Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells

Cell Biochemistry and Biophysics

Volumn 60, Issue 3, 2011, Pages 311-322

  Chen, Min Bin ^a   Wu, Xiao Yang ^a   Gu, Jin Hua ^a   Guo, Qing Tao ^b   Shen, Wen Xiang ^a   Lu, Pei Hua ^b  

^a KUNSHAN FIRST PEOPLE S HOSPITAL AFFILIATED TO JIANGSU UNIVERSITY   (China)

^b WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Doxorubicin; JNK; mTORC1; Myocardial toxicity; p53

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MTOR PROTEIN, RAT; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STK11 PROTEIN, RAT; STRESS ACTIVATED PROTEIN KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HEART MUSCLE; HEART MUSCLE CELL; METABOLISM; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE; DOXORUBICIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; MYOCYTES, CARDIAC; PROTEIN-SERINE-THREONINE KINASES; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 79958244812     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-011-9153-0     Document Type: Article

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