메뉴 건너뛰기




Volumn 42, Issue 2, 2010, Pages 117-122

Several common variants modulate heart rate, PR interval and QRS duration

Author keywords

[No Author keywords available]

Indexed keywords

ARHGAP24 GENE; ARTICLE; ATRIOVENTRICULAR BLOCK; CAV1 GENE; CHROMOSOME 10Q; CHROMOSOME 6P; CORRELATION ANALYSIS; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART RATE; HUMAN; ICELAND; MAJOR CLINICAL STUDY; MALE; MYH6 GENE; NORWAY; PR INTERVAL; PRIORITY JOURNAL; QRS COMPLEX; SCN10A GENE; TBX5 GENE;

EID: 75749122164     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.511     Document Type: Article
Times cited : (323)

References (56)
  • 1
    • 12344330346 scopus 로고    scopus 로고
    • Elevated heart rate: A major risk factor for cardiovascular disease
    • Palatini, P. & Julius, S. Elevated heart rate: a major risk factor for cardiovascular disease. Clin. Exp. Hypertens. 26, 637-644(2004).
    • (2004) Clin. Exp. Hypertens. , vol.26 , pp. 637-644
    • Palatini, P.1    Julius, S.2
  • 2
    • 75749141005 scopus 로고
    • Samband hjartslattartidni, heilsufarsthatta, reykinga og danarmeina
    • Bjornsson, S. et al. Samband hjartslattartidni, heilsufarsthatta, reykinga og danarmeina. Laeknabladid 79, 21-27(1993).
    • (1993) Laeknabladid , vol.79 , pp. 21-27
    • Bjornsson, S.1
  • 5
    • 67649218781 scopus 로고    scopus 로고
    • Long-term outcomes in individuals with prolonged PR interval or frst-degree atrioventricular block
    • Cheng, S. et al. Long-term outcomes in individuals with prolonged PR interval or frst-degree atrioventricular block. J. Am. Med. Assoc. 301, 2571-2577 (2009).
    • (2009) J. Am. Med. Assoc. , vol.301 , pp. 2571-2577
    • Cheng, S.1
  • 6
    • 0035119723 scopus 로고    scopus 로고
    • Complete bundle branch block as an independent predictor of all-cause mortality: Report of 7,073 patients referred for nuclear exercise testing
    • Hesse, B., Diaz, L.A., Snader, C.E., Blackstone, E.H. & Lauer, M.S. Complete bundle branch block as an independent predictor of all-cause mortality: report of 7,073 patients referred for nuclear exercise testing. Am. J. Med. 110, 253-259 (2001).
    • (2001) Am. J. Med. , vol.110 , pp. 253-259
    • Hesse, B.1    Diaz, L.A.2    Snader, C.E.3    Blackstone, E.H.4    Lauer, M.S.5
  • 7
    • 33745892610 scopus 로고    scopus 로고
    • Prognostic signifcance of quantitative QRS duration
    • Desai, A.D. et al. Prognostic signifcance of quantitative QRS duration. Am. J. Med. 119, 600-606 (2006).
    • (2006) Am. J. Med. , vol.119 , pp. 600-606
    • Desai, A.D.1
  • 8
    • 35748985581 scopus 로고    scopus 로고
    • Genome-wide association study of electrocardiographic and heart rate variability traits: The Framingham Heart Study
    • Newton-Cheh, C. et al. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med. Genet. 8 Suppl 1, S7 (2007).
    • (2007) BMC Med. Genet , vol.8 , Issue.SUPPL. 1
    • Newton-Cheh, C.1
  • 9
    • 0024502214 scopus 로고
    • Genetic factors in the electrocardiogram and heart rate of twins reared apart and together
    • Hanson, B. et al. Genetic factors in the electrocardiogram and heart rate of twins reared apart and together. Am. J. Cardiol. 63, 606-609(1989).
