Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Nature Genetics

Volumn 45, Issue 9, 2013, Pages 1044-1049

  Bezzina, Connie R ^a   Barc, Julien ^a,b   Mizusawa, Yuka ^a   Remme, Carol Ann ^a   Gourraud, Jean Baptiste ^c,d,e,f   Simonet, Floriane ^c,d,e   Verkerk, Arie O ^a   Schwartz, Peter J ^g,h,i,j,k,l   Crotti, Lia ^g,h,m   Dagradi, Federica ^g,h   Guicheney, Pascale ^n,o   Fressart, Véronique ^n,o,p   Leenhardt, Antoine ^n,q,r   Antzelevitch, Charles ^s   Bartkowiak, Susan ^s   Schulze Bahr, Eric ^t   Zumhagen, Sven ^t   Behr, Elijah R ^u   Bastiaenen, Rachel ^u   Tfelt Hansen, Jacob ^v,w   Olesen, Morten Salling ^v,w   Kääb, Stefan ^x,y   Beckmann, Britt M ^x   Weeke, Peter ^z   Watanabe, Hiroshi ^aa   Endo, Naoto ^aa   Minamino, Tohru ^aa   Horie, Minoru ^ab   Ohno, Seiko ^ab   Hasegawa, Kanae ^ab   Makita, Naomasa ^ac   Nogami, Akihiko ^ad   Shimizu, Wataru ^ae,af   Aiba, Takeshi ^af   Froguel, Philippe ^ag,ah,ai   Balkau, Beverley ^aj   Lantieri, Olivier ^ak   Torchio, Margherita ^g,h   Wiese, Cornelia ^al   Weber, David ^al   Wolswinkel, Rianne ^a   Coronel, Ruben ^a   Boukens, Bas J ^a   Bézieau, Stéphane ^f   Charpentier, Eric ^c,d,e   Chatel, Stéphanie ^c,d,f   Despres, Aurore ^c,d,f   Gros, Françoise ^c,d,e   Kyndt, Florence ^c,d,e,f   Lecointe, Simon ^c,d,e,f   Lindenbaum, Pierre ^c,d,e,f   Portero, Vincent ^c,d,e   Violleau, Jade ^c,d,e,f   Gessler, Manfred ^al   Tan, Hanno L ^a   Roden, Dan M ^z   Christoffels, Vincent M ^a   Le Marec, Hervé ^c,d,e,f   Wilde, Arthur A ^a   Probst, Vincent ^c,d,e,f   Schott, Jean Jacques ^c,d,e,f   Dina, Christian ^c,d,e,f   Redon, Richard ^c,d,e,f   more..

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c L INSTITUT DU THORAX   (France)

^d CNRS   (France)

^e UNIVERSITÉ DE NANTES   (France)

^f NANTES UNIVERSITY HOSPITAL   (France)

^g UNIVERSITY OF PAVIA   (Italy)

^h ISTITUTO AUXOLOGICO ITALIANO   (Italy)

ⁱ Hatter Institute for Cardiovascular Research in Africa   (South Africa)

^j UNIVERSITY OF CAPE TOWN   (South Africa)

^k STELLENBOSCH UNIVERSITY   (South Africa)

^l KING SAUD UNIVERSITY   (Saudi Arabia)

^m INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁿ INSERM   (France)

^o SORBONNE UNIVERSITÉ   (France)

^p PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^q BICHAT HOSPITAL   (France)

^r UNIVERSITÉ PARIS DESCARTES   (France)

^s MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^t UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^u ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^v UNIVERSITY OF COPENHAGEN   (Denmark)

^w Rigshospitalet   (Denmark)

^x LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^y DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^z VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aa NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^ab SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^ac NAGASAKI UNIVERSITY   (Japan)

^ad YOKOHAMA ROSAI HOSPITAL   (Japan)

^ae NIPPON MEDICAL SCHOOL   (Japan)

^af NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^ag INSTITUT PASTEUR DE LILLE   (France)

^ah UNIV LILLE   (France)

^ai HAMMERSMITH HOSPITAL   (United Kingdom)

^aj CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^ak Institut Inter Regional Pour la Santé IRSA   (France)

^al UNIVERSITY OF WÜRZBURG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; HEY2 PROTEIN; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.8; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HEY2 PROTEIN, HUMAN; REPRESSOR PROTEIN; SCN10A PROTEIN, HUMAN; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL;

ARTICLE; BRUGADA SYNDROME; CONTROLLED STUDY; DISEASE PREDISPOSITION; ELECTRIC ACTIVITY; GENE; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART CONDUCTION; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; SUDDEN CARDIAC DEATH; ALLELE; ANIMAL; CASE CONTROL STUDY; CHROMOSOME 3; CHROMOSOME 6; COMPLICATION; DEATH, SUDDEN, CARDIAC; FEMALE; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRUGADA SYNDROME; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 6; DEATH, SUDDEN, CARDIAC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MICE; MICE, KNOCKOUT; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRESSOR PROTEINS; SODIUM CHANNELS;

EID: 84883461171     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2712     Document Type: Article

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