Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats

Journal of Anesthesia

Volumn 25, Issue 6, 2011, Pages 942-945

  Kawano, Takashi ^a   Soga, Tomohiro ^b   Chi, Haidong ^a   Eguchi, Satoru ^c   Yamazaki, Fumimoto ^d   Kumagai, Naoko ^a   Yokoyama, Masataka ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d Department of Anesthesiology   (Japan)

Author keywords

Hyperalgesia; Neuropathic pain; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HYPERALGESIA; NEUROPATHIC PAIN; NONHUMAN; PATHOGENESIS; PERIPHERAL NERVE INJURY; RAT; STEROIDOGENESIS; TREATMENT OUTCOME;

ANESTHETICS; ANIMALS; BRAIN; HYPERALGESIA; NEURALGIA; NEUROTRANSMITTER AGENTS; PAIN; PERIPHERAL NERVE INJURIES; PREGNANOLONE; RATS; SPINAL CORD; SPINAL NERVES;

EID: 84355161737     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-011-1216-2     Document Type: Article

References (9)

1. AG Mensah-Nyagan JL Do-Rego D Beaujean V Luu-The G Pelletier H Vaudry 1999 Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system Pharmacol Rev 51 63 81 10049998 1:CAS:528:DyaK1MXitFWgurg%3D (Pubitemid 29113866)
2. SH Mellon LD Griffin 2002 Neurosteroids: biochemistry and clinical significance Trends Endocrinol Metab 13 35 43 11750861 10.1016/S1043-2760(01) 00503-3 1:CAS:528:DC%2BD3MXpt1anu7w%3D (Pubitemid 36734014)
3. SM Paul RH Purdy 1992 Neuroactive steroids FASEB J 6 2311 2322 1347506 1:CAS:528:DyaK38XhvVyisb4%3D
4. M Yoshimura S Nishi 1995 Primary afferent-evoked glycine- and GABA-mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro J Physiol 482 29 38 7730987 1:CAS:528:DyaK2MXjsVShsrw%3D
5. F di Michele D Lekieffre A Pasini G Bernardi J Benavides E Romeo 2000 Increased neurosteroids synthesis after brain and spinal cord injury in rats Neurosci Lett 284 65 68 10771163 10.1016/S0304-3940(00)00965-4 1:CAS:528:DC%2BD3cXisFGksLk%3D (Pubitemid 30193200)
6. C Patte-Mensah C Kibaly D Boudard V Schaeffer A Béglé S Saredi L Meyer AG Mensah-Nyagan 2006 Neurogenic pain and steroid synthesis in the spinal cord J Mol Neurosci 28 17 31 16632873 10.1385/JMN:28:1:17 1:CAS:528:DC%2BD28Xjs12htrs%3D (Pubitemid 43785966)
7. SH Kim JM Chung 1992 An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 355 363 1333581 10.1016/0304-3959(92)90041-9 1:STN:280:DyaK3s%2FoslShtw%3D%3D
8. Q Hogan D Sapunar K Modric-Jednacak JB McCallum 2004 Detection of neuropathic pain in a rat model of peripheral nerve injury Anesthesiology 101 476 487 15277932 10.1097/00000542-200408000-00030 (Pubitemid 38988505)
9. CA Frye LE Bayon NK Pursnani 1998 Purdy RH The neurosteroids, progesterone and 3α, 5α-THP, enhance sexual motivation, receptivity, and proceptivity in female rats Brain Res 808 72 83 9795145 10.1016/S0006-8993(98)00764-1 1:CAS:528:DyaK1cXms1Srtbk%3D (Pubitemid 29003202)