-
1
-
-
33748642599
-
Acc/aha/esc 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the american college of cardiology/american heart association task force and the european society of cardiology committee for practice guidelines
-
European Heart Rhythm Association et al.
-
European Heart Rhythm Association et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology committee for practice guidelines. J. Am. Coll. Cardiol. 48, e247-e346 (2006
-
(2006)
J. Am. Coll. Cardiol
, vol.48
-
-
-
2
-
-
0030695327
-
Out of hospital cardiac arrest in the 1990's: A population-based study in the Maastricht area on incidence, characteristics and survival
-
de Vreede-Swagemakers, J. J. et al. Out of hospital cardiac arrest in the 1990's: A population-based study in the Maastricht area on incidence, characteristics and survival. J. Am. Coll. Cardiol. 30, 1500-1505 (1997
-
(1997)
J. Am. Coll. Cardiol
, vol.30
, pp. 1500-1505
-
-
De Vreede-Swagemakers, J.J.1
-
3
-
-
84865229881
-
Implantable cardioverter-defibrillators have reduced the incidence of resuscitation for out of hospital cardiac arrest caused by lethal arrhythmias
-
Hulleman, M et Al. Implantable Cardioverter-defibrillators Have Reduced the Incidence of Resuscitation for out of Hospital Cardiac Arrest Caused by Lethal Arrhythmias. Circulation 126, 815-821 (2012
-
(2012)
Circulation
, vol.126
, pp. 815-821
-
-
Hulleman, M.1
-
4
-
-
84876338412
-
The ICD for primary prevention in patients with inherited cardiac diseases: Indications, use, and outcome: A comparison with secondary prevention
-
Olde Nordkamp, L. R. et al. The ICD for primary prevention in patients with inherited cardiac diseases: Indications, use, and outcome: A comparison with secondary prevention. Circ. Arrhythm. Electrophysiol. 6, 91-100 (2013
-
(2013)
Circ. Arrhythm. Electrophysiol
, vol.6
, pp. 91-100
-
-
Olde Nordkamp, L.R.1
-
5
-
-
79851476464
-
Systematic review of the incidence of sudden cardiac death in the United States
-
Kong, M. H. et al. Systematic review of the incidence of sudden cardiac death in the United States. J. Am. Coll. Cardiol. 57, 794-801 (2011
-
(2011)
J. Am. Coll. Cardiol
, vol.57
, pp. 794-801
-
-
Kong, M.H.1
-
6
-
-
84864646533
-
-
US and world population clock [online]
-
US Department of Commerce US and world population clock [online], http://www.census.gov/popclock (2013
-
(2013)
US Department of Commerce
-
-
-
7
-
-
0037132575
-
Changing incidence of out-of-hospital ventricular fibrillation 1980-2000
-
Cobb, L. A., Fahrenbruch, C. E., Olsufka, M. & Copass, M. K. Changing incidence of out-of-hospital ventricular fibrillation, 1980-2000. JAMA 288, 3008-3013 (2002
-
(2002)
JAMA
, vol.288
, pp. 3008-3013
-
-
Cobb, L.A.1
Fahrenbruch, C.E.2
Olsufka, M.3
Copass, M.K.4
-
8
-
-
0038755051
-
Prospective study of sudden cardiac death among women in the United States
-
Albert, C M. et al. Prospective study of sudden cardiac death among women in the United States. Circulation 107, 2096-2101 (2003
-
(2003)
Circulation
, vol.107
, pp. 2096-2101
-
-
Albert, C.M.1
-
9
-
-
0027495655
-
Sudden cardiac death: Epidemiology, transient risk, and intervention assessment
-
Myerburg, R. J., Kessler, K. M. & Castellanos, A. Sudden cardiac death: Epidemiology, transient risk, and intervention assessment. Ann. Intern. Med. 119, 1187-1197 (1993
-
(1993)
Ann. Intern. Med
, vol.119
, pp. 1187-1197
-
-
Myerburg, R.J.1
Kessler, K.M.2
Castellanos, A.3
-
10
-
-
84865052488
-
Epilepsy is a risk factor for sudden cardiac arrest in the general population
-
Bardai, A et al. Epilepsy is a risk factor for sudden cardiac arrest in the general population. PLoS ONE 7, e42749 (2012
-
(2012)
PLoS ONE
, vol.7
-
-
Bardai, A.1
-
11
-
-
0035891624
-
Sudden death due to cardiac arrhythmias
-
Huikuri, H. V., Castellanos, A. & Myerburg, R. J. Sudden death due to cardiac arrhythmias. N. Engl. J. Med. 345, 1473-1482 (2001
-
(2001)
N. Engl. J. Med
, vol.345
, pp. 1473-1482
-
-
Huikuri, H.V.1
Castellanos, A.2
Myerburg, R.J.3
-
12
-
-
0035975980
-
Sudden cardiac death in the United States 1989 to 1998
-
Zheng, Z. J., Croft, J. B., Giles, W. H. & Mensah, G. A. Sudden cardiac death in the United States, 1989 to 1998. Circulation 104, 2158-2163 (2001
-
(2001)
Circulation
, vol.104
, pp. 2158-2163
-
-
Zheng, Z.J.1
Croft, J.B.2
Giles, W.H.3
Mensah, G.A.4
-
13
-
-
84866251874
-
Incidence, causes, and survival trends from cardiovascular-related sudden cardiac arrest in children and young adults 0 to 35 years of age: A 30-year review
-
Meyer, L et al. Incidence, causes, and survival trends from cardiovascular-related sudden cardiac arrest in children and young adults 0 to 35 years of age: A 30-year review. Circulation 126, 1363-1372 (2012
-
(2012)
Circulation
, vol.126
, pp. 1363-1372
-
-
Meyer, L.1
-
14
-
-
0035028796
-
Sudden cardiac death in young people with apparently normal heart
-
Corrado, D., Basso, C. & Thiene, G. Sudden cardiac death in young people with apparently normal heart. Cardiovasc. Res. 50, 399-408 (2001
-
(2001)
Cardiovasc. Res
, vol.50
, pp. 399-408
-
-
Corrado, D.1
Basso, C.2
Thiene, G.3
-
15
-
-
22144439771
-
Sudden unexplained death: Heritability and diagnostic yield of cardiological and genetic examination in surviving relatives
-
Tan, H L., Hofman, N., van Langen, I. M., van der Wal, A. C. & Wilde, A. A. Sudden unexplained death: Heritability and diagnostic yield of cardiological and genetic examination in surviving relatives. Circulation 112, 207-213 (2005
-
(2005)
Circulation
, vol.112
, pp. 207-213
-
-
Tan, H.L.1
Hofman, N.2
Van Langen, I.M.3
Van Der Wal, A.C.4
Wilde, A.A.5
-
16
-
-
84873828284
-
Molecular and genetic basis of sudden cardiac death
-
George, A. L. Jr. Molecular and genetic basis of sudden cardiac death. J. Clin. Invest. 123, 75-83 (2013
-
(2013)
J. Clin. Invest
, vol.123
