Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord

FASEB Journal

Volumn 22, Issue 1, 2008, Pages 93-104

  Kibaly, Cherkaouia ^a   Meyer, Laurence ^a   Patte Mensah, Christine ^a   Mensah Nyagan, Ayikoe G ^a  

^a Hopitaux Universitaires de Strasbourg   (France)

Author keywords

Biochemistry of steroidogenic enzymes; Cytochrome P450c17; HPLC; Neurosteroids; Real time PCR

Indexed keywords

ANDROGEN; CYTOCHROME P450C17; KETOCONAZOLE; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; PRASTERONE; TESTOSTERONE; CYTOCHROME P450; ENZYME INHIBITOR; MESSENGER RNA; PRIMER DNA;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE SYNTHESIS; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCIATIC NEUROPATHY; SPINAL CORD; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; NUCLEOTIDE SEQUENCE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEHYDROEPIANDROSTERONE; DNA PRIMERS; ENZYME INHIBITORS; GENE EXPRESSION; INJECTIONS, SPINAL; KETOCONAZOLE; MALE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD;

EID: 38049141503     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-8930com     Document Type: Article

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