Treatment of metastatic gestational trophoblastic neoplasia

Lancet Oncology

Volumn 8, Issue 8, 2007, Pages 715-724

  El Helw, Loaie M ^a   Hancock, Barry W ^a  

^a WESTON PARK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GROWTH FACTOR ANTAGONIST; HYDROXYUREA; IFOSFAMIDE; IRINOTECAN; MELPHALAN; METHOTREXATE; OXALIPLATIN; PACLITAXEL; PLATINUM COMPLEX; PREDNISOLONE; TOPOTECAN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

BONE MARROW SUPPRESSION; BRAIN METASTASIS; CANCER LOCALIZATION; CANCER MORTALITY; CANCER REGRESSION; CANCER RELAPSE; CANCER RESISTANCE; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DRUG CHOICE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HYSTERECTOMY; KIDNEY METASTASIS; LIVER METASTASIS; LUNG METASTASIS; METASTASIS POTENTIAL; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NEPHROTOXICITY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SPLEEN CANCER; SURVIVAL RATE; SURVIVAL TIME; TROPHOBLASTIC TUMOR; UNSPECIFIED SIDE EFFECT; VISCERAL METASTASIS;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYCLOPHOSPHAMIDE; DACTINOMYCIN; ETOPOSIDE; FEMALE; GESTATIONAL TROPHOBLASTIC NEOPLASMS; HUMANS; METHOTREXATE; PREGNANCY; VINCRISTINE;

EID: 34547474285     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(07)70239-5     Document Type: Review

References (64)

1. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic disease. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield, UK
2. Dorreen M. The gestational trophoblastic diseases: a review of their presentation and management. Clin Oncol (R Coll Radiol) 5 (1993) 46-56
3. Coukos G., Makrigiannakis A., Chung J., Randall T., Rubin S., and Benjamin I. Complete hydatidiform mole. A disease with a changing profile. J Reprod Med 44 (1999) 698-704
4. Cohn D., and Herzog T. Gestational trophoblastic diseases: new standards for therapy. Curr Opin Oncol 12 (2000) 492-496
5. Newlands E. Presentation and management of persistent gestational trophoblastic disease (GTD) and gestational trophoblastic tumours (GTT) in the United Kingdom. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic disease. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield
6. Evans Jr. A., Soper J., and Hammond C. Clinical features of molar pregnancies and gestational trophoblastic tumours. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic disease. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield Gestational trophoblastic diseases.
7. Hancock B. Staging and classification of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol 6 (2003) 869-883
8. Bagshawe K. Risk and prognostic factors in trophoblastic neoplasia. Cancer 38 (1976) 1373-1385
9. Newlands E. Investigation and treatment of persistent trophoblastic disease and gestational trophoblastic tumours in the UK. In: Hancock B., Newlands E., and Berkowitz R. (Eds). Gestational trophoblastic diseases (1997), Chapman and Hall, London 173-190
10. World Health Organisation Scientific Group on Gestational Trophoblastic Diseases. Gestational Trophoblastic Diseases. Technical Report Series 692 (1983), WHO, Geneva
11. Dubuc-Lissoir J., Sweizig S., Schlaerth J., and Morrow C. Metastatic gestational trophoblastic disease: a comparison of prognostic classification systems. Gynecol Oncol 45 (1992) 40-45
12. Hammond C., Borchert L., Tyrey L., Creasman W., and Parker R. Treatment of metastatic trophoblastic disease: good and poor prognosis. Am J Obstet Gynecol 115 (1973) 451-457
13. Kohorn E. The trophoblastic Tower of Babel: classification systems for metastatic gestational trophoblastic neoplasia. Gynecol Oncol 56 (1995) 280-288
14. FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee. Int J Gynaecol Obstet 77 (2002) 285-287
15. Berkowitz R., and Goldstein D. Presentation and management of persistent gestational trophoblastic disease and gestational trophoblastic tumours in the USA. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic diseases. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield
16. Hertz R., Lewis Jr. J., and Lipsett M. Five years' experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Am J Obstet Gynecol 82 (1961) 631-640
17. Soper J., Clarke-Pearson D., Berchuck A., Rodriguez G., and Hammond C. 5-day methotrexate for women with metastatic gestational trophoblastic disease. Gynecol Oncol 54 (1994) 76-79
18. McNeish I., Strickland S., Holden L., et al. Low-risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000. J Clin Oncol 20 (2002) 1838-1844
19. Khan F., Everard J., Ahmed S., Coleman R., Aitken M., and Hancock B. Low-risk persistent gestational trophoblastic disease treated with low-dose methotrexate: efficacy, acute and long-term effects. Br J Cancer 89 (2003) 2197-2201
20. Xue Y., Zhang J., Wu T., and An R. Combination chemotherapy for high-risk gestational trophoblastic tumour. Cochrane Database Syst Rev 3 (2006) CD005196.
21. Curry S., Blessing J., DiSaia P., Soper J., and Twiggs L. A prospective randomized comparison of methotrexate, dactinomycin, and chlorambucil versus methotrexate, dactinomycin, cyclophosphamide, doxorubicin, melphalan, hydroxyurea, and vincristine in "poor prognosis" metastatic gestational trophoblastic disease: a Gynecologic Oncology Group study. Obstet Gynecol 73 (1989) 357-362
22. Brewer J., Eckman T., Dolkart R., Torok E., and Webster A. Gestational trophoblastic disease. A comparative study of the results of therapy in patients with invasive mole and with choriocarcinoma. Am J Obstet Gynecol 109 (1971) 335-340
23. Lurain J., and Brewer J. Treatment of high-risk gestational trophoblastic disease with methotrexate, actinomycin D, and cyclophosphamide chemotherapy. Obstet Gynecol 65 (1985) 830-836
24. Gordon A., Gershenson D., Copeland L., Saul P., Kavanagh J., and Edwards C. High-risk metastatic gestational trophoblastic disease. Obstet Gynecol 65 (1985) 550-556
25. Begent R., and Bagshawe K. The management of high-risk choriocarcinoma. Semin Oncol 9 (1982) 198-203
26. Wong L., Choo Y., and Ma H. Modified Bagshawe's regimen in high-risk gestational trophoblastic disease. Gynecol Oncol 23 (1986) 87-93
27. Newlands E., Bagshawe K., Begent R., Rustin G., and Holden L. Results with the EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) regimen in high risk gestational trophoblastic tumours, 1979 to 1989. Br J Obstet Gynaecol 98 (1991) 550-557
28. Newlands E., Bower M., Holden L., et al. The management of high-risk gestational trophoblastic tumours (GTT). Int J Gynaecol Obstet 60 suppl 1 (1998) S65-S70
29. Kim S., Bae S., Kim J., et al. Effects of multiagent chemotherapy and independent risk factors in the treatment of high-risk GTT-25 years experiences of KRI-TRD. Int J Gynaecol Obstet 60 suppl 1 (1998) S85-S96
30. Lurain J., Singh D., and Schink J. Primary treatment of metastatic high-risk gestational trophoblastic neoplasia with EMA-CO chemotherapy. J Reprod Med 51 (2006) 767-772
31. El-Lamie I., El Sayed H., Badawie A., et al. Evolution of treatment of high-risk metastatic gestational trophoblastic tumors: Ain Shams University experience. Int J Gynecol Cancer 16 (2006) 866-874
32. Dobson L., Lorigan P., Coleman R., and Hancock B. Persistent gestational trophoblastic disease: results of MEA (methotrexate, etoposide and dactinomycin) as first-line chemotherapy in high risk disease and EA (etoposide and dactinomycin) as second-line therapy for low risk disease. Br J Cancer 82 (2000) 1547-1552