, pp. 75-83
-
-
George Jr., A.L.1
-
17
-
-
84871969762
-
Large-scale association analysis identifies new risk loci for coronary artery disease
-
CARDIoGRAMplusC4D Consortium et al
-
CARDIoGRAMplusC4D Consortium et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet. 45, 25-33 (2013
-
(2013)
Nat. Genet
, vol.45
, pp. 25-33
-
-
-
18
-
-
0036224099
-
Sudden death and myocardial infarction in first degree relatives as predictors of primary cardiac arrest
-
Friedlander, Y et al. Sudden death and myocardial infarction in first degree relatives as predictors of primary cardiac arrest. Atherosclerosis 162, 211-216 (2002
-
(2002)
Atherosclerosis
, vol.162
, pp. 211-216
-
-
Friedlander, Y.1
-
19
-
-
0033586647
-
Predicting sudden death in the population: The Paris Prospective Study i
-
Jouven, X., Desnos, M., Guerot, C & Ducimetière, P. Predicting sudden death in the population: The Paris Prospective Study I. Circulation 99, 1978-1983 (1999
-
(1999)
Circulation
, vol.99
, pp. 1978-1983
-
-
Jouven, X.1
Desnos, M.2
Guerot, C.3
Ducimetière, P.4
-
20
-
-
0031940866
-
Family history as a risk factor for primary cardiac arrest
-
Friedlander, Y. et al. Family history as a risk factor for primary cardiac arrest. Circulation 97, 155-160 (1998
-
(1998)
Circulation
, vol.97
, pp. 155-160
-
-
Friedlander, Y.1
-
21
-
-
33748640974
-
Familial sudden death is an important risk factor for primary ventricular fibrillation: A case-control study in acute myocardial infarction patients
-
Dekker, L. R. et al. Familial sudden death is an important risk factor for primary ventricular fibrillation: A case-control study in acute myocardial infarction patients. Circulation 114, 1140-1145 (2006
-
(2006)
Circulation
, vol.114
, pp. 1140-1145
-
-
Dekker, L.R.1
-
22
-
-
33749527092
-
Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event
-
Kaikkonen, K. S., Kortelainen, M. L., Linna, E. & Huikuri, H. V. Family history and the risk of sudden cardiac death as a manifestation of an acute coronary event. Circulation 114, 1462-1467 (2006
-
(2006)
Circulation
, vol.114
, pp. 1462-1467
-
-
Kaikkonen, K.S.1
Kortelainen, M.L.2
Linna, E.3
Huikuri, H.V.4
-
23
-
-
0025167629
-
Parental history is an independent risk factor for coronary artery disease: The Framingham Study
-
Myers, R. H., Kiely, D. K., Cupples, L. A. & Kannel, W. B. Parental history is an independent risk factor for coronary artery disease: The Framingham Study. Am. Heart J. 120, 963-969 (1990
-
(1990)
Am. Heart J.
, vol.120
, pp. 963-969
-
-
Myers, R.H.1
Kiely, D.K.2
Cupples, L.A.3
Kannel, W.B.4
-
24
-
-
0018750123
-
Family (parental) history and prevalence of hypertension results of a nationwide screening program
-
Stamler, R., Stamler, J., Riedlinger, W. F., Algera, G. & Roberts, R. H. Family (parental) history and prevalence of hypertension. Results of a nationwide screening program. JAMA 241, 43-46 (1979
-
(1979)
JAMA
, vol.241
, pp. 43-46
-
-
Stamler, R.1
Stamler, J.2
Riedlinger, W.F.3
Algera, G.4
Roberts, R.H.5
-
25
-
-
0033645239
-
Parental transmission of type 2 diabetes: The Framingham Offspring Study
-
Meigs, J. B., Cupples, L. A. & Wilson, P. W. Parental transmission of type 2 diabetes: The Framingham Offspring Study. Diabetes 49, 2201-2207 (2000
-
(2000)
Diabetes
, vol.49
, pp. 2201-2207
-
-
Meigs, J.B.1
Cupples, L.A.2
Wilson, P.W.3
-
26
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
-
27
-
-
77955091644
-
Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction
-
Bezzina, C. R. et al. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nat. Genet. 42, 688-691 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 688-691
-
-
Bezzina, C.R.1
-
28
-
-
79959854942
-
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals
-
Arking, D. E. et al. Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet. 7, e1002158 (2011
-
(2011)
PLoS Genet
, vol.7
-
-
Arking, D.E.1
-
29
-
-
84862767304
-
The changing spectrum of arrhythmogenic (right ventricular) cardiomyopathy
-
Rizzo, S., Pilichou, K., Thiene, G. & Basso, C. The changing spectrum of arrhythmogenic (right ventricular) cardiomyopathy. Cell Tissue Res. 348, 319-323 (2012
-
(2012)
Cell Tissue Res
, vol.348
, pp. 319-323
-
-
Rizzo, S.1
Pilichou, K.2
Thiene, G.3
Basso, C.4
-
30
-
-
79955519460
-
Inherited cardiomyopathies
-
Watkins, H., Ashrafian, H. & Redwood, C. Inherited cardiomyopathies. N. Engl. J. Med. 364, 1643-1656 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, pp. 1643-1656
-
-
Watkins, H.1
Ashrafian, H.2
Redwood, C.3
-
31
-
-
64049101148
-
Arrhythmogenic right ventricular cardiomyopathy
-
Basso, C., Corrado, D., Marcus, F. I., Nava, A. & Thiene, G. Arrhythmogenic right ventricular cardiomyopathy. Lancet 373, 1289-1300 (2009
-
(2009)
Lancet
, vol.373
, pp. 1289-1300
-
-
Basso, C.1
Corrado, D.2
Marcus, F.I.3
Nava, A.4
Thiene, G.5
-
32
-
-
0035909017
-
Hypertrophic cardiomyopathy: Histopathological features of sudden death in cardiac troponin T disease
-
Varnava, A. M. et al. Hypertrophic cardiomyopathy: Histopathological features of sudden death in cardiac troponin T disease. Circulation 104, 1380-1384 (2001
-
(2001)
Circulation
, vol.104
, pp. 1380-1384
-
-
Varnava, A.M.1
-
33
-
-
84863723103
-
Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia
-
Schober, T. et al. Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia. Circ. Res. 111, 170-179 (2012
-
(2012)
Circ. Res
, vol.111
, pp. 170-179
-
-
Schober, T.1
-
34
-
-
84865214658
-
Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein 2 mutant mice prior to cardiomyopathic changes
-
Rizzo, S. et al. Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein 2 mutant mice prior to cardiomyopathic changes. Cardiovasc. Res. 95, 409-418 (2012
-
(2012)
Cardiovasc. Res
, vol.95
, pp. 409-418
-
-
Rizzo, S.1
-
35
-
-
84865221010
-
