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Volumn 116, Issue 18, 2010, Pages 3554-3563

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 17;

EID: 78149322663     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-05-283895     Document Type: Article
Times cited : (178)

References (42)
  • 2
    • 0033888977 scopus 로고    scopus 로고
    • Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
    • Lacey DL, Tan HL, Lu J, et al. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol. 2000;157(2):435-448.
    • (2000) Am J Pathol , vol.157 , Issue.2 , pp. 435-448
    • Lacey, D.L.1    Tan, H.L.2    Lu, J.3
  • 4
    • 37149016951 scopus 로고    scopus 로고
    • Myeloma cells and bone marrow osteoblast interactions: Role in the development of osteolytic lesions in multiple myeloma
    • Giuliani N, Rizzoli V. Myeloma cells and bone marrow osteoblast interactions: role in the development of osteolytic lesions in multiple myeloma. Leuk Lymphoma. 2007;48(12):2323-2329.
    • (2007) Leuk Lymphoma , vol.48 , Issue.12 , pp. 2323-2329
    • Giuliani, N.1    Rizzoli, V.2
  • 5
    • 38749106994 scopus 로고    scopus 로고
    • RANK ligand as a therapeutic target for bone metastases and multiple myeloma
    • Roodman GD, Dougall WC. RANK ligand as a therapeutic target for bone metastases and multiple myeloma. Cancer Treat Rev. 2008;34(1):92-101.
    • (2008) Cancer Treat Rev , vol.34 , Issue.1 , pp. 92-101
    • Roodman, G.D.1    Dougall, W.C.2
  • 7
    • 0036316236 scopus 로고    scopus 로고
    • Bone marrow CD8 T cells are in different activation state than those in lymphoid periphery
    • DOI 10.1002/1521-4141(200207)32:7<1873::AID-IMMU1873>3.0.CO;2-P
    • Di Rosa F, Santoni A. Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery. Eur J Immunol. 2002;32(7):1873-1880. (Pubitemid 34814542)
    • (2002) European Journal of Immunology , vol.32 , Issue.7 , pp. 1873-1880
    • Di Rosa, F.1    Santoni, A.2
  • 8
    • 0141796315 scopus 로고    scopus 로고
    • Bone marrow as a priming site for T-cell responses to blood-borne antigen
    • Feuerer M, Beckhove P, Garbi N, et al. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med. 2003;9(9):1151-1157.
    • (2003) Nat Med , vol.9 , Issue.9 , pp. 1151-1157
    • Feuerer, M.1    Beckhove, P.2    Garbi, N.3
  • 9
    • 8544281696 scopus 로고    scopus 로고
    • Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals
    • Zou L, Barnett B, Safah H, et al. Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res. 2004;64(22):8451-8455.
    • (2004) Cancer Res , vol.64 , Issue.22 , pp. 8451-8455
    • Zou, L.1    Barnett, B.2    Safah, H.3
  • 10
    • 20144389307 scopus 로고    scopus 로고
    • Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors
    • Noonan K, Matsui W, Serafini P, et al. Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors. Cancer Res. 2005;65(5):2026-2034.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 2026-2034
    • Noonan, K.1    Matsui, W.2    Serafini, P.3
  • 11
    • 33751531874 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    • Serafini P, Meckel K, Kelso M, et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med. 2006;203(12):2691-2702.
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2691-2702
    • Serafini, P.1    Meckel, K.2    Kelso, M.3
  • 12
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8(5):337-348.
    • (2008) Nat Rev Immunol , vol.8 , Issue.5 , pp. 337-348
    • Dong, C.1
  • 13
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6(11):1123-1132.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 14
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L, Ivanov II, Spolski R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8(9):967-974.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3
  • 15
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235-238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 16
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T-cell subset that links T cell activation and bone destruction
    • Sato K, Suematsu A, Okamoto K, et al. Th17 functions as an osteoclastogenic helper T-cell subset that links T cell activation and bone destruction. J Exp Med. 2006;203(12):2673-2682.
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3
  • 17
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A, Tato CM, Davidson TS, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity. 2007;26(3):371-381.