    • (1989) Am. J. Cardiol. , vol.63 , pp. 606-609
    • Hanson, B.1
  • 11
    • 0031894666 scopus 로고    scopus 로고
    • Heritability of ECG measurements in adult male twins
    • Russell, M.W., Law, I., Sholinsky, P. & Fabsitz, R.R. Heritability of ECG measurements in adult male twins. J. Electrocardiol. 30(Suppl), 64-68 (1998).
    • (1998) J. Electrocardiol. , vol.30 , Issue.SUPPL , pp. 64-68
    • Russell, M.W.1    Law, I.2    Sholinsky, P.3    Fabsitz, R.R.4
  • 12
    • 64949123001 scopus 로고    scopus 로고
    • Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population
    • Li, J. et al. Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population. Ann. Noninvasive Electrocardiol. 14, 147-152(2009).
    • (2009) Ann. Noninvasive Electrocardiol. , vol.14 , pp. 147-152
    • Li, J.1
  • 13
    • 58449127797 scopus 로고    scopus 로고
    • Genetic infuences on resting electrocardiographic variables in older women: A twin study
    • Mutikainen, S. et al. Genetic infuences on resting electrocardiographic variables in older women: a twin study. Ann. Noninvasive Electrocardiol. 14, 57-64(2009).
    • (2009) Ann. Noninvasive Electrocardiol. , vol.14 , pp. 57-64
    • Mutikainen, S.1
  • 14
    • 33745237158 scopus 로고    scopus 로고
    • A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
    • Arking, D.E. et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat. Genet. 38, 644-651(2006).
    • (2006) Nat. Genet. , vol.38 , pp. 644-651
    • Arking, D.E.1
  • 15
    • 61849130045 scopus 로고    scopus 로고
    • Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations
    • Kao, W.H. et al. Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation 119, 940-951(2009).
    • (2009) Circulation , vol.119 , pp. 940-951
    • Kao, W.H.1
  • 16
    • 63449136073 scopus 로고    scopus 로고
    • Common variants at ten loci infuence QT interval duration in the QTGEN Study
    • Newton-Cheh, C. et al. Common variants at ten loci infuence QT interval duration in the QTGEN Study. Nat. Genet. 41, 399-406(2009).
    • (2009) Nat. Genet. , vol.41 , pp. 399-406
    • Newton-Cheh, C.1
  • 17
    • 63449109595 scopus 로고    scopus 로고
    • Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    • Pfeufer, A. et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat. Genet. 41, 407-414 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 407-414
    • Pfeufer, A.1
  • 18
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors infuencing eight quantitative traits
    • Cho, Y.S. et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors infuencing eight quantitative traits. Nat. Genet. 41, 527-534 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 527-534
    • Cho, Y.S.1
  • 19
    • 64649093652 scopus 로고    scopus 로고
    • Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae
    • Smith, J.G. et al. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm 6, 634-641(2009).
    • (2009) Heart Rhythm , vol.6 , pp. 634-641
    • Smith, J.G.1
  • 20
    • 1842413728 scopus 로고    scopus 로고
    • Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury T gene family
    • Li, Q.Y. et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury T gene family. Nat. Genet. 15, 21-29(1997).
    • (1997) Nat. Genet. , vol.15 , pp. 21-29
    • Li, Q.Y.1
  • 21
    • 0030636780 scopus 로고    scopus 로고
    • Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome
    • erratum 15, 411
    • Basson, C.T. et al. Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Nat. Genet. 15, 30-35 1997); erratum 15, 411 (1997).
    • (1997) Nat. Genet. , vol.15 , pp. 30-35
    • Basson, C.T.1
  • 22
    • 0028281469 scopus 로고
    • The clinical and genetic spectrum of the Holt-Oram syndrome heart-hand syndrome
    • Basson, C.T. et al. The clinical and genetic spectrum of the Holt-Oram syndrome heart-hand syndrome). N. Engl. J. Med. 330, 885-891(1994).
    • (1994) N. Engl. J. Med. , vol.330 , pp. 885-891
    • Basson, C.T.1
  • 23
    • 4544277159 scopus 로고    scopus 로고
    • The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system
    • Moskowitz, I.P. et al. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131, 4107-4116 (2004).