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin 2 haploinsufficiency
-
Cerrone, M. et al. Sodium current deficit and arrhythmogenesis in a murine model of plakophilin 2 haploinsufficiency. Cardiovasc. Res. 95, 460-468 (2012
-
(2012)
Cardiovasc. Res
, vol.95
, pp. 460-468
-
-
Cerrone, M.1
-
36
-
-
0028905566
-
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
-
Wang, Q. et al. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80, 805-811 (1995
-
(1995)
Cell
, vol.80
, pp. 805-811
-
-
Wang, Q.1
-
37
-
-
0028914969
-
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
-
Curran, M. E. et al. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795-803 (1995
-
(1995)
Cell
, vol.80
, pp. 795-803
-
-
Curran, M.E.1
-
38
-
-
0028874658
-
Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate: Implications for gene-specific therapy
-
Schwartz, P. J. et al. Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate: Implications for gene-specific therapy. Circulation 92, 3381-3386 (1995
-
(1995)
Circulation
, vol.92
, pp. 3381-3386
-
-
Schwartz, P.J.1
-
39
-
-
0030968494
-
Pharmacological targeting of long QT mutant sodium channels
-
Wang, D. W., Yazawa, K., Makita, N., George, A. L. & Bennett, P. B. Pharmacological targeting of long QT mutant sodium channels. J. Clin. Invest. 99, 1714-1720 (1997
-
(1997)
J. Clin. Invest
, vol.99
, pp. 1714-1720
-
-
Wang, D.W.1
Yazawa, K.2
Makita, N.3
George, A.L.4
Bennett, P.B.5
-
40
-
-
59849102447
-
High efficacy of beta-blockers in long-qt syndrome type 1: Contribution of noncompliance and qt prolonging drugs to the occurrence of beta-blocker treatment failures
-
Vincent, G. M. et al. High efficacy of beta-blockers in long-QT syndrome type 1: Contribution of noncompliance and QT prolonging drugs to the occurrence of beta-blocker treatment failures. Circulation 119, 215-221 (2009
-
(2009)
Circulation
, vol.119
, pp. 215-221
-
-
Vincent, G.M.1
-
41
-
-
84860210760
-
Mutations in cytoplasmic loops of the kcnq1 channel and the risk of life-threatening events: Implications for mutation-specific response to β blocker therapy in type 1 long-qt syndrome
-
Barsheshet, A. et al. Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β blocker therapy in type 1 long-QT syndrome. Circulation 125, 1988-1996 (2012
-
(2012)
Circulation
, vol.125
, pp. 1988-1996
-
-
Barsheshet, A.1
-
42
-
-
84856058439
-
Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1
-
Heijman, J. et al. Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1. Circ. Res. 110, 211-219 (2012
-
(2012)
Circ. Res
, vol.110
, pp. 211-219
-
-
Heijman, J.1
-
43
-
-
78650939755
-
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain
-
Choveau, F. S. et al. KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. J. Biol. Chem. 286, 707-716 (2011
-
(2011)
J. Biol. Chem
, vol.286
, pp. 707-716
-
-
Choveau, F.S.1
-
44
-
-
64149085800
-
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
-
Watanabe, H. et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat. Med. 15, 380-383 (2009
-
(2009)
Nat. Med
, vol.15
, pp. 380-383
-
-
Watanabe, H.1
-
45
-
-
79957553666
-
Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia
-
van der Werf, C. et al. Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. J. Am. Coll. Cardiol. 57, 2244-2254 (2011
-
(2011)
J. Am. Coll. Cardiol
, vol.57
, pp. 2244-2254
-
-
Van Der Werf, C.1
-
46
-
-
80051710052
-
HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA
-
Ackerman, M. J. et al. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace 13, 1077-1109 (2011
-
(2011)
Europace
, vol.13
, pp. 1077-1109
-
-
Ackerman, M.J.1
-
47
-
-
84884591407
-
Genetic testing for inherited cardiac disease
-
Wilde, A. A. & Behr, E. R. Genetic testing for inherited cardiac disease. Nat. Rev. Cardiol. 10, 571-583 (2013
-
(2013)
Nat. Rev. Cardiol
, vol.10
, pp. 571-583
-
-
Wilde, A.A.1
Behr, E.R.2
-
48
-
-
84975795680
-
An integrated map of genetic variation from 1,092 human genomes
-
Genomes Project Consortium et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56-65 (2012
-
(2012)
Nature
, vol.491
, pp. 56-65
-
-
-
49
-
-
84893702334
-
-
1000 Genomes [online]
-
Genomes Project Consortium. 1000 Genomes [online], http://www. 1000genomes.org/ (2012
-
(2012)
Genomes Project Consortium
-
-
-
50
-
-
84863556835
-
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
-
Tennessen, J. A. et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337, 64-69 (2012
-
(2012)
Science
, vol.337
, pp. 64-69
-
-
Tennessen, J.A.1
-
51
-
-
84857121123
-
-
NHLBI GO Exome Sequencing Project (ESP
-
NHLBI GO Exome Sequencing Project (ESP). Exome Variant Server [online], http://evs.gs.washington.edu/EVS/ (2013
-
(2013)
Exome Variant Server Online
-
-
-
52
-
-
84890389952
-
New exome data question the pathogenicity of genetic variants previously associated with catecholaminergic polymorphic ventricular tachycardia
-
Jabbari, J. et al. New exome data question the pathogenicity of genetic variants previously associated with catecholaminergic polymorphic ventricular tachycardia. Circ. Cardiovasc. Genet. 6, 481-489 (2013
-
(2013)
Circ. Cardiovasc. Genet
, vol.6
, pp. 481-489
-
-
Jabbari, J.1
-
53
-
-
84885833187
-
High prevalence of genetic variants previously associated with Brugada syndrome in new exome data
-
Risgaard, B. et al. High prevalence of genetic variants previously associated with Brugada syndrome in new exome data. Clin. Genet. 84, 489-495 (2013
-
(2013)
Clin. Genet
, vol.84
, pp. 489-495
-
-
Risgaard, B.1
-
54
-
-
84875217898
-
Disease-targeted sequencing: A cornerstone in the clinic
-
Rehm, H. L. Disease-targeted sequencing: A cornerstone in the clinic. Nat. Rev. Genet. 14, 295-300 (2013
-
(2013)
Nat. Rev. Genet
, vol.14
, pp. 295-300
-
-
Rehm, H.L.1
-
55
-
-
80051968181
-
Needles in stacks of needles: Finding disease-causal variants in a wealth of genomic data