    • (2007) Immunity , vol.26 , Issue.3 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3
  • 18
    • 0022338260 scopus 로고
    • Monoclonal antibodies to osteoclastomas (giant cell bone tumors): Definition of osteoclast-specific cellular antigens
    • Horton MA, Lewis D, McNulty K, Pringle JA, Chambers TJ. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res. 1985;45(11):5663-5669.
    • (1985) Cancer Res , vol.45 , Issue.11 , pp. 5663-5669
    • Horton, M.A.1    Lewis, D.2    McNulty, K.3    Pringle, J.A.4    Chambers, T.J.5
  • 19
    • 40449134510 scopus 로고    scopus 로고
    • High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients
    • Mylin AK, Abildgaard N, Johansen JS, et al. High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. Eur J Haematol. 2008;80(4):310-317.
    • (2008) Eur J Haematol , vol.80 , Issue.4 , pp. 310-317
    • Mylin, A.K.1    Abildgaard, N.2    Johansen, J.S.3
  • 20
    • 0030305457 scopus 로고    scopus 로고
    • A language for data analysis and graphics
    • Ihaka R. A language for data analysis and graphics. J Comput Graphic Stat. 1996;5(5):299-314.
    • (1996) J Comput Graphic Stat , vol.5 , Issue.5 , pp. 299-314
    • Ihaka, R.1
  • 21
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman RC, Carey V, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5(10)[R80]:1465-6914.
    • (2004) Genome Biol , vol.5 , Issue.10 R80 , pp. 1465-6914
    • Gentleman, R.C.1    Carey, V.2    Bates, D.M.3
  • 22
    • 5644258322 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells
    • Zou W, Liu X, Yue P, et al. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res. 2004;64(20):7570-7578.
    • (2004) Cancer Res , vol.64 , Issue.20 , pp. 7570-7578
    • Zou, W.1    Liu, X.2    Yue, P.3
  • 23
    • 0024419152 scopus 로고
    • Production of cytokines by bone marrow cells obtained from patients with multiple myeloma
    • Lichtenstein A, Berenson J, Norman D, Chang MP, Carlile A. Production of cytokines by bone marrow cells obtained from patients with multiple myeloma. Blood. 1989;74(4):1266-1273. (Pubitemid 19227434)
    • (1989) Blood , vol.74 , Issue.4 , pp. 1266-1273
    • Lichtenstein, A.1    Berenson, J.2    Norman, D.3    Chang, M.-P.4    Carlile, A.5
  • 24
    • 43149089554 scopus 로고    scopus 로고
    • The pathogenesis of the bone disease of multiple myeloma
    • Edwards CM, Zhuang J, Mundy GR. The pathogenesis of the bone disease of multiple myeloma. Bone. 2008;42(6):1007-1013.
    • (2008) Bone , vol.42 , Issue.6 , pp. 1007-1013
    • Edwards, C.M.1    Zhuang, J.2    Mundy, G.R.3
  • 25
    • 57449112782 scopus 로고    scopus 로고
    • IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
    • Korn T, Mitsdoerffer M, Croxford AL, et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2008;105(47):18460-18465.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.47 , pp. 18460-18465
    • Korn, T.1    Mitsdoerffer, M.2    Croxford, A.L.3
  • 26
    • 0035383761 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand
    • Han JH, Choi SJ, Kurihara N, Koide M, Oba Y, Roodman GD. Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood. 2001;97(11):3349-3353.
    • (2001) Blood , vol.97 , Issue.11 , pp. 3349-3353
    • Han, J.H.1    Choi, S.J.2    Kurihara, N.3    Koide, M.4    Oba, Y.5    Roodman, G.D.6
  • 27
    • 33645959483 scopus 로고    scopus 로고
    • STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
    • Cho ML, Kang JW, Moon YM, et al. STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol. 2006;176(9):5652-5661.
    • (2006) J Immunol , vol.176 , Issue.9 , pp. 5652-5661
    • Cho, M.L.1    Kang, J.W.2    Moon, Y.M.3
  • 28
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24(2):179-189.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 29
    • 40849141379 scopus 로고    scopus 로고
    • CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
    • Atanackovic D, Cao Y, Luetkens T, et al. CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation. Haematologica. 2008;93(3):423-430.
