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Volumn 94, Issue 1, 2014, Pages 125-139

Signaling between tumor cells and the host bone marrow microenvironment

Author keywords

Bone marrow; Breast cancer; Myeloma; Osteoblast; Osteoclast; Prostate cancer

Indexed keywords

CELL SURFACE RECEPTOR; ENDOTHELIN 1; EPHRIN; FIBROBLAST GROWTH FACTOR 8; INTEGRIN; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; PLATELET DERIVED GROWTH FACTOR; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84893718890     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-013-9794-7     Document Type: Review
Times cited : (19)

References (145)
  • 1
    • 33750726077 scopus 로고    scopus 로고
    • Clinical features of metastatic bone disease and risk of skeletal morbidity
    • 17062708
    • Coleman RE (2006) Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 12:6243s-6249s
    • (2006) Clin Cancer Res , vol.12
    • Coleman, R.E.1
  • 2
    • 33748937854 scopus 로고    scopus 로고
    • Dormancy of solitary metastatic cells
    • 1:CAS:528:DC%2BD28Xht1Gnt7rO 16861927
    • Townson JL, Chambers AF (2006) Dormancy of solitary metastatic cells. Cell Cycle 5:1744-1750
    • (2006) Cell Cycle , vol.5 , pp. 1744-1750
    • Townson, J.L.1    Chambers, A.F.2
  • 4
    • 13244269963 scopus 로고    scopus 로고
    • The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis
    • 1:CAS:528:DC%2BD2MXhvFOitrg%3D 15844659
    • Arya M, Patel HR, McGurk C, Tatoud R, Klocker H, Masters J, Williamson M (2004) The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. J Exp Ther Oncol 4:291-303
    • (2004) J Exp Ther Oncol , vol.4 , pp. 291-303
    • Arya, M.1    Patel, H.R.2    McGurk, C.3    Tatoud, R.4    Klocker, H.5    Masters, J.6    Williamson, M.7
  • 7
    • 33644789290 scopus 로고    scopus 로고
    • Stromal cell derived factor-1: Its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
    • 1:CAS:528:DC%2BD2MXkt1Cjsrg%3D 1175055 15987445
    • Kang H, Watkins G, Parr C, Douglas-Jones A, Mansel RE, Jiang WG (2005) Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer. Breast Cancer Res 7:R402-R410
    • (2005) Breast Cancer Res , vol.7
    • Kang, H.1    Watkins, G.2    Parr, C.3    Douglas-Jones, A.4    Mansel, R.E.5    Jiang, W.G.6
  • 10
    • 33644529120 scopus 로고    scopus 로고
    • Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: The association with disease activity and survival
    • 1:CAS:528:DC%2BD28XisFWrsLw%3D 16461304
    • Vande Broek I, Leleu X, Schots R, Facon T, Vanderkerken K, Van Camp B, Van Riet I (2006) Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: the association with disease activity and survival. Haematologica 91:200-206
    • (2006) Haematologica , vol.91 , pp. 200-206
    • Vande Broek, I.1    Leleu, X.2    Schots, R.3    Facon, T.4    Vanderkerken, K.5    Van Camp, B.6    Van Riet, I.7
  • 11
    • 20144388592 scopus 로고    scopus 로고
    • Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    • 1:CAS:528:DC%2BD2MXitVOjsLw%3D 15753365
    • Zannettino AC, Farrugia AN, Kortesidis A, Manavis J, To LB, Martin SK, Diamond P, Tamamura H, Lapidot T, Fujii N, Gronthos S (2005) Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 65:1700-1709
    • (2005) Cancer Res , vol.65 , pp. 1700-1709
    • Zannettino, A.C.1    Farrugia, A.N.2    Kortesidis, A.3    Manavis, J.4    To, L.B.5    Martin, S.K.6    Diamond, P.7    Tamamura, H.8    Lapidot, T.9    Fujii, N.10    Gronthos, S.11
  • 13
    • 34347400986 scopus 로고    scopus 로고
    • Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation
    • 1:CAS:528:DC%2BD2sXnsVais7s%3D 17360942
    • Jung Y, Wang J, Song J, Shiozawa Y, Wang J, Havens A, Wang Z, Sun YX, Emerson SG, Krebsbach PH, Taichman RS (2007) Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood 110:82-90
    • (2007) Blood , vol.110 , pp. 82-90
    • Jung, Y.1    Wang, J.2    Song, J.3    Shiozawa, Y.4    Wang, J.5    Havens, A.6    Wang, Z.7    Sun, Y.X.8    Emerson, S.G.9    Krebsbach, P.H.10    Taichman, R.S.11
  • 15
    • 51049112515 scopus 로고    scopus 로고
    • Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone
    • 1:CAS:528:DC%2BD1cXptVWntb0%3D 18575746
    • Tamura D, Hiraga T, Myoui A, Yoshikawa H, Yoneda T (2008) Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. Int J Oncol 33:17-24
    • (2008) Int J Oncol , vol.33 , pp. 17-24
    • Tamura, D.1    Hiraga, T.2    Myoui, A.3    Yoshikawa, H.4    Yoneda, T.5
  • 24
    • 28544437394 scopus 로고    scopus 로고
    • The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma
    • 1:CAS:528:DC%2BD28Xks1ehsQ%3D%3D 16313353
    • Ehrlich LA, Roodman GD (2005) The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma. Immunol Rev 208:252-266
    • (2005) Immunol Rev , vol.208 , pp. 252-266
    • Ehrlich, L.A.1    Roodman, G.D.2
  • 27
    • 33745821237 scopus 로고    scopus 로고
    • Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation
    • 1:CAS:528:DC%2BD28Xnsl2mtL0%3D 16752412
    • Chen G, Sircar K, Aprikian A, Potti A, Goltzman D, Rabbani SA (2006) Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Cancer 107:289-298
    • (2006) Cancer , vol.107 , pp. 289-298
