Pharmacological enhancement of δ-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice

Pain

Volumn 152, Issue 6, 2011, Pages 1317-1326

  Bonin, Robert P ^a   Labrakakis, Charalampos ^b,c   Eng, David G ^d   Whissell, Paul D ^a   Koninck, Yves De ^b,c   Orser, Beverley A ^a,d,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Dorsal horn; GABA; Inhibition; Nociception; Sensitization

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FORMALDEHYDE; GABOXADOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; MALE; MOTOR COORDINATION; MOUSE; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NEUROPHARMACOLOGY; NEUROPHYSIOLOGY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TREATMENT RESPONSE; WHOLE CELL;

ACTION POTENTIALS; ANALGESICS; ANESTHETICS; ANIMALS; BICUCULLINE; DESOXYCORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FORMALDEHYDE; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HINDLIMB SUSPENSION; ISOXAZOLES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL INHIBITION; PAIN MEASUREMENT; PSYCHOMOTOR PERFORMANCE; RECEPTORS, GABA-A; SENSORY RECEPTOR CELLS; SPINAL CORD;

EID: 79956151011     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.02.011     Document Type: Article

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