    • (2004) Development , vol.131 , pp. 4107-4116
    • Moskowitz, I.P.1
  • 24
    • 64649085563 scopus 로고    scopus 로고
    • Physical interaction between TBX5 and MEF2C is required for early heart development
    • Ghosh, T.K. et al. Physical interaction between TBX5 and MEF2C is required for early heart development. Mol. Cell. Biol. 29, 2205-2218(2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2205-2218
    • Ghosh, T.K.1
  • 25
    • 67349208839 scopus 로고    scopus 로고
    • Genome-wide association study of blood pressure and hypertension
    • Levy, D. et al. Genome-wide association study of blood pressure and hypertension. Nat. Genet. 41, 677-687 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 677-687
    • Levy, D.1
  • 26
    • 0031740691 scopus 로고    scopus 로고
    • A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A
    • Rabert, D.K. et al. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain 78, 107-114 (1998).
    • (1998) Pain , vol.78 , pp. 107-114
    • Rabert, D.K.1
  • 27
    • 13344294399 scopus 로고    scopus 로고
    • Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specifc to sensory neurons
    • Sangameswaran, L. et al. Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specifc to sensory neurons. J. Biol. Chem. 271, 5953-5956 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 5953-5956
    • Sangameswaran, L.1
  • 28
    • 67649547603 scopus 로고    scopus 로고
    • Sodium channel mutations and arrhythmias
    • Ruan, Y., Liu, N. & Priori, S.G. Sodium channel mutations and arrhythmias. Nat. Rev. Cardiol. 6, 337-348 (2009).
    • (2009) Nat. Rev. Cardiol. , vol.6 , pp. 337-348
    • Ruan, Y.1    Liu, N.2    Priori, S.G.3
  • 29
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299-1320(2005).
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 30
    • 1442280664 scopus 로고    scopus 로고
    • And characterization of ARHGAP24 and ARHGAP25 genes in silico
    • Katoh, M. & Katoh, M. Identifcation and characterization of ARHGAP24 and ARHGAP25 genes in silico. Int. J. Mol. Med. 14, 333-338 (2004).
    • (2004) Int. J. Mol. Med. , vol.14 , pp. 333-338
    • Katoh, M.1    Identifcation, K.M.2
  • 31
    • 0037213689 scopus 로고    scopus 로고
    • Rho GTPase-activating proteins in cell regulation
    • Moon, S.Y. & Zheng, Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 13, 13-22 (2003).
    • (2003) Trends Cell Biol. , vol.13 , pp. 13-22
    • Moon, S.Y.1    Zheng, Y.2
  • 32
    • 0032471541 scopus 로고    scopus 로고
    • Molecular genetics of the caveolin gene family: Implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy
    • Engelman, J.A. et al. Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am. J. Hum. Genet. 63, 1578-1587 (1998).
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1578-1587
    • Engelman, J.A.1
  • 33
    • 0029125444 scopus 로고
    • The tumor suppression function of p21Waf is contained in its N-terminal half ′half-WAF′
    • Zakut, R. & Givol, D. The tumor suppression function of p21Waf is contained in its N-terminal half ′half-WAF′). Oncogene 11, 393-395 (1995).
    • (1995) Oncogene , vol.11 , pp. 393-395
    • Zakut, R.1    Givol, D.2
  • 34
    • 0023764031 scopus 로고
    • Molecular cloning and characterization of human cardiac alpha-and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium
    • Kurabayashi, M., Tsuchimochi, H., Komuro, I., Takaku, F. & Yazaki, Y. Molecular cloning and characterization of human cardiac alpha-and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium. J. Clin. Invest. 82, 524-531 (1988).
