Contactin-2 expression in the cardiac Purkinje fiber network

Circulation: Arrhythmia and Electrophysiology

Volumn 3, Issue 2, 2010, Pages 186-194

  Pallante, Benedetta A ^a   Giovannone, Steven ^a   Fang Yu, Liu ^a   Zhang, Jie ^a   Liu, Nian ^a   Kang, Guoxin ^a   Dun, Wen ^b   Boyden, Penelope A ^b   Fishman, Glenn I ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cell adhesion molecules; Electrophysiology; Genetics; Purkinje fiber

Indexed keywords

BETA GALACTOSIDASE; CALCIUM; CELL ADHESION MOLECULE; CONNEXIN 40; CONTACTIN; CONTACTIN 2; ENHANCED GREEN FLUORESCENT PROTEIN; GAP JUNCTION PROTEIN; ION CHANNEL; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GREEN FLUORESCENT PROTEIN; NERVE CELL ADHESION MOLECULE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE POTENTIAL; HEART VENTRICLE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATCH CLAMP; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PURKINJE CELL; PURKINJE FIBER; REPORTER GENE; TRANSGENIC MOUSE; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; CYTOLOGY; DOG; GENETICS; LACTOSE OPERON; METABOLISM; PHYSIOLOGY; SARCOLEMMA;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES, NEURONAL; DOGS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; LAC OPERON; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PURKINJE FIBERS; SARCOLEMMA;

EID: 77951923087     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.109.928820     Document Type: Article

References (48)