    • (2008) Haematologica , vol.93 , Issue.3 , pp. 423-430
    • Atanackovic, D.1    Cao, Y.2    Luetkens, T.3
  • 30
    • 0020960066 scopus 로고
    • Direct bone resorbing activity of murine myeloma cells
    • McDonald DF, Schofield BH, Prezioso EM, et al. Direct bone resorbing activity of murine myeloma cells. Cancer Lett. 1983;19(2):119-124.
    • (1983) Cancer Lett , vol.19 , Issue.2 , pp. 119-124
    • McDonald, D.F.1    Schofield, B.H.2    Prezioso, E.M.3
  • 31
    • 33846201640 scopus 로고    scopus 로고
    • Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: A new type of cancer-host partnership?
    • Andersen TL, Boissy P, Sondergaard TE, et al. Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership? J Pathol. 2007;211(1):10-17.
    • (2007) J Pathol , vol.211 , Issue.1 , pp. 10-17
    • Andersen, T.L.1    Boissy, P.2    Sondergaard, T.E.3
  • 32
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells. 2006;24(4):986-991.
    • (2006) Stem Cells , vol.24 , Issue.4 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 33
    • 0037114636 scopus 로고    scopus 로고
    • Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: A potential role in multiple myeloma bone disease
    • Giuliani N, Colla S, Sala R, et al. Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood. 2002;100(13):4615-4621.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4615-4621
    • Giuliani, N.1    Colla, S.2    Sala, R.3
  • 34
    • 69249092613 scopus 로고    scopus 로고
    • A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity
    • Huber M, Heink S, Grothe H, et al. A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur J Immunol. 2009;39(7):1716-1725.
    • (2009) Eur J Immunol , vol.39 , Issue.7 , pp. 1716-1725
    • Huber, M.1    Heink, S.2    Grothe, H.3
  • 35
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322(5899):271-275.
    • (2008) Science , vol.322 , Issue.5899 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 36
    • 47249103596 scopus 로고    scopus 로고
    • CTLA-4 directly inhibits osteoclast formation
    • Axmann R, Herman S, Zaiss M, et al. CTLA-4 directly inhibits osteoclast formation. Ann Rheum Dis. 2008;67(11):1603-1609.
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1603-1609
    • Axmann, R.1    Herman, S.2    Zaiss, M.3
  • 37
    • 34247593586 scopus 로고    scopus 로고
    • STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    • Yang XO, Panopoulos AD, Nurieva R, et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007;282(13):9358-9363.
    • (2007) J Biol Chem , vol.282 , Issue.13 , pp. 9358-9363
    • Yang, X.O.1    Panopoulos, A.D.2    Nurieva, R.3
  • 38
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126(6):1121-1133.
    • (2006) Cell , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3
  • 39
    • 37749021324 scopus 로고    scopus 로고
    • Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
    • Harris TJ, Grosso JF, Yen HR, et al. Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179(7):4313-4317.
    • (2007) J Immunol , vol.179 , Issue.7 , pp. 4313-4317
    • Harris, T.J.1    Grosso, J.F.2    Yen, H.R.3
  • 40
    • 33646383590 scopus 로고    scopus 로고
    • Recent advances in understanding the mechanism of action of bisphosphonates
    • Coxon FP, Thompson K, Rogers MJ. Recent advances in understanding the mechanism of action of bisphosphonates. Curr Opin Pharmacol. 2006;6(3):307-312.
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.3 , pp. 307-312
    • Coxon, F.P.1    Thompson, K.2    Rogers, M.J.3
  • 41
    • 15244344110 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
    • DOI 10.1016/j.immuni.2005.01.011
    • Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity. 2005;22(3):285-294. (Pubitemid 40387471)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 285-294
    • Stark, M.A.1    Huo, Y.2    Burcin, T.L.3    Morris, M.A.4    Olson, T.S.5    Ley, K.6
  • 42
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia. 2008;22(10):1925-1932.
    • (2008) Leukemia , vol.22 , Issue.10 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3


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