SDF-1α induces PDGF-B expression and the differentiation of bone marrow cells into pericytes

Molecular Cancer Research

Volumn 9, Issue 11, 2011, Pages 1462-1470

  Hamdan, Randala ^a   Zhou, Zhichao ^a   Kleinerman, Eugenie S ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESMIN; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR B; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR ELK 1;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL MATURATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EWING SARCOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHEMOKINE CXCL12; DESMIN; ETS-DOMAIN PROTEIN ELK-1; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C3H; PERICYTES; PROMOTER REGIONS, GENETIC; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECOMBINANT PROTEINS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 81755162058     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0190     Document Type: Article

References (30)

1. Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004;15:197-204. (Pubitemid 38781045)
2. Hellstrom M, Kalén M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999;126:3047-55. (Pubitemid 29378170)
3. Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 2005;7:870-9. (Pubitemid 41486287)
4. McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, et al. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 2007;117:2114-22. (Pubitemid 47219556)
5. Westermark B, Heldin CH. Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth. Acta Oncol 1993;32:101-5. (Pubitemid 23188521)
6. Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 1996;32:687-98. (Pubitemid 26332308)
7. Sennino B, Falcón BL, McCauley D, Le T, Kurz JC, Haskell A, et al. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res 2007;67:7358-67. (Pubitemid 47206566)
8. Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003;111:1287-95. (Pubitemid 36554699)
9. Lu C, Shahzad MM, Moreno-Smith M, Lin YG, Jennings NB, Allen JK, et al. Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models. Cancer Biol Ther 2010;9:176-82.
10. Kujoth GC, Robinson DF, Fahl WE. Binding of ETS family members is important for the function of the c-sis/platelet-derived growth factor-B TATA neighboring sequence in 12-O-tetradecanoylphorbol- 13-acetate-treated K562 cells. Cell Growth Differ 1998;9: 523-34. (Pubitemid 28345909)
11. Guan H, Zhou Z, Wang H, Jia SF, Liu W, Kleinerman ES. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 2005;11:2662-9. (Pubitemid 40569467)
12. Reddy K, Zhou Z, Jia SF, Lee TH, Morales-Arias J, Cao Y, et al. Stromal cell-derived factor-1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor. Int J Cancer 2008;123:831-7. (Pubitemid 352032409)
13. Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010;16:2927-31.
14. Horuk R. Chemokine receptors. Cytokine Growth Factor Rev 2001;12: 313-35. (Pubitemid 32851745)
15. Majka M, Ratajczak J, KowalskaMA, Ratajczak MZ. Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur J Haematol 2000;64:164-72. (Pubitemid 30158048)
16. Oettgen P. The role of ets factors in tumor angiogenesis. J Oncol 2010;2010:767384.
17. Lelièvre E, Lionneton F, Soncin F, Vandenbunder B. The Ets family contains transcriptional activators and repressors involved in angiogenesis. Int J Biochem Cell Biol 2001;33:391-407. (Pubitemid 32324006)
18. Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2001;2:827-37. (Pubitemid 33674083)
19. Buchwalter G, Gross C, Wasylyk B. Ets ternary complex transcription factors. Gene 2004;324:1-14. (Pubitemid 38030321)
20. Kasza A, Wyrzykowska P, Horwacik I, Tymoszuk P, Mizgalska D, Palmer K, et al. Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression. BMC Mol Biol 2010;11:14.
21. Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, Allendorf DJ, et al. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 2004;35:233-45. (Pubitemid 40585309)
22. Abramsson A, Lindblom P, Betsholtz C. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 2003; 112:1142-51. (Pubitemid 38056291)
23. Lee TH, Bolontrade MF, Worth LL, Guan H, Ellis LM, Kleinerman ES. Production of VEGF165 by Ewing's sarcoma cells induces vasculo-genesis and the incorporation of CD34+ stem cells into the expanding tumor vasculature. Int J Cancer 2006;119:839-46. (Pubitemid 44051447)
24. Reddy K, Cao Y, Zhou Z, Yu L, Jia SF, Kleinerman ES. VEGF(165) expression in the tumor microenvironment influences the differentiation of bone marrow-derived pericytes that contribute to the Ewing's sarcoma vasculature. Angiogenesis 2008;11:257-67.
25. Fomchenko EI, Holland EC. Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment. Neurosurg Clin N Am 2007;18:39-58, viii. (Pubitemid 46161193)
26. Onimaru M, Yonemitsu Y, Fuji T, Tanii M, Nakano T, Nakagawa K, et al. VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B. Am J Physiol Heart Circ Physiol 2009;297: H1685-96.
27. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passequ-e E, et al. HIF1 alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008;13:206-20. (Pubitemid 351318372)
28. Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 2005;7:452-64. (Pubitemid 41555617)
29. Lapidot T, Kollet O. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice. Leukemia 2002;16:1992-2003. (Pubitemid 35203441)
30. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska- Wieczorek A, et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF- 1-CXCR4 axis. Stem Cells 2005;23:879-94. (Pubitemid 41170944)