Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain

Progress in Neurobiology

Volumn 113, Issue , 2014, Pages 70-78

  Patte Mensah, C ^a   Meyer, L ^a   Taleb, O ^a   Mensah Nyagan, A G ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Neuropathic pain; Neuroprotection; Neurosteroid; Nociception; Therapeutic strategies

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ANTINEOPLASTIC AGENT; MEDROXYPROGESTERONE ACETATE; SMALL INTERFERING RNA;

ANALGESIA; ANTINOCICEPTION; DORSAL ROOT; HUMAN; NERVE TRACT; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PERIPHERAL NERVE; PRIORITY JOURNAL; REVIEW; SCIATIC NERVE INJURY; SPINAL CORD; SPINAL PAIN; SYNTHESIS;

17Β-HSD; 17Β-HYDROXYSTEROID DEHYDROGENASE; 21-HYDROXYLASE; 21-OHASE; 2′,3′-CYCLIC NUCLEOTIDE 3′-PHOSPHODIESTERASE; 3Α,5Α-TETRAHYDROPROGESTERONE OR ALLOPREGNANOLONE; 3Α-HSOR; 3Α-HYDROXYSTEROID OXIDO-REDUCTASE; 3Β-HSD; 3Β-HYDROXYSTEROID DEHYDROGENASE; 5Α-R; 5Α-REDUCTASE; AP; CNPASE; CONDUCTION VELOCITY; CV; CYTOCHROME P450C17 OR 17Α-HYDROXYLASE/17,20 LYASE; CYTOCHROME P450SIDE-CHAIN CLEAVAGE; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DEOXYCORTICOSTERONE; DH; DHDOC; DHEA; DHEAS; DHP; DHT; DIHYDRODEOXYCORTICOSTERONE; DIHYDROPROGESTERONE; DIHYDROTESTOSTERONE; DOC; DORSAL HORN; GABA; GAMMA-AMINOBUTYRIC ACID; HST; HYDROXYSULFOTRANSFERASE; IENF; INTRAEPIDERMAL NERVE FIBERS; NAP; NERVE ACTION POTENTIAL; NEUROPATHIC PAIN; NEUROPROTECTION; NEUROSTEROID; NOCICEPTION; OXAL; OXALIPLATIN; P450C17; P450SCC; PREG; PREGNENOLONE; PREGNENOLONE SULFATE; PREGS; PROG; PROGESTERONE; SC; SPINAL CORD; TETRAHYDRODEOXYCORTICOSTERONE; THDOC; THERAPEUTIC STRATEGIES; VINC; VINCRISTINE;

ANIMALS; HUMANS; NEURALGIA; PREGNANOLONE;

EID: 84892844097     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2013.07.004     Document Type: Review

References (125)

1. Adcock I.M., Caramori G., Kirkham P.A. Strategies for improving the efficacy and therapeutic ratio of glucocorticoids. Current Opinion in Pharmacology 2012, 12:246-251.
2. Aloisi A.M. Gonadal hormones and sex differences in pain reactivity. Clinical Journal of Pain 2003, 19:168-174.
3. Aloisi A.M., Ceccarelli I., Fiorenzani P., De Padova A.M., Massafra C. Testosterone affects formalin-induced responses differently in male and female rats. Neuroscience Letters 2004, 361:262-264.
4. Aloisi A.M., Bonifazi M. Sex hormones, central nervous system and pain. Hormones and Behavior 2006, 50:1-7.
5. Antoine J.C., Camdessanche J.P. Peripheral nervous system involvement in patients with cancer. Lancet Neurology 2007, 6:75-86.
6. Arendt-Nielsen L., Bajaj P., Drewes A.M. Visceral pain: gender differences in response to experimental and clinical pain. European Journal of Pain 2004, 8:465-472.
7. Authier N., Balayssac D., Marchand F., Ling B., Zangarelli A., Descoeur J., Coudore F., Bourinet E., Eschalier A. Animal models of chemotherapy-evoked painful peripheral neuropathies. Neurotherapeutics 2009, 6:620-629.
8. Baker D.E. Oxaliplatin: a new drug for the treatment of metastatic carcinoma of the colon or rectum. Reviews in Gastroenterological Disorders 2003, 3:31-38.
