Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency

Cardiovascular Research

Volumn 95, Issue 4, 2012, Pages 460-468

  Cerrone, Marina ^a   Noorman, Maartje ^a,b   Lin, Xianming ^a   Chkourko, Halina ^a   Liang, Feng Xia ^a   Van Der Nagel, Roel ^b   Hund, Thomas ^c,d   Birchmeier, Walter ^e   Mohler, Peter ^c,d   Van Veen, Toon A ^b   Van Rijen, Harold V ^b   Delmar, Mario ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c OHIO STATE UNIVERSITY   (United States)

^d THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Arrhythmia (mechanisms); ARVC; Cell communication; Genetic disorders; Ion channels; Nachannel; Right ventricular

Indexed keywords

FLECAINIDE; SODIUM CHANNEL;

ACTION POTENTIAL; ANESTHESIA; ANIMAL CELL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CARDIAC GATED IMAGING; CONTROLLED STUDY; DESMOSOME; ELECTROCARDIOGRAPHY; FATALITY; FEMALE; GENE; HAPLOINSUFFICIENCY; HEART MUSCLE CELL; HEART PERFUSION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE CONDUCTION; HETEROZYGOSITY; HISTOPATHOLOGY; INFORMATION PROCESSING; ISOLATED HEART; KINETICS; MALE; MOUSE; NONHUMAN; PLAKOPHILIN 2 GENE; PRIORITY JOURNAL; SODIUM CURRENT; SODIUM DEFICIENCY; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FLECAINIDE; GENETIC PREDISPOSITION TO DISEASE; HAPLOINSUFFICIENCY; ION CHANNEL GATING; KINETICS; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; PERFUSION; PHENOTYPE; PLAKOPHILINS; SODIUM; SODIUM CHANNELS; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84865221010     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs218     Document Type: Article

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