-
Cooper, G. M. & Shendure, J. Needles in stacks of needles: Finding disease-causal variants in a wealth of genomic data. Nat. Rev. Genet. 12, 628-640 (2011
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 628-640
-
-
Cooper, G.M.1
Shendure, J.2
-
56
-
-
68149165614
-
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
-
Kumar, P., Henikoff, S. & Ng, P. C. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4, 1073-1081 (2009
-
(2009)
Nat. Protoc
, vol.4
, pp. 1073-1081
-
-
Kumar, P.1
Henikoff, S.2
Ng, P.C.3
-
57
-
-
77951640946
-
A method and server for predicting damaging missense mutations
-
Adzhubei, I. A. et al. A method and server for predicting damaging missense mutations. Nat. Methods 7, 248-249 (2010
-
(2010)
Nat. Methods
, vol.7
, pp. 248-249
-
-
Adzhubei, I.A.1
-
58
-
-
84863877251
-
Paralogous annotation of disease-causing variants in long QT syndrome genes
-
Ware, J. S., Walsh, R., Cunningham, F., Birney, E. & Cook, S. A. Paralogous annotation of disease-causing variants in long QT syndrome genes. Hum. Mutat. 33, 1188-1191 (2012
-
(2012)
Hum. Mutat
, vol.33
, pp. 1188-1191
-
-
Ware, J.S.1
Walsh, R.2
Cunningham, F.3
Birney, E.4
Cook, S.A.5
-
59
-
-
22244452677
-
Distribution and intensity of constraint in mammalian genomic sequence
-
Cooper, G. M. et al. Distribution and intensity of constraint in mammalian genomic sequence. Genome Res. 15, 901-913 (2005
-
(2005)
Genome Res
, vol.15
, pp. 901-913
-
-
Cooper, G.M.1
-
60
-
-
84877999280
-
Molecular genetic testing and the future of clinical genomics
-
Katsanis, S. H. & Katsanis, N. Molecular genetic testing and the future of clinical genomics. Nat. Rev. Genet. 14, 415-426 (2013
-
(2013)
Nat. Rev. Genet
, vol.14
, pp. 415-426
-
-
Katsanis, S.H.1
Katsanis, N.2
-
61
-
-
84884416457
-
Rare-disease genetics in the era of next-generation sequencing: Discovery to translation
-
Boycott, K. M., Vanstone, M. R., Bulman, D. E. & Mackenzie, A. E. Rare-disease genetics in the era of next-generation sequencing: Discovery to translation. Nat. Rev. Genet. 14, 681-691 (2013
-
(2013)
Nat. Rev. Genet
, vol.14
, pp. 681-691
-
-
Boycott, K.M.1
Vanstone, M.R.2
Bulman, D.E.3
MacKenzie, A.E.4
-
62
-
-
84874664698
-
Calmodulin mutations associated with recurrent cardiac arrest in infants
-
Crotti, L. et al. Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation 127, 1009-1017 (2013
-
(2013)
Circulation
, vol.127
, pp. 1009-1017
-
-
Crotti, L.1
-
63
-
-
75749103383
-
Rate molecular spectrum, and consequences of human mutation
-
Lynch, M. Rate, molecular spectrum, and consequences of human mutation. Proc. Natl. Acad. Sci. USA 107, 961-968 (2010
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 961-968
-
-
Lynch, M.1
-
64
-
-
84892407727
-
A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence
-
Marsman, R. F. et al. A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence. J. Am. Coll. Cardiol. http://dx.doi.org/10.1016/j.jacc.2013.07.091
-
J. Am. Coll. Cardiol
-
-
Marsman, R.F.1
-
65
-
-
84884482008
-
Exome sequencing and systems biology converge to identify novel mutations in the L type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome
-
Boczek, N. J. et al. Exome sequencing and systems biology converge to identify novel mutations in the L type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome. Circ. Cardiovasc. Genet. 6, 279-289 (2013
-
(2013)
Circ. Cardiovasc. Genet
, vol.6
, pp. 279-289
-
-
Boczek, N.J.1
-
66
-
-
84893669575
-
Sudden death
-
eds Kulbertus, H. E. & Wellens, H. J. J
-
Schwartz, P. J. in Sudden death (eds Kulbertus, H. E. & Wellens, H. J. J.) 358-378 (Martinus Nijhoff Publishers, 1980
-
(1980)
Martinus Nijhoff Publishers
, pp. 358-378
-
-
Schwartz, P.J.1
-
67
-
-
0033533990
-
A single Na+ channel mutation causing both long-QT and Brugada syndromes
-
Bezzina, C. et al. A single Na+ channel mutation causing both long-QT and Brugada syndromes. Circ. Res. 85, 1206-1213 (1999
-
(1999)
Circ. Res
, vol.85
, pp. 1206-1213
-
-
Bezzina, C.1
-
68
-
-
70350540922
-
NOS1AP is a genetic modifier of the long-QT syndrome
-
Crotti, L. et al. NOS1AP is a genetic modifier of the long-QT syndrome. Circulation 120, 1657-1663 (2009
-
(2009)
Circulation
, vol.120
, pp. 1657-1663
-
-
Crotti, L.1
-
69
-
-
0033514263
-
Low penetrance in the long-QT syndrome: Clinical impact
-
Priori, S. G., Napolitano, C. & Schwartz, P. J. Low penetrance in the long-QT syndrome: Clinical impact. Circulation 99, 529-533 (1999
-
(1999)
Circulation
, vol.99
, pp. 529-533
-
-
Priori, S.G.1
Napolitano, C.2
Schwartz, P.J.3
-
70
-
-
0034649298
-
Clinical and genetic heterogeneity of right bundle branch block and ST segment elevation syndrome: A prospective evaluation of 52 families
-
Priori, S. G. et al. Clinical and genetic heterogeneity of right bundle branch block and ST segment elevation syndrome: A prospective evaluation of 52 families. Circulation 102, 2509-2515 (2000
-
(2000)
Circulation
, vol.102
, pp. 2509-2515
-
-
Priori, S.G.1
-
71
-
-
27444442331
-
Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population
-
Brink, P. A. et al. Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population. Circulation 112, 2602-2610 (2005
-
(2005)
Circulation
, vol.112
, pp. 2602-2610
-
-
Brink, P.A.1
-
72
-
-
0038415858
-
Risk stratification in the long-QT syndrome
-
Priori, S. G. et al. Risk stratification in the long-QT syndrome. N. Engl. J. Med. 348, 1866-1874 (2003
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 1866-1874
-
-
Priori, S.G.1
-
73
-
-
79961163474
-
Founder mutations in the Netherlands: Familial idiopathic ventricular fibrillation and DPP6
-
Postema, P. G. et al. Founder mutations in the Netherlands: Familial idiopathic ventricular fibrillation and DPP6. Neth. Heart J. 19, 290-296 (2011
-
(2011)
Neth. Heart J.