9. Barnes P.J., Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends in Pharmacological Sciences 1993, 14:436-441.
10. Barnes P.J. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clinical Science (London) 1998, 94:557-572.
11. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annual Review of Neuroscience 1984, 7:309-338.
12. Baulieu E.E., Robel P., Schumacher M. Contemporary Endocrinology 1999, Humana Press, Totowa.
13. Belelli D., Lambert J.J. Neurosteroids: endogenous regulators of the GABA(A) receptor. Nature Reviews Neuroscience 2005, 6:565-575.
14. Belvisi M.G., Hele D.J. Soft steroids: a new approach to the treatment of inflammatory airways diseases. Pulmonary Pharmacology and Therapeutics 2003, 16:321-325.
15. Benemei S., Nicoletti P., Capone J.G., Geppetti P. CGRP receptors in the control of pain and inflammation. Current Opinion in Pharmacology 2009, 9:9-14.
16. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33:87-107.
17. Bitran D., Hilvers R.J., Kellogg C.K. Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Research 1991, 561:157-161.
18. Bonin R.P., Labrakakis C., Eng D.G., Whissell P.D., De Koninck Y., Orser B.A. Pharmacological enhancement of delta-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. Pain 2011, 152:1317-1326.
19. Borgna M., Lombardi R., Lauria G., Grezzi P., Savino C., Bianchi R., Oggioni N., Canta A., Lanzani F., Galbiati S., Frigeni B., Giussani G., Tredici G., Cavaletti G. Intraepidermal innervation and tail nerve conduction velocity in neurotoxicity models: results of a correlation study in normal and pathological conditions. Journal of Peripheral Nervous System 2004, 9:104-105.
20. Brann D.W., Putnam C.D., Mahesh V.B. Dose-related effects of progesterone and 5 alpha-dihydroprogesterone upon estrogen-induced prolactin release. Journal of Neuroendocrinology 1990, 2:341-345.
21. Cashin M., Moravek V. The physiological action of cholesterol. American Journal of Physiology 1927, 82:294-298.
22. Ceccarelli I., Fiorenzani P., Massafra C., Aloisi A.M. Long-term ovariectomy changes formalin-induced licking in female rats: the role of estrogens. Reproductive Biology and Endocrinology 2003, 1:24-32.
23. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods 1994, 53:55-63.
24. Choi Y., Yoon Y.W., Na H.S., Kim S.H., Chung J.M. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain 1994, 59:369-376.
25. Clatworthy A.L., Illich P.A., Castro G.A., Walters E.T. Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neuroscience Letters 1995, 184:5-8.
26. Compagnone N.A., Mellon S.H. Neurosteroids: biosynthesis and function of these novel neuromodulators. Frontiers in Neuroendocrinology 2000, 21:1-56.
27. Craft R.M., Mogil J.S., Aloisi A.M. Sex differences in pain and analgesia: the role of gonadal hormones. European Journal of Pain 2004, 8:397-411.
28. Devor M., Govrin-Lippmann R., Raber P. Corticosteroids suppress ectopic neural discharge originating in experimental neuromas. Pain 1985, 22:127-137.
29. Dougherty P.M., Cata J.P., Burton A.W., Vu K., Weng H.R. Dysfunction in multiple primary afferent fiber subtypes revealed by quantitative sensory testing in patients with chronic vincristine-induced pain. Journal of Pain and Symptom Management 2007, 33:166-179.
30. Durand J.P., Alexandre J., Guillevin L., Goldwasser F. Clinical activity of venlafaxine and topiramate against oxaliplatin-induced disabling permanent neuropathy. Anti-Cancer Drugs 2005, 16:587-591.
31. Dworkin R.H., O'Connor A.B., Audette J., Baron R., Gourlay G.K., Haanpaa M.L., Kent J.L., Krane E.J., Lebel A.A., Levy R.M., Mackey S.C., Mayer J., Miaskowski C., Raja S.N., Rice A.S., Schmader K.E., Stacey B., Stanos S., Treede R.D., Turk D.C., Walco G.A., Wells C.D. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clinic Proceedings 2010, 85:S3-S14.