    • Chen, G.1    Sircar, K.2    Aprikian, A.3    Potti, A.4    Goltzman, D.5    Rabbani, S.A.6
  • 28
    • 0035021176 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone
    • 1:CAS:528:DC%2BD3MXjsl2ntr0%3D 209296 11375413
    • Zhang J, Dai J, Qi Y, Lin DL, Smith P, Strayhorn C, Mizokami A, Fu Z, Westman J, Keller ET (2001) Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest 107:1235-1244
    • (2001) J Clin Invest , vol.107 , pp. 1235-1244
    • Zhang, J.1    Dai, J.2    Qi, Y.3    Lin, D.L.4    Smith, P.5    Strayhorn, C.6    Mizokami, A.7    Fu, Z.8    Westman, J.9    Keller, E.T.10
  • 29
    • 35448974577 scopus 로고    scopus 로고
    • Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases
    • 2034387 17683568
    • Morrissey C, Kostenuik PL, Brown LG, Vessella RL, Corey E (2007) Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases. BMC Cancer 7:148
    • (2007) BMC Cancer , vol.7 , pp. 148
    • Morrissey, C.1    Kostenuik, P.L.2    Brown, L.G.3    Vessella, R.L.4    Corey, E.5
  • 31
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • 1:CAS:528:DC%2BD3sXntleku7w%3D 14500379
    • Farrugia AN, Atkins GJ, To LB, Pan B, Horvath N, Kostakis P, Findlay DM, Bardy P, Zannettino AC (2003) Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 63:5438-5445
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3    Pan, B.4    Horvath, N.5    Kostakis, P.6    Findlay, D.M.7    Bardy, P.8    Zannettino, A.C.9
  • 33
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • 1:CAS:528:DC%2BD3MXnt12js7w%3D 11562486
    • Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N, Michaeli J, Epstein J, Choi Y (2001) Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 98:11581-11586
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3    Wong, B.R.4    Liau, D.F.5    Colman, N.6    Michaeli, J.7    Epstein, J.8    Choi, Y.9
  • 34
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • 1:CAS:528:DC%2BD3MXptFOjsbk%3D 11739153
    • Giuliani N, Bataille R, Mancini C, Lazzaretti M, Barille S (2001) Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 98:3527-3533
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barille, S.5
  • 35
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • 1:CAS:528:DC%2BD3sXhs1agtb0%3D 12615702
    • Shipman CM, Croucher PI (2003) Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res 63:912-916
    • (2003) Cancer Res , vol.63 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 36
    • 33846433720 scopus 로고    scopus 로고
    • An osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma
    • 1:CAS:528:DC%2BD2sXisFSgtw%3D%3D 17210700
    • Heath DJ, Vanderkerken K, Cheng X, Gallagher O, Prideaux M, Murali R, Croucher PI (2007) An osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma. Cancer Res 67:202-208
    • (2007) Cancer Res , vol.67 , pp. 202-208
    • Heath, D.J.1    Vanderkerken, K.2    Cheng, X.3    Gallagher, O.4    Prideaux, M.5    Murali, R.6    Croucher, P.I.7
  • 38
    • 41149094679 scopus 로고    scopus 로고
    • Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
    • 1:CAS:528:DC%2BD1cXmtFyhtbs%3D 18064531
    • Canon JR, Roudier M, Bryant R, Morony S, Stolina M, Kostenuik PJ, Dougall WC (2008) Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin Exp Metastasis 25:119-129
    • (2008) Clin Exp Metastasis , vol.25 , pp. 119-129
    • Canon, J.R.1    Roudier, M.2    Bryant, R.3    Morony, S.4    Stolina, M.5    Kostenuik, P.J.6    Dougall, W.C.7
  • 39
    • 77953726348 scopus 로고    scopus 로고
    • Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis
    • 1:CAS:528:DC%2BC3cXhtVGksLnE 20150760
    • Holland PM, Miller R, Jones J, Douangpanya H, Piasecki J, Roudier M, Dougall WC (2010) Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis. Cancer Biol Ther 9:539-550
    • (2010) Cancer Biol Ther , vol.9 , pp. 539-550
    • Holland, P.M.1    Miller, R.2    Jones, J.3    Douangpanya, H.4    Piasecki, J.5    Roudier, M.6    Dougall, W.C.7
  • 40
    • 51049121618 scopus 로고    scopus 로고
    • RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis
    • 1:CAS:528:DC%2BD1cXoslCnsrw%3D 18606716
    • Miller RE, Roudier M, Jones J, Armstrong A, Canon J, Dougall WC (2008) RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis. Mol Cancer Ther 7:2160-2169
    • (2008) Mol Cancer Ther , vol.7 , pp. 2160-2169
    • Miller, R.E.1    Roudier, M.2    Jones, J.3    Armstrong, A.4    Canon, J.5    Dougall, W.C.6
  • 42
    • 63749094012 scopus 로고    scopus 로고
    • Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
    • 1:CAS:528:DC%2BD1MXltVOhtr0%3D 19237632
    • Fizazi K, Lipton A, Mariette X, Body JJ, Rahim Y, Gralow JR, Gao G, Wu L, Sohn W, Jun S (2009) Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 27:1564-1571
    • (2009) J Clin Oncol , vol.27 , pp. 1564-1571
    • Fizazi, K.1    Lipton, A.2    Mariette, X.3    Body, J.J.4    Rahim, Y.5    Gralow, J.R.6    Gao, G.7    Wu, L.8    Sohn, W.9    Jun, S.10
  • 43
    • 33846169078 scopus 로고    scopus 로고
    • Skeletal metastasis: Established and emerging roles of parathyroid hormone related protein (PTHrP)
    • 1:CAS:528:DC%2BD2sXisVyrtg%3D%3D 17165129