1. Jay V. The extraordinary career of Dr Purkinje. Arch Pathol Lab Med. 2000; 124: 662-663.
2. Suma K. Sunao Tawara: a father of modern cardiology. Pacing Clin Electrophysiol. 2001; 24: 88-96.
3. Scheinman MM. Role of the His-Purkinje system in the genesis of cardiac arrhythmia. Heart Rhythm. 2009; 6: 1050-1058.
4. Bogun F, Good E, Reich S, Elmouchi D, Igic P, Tschopp D, Dey S, Wimmer A, Jongnarangsin K, Oral H, Chugh A, Pelosi F, Morady F. Role of Purkinje fibers in post-infarction ventricular tachycardia. J Am Coll Cardiol. 2006; 48: 2500-2507.
5. Hayashi M, Kobayashi Y, Iwasaki YK, Morita N, Miyauchi Y, Kato T, Takano T. Novel mechanism of postinfarction ventricular tachycardia originating in surviving left posterior Purkinje fibers. Heart Rhythm. 2006; 3: 908-918.
6. Morishima I, Nogami A, Tsuboi H, Sone T. Verapamil-sensitive left anterior fascicular ventricular tachycardia associated with a healed myocardial infarction: changes in the delayed Purkinje potential during sinus rhythm. J Interv Card Electrophysiol. 2008; 22: 233-237.
7. Sinha AM, Schmidt M, Marschang H, Gutleben K, Ritscher G, Brachmann J, Marrouche NF. Role of left ventricular scar and Purkinje-like potentials during mapping and ablation of ventricular fibrillation in dilated cardiomyopathy. Pacing Clin Electrophysiol. 2009; 32: 286-290.
8. Haissaguerre M, Shoda M, Jais P, Nogami A, Shah DC, Kautzner J, Arentz T, Kalushe D, Lamaison D, Griffith M, Cruz F, de Paola A, Gaita F, Hocini M, Garrigue S, Macle L, Weerasooriya R, Clementy J. Mapping and ablation of idiopathic ventricular fibrillation. Circulation. 2002; 106: 962-967.
9. Cerrone M, Noujaim SF, Tolkacheva EG, Talkachou A, O'Connell R, Berenfeld O, Anumonwo J, Pandit SV, Vikstrom K, Napolitano C, Priori SG, Jalife J. Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2007; 101: 1039-1048. (Pubitemid 350084981)
10. Haissaguerre M, Extramiana F, Hocini M, Cauchemez B, Jais P, Cabrera JA, Farre J, Leenhardt A, Sanders P, Scavee C, Hsu LF, Weerasooriya R, Shah DC, Frank R, Maury P, Delay M, Garrigue S, Clementy J. Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes. Circulation. 2003; 108: 925-928.
11. Li ZY, Wang YH, Maldonado C, Kupersmith J. Role of junctional zone cells between Purkinje fibres and ventricular muscle in arrhythmogenesis. Cardiovasc Res. 1994; 28: 1277-1284.
12. Hatcher CJ, Basson CT. Specification of the cardiac conduction system by transcription factors. Circ Res. 2009; 105: 620-630.
13. Myers DC, Fishman GI. Molecular and functional maturation of the murine cardiac conduction system. Trends Cardiovasc Med. 2003; 13: 289-295.
14. Zhang S-S, Bruneau BG. Transcriptional control of the cardiac conduction system. Advances in Developmental Biology. Vol 18. Amsterdam, Elsevier B. V.; 2008: 219-258.
15. Nguyen-Tran VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 2000; 102: 671-682.
16. Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res. 1999; 84: 146-152.
17. Logan C, Khoo WK, Cado D, Joyner AL. Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts. Development. 1993; 117: 905-916.
18. Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI. Complex genomic rearrangement in CCS-LacZ transgenic mice. Genesis. 2007; 45: 76-82.
19. Rentschler S, Vaidya DM, Tamaddon H, Degenhardt K, Sassoon D, Morley GE, Jalife J, Fishman GI. Visualization and functional characterization of the developing murine cardiac conduction system. Development. 2001; 128: 1785-1792. (Pubitemid 32514858)
20. Myers DC, Fishman GI. Toward an understanding of the genetics of murine cardiac pacemaking and conduction system development. Anat Rec A Discov Mol Cell Evol Biol. 2004; 280: 1018-1021.
21. Coppen SR, Kaba RA, Halliday D, Dupont E, Skepper JN, Elneil S, Severs NJ. Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol Cell Biochem. 2003; 242: 121-127.
22. Miquerol L, Meysen S, Mangoni M, Bois P, van Rijen HV, Abran P, Jongsma H, Nargeot J, Gros D. Architectural and functional asymmetry of the His-Purkinje system of the murine heart. Cardiovasc Res. 2004; 63: 77-86.
23. Gu H, Smith FC, Taffet SM, Delmar M. High incidence of cardiac malformations in connexin40-deficient mice. CircRes. 2003; 93: 201-206.
24. Kirchhoff S, Nelles E, Hagendorff A, Kruger O, Traub O, Willecke K. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol. 1998; 8: 299-302.
25. Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, Eavey RD, Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG, Seidman CE. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet. 2009; 41: 931-935.
26. Ismat FA, Zhang M, Kook H, Huang B, Zhou R, Ferrari VA, Epstein JA, Patel VV. Homeobox protein Hop functions in the adult cardiac conduction system. Circ Res. 2005; 96: 898-903.
27. Poliak S, Salomon D, Elhanany H, Sabanay H, Kiernan B, Pevny L, Stewart CL, Xu X, Chiu SY, Shrager P, Furley AJ, Peles E. Juxtaparanodal clustering of Shaker-like K + channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol. 2003; 162: 1149-1160.
28. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods. 2001; 25: 402-408.
29. Hirose M, Stuyvers BD, Dun W, Ter Keurs HE, Boyden PA. Function of Ca release channels in Purkinje cells that survive in the infarcted canine heart: a mechanism for triggered Purkinje ectopy. Circ Arrhythm Electrophysiol. 2008; 1: 387-395.
30. Boyden PA, Albala A, Dresdner KP Jr. Electrophysiology and ultrastructure of canine subendocardial Purkinje cells isolated from control and 24-hour infarcted hearts. Circ Res. 1989; 65: 955-970.
31. Liu N, Colombi B, Memmi M, Zissimopoulos S, Rizzi N, Negri S, Imbriani M, Napolitano C, Lai FA, Priori SG. Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res. 2006; 99: 292-298.
32. Chambers JC, Zhao J, Terracciano CM, Bezzina CR, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi JS, Kooner MK, Deng G, Siedlecka U, Parasramka S, El-Hamamsy I, Wass MN, Dekker LR, de Jong JS, Sternberg MJ, McKenna W, Severs NJ, de Silva R, Wilde AA, Anand P, Yacoub M, Scott J, Elliott P, Wood JN, Kooner JS. Genetic variation in SCN10A influences cardiac conduction. Nat Genet. 2010; 42: 149-152.
33. Oosthoek PW, Viragh S, Mayen AE, van Kempen MJ, Lamers WH, Moorman AF. Immunohistochemical delineation of the conduction system, I: the sinoatrial node. Circ Res. 1993; 73: 473-481.
34. Walsh FS, Doherty P. Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. Annu Rev Cell Dev Biol. 1997; 13: 425-456.
35. Gong S, Zheng C, Doughty ML, Losos K, Didkovsky N, Schambra UB, Nowak NJ, Joyner A, Leblanc G, Hatten ME, Heintz N. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature. 2003; 425: 917-925.
36. Haissaguerre M, Shah DC, Jais P, Shoda M, Kautzner J, Arentz T, Kalushe D, Kadish A, Griffith M, Gaita F, Yamane T, Garrigue S, Hocini M, Clementy J. Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation. Lancet. 2002; 359: 677-678.
37. Wit AL, Bigger JT Jr. Possible electrophysiological mechanisms for lethal arrhythmias accompanying myocardial ischemia and infarction. Circulation. 1975; 52: III-96-III-115.
38. Deo M, Boyle P, Plank G, Vigmond E. Role of Purkinje system in cardiac arrhythmias. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008: 149-152.
39. Vigmond E, Vadakkumpadan F, Gurev V, Arevalo H, Deo M, Plank G, Trayanova N. Towards predictive modelling of the electrophysiology of the heart. Exp Physiol. 2009; 94: 563-577.
40. Cohen NR, Taylor JS, Scott LB, Guillery RW, Soriano P, Furley AJ. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Curr Biol. 1998; 8: 26-33.
41. Rasband MN, Shrager P. Ion channel sequestration in central nervous system axons. J Physiol. 2000; 525: 63-73.
42. Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi F, Watanabe K, Soliven B, Girault JA, Karagogeos D. Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol. 2003; 162: 1161-1172.
43. Malhotra JD, Tsiotra P, Karagogeos D, Hortsch M. Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion. J Biol Chem. 1998; 273: 33354-33359.
44. Bhat MA. Molecular organization of axo-glial junctions. Curr Opin Neurobiol. 2003; 13: 552-559.
45. Hashemi SM, Hund TJ, Mohler PJ. Cardiac ankyrins in health and disease. J Mol Cell Cardiol. 2009; 47: 203-209.
46. Mohler PJ, Rivolta I, Napolitano C, LeMaillet G, Lambert S, Priori SG, Bennett V. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci USA. 2004; 10: 17533-17538.
47. Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci USA. 2004; 101: 9137-9142.
48. Dun W, Robinson R, Lowe J, Mohler P, Boyden P. Ankyrin-G participates in the remodeling of INa in myocytes of the EBZ of the infarcted heart. Biophys J. 2008; 94: 1.