY; CELL LINE; HAPTENS; HUMANS; LOCAL LYMPH NODE ASSAY; MICE; NEURAL NETWORKS (COMPUTER); PROTEIN BINDING; SULFHYDRYL COMPOUNDS;

MURINAE;

EID: 84875627141     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.02.013     Document Type: Article

References (36)

1. Aiba S., Terunuma A., Manome H., Tagami H. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. European Journal of Immunology 1997, 27:3031-3038.
2. Aiba S., Tagami H. Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix. Journal of Dermatological Science 1998, 20:1-13.
3. Api A.M., Basketter D.A., Cadby P.A., Cano M.F., Ellis G., Gerberick G.F., Griem P., McNamee P.M., Ryan C.A., Safford R. Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Regulatory Toxicology and Pharmacology 2008, 52:3-23.
4. Ashikaga T., Sakaguchi H., Sono S., Kosaka N., Ishikawa M., Nukada Y., Miyazawa M., Ito Y., Nishiyama N., Itagaki H. A comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA). Alternatives to Laboratory Animals 2010, 38:275-284.
5. Ashikaga T., Yoshida Y., Hirota M., Yoneyama K., Itagaki H., Sakaguchi H., Miyazawa M., Ito Y., Suzuki H., Toyoda H. Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT) I. Optimization of the h-CLAT protocol. Toxicology in Vitro 2006, 20:767-773.
6. Azam P., Peiffer J.L., Chamousset D., Tissier M.H., Bonnet P.A., Vian L., Fabre I., Ourlin J.C. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicology and Applied Pharmacology 2006, 212:14-23.
7. Basketter D.A., Scholes E.W. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food and Chemical Toxicology 1992, 30:65-69.
8. Basketter D.A., Clapp C., Jefferies D., Safford B., Ryan C.A., Gerberick F., Dearman R.J., Kimber I. Predictive identification of human skin sensitization thresholds. Contact Dermatitis 2005, 53:260-267.
9. Basketter D.A., Sanders D., Jowsey I.R. The skin sensitization potential of resorcinol: experience with the local lymph node assay. Contact Dermatitis 2007, 56:196-200.
10. Basketter D.A. Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment. Cutaneous and Ocular Toxicology 2010, 29:4-9.
11. Basketter D.A., Kimber I. Predictive tests for irritants and allergens and their use in quantitative risk assessment. Contact Dermatitis 2011, 229-240. Springer, Berlin, (Chapter 13). fifth ed. J.D. Johansen, P.F. Frosch, J.-P. Lepoittevin (Eds.).
12. Boisleve F., Kerdine-Romer S., Rougier-Larzat N., Pallardy M. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. Journal of Investigative Dermatology 2004, 123:494-502.
13. Emter R., Ellis G., Natsch A. Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicology and Applied Pharmacology 2010, 245:281-290.
14. Gerberick G.F., Ryan C.A., Kern P.S., Dearman R.J., Kimber I., Patlewicz G.Y., Basketter D.A. A chemical dataset for evaluation of alternative approaches to skin-sensitization testing. Contact Dermatitis 2004, 50:274-288.
15. Gerberick G.F., Vassallo J.D., Bailey R.E., Chaney J.E., Morrall S.W., Lepoittevin J.P. Development of a peptide reactivity assay for screening contact allergens. Toxicological Sciences 2004, 81:332-343.
16. Gerberick G.F., Ryan C.A., Kern P.S., Schlatter K.H., Dearman R.J., Kimber I., Patlewicz G.Y., Basketter D.A. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 2005, 16:157-202.
17. Gerberick G.F., Vassallo J.D., Foertsch L.M., Price B.B., Chaney J.G., Lepoittevin J.P. Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicological Sciences 2007, 97:417-427.
18. Hagan M.T., Demuth H.B., Beale M.H. Neural Network Design 1996, PWS Publishing Company, Bostone, MA.
19. Hirota M., Suzuki M., Hagino S., Kagatani S., Sasaki Y., Aiba S., Itagaki H. Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate. Journal of Toxicological Sciences 2009, 34:139-150.
20. Hoya M., Hirota M., Suzuki M., Hagino S., Itagaki H., Aiba S. Development of an in vitro photosensitization assay using human monocyte-derived cells. Toxicology in Vitro 2009, 23:911-918.
21. Jaworska J., Harol A., Kern S.P., Gerberick G.F. Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case. ALTEX 2011, 28:211-225.
22. Jowsey I.R., Basketter D.A., Westmoreland C., Kimber I. A future approach to measuring relative skin sensitizing potency: a proposal. Journal of Applied Toxicology 2006, 26:341-350.
23. Kagatani S., Sasaki Y., Hirota M., Mizuashi M., Suzuki M., Ohtani T., Itagaki H., Aiba S. Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells. Journal of Investigative Dermatology 2010, 130:175-183.
24. Kimber I., Basketter D.A., Butler M., Gamer A., Garrigue J.L., Gerberick G.F., Newsome C., Steiling W., Vohr H.W. Classification of contact allergens according to potency: proposals. Food and Chemical Toxicology 2003, 41:1799-1809.
25. Magnusson B., Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. Journal of Investigative Dermatology 1969, 52:268-276.
26. Mossmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983, 65:55-63.
27. Natsch A., Emter R. Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals. Toxicological Sciences 2008, 102:110-119.
28. Natsch A., Emter R., Ellis G. Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing. Toxicological Sciences 2009, 107:106-121.
29. Nukada Y., Ashikaga T., Miyazawa M., Sono S., Sakaguchi H., Sasa H., Nishiyama A. Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt of classification of skin sensitization potency. Toxicology in Vitro 2012, 26:1150-1160.
30. Organization for Economic Cooperation and Development, 2010. OECD Guideline for testing chemicals. Guideline no. 429. skin sensitization: the Local lymph node assay. Paris: Organization for Economic Cooperation and, Development.
31. Pasomsub E., Sukasem C., Sungkanuparph S., Kijsirikul B., Chantratita W. The application of artificial neural networks for phenotypic drug resistance prediction: evaluation and comparison with other interpretation systems. Japanese Journal of Infectious Diseases 2010, 63:87-94.
32. Python F., Goebel C., Aeby P. Assessment of the U937 cell line for the detection of contact allergens. Toxicology and Applied Pharmacology 2007, 220:113-124.
33. Ryan C.A., Cruse L.W., Skinner R.A., Dearman R.J., Kimber I., Gerberick G.F. Examination of a vehicle for use with water soluble materials in the murine local lymph node assay. Food and Chemical Toxicology 2002, 40:1719-1725.
34. Safford R.J., Aptula A.O., Gilmour N. Refinement of the Dermal Sensitisation Threshold (DST) approach using a larger dataset and incorporating mechanistic chemistry domains. Regulatory Toxicology and Pharmacology 2011, 60:218-224.
35. Sakaguchi H., Ashikaga T., Miyazawa M., Yoshida Y., Ito Y., Yoneyama K., Hirota M., Itagaki H., Toyoda H., Suzuki H. Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT) II. An inter-laboratory study of the h-CLAT. Toxicology in Vitro 2006, 20:774-784.
36. Suzuki M., Hirota M., Hagino S., Itagaki H., Aiba S. Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test. Toxicology in Vitro 2009, 23:687-696.