    • Liao J, McCauley LK (2006) Skeletal metastasis: established and emerging roles of parathyroid hormone related protein (PTHrP). Cancer Metastasis Rev 25:559-571
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 559-571
    • Liao, J.1    McCauley, L.K.2
  • 44
    • 0030861712 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein and bone metastases
    • 1:CAS:528:DyaK2sXmvFyht7w%3D 9362424
    • Guise TA (1997) Parathyroid hormone-related protein and bone metastases. Cancer 80:1572-1580
    • (1997) Cancer , vol.80 , pp. 1572-1580
    • Guise, T.A.1
  • 45
    • 0025821071 scopus 로고
    • Localization of parathyroid hormone-related protein in breast cancer metastases: Increased incidence in bone compared with other sites
    • 1:STN:280:DyaK3M3jsFaiuw%3D%3D 2032246
    • Powell GJ, Southby J, Danks JA, Stillwell RG, Hayman JA, Henderson MA, Bennett RC, Martin TJ (1991) Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 51:3059-3061
    • (1991) Cancer Res , vol.51 , pp. 3059-3061
    • Powell, G.J.1    Southby, J.2    Danks, J.A.3    Stillwell, R.G.4    Hayman, J.A.5    Henderson, M.A.6    Bennett, R.C.7    Martin, T.J.8
  • 46
    • 10144241022 scopus 로고    scopus 로고
    • Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis
    • 1:CAS:528:DyaK28XmtVCmu70%3D 507586 8833902
    • Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, Yoneda T, Mundy GR (1996) Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 98:1544-1549
    • (1996) J Clin Invest , vol.98 , pp. 1544-1549
    • Guise, T.A.1    Yin, J.J.2    Taylor, S.D.3    Kumagai, Y.4    Dallas, M.5    Boyce, B.F.6    Yoneda, T.7    Mundy, G.R.8
  • 47
    • 79551514021 scopus 로고    scopus 로고
    • TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling
    • 1:CAS:528:DC%2BC3MXhsVCisbg%3D 3077118 21189326
    • Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR, Sterling JA (2011) TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res 71:822-831
    • (2011) Cancer Res , vol.71 , pp. 822-831
    • Johnson, R.W.1    Nguyen, M.P.2    Padalecki, S.S.3    Grubbs, B.G.4    Merkel, A.R.5    Oyajobi, B.O.6    Matrisian, L.M.7    Mundy, G.R.8    Sterling, J.A.9
  • 48
    • 0033305046 scopus 로고    scopus 로고
    • Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: Correlation with osteoclast-like cell formation
    • 1:CAS:528:DyaK1MXkslKru74%3D 10433211
    • Lee SK, Lorenzo JA (1999) Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology 140:3552-3561
    • (1999) Endocrinology , vol.140 , pp. 3552-3561
    • Lee, S.K.1    Lorenzo, J.A.2
  • 49
    • 0036472717 scopus 로고    scopus 로고
    • Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases
    • 1:CAS:528:DC%2BD38XisFOlsrs%3D 2375222 11875691
    • Bryden AA, Hoyland JA, Freemont AJ, Clarke NW, George NJ (2002) Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases. Br J Cancer 86:322-325
    • (2002) Br J Cancer , vol.86 , pp. 322-325
    • Bryden, A.A.1    Hoyland, J.A.2    Freemont, A.J.3    Clarke, N.W.4    George, N.J.5
  • 52
    • 0037105542 scopus 로고    scopus 로고
    • IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvariae
    • 1:CAS:528:DC%2BD38XntFags70%3D 12218157
    • Palmqvist P, Persson E, Conaway HH, Lerner UH (2002) IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvariae. J Immunol 169:3353-3362
    • (2002) J Immunol , vol.169 , pp. 3353-3362
    • Palmqvist, P.1    Persson, E.2    Conaway, H.H.3    Lerner, U.H.4
  • 53
    • 0033921535 scopus 로고    scopus 로고
    • Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue
    • 1:CAS:528:DC%2BD3cXltlygsrk%3D 10878544
    • Hobisch A, Rogatsch H, Hittmair A, Fuchs D, Bartsch G Jr, Klocker H, Bartsch G, Culig Z (2000) Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue. J Pathol 191:239-244
    • (2000) J Pathol , vol.191 , pp. 239-244
    • Hobisch, A.1    Rogatsch, H.2    Hittmair, A.3    Fuchs, D.4    Bartsch, Jr.G.5    Klocker, H.6    Bartsch, G.7    Culig, Z.8
  • 54
    • 0025677214 scopus 로고
    • Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells
    • 1:CAS:528:DyaK3MXit1agtw%3D%3D 2253221
    • Siegall CB, Schwab G, Nordan RP, FitzGerald DJ, Pastan I (1990) Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells. Cancer Res 50:7786-7788
    • (1990) Cancer Res , vol.50 , pp. 7786-7788
    • Siegall, C.B.1    Schwab, G.2    Nordan, R.P.3    Fitzgerald, D.J.4    Pastan, I.5
  • 56
    • 36549049974 scopus 로고    scopus 로고
    • Metastatic breast cancer induces an osteoblast inflammatory response
    • 1:CAS:528:DC%2BD2sXhtlyrtrvE 17976581
    • Kinder M, Chislock E, Bussard KM, Shuman L, Mastro AM (2008) Metastatic breast cancer induces an osteoblast inflammatory response. Exp Cell Res 314:173-183
    • (2008) Exp Cell Res , vol.314 , pp. 173-183
    • Kinder, M.1    Chislock, E.2    Bussard, K.M.3    Shuman, L.4    Mastro, A.M.5
  • 57
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    • 1:CAS:528:DC%2BC3MXhvFeksbo%3D 3040415 21295524
    • Sethi N, Dai X, Winter CG, Kang Y (2011) Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 19:192-205
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.2    Winter, C.G.3    Kang, Y.4
  • 58
    • 0037114636 scopus 로고    scopus 로고
    • Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: A potential role in multiple myeloma bone disease
    • 1:CAS:528:DC%2BD38XpsFCqt78%3D 12393684
    • Giuliani N, Colla S, Sala R, Moroni M, Lazzaretti M, La Monica S, Bonomini S, Hojden M, Sammarelli G, Barille S, Bataille R, Rizzoli V (2002) Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood 100:4615-4621
    • (2002) Blood , vol.100 , pp. 4615-4621
    • Giuliani, N.1    Colla, S.2    Sala, R.3    Moroni, M.4    Lazzaretti, M.5    La Monica, S.6    Bonomini, S.7    Hojden, M.8    Sammarelli, G.9    Barille, S.10    Bataille, R.11    Rizzoli, V.12
  • 59
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    • 1:CAS:528:DC%2BD2MXhtVKqt73K 15933061
    • Giuliani N, Colla S, Morandi F, Lazzaretti M, Sala R, Bonomini S, Grano M, Colucci S, Svaldi M, Rizzoli V (2005) Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood 106:2472-2483
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3    Lazzaretti, M.4    Sala, R.5    Bonomini, S.6    Grano, M.7    Colucci, S.8    Svaldi, M.9    Rizzoli, V.10
  • 60
    • 0042707678 scopus 로고    scopus 로고
    • Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
    • 1:CAS:528:DC%2BD3sXmt1KjsLw%3D 12919697
    • Bendre MS, Montague DC, Peery T, Akel NS, Gaddy D, Suva LJ (2003) Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone 33:28-37
    • (2003) Bone , vol.33 , pp. 28-37
    • Bendre, M.S.1    Montague, D.C.2    Peery, T.3    Akel, N.S.4    Gaddy, D.5    Suva, L.J.6
  • 62
    • 18144383028 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts
    • 1:CAS:528:DC%2BD2MXjvVOisbw%3D 15794931
    • Wright LM, Maloney W, Yu X, Kindle L, Collin-Osdoby P, Osdoby P (2005) Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts. Bone 36:840-853
    • (2005) Bone , vol.36 , pp. 840-853
    • Wright, L.M.1    Maloney, W.2    Yu, X.3    Kindle, L.4    Collin-Osdoby, P.5    Osdoby, P.6
  • 63
    • 0035383761 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand
    • 1:CAS:528:DC%2BD3MXktFOkt7o%3D 11369623
    • Han JH, Choi SJ, Kurihara N, Koide M, Oba Y, Roodman GD (2001) Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 97:3349-3353
    • (2001) Blood , vol.97 , pp. 3349-3353
    • Han, J.H.1    Choi, S.J.2    Kurihara, N.3    Koide, M.4    Oba, Y.5    Roodman, G.D.6
  • 64
    • 0037105599 scopus 로고    scopus 로고
    • Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma
    • 1:CAS:528:DC%2BD38Xnt1yhsb4%3D 12200385
    • Abe M, Hiura K, Wilde J, Moriyama K, Hashimoto T, Ozaki S, Wakatsuki S, Kosaka M, Kido S, Inoue D, Matsumoto T (2002) Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma. Blood 100:2195-2202
    • (2002) Blood , vol.100 , pp. 2195-2202
    • Abe, M.1    Hiura, K.2    Wilde, J.3    Moriyama, K.4    Hashimoto, T.5    Ozaki, S.6    Wakatsuki, S.7    Kosaka, M.8    Kido, S.9    Inoue, D.10    Matsumoto, T.11
  • 65
    • 0038579121 scopus 로고    scopus 로고
    • Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    • 1:CAS:528:DC%2BD3sXltFelsrw%3D 12649140
    • Oyajobi BO, Franchin G, Williams PJ, Pulkrabek D, Gupta A, Munoz S, Grubbs B, Zhao M, Chen D, Sherry B, Mundy GR (2003) Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood 102:311-319
    • (2003) Blood , vol.102 , pp. 311-319
    • Oyajobi, B.O.1    Franchin, G.2    Williams, P.J.3    Pulkrabek, D.4    Gupta, A.5    Munoz, S.6    Grubbs, B.7    Zhao, M.8    Chen, D.9    Sherry, B.10    Mundy, G.R.11
  • 66
    • 34548689594 scopus 로고    scopus 로고
    • The mouse mammary carcinoma 4T1: Characterization of the cellular landscape of primary tumors and metastatic tumor foci
    • 1:CAS:528:DC%2BD2sXht1WmsL7F 2517332 17877537
    • DuPre SA, Redelman D, Hunter KW Jr (2007) The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumors and metastatic tumor foci. Int J Exp Pathol 88:351-360
    • (2007) Int J Exp Pathol , vol.88 , pp. 351-360
    • Dupre, S.A.1    Redelman, D.2    Hunter, Jr.K.W.3
  • 67
    • 0034194652 scopus 로고    scopus 로고
    • Integrins and signaling in osteoclast function
    • 1:CAS:528:DC%2BD3cXkt1aqu74%3D 10842093
    • Duong LT, Lakkakorpi P, Nakamura I, Rodan GA (2000) Integrins and signaling in osteoclast function. Matrix Biol 19:97-105
    • (2000) Matrix Biol , vol.19 , pp. 97-105
    • Duong, L.T.1    Lakkakorpi, P.2    Nakamura, I.3    Rodan, G.A.4
  • 69
    • 77951709842 scopus 로고    scopus 로고
    • Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface
    • 1:CAS:528:DC%2BC3cXltlegu7c%3D 2862120 20406980
    • Nannuru KC, Futakuchi M, Varney ML, Vincent TM, Marcusson EG, Singh RK (2010) Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface. Cancer Res 70:3494-3504
    • (2010) Cancer Res , vol.70 , pp. 3494-3504
    • Nannuru, K.C.1    Futakuchi, M.2    Varney, M.L.3    Vincent, T.M.4    Marcusson, E.G.5    Singh, R.K.6
  • 71
    • 78650304107 scopus 로고    scopus 로고
    • Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis
    • 1:CAS:528:DC%2BC3cXhs1Wgu7rI 20601294
    • Lynch CC (2011) Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis. Bone 48:44-53
    • (2011) Bone , vol.48 , pp. 44-53
    • Lynch, C.C.1
  • 72
    • 69249094919 scopus 로고    scopus 로고
    • Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis
    • 1:CAS:528:DC%2BD1MXpvFeju7c%3D 2745595 19679556
    • Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC (2009) Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res 69:6747-6755
    • (2009) Cancer Res , vol.69 , pp. 6747-6755
    • Thiolloy, S.1    Halpern, J.2    Holt, G.E.3    Schwartz, H.S.4    Mundy, G.R.5    Matrisian, L.M.6    Lynch, C.C.7
  • 73
    • 84876768839 scopus 로고    scopus 로고
    • Circulating levels of transforming growth factor-beta (TGF-beta) and chemokine (C-X-C motif) ligand-1 (CXCL1) as predictors of distant seeding of circulating tumor cells in patients with metastatic breast cancer
    • 1:CAS:528:DC%2BC3sXntVyitbo%3D 23564790
    • Divella R, Daniele A, Savino E, Palma F, Bellizzi A, Giotta F, Simone G, Lioce M, Quaranta M, Paradiso A, Mazzocca A (2013) Circulating levels of transforming growth factor-beta (TGF-beta) and chemokine (C-X-C motif) ligand-1 (CXCL1) as predictors of distant seeding of circulating tumor cells in patients with metastatic breast cancer. Anticancer Res 33:1491-1497
    • (2013) Anticancer Res , vol.33 , pp. 1491-1497
    • Divella, R.1    Daniele, A.2    Savino, E.3    Palma, F.4    Bellizzi, A.5    Giotta, F.6    Simone, G.7    Lioce, M.8    Quaranta, M.9    Paradiso, A.10    Mazzocca, A.11
  • 74
    • 33747691662 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
    • 1:CAS:528:DC%2BD28Xot1eqsrY%3D 16815840
    • McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM (2006) Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J Biol Chem 281:24171-24181
    • (2006) J Biol Chem , vol.281 , pp. 24171-24181
    • McMahon, S.1    Charbonneau, M.2    Grandmont, S.3    Richard, D.E.4    Dubois, C.M.5
  • 75
    • 84865206098 scopus 로고    scopus 로고
    • Intravenous administration of adenoviruses targeting transforming growth factor beta signaling inhibits established bone metastases in 4T1 mouse mammary tumor model in an immunocompetent syngeneic host
    • 1:CAS:528:DC%2BC38XpsVWitb0%3D 3424293 22744210
    • Zhang Z, Hu Z, Gupta J, Krimmel JD, Gerseny HM, Berg AF, Robbins JS, Du H, Prabhakar B, Seth P (2012) Intravenous administration of adenoviruses targeting transforming growth factor beta signaling inhibits established bone metastases in 4T1 mouse mammary tumor model in an immunocompetent syngeneic host. Cancer Gene Ther 19:630-636
    • (2012) Cancer Gene Ther , vol.19 , pp. 630-636
    • Zhang, Z.1    Hu, Z.2    Gupta, J.3    Krimmel, J.D.4    Gerseny, H.M.5    Berg, A.F.6    Robbins, J.S.7    Du, H.8    Prabhakar, B.9    Seth, P.10
  • 77
    • 0029422455 scopus 로고
    • Bone morphogenetic protein-6 expression in normal and malignant prostate
    • 1:STN:280:DyaK2s%2FmtlGjsg%3D%3D 9116752
    • Barnes J, Anthony CT, Wall N, Steiner MS (1995) Bone morphogenetic protein-6 expression in normal and malignant prostate. World J Urol 13:337-343
    • (1995) World J Urol , vol.13 , pp. 337-343
    • Barnes, J.1    Anthony, C.T.2    Wall, N.3    Steiner, M.S.4
  • 79
    • 24944480253 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism
    • 1:CAS:528:DC%2BD2MXhtVShsbjK 16166304
    • Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET (2005) Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res 65:8274-8285
    • (2005) Cancer Res , vol.65 , pp. 8274-8285
    • Dai, J.1    Keller, J.2    Zhang, J.3    Lu, Y.4    Yao, Z.5    Keller, E.T.6
  • 82
    • 67449094018 scopus 로고    scopus 로고
    • Loss of inhibition over master pathways of bone mass regulation results in osteosclerotic bone metastases in prostate cancer
    • 1:STN:280:DC%2BD1MzisVanuw%3D%3D
    • Rentsch CA, Cecchini MG, Thalmann GN (2009) Loss of inhibition over master pathways of bone mass regulation results in osteosclerotic bone metastases in prostate cancer. Swiss Med Weekly 139:220-225
    • (2009) Swiss Med Weekly , vol.139 , pp. 220-225
    • Rentsch, C.A.1    Cecchini, M.G.2    Thalmann, G.N.3
  • 83
    • 79251571488 scopus 로고    scopus 로고
    • The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis
    • 1:CAS:528:DC%2BC3MXhtFWnsLk%3D 3020964 21249149
    • Secondini C, Wetterwald A, Schwaninger R, Thalmann GN, Cecchini MG (2011) The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis. PloS One 6:e16078
    • (2011) PloS One , vol.6 , pp. 16078
    • Secondini, C.1    Wetterwald, A.2    Schwaninger, R.3    Thalmann, G.N.4    Cecchini, M.G.5
  • 86
    • 84867135322 scopus 로고    scopus 로고
    • Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; No alterations post-lenalidomide and dexamethasone therapy
    • 1:STN:280:DC%2BC38rktVSquw%3D%3D 22492699
    • Terpos E, Kastritis E, Christoulas D, Gkotzamanidou M, Eleutherakis-Papaiakovou E, Kanellias N, Papatheodorou A, Dimopoulos MA (2012) Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; no alterations post-lenalidomide and dexamethasone therapy. Ann Oncol 23:2681-2686
    • (2012) Ann Oncol , vol.23 , pp. 2681-2686
    • Terpos, E.1    Kastritis, E.2    Christoulas, D.3    Gkotzamanidou, M.4    Eleutherakis-Papaiakovou, E.5    Kanellias, N.6    Papatheodorou, A.7    Dimopoulos, M.A.8
  • 88
    • 69249230778 scopus 로고    scopus 로고
    • Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, activin and inhibin
    • 1:CAS:528:DC%2BD1MXhtVKlsr%2FJ 2951729 19615428
    • Nicks KM, Perrien DS, Akel NS, Suva LJ, Gaddy D (2009) Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, activin and inhibin. Mol Cell Endocrinol 310:11-20
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 11-20
    • Nicks, K.M.1    Perrien, D.S.2    Akel, N.S.3    Suva, L.J.4    Gaddy, D.5
  • 90
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • 1:CAS:528:DC%2BD3sXhtVWit7zO 14695408
    • Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, Shaughnessy JD Jr (2003) The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 349:2483-2494
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6    Shaughnessy, Jr.J.D.7
  • 91
    • 4444326415 scopus 로고    scopus 로고
    • Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: Potential pathogenetic and prognostic implications
    • 1:CAS:528:DC%2BD2cXotFWnsLk%3D 15316903
    • Chen G, Shukeir N, Potti A, Sircar K, Aprikian A, Goltzman D, Rabbani SA (2004) Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. Cancer 101:1345-1356
    • (2004) Cancer , vol.101 , pp. 1345-1356
    • Chen, G.1    Shukeir, N.2    Potti, A.3    Sircar, K.4    Aprikian, A.5    Goltzman, D.6    Rabbani, S.A.7
  • 92
    • 33645006198 scopus 로고    scopus 로고
    • Role of Wnts in prostate cancer bone metastases
    • 1:CAS:528:DC%2BD28Xis1Crs7o%3D 16447163
    • Hall CL, Kang S, MacDougald OA, Keller ET (2006) Role of Wnts in prostate cancer bone metastases. J Cell Biochem 97:661-672
    • (2006) J Cell Biochem , vol.97 , pp. 661-672
    • Hall, C.L.1    Kang, S.2    Macdougald, O.A.3    Keller, E.T.4
  • 95
    • 24744439747 scopus 로고    scopus 로고
    • Prostate cancer cells promote osteoblastic bone metastases through Wnts
    • 1:CAS:528:DC%2BD2MXpslaitL4%3D 16140917
    • Hall CL, Bafico A, Dai J, Aaronson SA, Keller ET (2005) Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res 65:7554-7560
    • (2005) Cancer Res , vol.65 , pp. 7554-7560
    • Hall, C.L.1    Bafico, A.2    Dai, J.3    Aaronson, S.A.4    Keller, E.T.5
  • 99
    • 47249149740 scopus 로고    scopus 로고
    • Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases
    • 1:CAS:528:DC%2BD1cXhtVSrsLvK 3732167 18546262
    • Bu G, Lu W, Liu CC, Selander K, Yoneda T, Hall C, Keller ET, Li Y (2008) Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer 123:1034-1042
    • (2008) Int J Cancer , vol.123 , pp. 1034-1042
    • Bu, G.1    Lu, W.2    Liu, C.C.3    Selander, K.4    Yoneda, T.5    Hall, C.6    Keller, E.T.7    Li, Y.8
  • 100
    • 48649090754 scopus 로고    scopus 로고
    • Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms
    • 1:CAS:528:DC%2BD1cXovVCnsL0%3D 18632632
    • Dai J, Hall CL, Escara-Wilke J, Mizokami A, Keller JM, Keller ET (2008) Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. Cancer Res 68:5785-5794
    • (2008) Cancer Res , vol.68 , pp. 5785-5794
    • Dai, J.1    Hall, C.L.2    Escara-Wilke, J.3    Mizokami, A.4    Keller, J.M.5    Keller, E.T.6
  • 101
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A, Szydlo R, Anagnostopoulos A, Dimopoulos MA, Croucher PI, Terpos E (2006) Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 19:1728-1731
    • (2006) Int J Cancer , vol.19 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3    Szydlo, R.4    Anagnostopoulos, A.5    Dimopoulos, M.A.6    Croucher, P.I.7    Terpos, E.8
  • 102
    • 34548008809 scopus 로고    scopus 로고
    • Production of Wnt inhibitors by myeloma cells: Potential effects on canonical Wnt pathway in the bone microenvironment
    • 1:CAS:528:DC%2BD2sXptVGlsLY%3D 17702698
    • Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V (2007) Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res 67:7665-7674
    • (2007) Cancer Res , vol.67 , pp. 7665-7674
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3    Lazzaretti, M.4    Donofrio, G.5    Bonomini, S.6    Sala, R.7    Mangoni, M.8    Rizzoli, V.9
  • 105
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • 1:CAS:528:DC%2BD1cXjs1Whurk%3D 18294945
    • Qiang YW, Barlogie B, Rudikoff S, Shaughnessy JD Jr (2008) Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 42:669-680
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy, Jr.J.D.4
  • 106
    • 84860537254 scopus 로고    scopus 로고
    • Bone marrow stromal cells create a permissive microenvironment for myeloma development: A new stromal role for Wnt inhibitor Dkk1
    • 1:CAS:528:DC%2BC38Xmt1ymsLg%3D 3775476 22374979
    • Fowler JA, Mundy GR, Lwin ST, Edwards CM (2012) Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1. Cancer Res 72:2183-2189
    • (2012) Cancer Res , vol.72 , pp. 2183-2189
    • Fowler, J.A.1    Mundy, G.R.2    Lwin, S.T.3    Edwards, C.M.4
  • 108
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • 1:CAS:528:DC%2BD2sXjtFequrY%3D 17068150
    • Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr (2007) Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109:2106-2111
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy, Jr.J.D.6
  • 110
    • 41949093576 scopus 로고    scopus 로고
    • Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    • 1:CAS:528:DC%2BD1cXivFakurs%3D 18094333
    • Edwards CM, Edwards JR, Lwin ST, Esparza J, Oyajobi BO, McCluskey B, Munoz S, Grubbs B, Mundy GR (2008) Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood 111:2833-2842
    • (2008) Blood , vol.111 , pp. 2833-2842
    • Edwards, C.M.1    Edwards, J.R.2    Lwin, S.T.3    Esparza, J.4    Oyajobi, B.O.5    McCluskey, B.6    Munoz, S.7    Grubbs, B.8    Mundy, G.R.9
  • 114
    • 80054954943 scopus 로고    scopus 로고
    • Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFbeta-dependent expression of the Wnt antagonist, sclerostin
    • 1:CAS:528:DC%2BC38Xms1CmsQ%3D%3D 3262219 22032690
    • Mendoza-Villanueva D, Zeef L, Shore P (2011) Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFbeta-dependent expression of the Wnt antagonist, sclerostin. Breast Cancer Res 13:R106
    • (2011) Breast Cancer Res , vol.13 , pp. 106
    • Mendoza-Villanueva, D.1    Zeef, L.2    Shore, P.3
  • 115
    • 84880570863 scopus 로고    scopus 로고
    • Endothelin antagonists in hypertension and kidney disease
    • 23070275
    • Meyers KE, Sethna C (2013) Endothelin antagonists in hypertension and kidney disease. Pediatr Nephrol 28:711-720
    • (2013) Pediatr Nephrol , vol.28 , pp. 711-720
    • Meyers, K.E.1    Sethna, C.2
  • 117
    • 6344266822 scopus 로고    scopus 로고
    • Endothelins in bone cancer metastases
    • 1:CAS:528:DC%2BD2cXnsFOkur8%3D 15043194
    • Guise TA, Mohammad KS (2004) Endothelins in bone cancer metastases. Cancer Treat Res 118:197-212
    • (2004) Cancer Treat Res , vol.118 , pp. 197-212
    • Guise, T.A.1    Mohammad, K.S.2
  • 118
  • 121
    • 62649134676 scopus 로고    scopus 로고
    • Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: A double-blind, placebo-controlled, randomised, phase 2 trial
    • 1:CAS:528:DC%2BD1MXnvF2qtrk%3D 19042080
    • James ND, Caty A, Borre M, Zonnenberg BA, Beuzeboc P, Morris T, Phung D, Dawson NA (2009) Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial. Eur Urol 55:1112-1123
    • (2009) Eur Urol , vol.55 , pp. 1112-1123
    • James, N.D.1    Caty, A.2    Borre, M.3    Zonnenberg, B.A.4    Beuzeboc, P.5    Morris, T.6    Phung, D.7    Dawson, N.A.8
  • 123
    • 0034619758 scopus 로고    scopus 로고
    • The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
    • 1:CAS:528:DC%2BD3MXhsFCrsw%3D%3D 11146556
    • Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB (2000) The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 19:6043-6052
    • (2000) Oncogene , vol.19 , pp. 6043-6052
    • Ogawa, K.1    Pasqualini, R.2    Lindberg, R.A.3    Kain, R.4    Freeman, A.L.5    Pasquale, E.B.6
  • 124
    • 0035266163 scopus 로고    scopus 로고
    • EphA2 overexpression causes tumorigenesis of mammary epithelial cells
    • 1:CAS:528:DC%2BD3MXit1Ogt7k%3D 11280802
    • Zelinski DP, Zantek ND, Stewart JC, Irizarry AR, Kinch MS (2001) EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res 61:2301-2306
    • (2001) Cancer Res , vol.61 , pp. 2301-2306
    • Zelinski, D.P.1    Zantek, N.D.2    Stewart, J.C.3    Irizarry, A.R.4    Kinch, M.S.5
  • 125
    • 67649811207 scopus 로고    scopus 로고
    • Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis
    • 1:CAS:528:DC%2BD1MXlvV2isL8%3D 19299512
    • Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K (2009) Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J Biol Chem 284:14637-14644
    • (2009) J Biol Chem , vol.284 , pp. 14637-14644
    • Irie, N.1    Takada, Y.2    Watanabe, Y.3    Matsuzaki, Y.4    Naruse, C.5    Asano, M.6    Iwakura, Y.7    Suda, T.8    Matsuo, K.9
  • 126
    • 70349263942 scopus 로고    scopus 로고
    • The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth
    • 1:CAS:528:DC%2BD1MXhtFWgsbbL 19597185
    • Pennisi A, Ling W, Li X, Khan S, Shaughnessy JD Jr, Barlogie B, Yaccoby S (2009) The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth. Blood 114:1803-1812
    • (2009) Blood , vol.114 , pp. 1803-1812
    • Pennisi, A.1    Ling, W.2    Li, X.3    Khan, S.4    Shaughnessy, Jr.J.D.5    Barlogie, B.6    Yaccoby, S.7
  • 127
    • 0029039982 scopus 로고
    • Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma
    • 1:CAS:528:DyaK2MXmtlWrtL4%3D 7780988
    • Coltrera MD, Wang J, Porter PL, Gown AM (1995) Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma. Cancer Res 55:2703-2708
    • (1995) Cancer Res , vol.55 , pp. 2703-2708
    • Coltrera, M.D.1    Wang, J.2    Porter, P.L.3    Gown, A.M.4
  • 128
    • 0027488086 scopus 로고
    • Tissue platelet-derived growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer
    • 1:STN:280:DyaK2c%2Fnt1Ontw%3D%3D 8251649
    • Seymour L, Dajee D, Bezwoda WR (1993) Tissue platelet-derived growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer. Breast Cancer Res Treat 26:247-252
    • (1993) Breast Cancer Res Treat , vol.26 , pp. 247-252
    • Seymour, L.1    Dajee, D.2    Bezwoda, W.R.3
  • 129
    • 0001871671 scopus 로고    scopus 로고
    • Platelet-derived growth factor and the skeleton
    • J.B. Bilezikian L.G. Raisz A. Rodan (eds) Academic Press San Diego, CA