, vol.19
, pp. 290-296
-
-
Postema, P.G.1
-
74
-
-
38649121254
-
Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome
-
Schwartz, P. J. et al. Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J. Am. Coll. Cardiol. 51, 920-929 (2008
-
(2008)
J. Am. Coll. Cardiol
, vol.51
, pp. 920-929
-
-
Schwartz, P.J.1
-
75
-
-
1442306232
-
Drug-induced prolongation of the QT interval
-
Roden, D. M. Drug-induced prolongation of the QT interval. N. Engl. J. Med. 350, 1013-1022 (2004
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 1013-1022
-
-
Roden, D.M.1
-
76
-
-
0242635451
-
How really rare are rare diseases? the intriguing case of independent compound mutations in the long QT syndrome
-
Schwartz, P. J., Priori, S. G. & Napolitano, C. How really rare are rare diseases? The intriguing case of independent compound mutations in the long QT syndrome. J. Cardiovasc. Electrophysiol. 14, 1120-1121 (2003
-
(2003)
J. Cardiovasc. Electrophysiol
, vol.14
, pp. 1120-1121
-
-
Schwartz, P.J.1
Priori, S.G.2
Napolitano, C.3
-
77
-
-
1942534554
-
Compound mutations: A common cause of severe long-QT syndrome
-
Westenskow, P., Splawski, I., Timothy, K. W., Keating, M. T. & Sanguinetti, M. C. Compound mutations: A common cause of severe long-QT syndrome. Circulation 109, 1834-1841 (2004
-
(2004)
Circulation
, vol.109
, pp. 1834-1841
-
-
Westenskow, P.1
Splawski, I.2
Timothy, K.W.3
Keating, M.T.4
Sanguinetti, M.C.5
-
78
-
-
84878031767
-
Prevalence and potential genetic determinants of sensorineural deafness in KCNQ1 homozygosity and compound heterozygosity
-
Giudicessi, J. R. & Ackerman, M. J. Prevalence and potential genetic determinants of sensorineural deafness in KCNQ1 homozygosity and compound heterozygosity. Circ. Cardiovasc. Genet. 6, 193-200 (2013
-
(2013)
Circ. Cardiovasc. Genet
, vol.6
, pp. 193-200
-
-
Giudicessi, J.R.1
Ackerman, M.J.2
-
79
-
-
68949209933
-
Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test
-
Kapplinger, J. D. et al. Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test. Heart Rhythm 6, 1297-1303 (2009
-
(2009)
Heart Rhythm
, vol.6
, pp. 1297-1303
-
-
Kapplinger, J.D.1
-
80
-
-
34248512934
-
Clinical aspects of type 1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
-
Moss, A. J. et al. Clinical aspects of type 1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation 115, 2481-2489 (2007
-
(2007)
Circulation
, vol.115
, pp. 2481-2489
-
-
Moss, A.J.1
-
81
-
-
71849098104
-
Genotype-phenotype aspects of type 2 long QT syndrome
-
Shimizu, W. et al. Genotype-phenotype aspects of type 2 long QT syndrome. J. Am. Coll. Cardiol. 54, 2052-2062 (2009
-
(2009)
J. Am. Coll. Cardiol
, vol.54
, pp. 2052-2062
-
-
Shimizu, W.1
-
82
-
-
77953144675
-
Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome
-
Tomás, M. et al. Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome. J. Am. Coll. Cardiol. 55, 2745-2752 (2010
-
(2010)
J. Am. Coll. Cardiol
, vol.55
, pp. 2745-2752
-
-
Tomás, M.1
-
83
-
-
84883461171
-
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
-
Bezzina, C. R. et al. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat. Genet. 9, 1044-1049 (2013
-
(2013)
Nat. Genet
, vol.9
, pp. 1044-1049
-
-
Bezzina, C.R.1
-
84
-
-
84884514304
-
Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome
-
Duchatelet, S. et al. Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome. Circ. Cardiovasc. Genet. 6, 354-361 (2013
-
(2013)
Circ. Cardiovasc. Genet
, vol.6
, pp. 354-361
-
-
Duchatelet, S.1
-
85
-
-
33745237158
-
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
-
Arking, D. E. et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat. Genet. 38, 644-651 (2006
-
(2006)
Nat. Genet
, vol.38
, pp. 644-651
-
-
Arking, D.E.1
-
86
-
-
63449109595
-
Common variants at ten loci modulate the QT interval duration in the QTSCD study
-
Pfeufer, A. et al. Common variants at ten loci modulate the QT interval duration in the QTSCD study. Nat. Genet. 41, 407-414 (2009
-
(2009)
Nat. Genet
, vol.41
, pp. 407-414
-
-
Pfeufer, A.1
-
87
-
-
63449136073
-
Common variants at ten loci influence QT interval duration in the QTGEN study
-
Newton-Cheh, C. et al. Common variants at ten loci influence QT interval duration in the QTGEN study. Nat. Genet. 41, 399-406 (2009
-
(2009)
Nat. Genet
, vol.41
, pp. 399-406
-
-
Newton-Cheh, C.1
-
88
-
-
84858417162
-
Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner
-
Amin, A. S. et al. Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner. Eur. Heart J. 33, 714-723 (2012
-
(2012)
Eur. Heart J.
