Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Journal of Medicinal Chemistry

Volumn 57, Issue 2, 2014, Pages 495-506

  Luci, Diane K ^a   Jameson, J Brian ^b   Yasgar, Adam ^a   Diaz, Giovanni ^b   Joshi, Netra ^b   Kantz, Auric ^b   Markham, Kate ^b   Perry, Steve ^b   Kuhn, Norine ^c   Yeung, Jennifer ^d   Kerns, Edward H ^a   Schultz, Lena ^a   Holinstat, Michael ^d   Nadler, Jerry L ^c   Taylor Fishwick, David A ^c   Jadhav, Ajit ^a   Simeonov, Anton ^a   Holman, Theodore R ^b   Maloney, David J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 4 [(2 HYDROXY 3 METHOXYBENZYL)AMINO]BENZENESULFONAMIDE DERIVATIVE; ARACHIDONATE 12 LIPOXYGENASE; BENZENESULFONAMIDE DERIVATIVE; LIPOXYGENASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; PANCREAS ISLET BETA CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; BENZENE DERIVATIVES; BIOLOGICAL AVAILABILITY; BLOOD PLATELETS; CALCIUM; HUMANS; ISLETS OF LANGERHANS; LIPOXYGENASE INHIBITORS; MICE; PLATELET AGGREGATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84893052137     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4016476     Document Type: Article

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