Polymorphisms in the NOS1AP Gene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome

Journal of the American College of Cardiology

Volumn 55, Issue 24, 2010, Pages 2745-2752

  Tomás, Marta ^a,b   Napolitano, Carlo ^a,c   De Giuli, Luciana ^a   Bloise, Raffaella ^a   Subirana, Isaac ^b,d   Malovini, Alberto ^e,f   Bellazzi, Riccardo ^e   Arking, Dan E ^g   Marban, Eduardo ^h   Chakravarti, Aravinda ^g   Spooner, Peter M ^g   Priori, Silvia G ^a,c,e  

^a IRCCS   (Italy)

^b INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^e UNIVERSITY OF PAVIA   (Italy)

^f IRCCS MULTIMEDICA   (Italy)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

cardiac arrhythmias; genetics; long QT syndrome; risk stratification; single nucleotide polymorphisms

Indexed keywords

ADAPTOR PROTEIN; NITRIC OXIDE 1 ADAPTOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CARDIOVASCULAR RISK; FEMALE; GENE LOCUS; GENETIC MODEL; GENETIC POLYMORPHISM; GENOTYPE; HEART ARRHYTHMIA; HEART REPOLARIZATION; HUMAN; INCIDENCE; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QT INTERVAL; QT PROLONGATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; DNA; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INCIDENCE; LONG QT SYNDROME; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS;

EID: 77953144675     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.12.065     Document Type: Article

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