, vol.33
, pp. 714-723
-
-
Amin, A.S.1
-
89
-
-
40149090710
-
Differential allelic expression in the human genome: A robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression
-
Serre, D. et al. Differential allelic expression in the human genome: A robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. PLoS Genet. 4, e1000006 (2008
-
(2008)
PLoS Genet
, vol.4
-
-
Serre, D.1
-
91
-
-
84867081985
-
Spectrum and prevalence of mutations involving BrS1-through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: Implications for genetic testing
-
Crotti, L. et al. Spectrum and prevalence of mutations involving BrS1-through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: Implications for genetic testing. J. Am. Coll. Cardiol. 60, 1410-1418 (2012
-
(2012)
J. Am. Coll. Cardiol
, vol.60
, pp. 1410-1418
-
-
Crotti, L.1
-
92
-
-
75749102498
-
Genetic variation in SCN10A influences cardiac conduction
-
Chambers, J. C. et al. Genetic variation in SCN10A influences cardiac conduction. Nat. Genet. 42, 149-152 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 149-152
-
-
Chambers, J.C.1
-
93
-
-
75749122164
-
Several common variants modulate heart rate PR interval and QRS duration
-
Holm, H. et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat. Genet. 42, 117-122 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 117-122
-
-
Holm, H.1
-
94
-
-
75749097235
-
Genome-wide association study of PR interval
-
Pfeufer, A. et al. Genome-wide association study of PR interval. Nat. Genet. 42, 153-159 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 153-159
-
-
Pfeufer, A.1
-
95
-
-
84947899543
-
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
-
Sotoodehnia, N. et al. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat. Genet. 42, 1068-1076 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 1068-1076
-
-
Sotoodehnia, N.1
-
96
-
-
0043062774
-
Hey genes in cardiovascular development
-
Fischer, A. & Gessler, M. Hey genes in cardiovascular development. Trends Cardiovasc. Med. 13, 221-226 (2003
-
(2003)
Trends Cardiovasc. Med
, vol.13
, pp. 221-226
-
-
Fischer, A.1
Gessler, M.2
-
97
-
-
77954680724
-
Common variants in cardiac ion channel genes are associated with sudden cardiac death
-
Albert, C. M. et al. Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ. Arrhythm. Electrophysiol. 3, 222-229 (2010
-
(2010)
Circ. Arrhythm. Electrophysiol
, vol.3
, pp. 222-229
-
-
Albert, C.M.1
-
98
-
-
80052703933
-
Common variants in CASQ2 GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease
-
Westaway, S. K. et al. Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease. Circ. Cardiovasc. Genet. 4, 397-402 (2011
-
(2011)
Circ. Cardiovasc. Genet
, vol.4
, pp. 397-402
-
-
Westaway, S.K.1
-
99
-
-
33646777139
-
Allelic variants of SCN5A and risk of sudden cardiac arrest in patients with coronary artery disease
-
Stecker, E. C. et al. Allelic variants of SCN5A and risk of sudden cardiac arrest in patients with coronary artery disease. Heart Rhythm 3, 697-700 (2006
-
(2006)
Heart Rhythm
, vol.3
, pp. 697-700
-
-
Stecker, E.C.1
-
100
-
-
23844527207
-
Role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks
-
Burke, A. et al. Role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks. Circulation 112, 798-802 (2005
-
(2005)
Circulation
, vol.112
, pp. 798-802
-
-
Burke, A.1
-
101
-
-
18544383162
-
Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia
-
Splawski, I. et al. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 297, 1333-1336 (2002
-
(2002)
Science
, vol.297
, pp. 1333-1336
-
-
Splawski, I.1
-
102
-
-
37349080496
-
Cardiac sodium channel gene variants and sudden cardiac death in women
-
Albert, C. M. et al. Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation 117, 16-23 (2008
-
(2008)
Circulation
, vol.117
, pp. 16-23
-
-
Albert, C.M.1
-
103
-
-
84862849809
-
Torsades de pointes following acute myocardial infarction: Evidence for a deadly link with a common genetic variant
-
Crotti, L. et al. Torsades de pointes following acute myocardial infarction: Evidence for a deadly link with a common genetic variant. Heart Rhythm 9, 1104-1112 (2012
-
(2012)
Heart Rhythm
, vol.9
, pp. 1104-1112
-
-
Crotti, L.1
-
104
-
-
33646183895
-
β2 Adrenergic receptor genetic variants and risk of sudden cardiac death
-
Sotoodehnia, N. et al. β2 Adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation 113, 1842-1848 (2006
-
(2006)
Circulation
, vol.113
, pp. 1842-1848
-
-
Sotoodehnia, N.1
-
105
-
-
46349106706
-
Common β adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease
-
Tseng, Z. H. et al. Common β adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease. Heart Rhythm 5, 814-821 (2008
-
(2008)
Heart Rhythm
, vol.5
, pp. 814-821
-
-
Tseng, Z.H.1
-
106
-
-
79955375473
-
A common variant in the β2 adrenergic receptor and risk of sudden cardiac death
-
Gavin, M. C. et al. A common variant in the β2 adrenergic receptor and risk of sudden cardiac death. Heart Rhythm 8, 704-710 (2011
-
(2011)
Heart Rhythm
, vol.8
, pp. 704-710
-
-
Gavin, M.C.1
-
107
-
-
0035928604
-
Platelet glycoprotein Ibα HPA 2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death
-
Mikkelsson, J., Perola, M., Penttilä, A. & Karhunen, P. J. Platelet glycoprotein Ibα HPA 2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death. Circulation 104, 876-880 (2001
-
(2001)
Circulation
, vol.104
, pp. 876-880
-
-
Mikkelsson, J.1
Perola, M.2
Penttilä, A.3
Karhunen, P.J.4
-
108
-
-
0033810084
-
Glycoprotein IIIa Pl(A1/A2) polymorphism and sudden cardiac death
-
Mikkelsson, J., Perola, M., Laippala, P., Penttilä, A. & Karhunen, P. J. Glycoprotein IIIa Pl(A1/A2) polymorphism and sudden cardiac death. J. Am. Coll. Cardiol. 36, 1317-1323 (2000
-
(2000)
J. Am. Coll. Cardiol
, vol.36
, pp. 1317-1323
-
-
Mikkelsson, J.1
Perola, M.2
Laippala, P.3
Penttilä, A.4
Karhunen, P.J.5
-
109
-
-
68949200176
-
Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk
-
Sotoodehnia, N. et al. Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. Heart Rhythm 6, 1306-1314 (2009
-
(2009)
Heart Rhythm
, vol.6
, pp. 1306-1314
-
-
Sotoodehnia, N.1
-
110
-
-
84879501615
-
A common missense variant in the neuregulin1 gene is associated with both schizophrenia and sudden cardiac death
-
Huertas-Vazquez, A. et al. A common missense variant in the neuregulin1 gene is associated with both schizophrenia and sudden cardiac death. Heart Rhythm 10, 994-998 (2013
-
(2013)
Heart Rhythm
, vol.10
, pp. 994-998
-
-
Huertas-Vazquez, A.1
-
111
-
-
73449091829
-
A common variant at 9p21 is associated with sudden and arrhythmic cardiac death
-
Newton-Cheh, C. et al. A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation 120, 2062-2068 (2009
-
(2009)
Circulation
, vol.120
, pp. 2062-2068
-
-
Newton-Cheh, C.1
-
112
-
-
84865693681
-
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits
-
Voight, B. F. et al. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 8, e1002793 (2012
-
(2012)
PLoS Genet
, vol.8
-
-
Voight, B.F.1
-
113
-
-
84875921005
-
Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease
-
Huertas-Vazquez, A. et al. Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease. PLoS ONE 8, e59905 (2013
-
(2013)
PLoS ONE
, vol.8
-
-
Huertas-Vazquez, A.1
-
114
-
-
77952636003
-
Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest
-
Arking, D. E. et al. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. PLoS ONE 5, e9879 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Arking, D.E.1
-
115
-
-
79960631229
-
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease
-
Aouizerat, B. E. et al. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. BMC Cardiovasc. Disord. 11, 29 (2011
-
(2011)
BMC Cardiovasc. Disord
, vol.11
, pp. 29
-
-
Aouizerat, B.E.1
-
116
-
-
0035902540
-
Human coxsackie-adenovirus receptor is colocalized with integrins αvβ3 and αvβ5 on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: Implications for cardiotropic viral infections
-
Noutsias, M. et al. Human coxsackie-adenovirus receptor is colocalized with integrins αvβ3 and αvβ5 on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: Implications for cardiotropic viral infections. Circulation 104, 275-280 (2001
-
(2001)
Circulation
, vol.104
, pp. 275-280