32. El-Helw L.M., Hancock B.W. Treatment of metastatic gestational trophoblastic neoplasia. Lancet Oncology 2007, 8:715-724.
33. Fakih M., Johnson C.S., Trump D.L. Glucocorticoids and treatment of prostate cancer: a preclinical and clinical review. Urology 2002, 60:553-561.
34. Fillingim R.B., Gear R.W. Sex differences in opioid analgesia: clinical and experimental findings. European Journal of Pain 2004, 8:413-425.
35. Finn D.A., Beadles-Bohling A.S., Beckley E.H., Ford M.M., Gililland K.R., Gorin-Meyer R.E., Wiren K.M. A new look at the 5alpha-reductase inhibitor Finasteride. CNS Drug Reviews 2006, 12:53-76.
36. Firestein G.S., Paine M.M., Littman B.H. Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids. Arthritis and Rheumatism 1991, 34:1094-1105.
37. Frye C.A., Hirst J.J., Brunton P.J., Russell J.A. Neurosteroids for a successful pregnancy. Stress 2011, 14:1-5.
38. Gambhir M., Mediratta P.K., Sharma K.K. Evaluation of the analgesic effect of neurosteroids and their possible mechanism of action. Indian Journal of Physiology and Pharmacology 2002, 46:202-208.
39. Gamelin L., Boisdron-Celle M., Delva R., Guerin-Meyer V., Ifrah N., Morel A., Gamelin E. Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer. Clinical Cancer Research 2004, 10:4055-4061.
40. Gaumond I., Arsenault P., Marchand S. Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses. Brain Research 2005, 1052:105-111.
41. Goodchild C.S., Guo Z., Nadeson R. Antinociceptive properties of neurosteroids I. Spinally-mediated antinociceptive effects of water-soluble aminosteroids. Pain 2000, 88:23-29.
42. Goodchild C.S., Robinson A., Nadeson R. Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans. British Journal of Anaesthesia 2001, 86:528-534.
43. Green P.S., Bishop J., Simpkins J.W. 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells. Journal of Neuroscience 1997, 17:511-515.
44. Haines D.E., Mihailoff G.A., Yezierski R.P. The spinal cord. Fundamental Neuroscience 1997, 129-141. Churchill Livingstone Inc., New York. D.E. Haines (Ed.).
45. Hau M., Dominguez O.A., Evrard H.C. Testosterone reduces responsiveness to nociceptive stimuli in a wild bird. Hormones and Behavior 2004, 46:165-170.
46. Hayashi R., Xiao W., Kawamoto M., Yuge O., Bennett G.J. Systemic glucocorticoid therapy reduces pain and the number of endoneurial tumor necrosis factor-alpha (TNFalpha)-positive mast cells in rats with a painful peripheral neuropathy. Journal of Pharmacological Sciences 2008, 106:559-565.
47. Holmberg E., Backstrom T., Johansson M., Lofgren M., Haage D. Allopregnanolone induces a diurnally dependent hyperphagic effect and alters feeding latency and duration in male Wistar rats. Acta Physiologica (Oxford) 2013, 10.1111/apha.12100.
48. Holzbauer M. Proceedings: physiological aspects of the hypnotic properties of steroid hormones. British Journal of Pharmacology 1976, 56:382-383.
49. Hosie A.M., Wilkins M.E., da Silva H.M., Smart T.G. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature 2006, 444:486-489.
50. Jamieson S., Subramaniam J., Liu J., Jong N., Ip V., Connor B., McKeage M. Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue. Molecular Pain 2009, 5:66-74.
51. Jha M.K., Jeon S., Suk K. Glia as a link between neuroinflammation and neuropathic pain. Immune Network 2012, 12:41-47.
52. Johansson A., Bennett G.J. Effect of local methylprednisolone on pain in a nerve injury model. A pilot study. Regional Anesthesia 1997, 22:59-65.
53. Jones K.J. Gonadal steroids and neuronal regeneration. A therapeutic role. Advances in Neurology 1993, 59:227-240.
54. Julien N., Goffaux P., Arsenault P., Marchand S. Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain 2005, 114:295-302.
