Systemic glucocorticoid therapy reduces pain and the number of endoneurial Tumor Necrosis Factor-alpha (TNFα)-positive mast cells in rats with a painful peripheral neuropathy

Journal of Pharmacological Sciences

Volumn 106, Issue 4, 2008, Pages 559-565

  Hayashi, Reiko ^a   Xiao, Wenhua ^b   Kawamoto, Masashi ^a   Yuge, Osafumi ^a   Bennett, Gary J ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Glucocorticoid; Hyperalgesia; Mast cell; Neuropathic pain; Tumor necrosis factor alpha (TNF )

Indexed keywords

GLUCOCORTICOID; TRIAMCINOLONE; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL PAIN; ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG EFFECT; HYPERALGESIA; IMMUNOCYTOCHEMISTRY; MALE; MAST CELL; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NEUROPATHY; PROTEIN EXPRESSION; RAT; SCHWANN CELL; STATISTICAL SIGNIFICANCE;

EID: 42349090185     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0072181     Document Type: Article

References (38)

1. Kingery W. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain. 1997;73:123-139.
2. Wareham D. Postherpetic neuralgia. Clin Evid. 2004;12:1182-1193.
3. Lussier D, Huskey AG, Portenoy RK. Adjuvant analgesics in cancer pain management. Oncologist. 2004;9:571-591.
4. Devor M, Govrin-Lippmann R, Raber P. Corticosteriods suppress ectopic neural discharge originating in experimental neuromas. Pain. 1985;22:127-137.
5. Clatworthy AL, Illiich PA, Castro GA, Walters ET. Role of periaxonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neurosci Lett. 1995;184:5-8.
6. Johansson A, Bennett G. Effect of methylprednisolone on pain in a nerve injury model. Reg Anesth. 1997;22:59-65.
7. Kingery W, Castellote JM, Maze M. Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Pain. 1999;80:555-566.
8. Takeda K, Sawamura S, Sekiyama H, Tamai H, Hanaoka K. Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. Anesthesiology. 2004;100:1249-1257.
9. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett. 2004;361:184-187.
10. Bennett GJ, Xie Y-K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1998;33:87-107.
11. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109-110.
12. Lewis EJ, Bishop J, Aspinall SJ. A simple inflammation model that distinguishes between the actions of anti-inflammatory and anti-rheumatic drugs. Inflamm Res. 1998;47:26-35.
13. Tal M, Bennett GJ. Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain. 1994;57:375-382.
14. Choi Y, Yoon YW, Na H, Kim SH, Chung JM. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain. 1994;59:369-376.
15. Munger BL, Bennett GJ, Kajander KC. The chronic constriction model of peripheral neuropathy. I. Axonal pathology in the sciatic nerve. Exp Neurol. 1992;118:204-214.
16. Wagner R, Myers RR. Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves. Neuroscience. 1996;73:625-629.
17. Cui JG, Holmin S, Mathiesen T, Meyerson BA, Linderoth B. Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy. Pain. 2000;88:239-248.
18. George A, Marziniak M, Schafers M, Toyka KV, Sommer C. Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain. 2000;88:267-275.
19. Woolf C, Bennett GJ, Doherty M, Dubner R, Kidd B, Koltzenburg M, et al. Towards a mechanism-based classification of pain? Pain. 1998;77:227-229.
20. Yates JM, Smith KG, Robinson PP. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004;111:261-269.
21. Minami M, Katayama T, Satoh M. Brain cytokines and chemokines: roles in ischemic injury and pain. J Pharmacol Sci. 2006;100:461-470.
22. Wagner R, Myers RR. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport. 1996;7:2897-2901.
23. Zelenka M, Schafers M, Sommer C. Intraneural injection of interleukin-1β and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain. Pain. 2005;116:257-263.
24. Sorkin LS, Xiao WH, Wagner R, Myers RR. Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience. 1997;81:255-262.
25. Schafers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003;23:3028-3038.
26. George A, Schmidt C, Weishaupt A, Toyka KV, Sommer C. Serial determination of tumor necrosis factor-alpha content in rat sciatic nerve after chronic constriction injury. Exp Neurol. 1999;160:124-132.
27. George A, Buehl A, Sommer C. Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineural tumor necrosis factor-alpha protein. Neurosci Lett. 2004;372:215-219.
28. Sommer C, Schafers M, Marziniak M, Toyka KV. Etanercept reduces hyperalgesia in experimental painful neuropathy. J Peripher Nerv Syst. 2001;6:67-72.
29. Sommer C, Lindenlaub T, Teuteberg P, Schafers M, Hartung T, Toyka KV. Anti-TNF-neutralizing antibodies reduce pain-related behaviors in two different mouse models of painful mononeuropathy. Brain Res. 2001;913:86-89.
30. Zuo Y, Perkins NM, Tracey DJ, Geczy CL. Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells. Pain. 2003;105:467-479.
31. Theodosiou M, Rush RA, Zhou XF, Hu D, Walker JS, Tracey DJ. Hyperalgesia due to nerve damage: role of nerve growth factor. Pain. 1999;81:245-255.
32. Huygen FJ, Ramdhani N, van Toorenenbergen A, Klein J, Zijlstra FJ. Mast cells are involved in inflammatory reactions during complex regional pain syndrome type 1. Immunol Lett. 2004;91:47-54.
33. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology. 2004;126:693-702.
34. Rutkowski MD, Pahl JL, Sweitzer S, van Rooijen N, DeLeo JA. Limited role of macrophages in generation of nerve injury-induced mechanical allodynia. Physiol Behav. 2000;71:225-235.
35. Shamash S, Reichert F, Rotshenker S. The cytokine network of Wallerian degeneration: tumor necrosis factor-alpha, interleukin-1-alpha, and interleukin-1-beta. J Neurosci. 2002;22:3052-3060.
36. Xie W, Liu X, Xuan H, Luo S, Zhao X, Zhou Z, et al. Effect of betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines. Neurosci Lett. 2006;393:255-259.
37. Wang S, Lim G, Yang L, Sung B, Mao J. Downregulation of spinal glutamate transporter EAACI following nerve injury is regulated by central glucocorticoid receptors in rats. Pain. 2006;120:78-85.
38. Wang S, Lim G, Zeng Q, Sung B, Yang L, Mao J. Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. J Neurosci. 2005;25:488-495.