    • (1988) J. Clin. Invest. , vol.82 , pp. 524-531
    • Kurabayashi, M.1    Tsuchimochi, H.2    Komuro, I.3    Takaku, F.4    Yazaki, Y.5
  • 35
    • 0021207310 scopus 로고
    • Cardiac alpha-and beta-myosin heavy chain genes are organized in tandem
    • Mahdavi, V., Chambers, A.P. & Nadal-Ginard, B. Cardiac alpha-and beta-myosin heavy chain genes are organized in tandem. Proc. Natl. Acad. Sci. USA 81, 2626-2630 (1984).
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 2626-2630
    • Mahdavi, V.1    Chambers, A.P.2    Nadal-Ginard, B.3
  • 36
    • 0032052025 scopus 로고    scopus 로고
    • Patterns of expression in the developing myocardium: Towards a morphologically integrated transcriptional model
    • Franco, D., Lamers, W.H. & Moorman, A.F. Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model. Cardiovasc. Res. 38, 25-53 (1998).
    • (1998) Cardiovasc. Res. , vol.38 , pp. 25-53
    • Franco, D.1    Lamers, W.H.2    Moorman, A.F.3
  • 37
    • 0021153417 scopus 로고
    • Expression of the cardiac ventricular alpha-and beta-myosin heavy chain genes is developmentally and hormonally regulated
    • Lompré, A.M., Nadal-Ginard, B. & Mahdavi, V. Expression of the cardiac ventricular alpha-and beta-myosin heavy chain genes is developmentally and hormonally regulated. J. Biol. Chem. 259, 6437-6446 (1984).
    • (1984) J. Biol. Chem. , vol.259 , pp. 6437-6446
    • Lompré, A.M.1    Nadal-Ginard, B.2    Mahdavi, V.3
  • 38
    • 0037076795 scopus 로고    scopus 로고
    • Small amounts of alpha-myosin heavy chain isoform expression signifcantly increase power output of rat cardiac myocyte fragments
    • Herron, T.J. & McDonald, K.S. Small amounts of alpha-myosin heavy chain isoform expression signifcantly increase power output of rat cardiac myocyte fragments. Circ. Res. 90, 1150-1152 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 1150-1152
    • Herron, T.J.1    McDonald, K.S.2
  • 39
    • 21844463045 scopus 로고    scopus 로고
    • Alpha-myosin heavy chain: A sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy
    • Carniel, E. et al. Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation 112, 54-59 (2005).
    • (2005) Circulation , vol.112 , pp. 54-59
    • Carniel, E.1
  • 40
    • 20144387341 scopus 로고    scopus 로고
    • Mutation in myosin heavy chain 6 causes atrial septal defect
    • Ching, Y.H. et al. Mutation in myosin heavy chain 6 causes atrial septal defect. Nat. Genet. 37, 423-428 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 423-428
    • Ching, Y.H.1
  • 41
    • 41349095280 scopus 로고    scopus 로고
    • Genetics of gene expression and its effect on disease
    • Emilsson, V. et al. Genetics of gene expression and its effect on disease. Nature 452, 423-428 (2008).
    • (2008) Nature , vol.452 , pp. 423-428
    • Emilsson, V.1
  • 42
    • 1642370591 scopus 로고    scopus 로고
    • Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart
    • Maier, S.K. et al. Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation 109, 1421-1427 (2004).
    • (2004) Circulation , vol.109 , pp. 1421-1427
    • Maier, S.K.1
  • 43
    • 84942560911 scopus 로고
    • Familial atrial tachyarrhythmia with short PR interval
    • Brodsky, M., Wu, D., Denes, P. & Rosen, K.M. Familial atrial tachyarrhythmia with short PR interval. Arch. Intern. Med. 137, 165-169 (1977).
    • (1977) Arch. Intern. Med. , vol.137 , pp. 165-169
    • Brodsky, M.1    Wu, D.2    Denes, P.3    Rosen, K.M.4
  • 44
    • 0002719789 scopus 로고
    • The syndrome of short P-R interval, normal QRS complex and paroxysmal rapid heart action
    • Lown, B., Ganong, W.F. & Levine, S.A. The syndrome of short P-R interval, normal QRS complex and paroxysmal rapid heart action. Circulation 5, 693-706 (1952).