55. Kawano T., Soga T., Chi H., Eguchi S., Yamazaki F., Kumagai N., Yokoyama M. Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats. Journal of Anesthesia 2011, 25:942-945.
56. Kibaly C., Patte-Mensah C., Mensah-Nyagan A.G. Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord. Journal of Neurochemistry 2005, 93:1220-1230.
57. Kibaly C., Meyer L., Patte-Mensah C., Mensah-Nyagan A.G. Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. FASEB Journal 2008, 22:93-104.
58. Kilts J.D., Tupler L.A., Keefe F.J., Payne V.M., Hamer R.M., Naylor J.C., Calnaido R.P., Morey R.A., Strauss J.L., Parke G., Massing M.W., Youssef N.A., Shampine L.J., Marx C.E. Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001. Pain Medicine 2010, 11:1469-1476.
59. Kimonides V.G., Khatibi N.H., Svendsen C.N., Sofroniew M.V., Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:1852-1857.
60. Kingery W.S. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 1997, 73:123-139.
61. Kingery W.S., Castellote J.M., Maze M. Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Pain 1999, 80:555-566.
62. Kraulis, Foldes I., Traikov G., Dubrovsky H., Birmingham B. Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system. Brain Research 1975, 88:1-14.
63. Lang E., Hord A.H., Denson D. Venlafaxine hydrochloride (Effexor) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. Pain 1996, 68:151-155.
64. Le Goascogne C., Robel P., Gouezou M., Sananes N., Baulieu E.E., Waterman M. Neurosteroids: cytochrome P-450scc in rat brain. Science 1987, 237:1212-1215.
65. Ling B., Authier N., Balayssac D., Eschalier A., Coudore F. Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. Pain 2007, 128:225-234.
66. Ling B., Coudore-Civiale M.A., Balayssac D., Eschalier A., Coudore F., Authier N. Behavioral and immunohistological assessment of painful neuropathy induced by a single oxaliplatin injection in the rat. Toxicology 2007, 234:176-184.
67. Lussier D., Huskey A.G., Portenoy R.K. Adjuvant analgesics in cancer pain management. Oncologist 2004, 9:571-591.
68. Magrinelli F., Zanette G., Tamburin S. Neuropathic pain: diagnosis and treatment. Practical Neurology 2013, 10.1136/practneurol-2013-000536.
69. Majewska M.D. Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. Progress in Neurobiology 1992, 38:379-395.
70. Marchand F., Alloui A., Chapuy E., Jourdan D., Pelissier T., Ardid D., Hernandez A., Eschalier A. Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats. Pain 2003, 103:229-235.
71. McEwen B.S. Endocrine effects on the brain and their relationship to behavior. Basic Neurochemistry 1994, 1003-1023. Raven Press, New York. G.J. Siegel, B.W. Agranoff, R.W. Albers, B. Molinoff (Eds.).
72. Melcangi R.C., Garcia-Segura L.M., Mensah-Nyagan A.G. Neuroactive steroids: state of the art and new perspectives. Cellular and Molecular Life Sciences 2008, 65:777-797.
73. Mellon S.H., Griffin L.D. Neurosteroids: biochemistry and clinical significance. Trends in Endocrinology and Metabolism 2002, 13:35-43.
74. Mensah-Nyagan A.G., Do-Rego J.L., Feuilloley M., Marcual A., Lange C., Pelletier G., Vaudry H. In vivo and in vitro evidence for the biosynthesis of testosterone in the telencephalon of the female frog. Journal of Neurochemistry 1996, 67:413-422.
75. Mensah-Nyagan A.G., Feuilloley M., Do-Rego J.L., Marcual A., Lange C., Tonon M.C., Pelletier G., Vaudry H. Localization of 17beta-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:1423-1428.
76. Mensah-Nyagan A.G., Do-Rego J.L., Beaujean D., Luu-The V., Pelletier G., Vaudry H. Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacological Reviews 1999, 51:63-81.
77. Mensah-Nyagan A.G., Do-Rego J.L., Beaujean D., Luu-The V., Pelletier G., Vaudry H. Regulation of neurosteroid biosynthesis in the frog diencephalon by GABA and endozepines. Hormones and Behavior 2001, 40:218-225.