-
-
Noutsias, M.1
-
117
-
-
48749127844
-
Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
-
Lim, B. et al. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J. Clin. Invest. 118, 2758-2770 (2008
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2758-2770
-
-
Lim, B.1
-
118
-
-
53349097084
-
The tight junction protein CAR regulates cardiac conduction and cell-cell communication
-
Lisewski, U. et al. The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J. Exp. Med. 205, 2369-2379 (2008
-
(2008)
J. Exp. Med
, vol.205
, pp. 2369-2379
-
-
Lisewski, U.1
-
119
-
-
79960259208
-
No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population
-
Bugert, P. et al. No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population. Clin. Chem. Lab. Med. 49, 1237-1239 (2011
-
(2011)
Clin. Chem. Lab. Med
, vol.49
, pp. 1237-1239
-
-
Bugert, P.1
-
120
-
-
77954133026
-
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
-
Park, J. H. et al. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat. Genet. 42, 570-575 (2010
-
(2010)
Nat. Genet
, vol.42
, pp. 570-575
-
-
Park, J.H.1
-
121
-
-
84857633679
-
Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death
-
Kolder, I. C., Tanck, M. W. & Bezzina, C. R. Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death. J. Mol. Cell. Cardiol. 52, 620-629 (2012
-
(2012)
J. Mol. Cell. Cardiol
, vol.52
, pp. 620-629
-
-
Kolder, I.C.1
Tanck, M.W.2
Bezzina, C.R.3
-
122
-
-
30344462409
-
Prolonged QTc interval and risk of sudden cardiac death in a population of older adults
-
Straus, S. M. et al. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J. Am. Coll. Cardiol. 47, 362-367 (2006
-
(2006)
J. Am. Coll. Cardiol
, vol.47
, pp. 362-367
-
-
Straus, S.M.1
-
123
-
-
0017843995
-
QT interval prolongation as predictor of sudden death in patients with myocardial infarction
-
Schwartz, P. J. & Wolf, S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation 57, 1074-1077 (1978
-
(1978)
Circulation
, vol.57
, pp. 1074-1077
-
-
Schwartz, P.J.1
Wolf, S.2
-
124
-
-
61549120063
-
Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: The Oregon Sudden Unexpected Death Study
-
Chugh, S. S. et al. Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: The Oregon Sudden Unexpected Death Study. Circulation 119, 663-670 (2009
-
(2009)
Circulation
, vol.119
, pp. 663-670
-
-
Chugh, S.S.1
-
125
-
-
28944441590
-
Significance of QRS complex duration in patients with heart failure
-
Kashani, A. & Barold, S. S. Significance of QRS complex duration in patients with heart failure. J. Am. Coll. Cardiol. 46, 2183-2192 (2005
-
(2005)
J. Am. Coll. Cardiol
, vol.46
, pp. 2183-2192
-
-
Kashani, A.1
Barold, S.S.2
-
126
-
-
4143131954
-
Electrocardiographic predictors of arrhythmic death and total mortality in the Multicenter Unsustained Tachycardia Trial
-
Zimetbaum, P. J. et al. Electrocardiographic predictors of arrhythmic death and total mortality in the Multicenter Unsustained Tachycardia Trial. Circulation 110, 766-769 (2004
-
(2004)
Circulation
, vol.110
, pp. 766-769
-
-
Zimetbaum, P.J.1
-
127
-
-
0032933769
-
Heritability of heart rate variability: The Framingham Heart Study
-
Singh, J. P. et al. Heritability of heart rate variability: The Framingham Heart Study. Circulation 99, 2251-2254 (1999
-
(1999)
Circulation
, vol.99
, pp. 2251-2254
-
-
Singh, J.P.1
-
128
-
-
0032725330
-
Genetic and environmental sources of QT interval variability in Israeli families: The Kibbutz Settlements Family Study
-
Friedlander, Y., Lapidos, T., Sinnreich, R. & Kark, J. D. Genetic and environmental sources of QT interval variability in Israeli families: The Kibbutz Settlements Family Study. Clin. Genet. 56, 200-209 (1999
-
(1999)
Clin. Genet
, vol.56
, pp. 200-209
-
-
Friedlander, Y.1
Lapidos, T.2
Sinnreich, R.3
Kark, J.D.4
-
129
-
-
84878726099
-
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
-
den Hoed, M. et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat. Genet. 45, 621-631 (2013
-
(2013)
Nat. Genet
, vol.45
, pp. 621-631
-
-
Den Hoed, M.1
-
130
-
-
67349188883
-
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
-
Cho, Y. S. et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41, 527-534 (2009
-
(2009)
Nat. Genet
, vol.41
, pp. 527-534
-
-
Cho, Y.S.1
-
131
-
-
77956512209
-
Genome-wide association analysis identifies multiple loci related to resting heart rate
-
Eijgelsheim, M. et al. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum. Mol. Genet. 19, 3885-3894 (2010
-
(2010)
Hum. Mol. Genet
, vol.19
, pp. 3885-3894
-
-
Eijgelsheim, M.1
-
132
-
-
67650280679
-
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: Meta-analysis of three genome-wide association studies
-
Nolte, I. M. et al. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: Meta-analysis of three genome-wide association studies. PLoS ONE 4, e6138 (2009
-
(2009)
PLoS ONE
, vol.4
-
-
Nolte, I.M.1
-
133
-
-
79952257689
-
Genome-wide association studies of the pr interval in african americans
-
Smith, J. G. et al. Genome-wide association studies of the PR interval in African Americans. PLoS Genet. 7, e1001304 (2011
-
(2011)
PLoS Genet
, vol.7
-
-
Smith, J.G.1
-
134
-
-
77449100755
-
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: The EUROSPAN project
-
Marroni, F. et al. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: The EUROSPAN project. Circ. Cardiovasc. Genet. 2, 322-328 (2009
-
(2009)
Circ. Cardiovasc. Genet
, vol.2
, pp. 322-328
-
-
Maarroni, F.1
-
135
-
-
61849130045
-
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations
-
Kao, W. H. et al. Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation 119, 940-951 (2009
-
(2009)
Circulation
, vol.119
, pp. 940-951
-
-
Kao, W.H.1
-
136
-
-
80052694116
-
Common genetic variants qt interval, and sudden cardiac death in a finnish population-based study
-
Noseworthy, P. A. et al. Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study. Circ. Cardiovasc. Genet. 4, 305-311 (2011
-
(2011)
Circ. Cardiovasc. Genet
, vol.4
, pp. 305-311
-
-
Noseworthy, P.A.1
-
137
-
-
84874263397
-
SNPs identified as modulators of ECG traits in the general population do not markedly affect ECG traits during acute myocardial infarction nor ventricular fibrillation risk in this condition
-
Pazoki, R. et al. SNPs identified as modulators of ECG traits in the general population do not markedly affect ECG traits during acute myocardial infarction nor ventricular fibrillation risk in this condition. PLoS ONE 8, e57216 (2013
-
(2013)
PLoS ONE
, vol.8
-
-
Pazoki, R.1
-
138
-
-
84875931887
-
Genome-and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk
-
Ritchie, M. D. et al. Genome-and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation 127, 1377-1385 (2013
-
(2013)
Circulation
, vol.127
, pp. 1377-1385
-
-
Ritchie, M.D.1
-
139
-
-
0024325322
-
Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction
-
Janse, M. J. & Wit, A. L. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol. Rev. 69, 1049-1169 (1989
-
(1989)
Physiol. Rev
, vol.69
, pp. 1049-1169
-
-
Janse, M.J.1
Wit, A.L.2
-
140
-
-
34248595219
-
Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation
-
Nattel, S., Maguy, A., Le Bouter, S. & Yeh, Y. H. Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation. Physiol. Rev. 87, 425-456 (2007
-
(2007)
Physiol. Rev
, vol.87
, pp. 425-456
-
-
Nattel, S.1
Maguy, A.2
Le Bouter, S.3
Yeh, Y.H.4
-
141
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff, L. A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. USA 106, 9362-9367 (2009
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
-
142
-
-
79957604678
-
Principles for the post-GWAS functional characterisation of cancer risk loci
-
Freedman, M. et al. Principles for the post-GWAS functional characterisation of cancer risk loci. Nat. Genet. 43, 513-518 (2011
-
(2011)
Nat. Genet
, vol.43
, pp. 513-518
-
-
Freedman, M.1
-
143
-
-
84858383447
-
Genetics of human cardiovascular disease
-
Kathiresan, S & Srivastava, D. Genetics of human cardiovascular disease. Cell 148, 1242-1257 (2012
-
(2012)
Cell
, vol.148
, pp. 1242-1257
-
-
Kathiresan, S.1
Srivastava, D.2
-
144
-
-
84865790047
-
An integrated encyclopedia of dna elements in the human genome
-
ENCODE Project Consortium.et al.