    • (1952) Circulation , vol.5 , pp. 693-706
    • Lown, B.1    Ganong, W.F.2    Levine, S.A.3
  • 45
    • 44949230354 scopus 로고    scopus 로고
    • A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation
    • Postma, A.V. et al. A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fbrillation. Circ. Res. 102, 1433-1442 (2008).
    • (2008) Circ. Res. , vol.102 , pp. 1433-1442
    • Postma, A.V.1
  • 46
    • 41649103052 scopus 로고    scopus 로고
    • A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    • Thorgeirsson, T.E. et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452, 638-642 (2008).
    • (2008) Nature , vol.452 , pp. 638-642
    • Thorgeirsson, T.E.1
  • 47
    • 61349089164 scopus 로고    scopus 로고
    • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    • Gudbjartsson, D.F. et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat. Genet. 41, 342-347 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 342-347
    • Gudbjartsson, D.F.1
  • 48
    • 38649125868 scopus 로고    scopus 로고
    • Newly identifed loci that infuence lipid concentrations and risk of coronary artery disease
    • Willer, C.J. et al. Newly identifed loci that infuence lipid concentrations and risk of coronary artery disease. Nat. Genet. 40, 161-169 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 161-169
    • Willer, C.J.1
  • 49
    • 58449131891 scopus 로고    scopus 로고
    • Philips QT interval measurement algorithms for diagnostic ambulatory and patient monitoring ECG applications
    • Zhou, S.H., Helfenbein, E.D., Lindauer, J.M., Gregg, R.E. & Feild, D.Q. Philips QT interval measurement algorithms for diagnostic, ambulatory, and patient monitoring ECG applications. Ann. Noninvasive Electrocardiol. 14 Suppl 1, S3-S8 (2009).
    • (2009) Ann. Noninvasive Electrocardiol , vol.14 , Issue.SUPPL. 1
    • Zhou, S.H.1    Helfenbein, E.D.2    Lindauer, J.M.3    Gregg, R.E.4    Feild, D.Q.5
  • 51
    • 68149137739 scopus 로고    scopus 로고
    • A sequence variant in ZFHX3 on 16q22 associates with atrial fbrillation and ischemic stroke
    • Gudbjartsson, D.F. et al. A sequence variant in ZFHX3 on 16q22 associates with atrial fbrillation and ischemic stroke. Nat. Genet. 41, 876-878 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 876-878
    • Gudbjartsson, D.F.1
  • 52
    • 33750985094 scopus 로고    scopus 로고
    • A novel endonuclease IV post-PCR genotyping system
    • Kutyavin, I.V. et al. A novel endonuclease IV post-PCR genotyping system. Nucleic Acids Res. 34, e128 (2006).
    • (2006) Nucleic Acids Res. , vol.34
    • Kutyavin, I.V.1
  • 53
    • 16544380910 scopus 로고    scopus 로고
    • Genomic control to the extreme
    • author reply 1131
    • Devlin, B., Bacanu, S.A. & Roeder, K. Genomic control to the extreme. Nat. Genet. 36, 1129-1130 author reply 1131 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 1129-1130
    • Devlin, B.1    Bacanu, S.A.2    Roeder, K.3
  • 54
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • DOI 10.1038/ng2088, PII NG2088
    • Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906-913 (2007). (Pubitemid 47014502)
    • (2007) Nature Genetics , vol.39 , Issue.7 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3    McVean, G.4    Donnelly, P.5
  • 55
    • 0141819194 scopus 로고    scopus 로고
    • The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
    • Gretarsdottir, S. et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat. Genet. 35, 131-138 (2003).
    • (2003) Nat. Genet. , vol.35 , pp. 131-138
    • Gretarsdottir, S.1
  • 56
    • 13944278863 scopus 로고    scopus 로고
    • A common inversion under selection in Europeans
    • Stefansson, H. et al. A common inversion under selection in Europeans. Nat. Genet. 37, 129-137 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 129-137
    • Stefansson, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.