33. Wang S., An R., Han X., Zhu K., and Xue Y. Combination chemotherapy with 5-fluorouracil, methotrexate and etoposide for patients with high-risk gestational trophoblastic tumors: a report based on our 11-year clinical experiences. Gynecol Oncol 103 (2006) 1105-1108
34. Newlands E. Investigation and treatment of patients with persistent gestational trophoblastic disease and gestational trophoblastic tumours in the United Kingdom. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic diseases. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield
35. Theodore C., Azab M., Droz J., et al. Treatment of high-risk gestational trophoblastic disease with chemotherapy combinations containing cisplatin and etoposide. Cancer 64 (1989) 1824-1828
36. Lurain J. Treatment of metastatic gestational trophoblastic tumors. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic diseases. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield
37. Yordan Jr. E., Schlaerth J., Gaddis O., and Morrow C. Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system. Obstet Gynecol 69 (1987) 627-630
38. Evans Jr. A., Soper J., Clarke-Pearson D., Berchuck A., Rodriguez G., and Hammond C. Gestational trophoblastic disease metastatic to the central nervous system. Gynecol Oncol 59 (1995) 226-230
39. Newlands E., Holden L., Seckl M., McNeish I., Strickland S., and Rustin G. Management of brain metastases in patients with high-risk gestational trophoblastic tumors. J Reprod Med 47 (2002) 465-471
40. Cagayan M., and Lu-Lasala L. Management of gestational trophoblastic neoplasia with metastasis to the central nervous system: a 12-year review at the Philippine General Hospital. J Reprod Med 51 (2006) 785-792
41. Rustin G., Newlands E., Begent R., Dent J., and Bagshawe K. Weekly alternating etoposide, methotrexate, and actinomycin/vincristine and cyclophosphamide chemotherapy for the treatment of CNS metastases of choriocarcinoma. J Clin Oncol 7 (1989) 900-903
42. Athanassiou A., Begent R., Newlands E., Parker D., Rustin G., and Bagshawe K. Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital. Cancer 52 (1983) 1728-1735
43. Gillespie A., Siddiqui N., Coleman R., and Hancock B. Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role?. Br J Cancer 79 (1999) 1270-1272
44. Bakri Y., Berkowitz R., Khan J., Goldstein D., von Sinner W., and Jabbar F. Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure. J Reprod Med 39 (1994) 175-178
45. Kelly M., Rustin G., Ivory C., Phillips P., and Bagshawe K. Respiratory failure due to choriocarcinoma: a study of 103 dyspneic patients. Gynecol Oncol 38 (1990) 149-154
46. Sheridan E., Hancock B., Smith S., et al. Gestational trophoblastic disease: experience of Sheffield (United Kingdom) supraregional screening and treatment service. Int J Oncol 3 (1993) 149-155
47. Grumbine F., Rosenshein N., Brereton H., and Kaufman S. Management of liver metastasis from gestational trophoblastic neoplasia. Am J Obstet Gynecol 137 (1980) 959-961
48. Method M., Hirschfield M., and Averette H. Angiographic-guided embolization of metastatic invasive mole. Gynecol Oncol 61 (1996) 442-445
49. Hassadia A., Gillespie A., Tidy J., Everard R., Wells M., Coleman R., and Hancock B. Placental site trophoblastic tumour: clinical features and management. Gynecol Oncol 99 (2005) 603-607
50. Newlands E., Mulholland P., Holden L., Seckl M., and Rustin G. Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors. J Clin Oncol 18 (2000) 854-859
51. Yang J., Xiang Y., Wan X., and Yang X. Recurrent gestational trophoblastic tumour: management and risk factors for recurrence. Gynecol Oncol 103 (2006) 587-590
52. Ross G., Goldstein D., Hertz R., Lipsett M., and Odell W. Sequential use of methotrexate and actinomycin D in the treatment of metastatic choriocarcinoma and related trophoblastic diseases in women. Am J Obstet Gynecol 93 (1965) 223-229
53. Azab M., Droz J., Theodore C., Wolff J., and Amiel J. Cisplatin, vinblastine, and bleomycin combination in the treatment of resistant high-risk gestational trophoblastic tumors. Cancer 64 (1989) 1829-1832
54. Chen L., Cai S., Fan J., and Li Z. PEBA regimen (cisplatin, etoposide, bleomycin, and Adriamycin) in the treatment of drug-resistant choriocarcinoma. Gynecol Oncol 56 (1995) 231-234
55. Mangili G., Garavaglia E., Frigerio L., Candotti G., and Ferrari A. Management of low-risk gestational trophoblastic tumors with etoposide (VP16) in patients resistant to methotrexate. Gynecol Oncol 61 (1996) 218-220
56. Osborne R., Covens A., Merchandani D., Merchandani D., and Gerulath A. Successful salvage of relapsed high-risk gestational trophoblastic neoplasia patients using a novel paclitaxel-containing doublet. J Reprod Med 49 (2004) 655-661
57. Ngan H., Tam K., Lam K., and Chan K. Relapsed gestational trophoblastic neoplasia: a 20-year experience. J Reprod Med 51 (2006) 829-834
58. El-Helw L., Seckl M., Haynes R., et al. High-dose chemotherapy and peripheral blood stem cell support in refractory gestational trophoblastic neoplasia. Br J Cancer 93 (2005) 620-621
59. Newlands E., Hancock B., Cole L., and Berkowitz R. Future prospects. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic diseases. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield
60. Tidy J. The role of surgery in the management of gestational trophoblastic disease. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic diseases. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield
61. Pisal N., North C., Tidy J., and Hancock B. Role of hysterectomy in management of gestational trophoblastic disease. Gynecol Oncol 87 (2002) 190-192
62. Lurain J., Singh D., and Schink J. Role of surgery in the management of high-risk gestation trophoblastic neoplasia. J Reprod Med 51 (2006) 773-776
63. Rustin G., Newland E., Lutz J., et al. Combination but not single-agent methotrexate chemotherapy for gestational trophoblastic tumors increases the incidence of second tumors. J Clin Oncol 14 (1996) 2769-2773
64. Seckl M., and Rustin G. Late toxicity after therapy of gestational trophoblastic tumours. In: Hancock B., Newlands E., Berkowitz R., and Cole L. (Eds). Gestational trophoblastic diseases. 2nd edn. (2003), International Society for the Study of Trophoblastic Diseases, Sheffield