    • Canalis E, Rydziel S (1996) Platelet-derived growth factor and the skeleton. In: Bilezikian JB, Raisz LG, Rodan A (eds) Principles of bone biology. Academic Press, San Diego, CA, pp 619-626
    • (1996) Principles of Bone Biology , pp. 619-626
    • Canalis, E.1    Rydziel, S.2
  • 130
    • 81355138197 scopus 로고    scopus 로고
    • Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts
    • 1:CAS:528:DC%2BC38XpvVejtg%3D%3D 3231994 22104124
    • Vordemvenne T, Paletta JR, Hartensuer R, Pap T, Raschke MJ, Ochman S (2011) Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts. BMC Musculoskelet Disord 12:263
    • (2011) BMC Musculoskelet Disord , vol.12 , pp. 263
    • Vordemvenne, T.1    Paletta, J.R.2    Hartensuer, R.3    Pap, T.4    Raschke, M.J.5    Ochman, S.6
  • 131
    • 0028807859 scopus 로고
    • Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage
    • 1:CAS:528:DyaK2MXps1Kisrs%3D 7588297
    • Franchimont N, Canalis E (1995) Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage. Endocrinology 136:5469-5475
    • (1995) Endocrinology , vol.136 , pp. 5469-5475
    • Franchimont, N.1    Canalis, E.2
  • 132
    • 81755162058 scopus 로고    scopus 로고
    • SDF-1alpha induces PDGF-B expression and the differentiation of bone marrow cells into pericytes
    • 1:CAS:528:DC%2BC3MXhsVOhtb7M 3219839 21911740
    • Hamdan R, Zhou Z, Kleinerman ES (2011) SDF-1alpha induces PDGF-B expression and the differentiation of bone marrow cells into pericytes. Mol Cancer Res 9:1462-1470
    • (2011) Mol Cancer Res , vol.9 , pp. 1462-1470
    • Hamdan, R.1    Zhou, Z.2    Kleinerman, E.S.3
  • 135
    • 28244481510 scopus 로고    scopus 로고
    • Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity
    • 1:CAS:528:DC%2BD2MXht1KjsrzM 16322239
    • Kitagawa Y, Dai J, Zhang J, Keller JM, Nor J, Yao Z, Keller ET (2005) Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity. Cancer Res 65:10921-10929
    • (2005) Cancer Res , vol.65 , pp. 10921-10929
    • Kitagawa, Y.1    Dai, J.2    Zhang, J.3    Keller, J.M.4    Nor, J.5    Yao, Z.6    Keller, E.T.7
  • 136
    • 77954563614 scopus 로고    scopus 로고
    • Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
    • 2865635 20405169
    • DeNardo DG, Andreu P, Coussens LM (2010) Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity. Cancer Metastasis Rev 29:309-316
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 309-316
    • Denardo, D.G.1    Andreu, P.2    Coussens, L.M.3
  • 137
    • 78149322663 scopus 로고    scopus 로고
    • A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    • 1:CAS:528:DC%2BC3cXhsVKksb7E 20664052
    • Noonan K, Marchionni L, Anderson J, Pardoll D, Roodman GD, Borrello I (2010) A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 116:3554-3563
    • (2010) Blood , vol.116 , pp. 3554-3563
    • Noonan, K.1    Marchionni, L.2    Anderson, J.3    Pardoll, D.4    Roodman, G.D.5    Borrello, I.6
  • 139
    • 84867911410 scopus 로고    scopus 로고
    • Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells
    • 1:CAS:528:DC%2BC38XhsFersLbJ 3531993 23018462
    • Sawant A, Hensel JA, Chanda D, Harris BA, Siegal GP, Maheshwari A, Ponnazhagan S (2012) Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells. J Immunol 189:4258-4265
    • (2012) J Immunol , vol.189 , pp. 4258-4265
    • Sawant, A.1    Hensel, J.A.2    Chanda, D.3    Harris, B.A.4    Siegal, G.P.5    Maheshwari, A.6    Ponnazhagan, S.7
  • 140
    • 84878069933 scopus 로고    scopus 로고
    • Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies
    • 1:CAS:528:DC%2BC3sXnvVWru7g%3D 23630345
    • Zirakzadeh AA, Marits P, Sherif A, Winqvist O (2013) Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies. J Immunol 190:5847-5855
    • (2013) J Immunol , vol.190 , pp. 5847-5855
    • Zirakzadeh, A.A.1    Marits, P.2    Sherif, A.3    Winqvist, O.4
  • 143
    • 78649586268 scopus 로고    scopus 로고
    • The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity
    • 1:CAS:528:DC%2BC3cXhtl2isbfK 3277452 21061430
    • Youn JI, Gabrilovich DI (2010) The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Eur J Immunol 40:2969-2975
    • (2010) Eur J Immunol , vol.40 , pp. 2969-2975
    • Youn, J.I.1    Gabrilovich, D.I.2
  • 144
    • 84881401714 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction
    • 3525604 23264895
    • Danilin S, Merkel AR, Johnson JR, Johnson RW, Edwards JR, Sterling JA (2012) Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction. Oncoimmunology 1:1484-1494
    • (2012) Oncoimmunology , vol.1 , pp. 1484-1494
    • Danilin, S.1    Merkel, A.R.2    Johnson, J.R.3    Johnson, R.W.4    Edwards, J.R.5    Sterling, J.A.6
  • 145
    • 84869222349 scopus 로고    scopus 로고
    • Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid- derived suppressor cells
    • 1:CAS:528:DC%2BC38XhvVShs7fN 3500251 23173040
    • Zhuang J, Zhang J, Lwin ST, Edwards JR, Edwards CM, Mundy GR, Yang X (2012) Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid- derived suppressor cells. PloS One 7:e48871
    • (2012) PloS One , vol.7 , pp. 48871
    • Zhuang, J.1    Zhang, J.2    Lwin, S.T.3    Edwards, J.R.4    Edwards, C.M.5    Mundy, G.R.6    Yang, X.7


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