Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1

Circulation Research

Volumn 110, Issue 2, 2012, Pages 211-219

  Heijman, Jordi ^a   Spätjens, Roel L H M G ^a   Seyen, Sandrine R M ^a   Lentink, Viola ^a   Kuijpers, Helma J H ^b,c   Boulet, Inge R ^a   De Windt, Leon J ^a   David, Miren ^a   Volders, Paul G A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ion channels; long QT syndrome; potassium; torsade de pointes

Indexed keywords

CYCLIC AMP; POTASSIUM CHANNEL KCNQ1;

ALPHA ADRENERGIC STIMULATION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC RISK; HEART REPOLARIZATION; HETEROZYGOTE; IMMUNOPRECIPITATION; LONG QT SYNDROME; LONG QT SYNDROME TYPE 1; MUTANT; NONHUMAN; PHENOTYPE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RISK ASSESSMENT; UPREGULATION; WESTERN BLOTTING; WILD TYPE;

ADRENERGIC BETA-AGONISTS; ALANINE; ANIMALS; ASPARTIC ACID; BLOTTING, WESTERN; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; CYCLIC AMP; DOGS; GENES, DOMINANT; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; IMMUNOPRECIPITATION; KCNQ1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MODELS, CARDIOVASCULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYOCYTES, CARDIAC; PHENOTYPE; PHOSPHORYLATION; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN PROCESSING, POST-TRANSLATIONAL; ROMANO-WARD SYNDROME; TIME FACTORS; TRANSFECTION;

EID: 84856058439     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.249482     Document Type: Article

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