78. Mensah-Nyagan A.G., Kibaly C., Schaeffer V., Venard C., Meyer L., Patte-Mensah C. Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation. The Journal of Steroid Biochemistry and Molecular Biology 2008, 109:286-293.
79. Mensah-Nyagan A.G., Meyer L., Schaeffer V., Kibaly C., Patte-Mensah C. Evidence for a key role of steroids in the modulation of pain. Psychoneuroendocrinology 2009, 34(Suppl. 1):S169-S177.
80. Meyer L., Venard C., Schaeffer V., Patte-Mensah C., Mensah-Nyagan A.G. The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiology of Disease 2008, 30:30-41.
81. Meyer L., Patte-Mensah C., Taleb O., Mensah-Nyagan A.G. Cellular and functional evidence for a protective action of neurosteroids against vincristine chemotherapy-induced painful neuropathy. Cellular and Molecular Life Sciences 2010, 67:3017-3034.
82. Meyer L., Patte-Mensah C., Taleb O., Mensah-Nyagan A.G. Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence. Pain 2011, 152:170-181.
83. Millan M.J. The induction of pain: an integrative review. Progress in Neurobiology 1999, 57:1-164.
84. Millan M.J. Descending control of pain. Progress in Neurobiology 2002, 66:355-474.
85. Mitchell E.A., Gentet L.J., Dempster J., Belelli D. GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids. Journal of Physiology 2007, 583:1021-1040.
86. Moore A., Pinkerton R. Vincristine: can its therapeutic index be enhancedα. Pediatric Blood and Cancer 2009, 53:1180-1187.
87. Nadeson R., Goodchild C.S. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain 2000, 88:31-39.
88. Nadeson R., Goodchild C.S. Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically. British Journal of Anaesthesia 2001, 86:704-708.
89. Ocvirk R., Pearson Murphy B.E., Franklin K.B., Abbott F.V. Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test. Pain 2008, 138:402-409.
90. Pathirathna S., Brimelow B.C., Jagodic M.M., Krishnan K., Jiang X., Zorumski C.F., Mennerick S., Covey D.F., Todorovic S.M., Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain 2005, 114:429-443.
91. Patte-Mensah C., Kappes V., Freund-Mercier M.J., Tsutsui K., Mensah-Nyagan A.G. Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathways. Journal of Neurochemistry 2003, 86:1233-1246.
92. Patte-Mensah C., Li S., Mensah-Nyagan A.G. Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks. Cellular and Molecular Life Sciences 2004, 61:2274-2284.
93. Patte-Mensah C., Penning T.M., Mensah-Nyagan A.G. Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord. Journal of Comparative Neurology 2004, 477:286-299.
94. Patte-Mensah C., Kibaly C., Mensah-Nyagan A.G. Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:9044-9049.
95. Patte-Mensah C., Kibaly C., Boudard D., Schaeffer V., Begle A., Saredi S., Meyer L., Mensah-Nyagan A.G. Neurogenic pain and steroid synthesis in the spinal cord. Journal of Molecular Neuroscience 2006, 28:17-31.
96. Patte-Mensah C., Meyer L., Schaeffer V., Mensah-Nyagan A.G. Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: a possible mechanism to cope with peripheral nerve injury-induced chronic pain. Pain 2010, 150:522-534.
97. Petit T., Benider A., Yovine A., Bougnoux P., Spaeth D., Maindrault-Goebel F., Serin D., Tigaud J.D., Eymard J.C., Simon H., Bertaux B., Brienza S., Cvitkovic E. Phase II study of an oxaliplatin/vinorelbine combination in patients with anthracycline- and taxane-pre-treated metastatic breast cancer. Anti-Cancer Drugs 2006, 17:337-343.
98. Polomano R.C., Bennett G.J. Chemotherapy-evoked painful peripheral neuropathy. Pain Medicine 2001, 2:8-14.
99. Purdy R.H., Morrow A.L., Moore P.H., Paul S.M. Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:4553-4557.
100. Ravula S.K., Wang M.S., McClain M.A., Asress S.A., Frazier B., Glass J.D. Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration. Neuroscience Letters 2007, 415:34-39.
