Antinociceptive properties of neurosteroids IV: Pilot study demonstrating the analgesic effects of alphadolone administered orally to humans

British Journal of Anaesthesia

Volumn 86, Issue 4, 2001, Pages 528-534

  Goodchild, C S ^a   Robinson, A ^a   Nadeson, R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Alphadolone; Analgesics non opioid; Pain; Post operative

Indexed keywords

ALFADOLONE; ALTHESIN; ANESTHETIC AGENT; LACTOSE; MORPHINE; NEUROSTEROID; PLACEBO; PROPOFOL;

ADULT; AGED; ANALGESIA; ANTINOCICEPTION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG USE; FEMALE; GENERAL ANESTHESIA; HUMAN; KNEE ARTHROPLASTY; MALE; NAUSEA; ORTHOPEDICS; PAIN ASSESSMENT; PASSIVE MOVEMENT; PATIENT CONTROLLED ANALGESIA; PATIENT SCHEDULING; PHYSIOTHERAPY; PILOT STUDY; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SEDATION; SIDE EFFECT; STANDARDIZATION; STATISTICS; TIME; VERBAL BEHAVIOR; VOMITING;

EID: 0035065192     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/86.4.528     Document Type: Article

References (47)

1. The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord
2. A receptors
3. A receptors
4. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: Evidence for multiple steroid recognition sites
5. B receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy
6. Benzodiazepine receptors in the human spinal cord: A detailed anatomical and pharmacological study
7. Regulation of flunitrazepam binding in the dorsal horn of the spinal cord by adrenalectomy and corticosteroids
8. Spinally mediated antinociception following intrathecal chlordiazepoxide - Further evidence for a benzodiazepine spinal analgesic effect
9. Reversal by naloxone of spinal antinociceptive effects of fentanyl, ketocyclazocine and midazolam
10. Correlates of anesthetic properties in isolated spinal cord: Cyclobutanes
11. A receptor function
12. Antinociceptive properties of neurosteroids. I: Spinally mediated antinociceptive effects of water-soluble aminosteroids
13. Antinociceptive properties of neurosteroids. II: Experiments with Saffan® and its components alphaxalone and alphadolone to reveal separation of anesthetic and antinociceptive effects and the involvement receptors
14. Antinociceptive properties of neurosteroids. III: Experiments with alphadolone given intravenously intraperitoneally and intragastrically
15. The anaesthetic effect of steroid hormones
16. Studies concerning the correlation between anesthetic potency, hormonal activity and chemical structure among steroid compounds
17. A receptor by steroids
18. Neuroactive steroids
19. A receptors
20. Neurosteroid modulation of native and recombinant GABAA receptors
21. A receptor function
22. Steroidal anaesthesia
23. Steroid anaesthetic agents
24. Dose-response relationships for infusions of Althesin or methohexitone
25. Intra-patient comparison of the kinetics of alphaxalone and alphadolone in man
26. A receptors
27. A receptor activity by the novel water-soluble aminosteroid Org 20599
28. Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity
29. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid (A) receptor
30. Effects of negative allosteric modulators of gamma-aminobutyric acid A receptors on complex behavioral processes in monkeys
31. The actions of endogenous and synthetic pregnane steroids on GABAA receptors
32. A receptors
33. Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled l-azabicyclo[2.2.2]oct-3-yl α-hydroxy-α-(l-iodo-l-propen-3-yl)-α-phenylacetate: A high-affinity ligand for the muscarinic receptor
34. Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity
35. A double blind study of Ganaxolone in acute treatment of migraine headaches with or without aura in premenopausal females
36. A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons
37. A receptor complex: Electrophysiological studies
38. Analgesic effects of intrathecally-administered 3 alpha-hydroxy-5 alpha-pregnan-20-one in a rat mechanical visceral pain model
39. Alterations in response to somatic pain associated with anaesthesia. Althesin (CT 1341)
40. Some aspects of the clinical pharmacology of Althesin
41. Influence of sub-narcotic dose of Althesin (CT 1341) on pain induced by two types of pain stimulus
42. The effects in man of infusions of Althesin with particular regard to the cardiovascular system
43. Gestational and ovarian sex steroid antinociception: Synergy between spinal kappa and δ opioid systems
44. 17-β-estradiol and progesterone modulate an intrinsic opioid analgesic system
45. 17 beta-estradiol and progesterone positively modulate spinal cord dynorphin: Relevance to the analgesia of pregnancy
46. A receptors