Protective effect of ginsenoside Rg1 on glutamate-induced lung injury

Acta Pharmacologica Sinica

Volumn 28, Issue 3, 2007, Pages 392-397

  Shen, Li ^a   Han, Jian Zhong ^a   Li, Chen ^a   Yue, Shao Jie ^a   Liu, Yong ^a   Qin, Xiao Qun ^a   Liu, Hui Jun ^a   Luo, Zi Qiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Acute lung injury nitrogen monoxide; Ginsenoside Rg1; Glutamate; Reactive oxygen species

Indexed keywords

CATALASE; GINSENOSIDE RG 1; GLUTAMIC ACID; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREATHING RATE; CONTROLLED STUDY; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG MECHANISM; ENZYME ACTIVITY; HEART RATE; IN VIVO STUDY; LUNG HOMOGENATE; LUNG INJURY; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; PROPHYLAXIS; TREATMENT DURATION;

ANIMALS; ANTIOXIDANTS; BODY WEIGHT; GINSENOSIDES; GLUTAMIC ACID; HEART RATE; LUNG DISEASES; MALE; MICE; ORGAN SIZE; PROTECTIVE AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; RESPIRATION;

EID: 33847184259     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00511.x     Document Type: Article

References (28)

1. Avignone E, Frenguelli BG, Irving AJ. Differential responses to NMDA receptor activation in rat hippocampal interneurons and pyramidal cells may under lie enhanced pyramidal cell vulnerability. Eur J Neurosci 2005; 22: 3077-90.
2. Said SI, Berisha HI, Pakbaz H. Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly (ADP-ribose) polymerase. Proc Natl Acad Sci USA 1996; 93: 4688-92.
3. Radad K, Gille G, Moldzio R, Saito H, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res. 2004; 1021: 41-53.
4. Liu M, Zhang JT. Protective effects of ginsenoside Rb1 and Rg1 on cultured hippocampal neurons. Yao Xue Xue Bao 1995; 30: 674-8. Chinese.
5. Liao B, Newmark H, Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol 2002; 173: 224-34.
6. Peterson BT, Brooks JA, Zack AG. Use of microwave oven for determination of postmortem water volume of lungs. J Appl Physiol 1982; 52: 1661-3.
7. Hartree EF. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem 1972; 48: 422-7.
8. Esper AM, Martin GS. Evolution of treatments for patients with acute lung injury. Expert Opin Investig Drugs 2005; 14: 633-45.
9. Collard CD, Park KA, Montalto MC, Alapati S, Buras JA, Stahl GL, et al. Neutrophil-derived Glutamate Regulates Vascular Endothelial Barrier Function. J Biol Chem 2002; 277: 14801-11.
10. Jiang ZG, Piggee C, Heyes MP, Murphy C, Quearry B, Bauer M, et al. Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages. J Neuroimmunol 2001; 117: 97-107.
11. Ardawi MS. Glutamine and alanine metabolism in lungs of septic rats. Clin Sci (Lond) 1991; 81: 603-9.
12. Danilczuk Z, Ossowska G, Lupina T, Cieslik K, Zebrowska-Lupina I. Effect of NMDA receptor antagonists on behavioral impairment induced by chronic t reatment with dexamethasone. Pharmacol Rep 2005; 57: 47-54.
13. Ro JY, Kim KH. The effects of single component of ginsenosides on the mechanism of mediator release in the allergic hypersensitivity. Korean J Pharmacol 1994; 30: 243-54
14. Luo ZQ, Feng DD, Yue SJ. Effect of shenfu injection on the synthesis of pulmonary surfactant in cultured lung explants. Bull Hu-nan Med Univ 2003; 28: 137-40. Chinese.
15. Dutrait N, Culcasi M, Cazevieille C, Pietri S, Tordo P, Bonne C, et al. Calcium-dependent free radical generation in cultured retinal neurons injured by kainate. Neurosci Lett 1995; 198: 13-6.
16. Maia L, Vala A, Mira L. NADH oxidase activity of rat liver xanthine dehydrogenase and xanthine oxidase-contribution for damage mechanisms. Free Radic Res 2005; 39: 979-86.
17. Georgieva NV, Koinarski V, Gadjeva V. Antioxidant status during the course of Eimeria tenella infection in broiler chickens. Vet J 2005; Epub ahead of print
18. +-ATPase. Am J Respir Cell Mol Biol 2005; 33: 343-54.
19. Deng HL, Zhang JT. Anti-lipid peroxilative effect of ginsenoside Rb1 and Rg1. Chin Med J (Engl) 1991; 104: 395-8.
20. Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM. Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress. Acta Pharmacol Sin 2005; 26: 56-62.
21. 3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1. Pharmacol Res 2001; 43: 473-9.
22. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 1993; 13: 2651-61.
23. Beckman JS, WH Koppenol. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996; 271: C1424-37.
24. Wizemann TM, CR Gardner JD. Laskin SS, Quinones SK, Durham et al. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. J Leukoc Biol 1994; 56: 759-68.
25. Kaminska B, Gaweda-Walerych K, Zawadzka M. Molecular mechanisms of neuroprotective action of immunosuppressants - facts and hypotheses. J Cell Mol Med 2004; 8: 45-58.
26. Glezer I, Munhoz CD, Kawamoto EM, Marcourakis T, Avellar MC, Scavone C. MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS. Neuropharmacology 2003; 45: 1120-9.
27. Deckel AW. Nitric oxide and nitric oxide synthase in Huntington's disease. J Neurosci Res 2001; 64: 99-107.
28. Fagan KA, Tyler RC, Sato k, Fouty BW, Morris KG Jr, Huang PL, et al. Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 1999; 277: L472-8.