Involvement of IGF-I receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 against Aβ25-35-induced toxicity in PC12 cells

Neurochemistry International

Volumn 62, Issue 8, 2013, Pages 1065-1071

  Chen, Wen Fang ^a   Zhou, Li Ping ^a   Chen, Lei ^a   Wu, Lin ^a   Gao, Quan Gui ^a,b   Wong, Man Sau ^b  

^a QINGDAO UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Amyloid peptide; Estrogen receptor; Ginsenoside Rg1; Insulin like growth factor I receptor; PC12 cells

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; GINSENOSIDE RG 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; SOMATOMEDIN C RECEPTOR; TRIMETREXATE;

ARTICLE; BIOLOGICAL ACTIVITY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; DOSE RESPONSE; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; HIPPOCAMPUS; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NEUROTOXICITY; PC12 CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

AMYLOID BETA-PEPTIDES; ANIMALS; CELL DEATH; GINSENOSIDES; PC12 CELLS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTOR, IGF TYPE 1; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84877090504     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.03.018     Document Type: Article

References (29)

1. G.P. Cardona-Gomez, P. Mendez, L.L. DonCarlos, I. Azcoitia, and L.M. Garcia-Segura Interactions of estrogen and insulin-like growth factor-I in the brain: molecular mechanisms and functional implications J. Steroid Biochem. Mol. Biol. 83 2003 211 217
2. J.C. Carroll, and E.R. Rosario The potential use of hormone-based therapeutics for the treatment of Alzheimer's disease Curr. Alzheimer Res. 9 2012 18 34
3. R.Y. Chan, W.F. Chen, A. Dong, D. Guo, and M.S. Wong Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng J. Clin. Endocrinol. Metab. 87 2002 3691 3695
4. W.F. Chen, W.S. Lau, P.Y. Cheung, D.A. Guo, and M.S. Wong Activation of insulin-like growth factor I receptor-mediated pathway by ginsenoside Rg1 Br. J. Pharmacol. 147 2006 542 551
5. M.M. Chitnis, J.S. Yuen, A.S. Protheroe, M. Pollak, and V.M. Macaulay The type 1 insulin-like growth factor receptor pathway Clin. Cancer Res. 14 2008 6364 6370
6. L.P. Christensen Ginsenoside chemistry, biosynthesis, analysis, and potential effects Adv. Food Nutr. Res. 55 2009 1 99
7. S. Cory, and L.M. Adams The Bcl-2 family, regulators of cellular life-or-death switch Nat. Rev. Cancer 2 2002 647 656
8. A. Fifre, I. Sponne, V. Koziel, B. Kriem, F.T.Y. Potin, B.E. Bihain, J.L. Olivier, T. Oster, and T. Pillot Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid b-peptideinduced neuronal apoptosis. Synergistic involvement of calpain and caspase-3 J. Biol. Chem. 281 2006 229 240
9. Q.G. Gao, W.F. Chen, J.X. Xie, and M.S. Wong Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways J. Neurochem. 109 2009 1338 1347
10. L.M. Garcia-Segura, I. Azcoitia, and L.L. DonCarlos Neuroprotection by estradiol Prog. Neurobiol. 63 2001 29 60
11. L.M. Garcia-Segura, M.A. Arévalo, and I. Azcoitia Interactions of estradiol and insulin-like growth factor-I signalling in the nervous system: new advances Prog. Brain Res. 181 2010 251 272
12. L. Gong, S.L. Li, H. Li, and L. Zhang Ginsenoside Rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by β-amyloid protein Pharm. Biol. 49 2011 501 507
13. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
14. T.A. Ishunina, D.F. Fischer, and D.F. Swaab Estrogen receptor alpha and its splice variants in the hippocampus in aging and Alzheimer's disease Neurobiol. Aging 28 2007 1670 1681
15. T. Ivanova, M. Karolczak, and C. Beyer Estrogen stimulates the mitogen-activated protein kinase pathway in midbrain astroglia Brain Res. 889 2001 264 269
16. W.S. Lau, R.Y. Chan, G.A. Guo, and M.S. Wong Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway J. Steroid Biochem. Mol. Biol. 108 2008 64 71
17. W.S. Lau, W.F. Chen, R.Y. Chan, D.A. Guo, and M.S. Wong Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells Br. J. Pharmacol. 156 2009 1136 1146
18. A. Morinaga, K. Ono, J. Takasaki, T. Ikeda, M. Hirohata, and M. Yamada Effects of sex hormones on Alzheimer's disease-associated β-amyloid oligomer formation in vitro Exp. Neurol. 228 2011 298 302
19. M. Perez-Martin, I. Azcoitia, J.L. Trejo, A. Sierra, and L.M. Garcia-Segura An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat Eur. J. Neurosci. 18 2003 923 930
20. L.W. Qi, C.Z. Wang, and C.S. Yuan American ginseng: potential structure-function relationship in cancer chemoprevention Biochem. Pharmacol. 80 2010 947 954
21. G.K. Reeves, V. Beral, J. Green, T. Gathani, D. Bull Million Women Study Collaborators Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis Lancet Oncol. 7 2006 910 918
22. C. Shi, D.D. Zheng, L. Fang, F. Wu, W.H. Kwong, and J. Xu Ginsenoside Rg1 promotes nonamyloidgenic cleavage of APP via estrogen receptor signaling to MAPK/ERK and PI3K/Akt Biochim. Biophys. Acta 1820 2011 453 460
23. Y.Q. Shi, T.W. Huang, L.M. Chen, X.D. Pan, J. Zhang, Y.G. Zhu, and X.C. Chen Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice J. Alzheimer's Dis. 19 2010 977 989
24. L. Xu, W.F. Chen, and M.S. Wong Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through IGF-I receptor signaling pathway Br. J. Pharmacol. 158 2009 738 748
25. X.Y. Wang, J. Chen, and J.T. Zhang Effect of ginsenoside Rg1 on learning and memory impairment induced by beta-amyloid peptide(25-35) and its mechanism of action Yao Xue Xue Bao 36 2001 1 4
26. Y.H. Wang, and G.H. Du Ginsenoside Rg1 inhibits beta-secretase activity in vitro and protects against Abeta-induced cytotoxicity in PC12 cells J. Asian Nat. Prod. Res. 11 2009 604 612
27. Z. Wei, D.D. Mousseau, J.S. Richardson, L.E. Dyck, and X.M. Li A typical antipsychotics attenuate neurotoxicity of b-amyloid(25-35) by modulating Bax and Bcl-X(l/s) expression and localization J. Neurosci. Res. 74 2003 942 947
28. W. Wharton, L.D. Baker, C.E. Gleason, M. Dowling, J.H. Barnet, S. Johnson, C. Carlsson, S. Craft, and S. Asthana Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial J. Alzheimer's Dis. 26 2011 495 505
29. S. Yoon, and R. Seger The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions Growth Factors 24 2006 21 44