101. Roglio I., Bianchi R., Camozzi F., Carozzi V., Cervellini I., Crippa D., Lauria G., Cavaletti G., Melcangi R.C. Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model. Journal of Peripheral Nervous System 2009, 14:347-355.
102. Sapolsky R.M. Stress, glucocorticoids, and damage to the nervous system: the current state of confusion. Stress 1996, 1:1-19.
103. Sayeed I., Guo Q., Hoffman S.W., Stein D.G. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Annals of Emergency Medicine 2006, 47:381-389.
104. Schaeffer V., Meyer L., Patte-Mensah C., Eckert A., Mensah-Nyagan A.G. Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons. Glia 2010, 58:169-180.
105. Schaeffer V., Meyer L., Patte-Mensah C., Mensah-Nyagan A.G. Progress in dorsal root ganglion neurosteroidogenic activity: basic evidence and pathophysiological correlation. Progress in Neurobiology 2010, 92:33-41.
106. Seckl J.R. 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid actionα. Frontiers in Neuroendocrinology 1997, 18:49-99.
107. Selye H., Masson G. Additional steroids with luteoid activity. Science 1942, 96:358.
108. Siau C., Xiao W., Bennett G.J. Paclitaxel- and vincristine-evoked painful peripheral neuropathies: loss of epidermal innervation and activation of Langerhans cells. Experimental Neurology 2006, 201:507-514.
109. Sibilia J. Corticosteroids and inflammation. Revue du Praticien 2003, 53:495-501.
110. Smith S.S., Shen H., Gong Q.H., Zhou X. Neurosteroid regulation of GABA(A) receptors: focus on the alpha4 and delta subunits. Pharmacology and Therapeutics 2007, 116:58-76.
111. Sommer C., Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neuroscience Letters 2004, 361:184-187.
112. Stoner E. The clinical development of a 5alpha-reductase inhibitor, finasteride. Journal of Steroid Biochemistry and Molecular Biology 1990, 37:375-378.
113. Takeda K., Sawamura S., Sekiyama H., Tamai H., Hanaoka K. Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. Anesthesiology 2004, 100:1249-1257.
114. Tarner I.H., Englbrecht M., Schneider M., van der Heijde D.M., Muller-Ladner U. The role of corticosteroids for pain relief in persistent pain of inflammatory arthritis: a systematic literature review. Journal of Rheumatology Supplement 2012, 90:17-20.
115. Timby E., Balgard M., Nyberg S., Spigset O., Andersson A., Porankiewicz-Asplund J., Purdy R.H., Zhu D., Backstrom T., Poromaa I.S. Pharmacokinetic and behavioral effects of allopregnanolone in healthy women. Psychopharmacology (Berlin) 2006, 186:414-424.
116. Treede R.D., Jensen T.S., Campbell J.N., Cruccu G., Dostrovsky J.O., Griffin J.W., Hansson P., Hughes R., Nurmikko T., Serra J. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 2008, 70:1630-1635.
117. U S Food and Drug Administration website. http://www.fda.gov/.
118. Uno H., Tarara R., Else J.G., Suleman M.A., Sapolsky R.M. Hippocampal damage associated with prolonged and fatal stress in primates. Journal of Neuroscience 1989, 9:1705-1711.
119. Uzunova V., Sheline Y., Davis J.M., Rasmusson A., Uzunov D.P., Costa E., Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:3239-3244.
120. Venard C., Boujedaini N., Belon P., Mensah-Nyagan A.G., Patte-Mensah C. Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience 2008, 153:154-161.
121. Wang J.M., Singh C., Liu L., Irwin R.W., Chen S., Chung E.J., Thompson R.F., Brinton R.D. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:6498-6503.
122. Wareham D. Postherpetic neuralgia. Clinical Evidence 2004, 12:1182-1193.
123. White F.A., Bhangoo S.K., Miller R.J. Chemokines: integrators of pain and inflammation. Nature Reviews Drug Discovery 2005, 4:834-844.
124. Wolfe G.I., Trivedi J.R. Painful peripheral neuropathy and its nonsurgical treatment. Muscle and Nerve 2004, 30:3-19.
125. Yu W.H. Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment. Brain Research 1989, 491:379-382.