-
ENCODE Project Consortium. et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
145
-
-
60149091656
-
ChIP-seq accurately predicts tissue-specific activity of enhancers
-
Visel, A. et al. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457, 854-858 (2009
-
(2009)
Nature
, vol.457
, pp. 854-858
-
-
Visel, A.1
-
146
-
-
84655164920
-
Large-scale discovery of enhancers from human heart tissue
-
May, D. et al. Large-scale discovery of enhancers from human heart tissue. Nat. Genet. 44, 89-93 (2012
-
(2012)
Nat. Genet
, vol.44
, pp. 89-93
-
-
May, D.1
-
147
-
-
79955027617
-
Co occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart
-
He, A., Kong, S. W., Ma, Q. & Pu, W. T. Co occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc. Natl. Acad. Sci. USA 108, 5632-5637 (2011
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 5632-5637
-
-
He, A.1
Kong, S.W.2
Ma, Q.3
Pu, W.T.4
-
148
-
-
84863541919
-
Genetic variation in T box binding element functionally affects SCN5A/SCN10A enhancer
-
van den Boogaard, M. et al. Genetic variation in T box binding element functionally affects SCN5A/SCN10A enhancer. J. Clin. Invest. 122, 2519-2530 (2012
-
(2012)
J. Clin. Invest
, vol.122
, pp. 2519-2530
-
-
Van Den Boogaard, M.1
-
149
-
-
84863543347
-
TBX5 drives Scn5a expression to regulate cardiac conduction system function
-
Arnolds, D. E. et al. TBX5 drives Scn5a expression to regulate cardiac conduction system function. J. Clin. Invest. 122, 2509-2518 (2012
-
(2012)
J. Clin. Invest
, vol.122
, pp. 2509-2518
-
-
Arnolds, D.E.1
-
150
-
-
0030041548
-
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
-
Akopian, A. N., Sivilotti, L. & Wood, J. N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379, 257-262 (1996
-
(1996)
Nature
, vol.379
, pp. 257-262
-
-
Akopian, A.N.1
Sivilotti, L.2
Wood, J.N.3
-
151
-
-
84864262471
-
Functional Nav1.8 channels in intracardiac neurons: The link between SCN10A and cardiac electrophysiology
-
Verkerk, A. O. et al. Functional Nav1.8 channels in intracardiac neurons: The link between SCN10A and cardiac electrophysiology. Circ. Res. 111, 333-343 (2012
-
(2012)
Circ. Res
, vol.111
, pp. 333-343
-
-
Verkerk, A.O.1
-
152
-
-
84864290080
-
Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic
-
Yang, T. et al. Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ. Res. 111, 322-332 (2012
-
(2012)
Circ. Res
, vol.111
, pp. 322-332
-
-
Yang, T.1
-
153
-
-
77951923087
-
Contactin 2 expression in the cardiac Purkinje fiber network
-
Pallante, B. A. et al. Contactin 2 expression in the cardiac Purkinje fiber network. Circ. Arrhythm. Electrophysiol. 3, 186-194 (2010
-
(2010)
Circ. Arrhythm. Electrophysiol
, vol.3
, pp. 186-194
-
-
Pallante, B.A.1
-
154
-
-
79953212557
-
A rare variant in MYH6 is associated with high risk of sick sinus syndrome
-
Holm, H. et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat. Genet. 43, 316-320 (2011
-
(2011)
Nat. Genet
, vol.43
, pp. 316-320
-
-
Holm, H.1
-
155
-
-
84893652737
-
-
Nature Publishing Group
-
Nature Publishing Group. ENCODE [online], http://www.nature.com/encode/ threads (2013
-
(2013)
ENCODE [Online]
-
-
-
156
-
-
84893641736
-
-
1000 Genomes Browser [online]
-
Genomes Project Consortium. 1000 Genomes Browser [online], http://www.ncbi.nlm.nih.gov/variation/tools/1000genomes/ (2013
-
(2013)
Genomes Project Consortium
-
-
-
157
-
-
81355146439
-
Impact of onsite or dispatched automated external defibrillator use on survival after out-of-hospital cardiac arrest
-
Berdowski, J. et al. Impact of onsite or dispatched automated external defibrillator use on survival after out-of-hospital cardiac arrest. Circulation 124, 2225-2232 (2011
-
(2011)
Circulation
, vol.124
, pp. 2225-2232
-
-
Berdowski, J.1
-
158
-
-
11144339384
-
Long-range control of gene expression: Emerging mechanisms and disruption in disease
-
Kleinjan, D. & van Heyningen, V. Long-range control of gene expression: Emerging mechanisms and disruption in disease. Am. J. Hum. Genet. 76, 8-32 (2005
-
(2005)
Am. J. Hum. Genet
, vol.76
, pp. 8-32
-
-
Kleinjan, D.1
Van Heyningen, V.2
-
159
-
-
9044240040
-
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
-
Wang, Q. et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12, 17-23 (1996
-
(1996)
Nat. Genet
, vol.12
, pp. 17-23
-
-
Wang, Q.1
|