Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Circulation

Volumn 125, Issue 16, 2012, Pages 1988-1996

  Barsheshet, Alon ^a   Goldenberg, Ilan ^a   O Uchi, Jin ^b   Moss, Arthur J ^a   Jons, Christian ^d   Shimizu, Wataru ^e   Wilde, Arthur A ^e   McNitt, Scott ^a   Peterson, Derick R ^a   Zareba, Wojciech ^a   Robinson, Jennifer L ^a   Ackerman, Michael J ^f   Cypress, Michael ^a   Gray, Daniel A ^a   Hofman, Nynke ^e   Kanters, Jorgen K ^c   Kaufman, Elizabeth S ^g   Platonov, Pyotr G ^h   Qi, Ming ^b   Towbin, Jeffrey A ⁱ   Vincent, G Michael ^j   Lopes, Coeli M ^b   more..

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

^f MAYO CLINIC   (United States)

^g CASE WESTERN RESERVE UNIVERSITY   (United States)

^h LUND UNIVERSITY   (Sweden)

ⁱ CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^j UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

more..

Author keywords

adrenergic beta antagonists; ion channels; long QT syndrome; mutation

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; POTASSIUM CHANNEL KCNQ1;

ADOLESCENT; ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; ARTIFICIAL HEART PACEMAKER; BETA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC STIMULATION; CARBOXY TERMINAL SEQUENCE; CARDIOVASCULAR RISK; CHILD; CYTOPLASM; DEFIBRILLATOR; FEMALE; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENETIC RISK; HEART ARREST; HEART DISEASE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; QT PROLONGATION; SCHOOL CHILD; SUDDEN DEATH; SYMPATHECTOMY; TREATMENT RESPONSE;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ADULT; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEART ARREST; HUMANS; KCNQ1 POTASSIUM CHANNEL; MALE; MUTATION; RISK; ROMANO-WARD SYNDROME; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84860210760     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.048041     Document Type: Article

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