-
1
-
-
67649827390
-
Intramembrane-cleaving proteases
-
PMID:19189971
-
Wolfe MS. Intramembrane-cleaving proteases. J Biol Chem 2009; 284: 13969-73; PMID:19189971; http://dx.doi.org/10.1074/jbc.R800039200
-
(2009)
J Biol Chem
, vol.284
, pp. 13969-13973
-
-
Wolfe, M.S.1
-
2
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-Secretase complex
-
DOI 10.1016/S0896-6273(03)00205-8
-
De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 2003; 38: 9-12; PMID:12691659; http://dx.doi.org/10.1016/S0896-6273(03)00205-8 (Pubitemid 36423348)
-
(2003)
Neuron
, vol.38
, Issue.1
, pp. 9-12
-
-
De Strooper, B.1
-
3
-
-
79959636033
-
The many substrates of presenilin/γ-secretase
-
PMID:21335653
-
Haapasalo A, Kovacs DM. The many substrates of presenilin/γ- secretase. J Alzheimers Dis 2011; 25:3-28; PMID:21335653
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 3-28
-
-
Haapasalo, A.1
Kovacs, D.M.2
-
4
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
DOI 10.1126/science.284.5415.770
-
Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770-6; PMID:10221902; http://dx.doi.org/10.1126/science.284.5415.770 (Pubitemid 29291335)
-
(1999)
Science
, vol.284
, Issue.5415
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
5
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
DOI 10.1038/nrm2009, PII NRM2009
-
Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006; 7:678-89; PMID:16921404; http://dx.doi.org/10.1038/nrm2009 (Pubitemid 44268213)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.9
, pp. 678-689
-
-
Bray, S.J.1
-
6
-
-
84880306937
-
The Notch signaling pathway as a mediator of tumor survival
-
PMID:23585460
-
Capaccione KM, Pine SR. The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis 2013; 34: 1420-30; PMID:23585460; http://dx.doi.org/10.1093/carcin/bgt127
-
(2013)
Carcinogenesis
, vol.34
, pp. 1420-1430
-
-
Capaccione, K.M.1
Pine, S.R.2
-
7
-
-
33747874155
-
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
-
DOI 10.1158/0008-5472.CAN-06-0858
-
Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, Eberhart CG. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006; 66: 7445-52; PMID:16885340; http://dx.doi.org/10. 1158/0008-5472.CAN-06-0858 (Pubitemid 44289197)
-
(2006)
Cancer Research
, vol.66
, Issue.15
, pp. 7445-7452
-
-
Fan, X.1
Matsui, W.2
Khaki, L.3
Stearns, D.4
Chun, J.5
Li, Y.-M.6
Eberhart, C.G.7
-
8
-
-
75349105363
-
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
-
PMID:19904829
-
Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J, et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010; 28: 5-16; PMID:19904829
-
(2010)
Stem Cells
, vol.28
, pp. 5-16
-
-
Fan, X.1
Khaki, L.2
Zhu, T.S.3
Soules, M.E.4
Talsma, C.E.5
Gul, N.6
Koh, C.7
Zhang, J.8
Li, Y.M.9
Maciaczyk, J.10
-
9
-
-
76549084826
-
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor
-
PMID:20068161
-
Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR, Bundred NJ, Clarke RB. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res 2010; 70: 709-18; PMID:20068161; http://dx.doi.org/10.1158/0008-5472.CAN-09-1681
-
(2010)
Cancer Res
, vol.70
, pp. 709-718
-
-
Harrison, H.1
Farnie, G.2
Howell, S.J.3
Rock, R.E.4
Stylianou, S.5
Brennan, K.R.6
Bundred, N.J.7
Clarke, R.B.8
-
10
-
-
77956623598
-
Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
-
PMID:20506127
-
Hovinga KE, Shimizu F, Wang R, Panagiotakos G, Van Der Heijden M, Moayedpardazi H, Correia AS, Soulet D, Major T, Menon J, et al. Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells 2010; 28: 1019-29; PMID:20506127; http://dx.doi.org/10.1002/stem.429
-
(2010)
Stem Cells
, vol.28
, pp. 1019-1029
-
-
Hovinga, K.E.1
Shimizu, F.2
Wang, R.3
Panagiotakos, G.4
Van Der Heijden, M.5
Moayedpardazi, H.6
Correia, A.S.7
Soulet, D.8
Major, T.9
Menon, J.10
-
11
-
-
76749112922
-
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
-
PMID:20145124
-
Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res 2010; 70: 1469-78; PMID:20145124; http://dx.doi.org/10. 1158/0008-5472.CAN-09-2557
-
(2010)
Cancer Res
, vol.70
, pp. 1469-1478
-
-
Sikandar, S.S.1
Pate, K.T.2
Anderson, S.3
Dizon, D.4
Edwards, R.A.5
Waterman, M.L.6
Lipkin, S.M.7
-
12
-
-
80051640151
-
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL
-
PMID:21670468
-
Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood 2011; 118: 1579-90; PMID:21670468; http://dx.doi.org/10. 1182/blood-2010-08-300343
-
(2011)
Blood
, vol.118
, pp. 1579-1590
-
-
Tatarek, J.1
Cullion, K.2
Ashworth, T.3
Gerstein, R.4
Aster, J.C.5
Kelliher, M.A.6
-
13
-
-
80052795862
-
Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells
-
PMID:21788346
-
Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, He X, Hervey-Jumper SL, Heth JA, Muraszko KM, et al. Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res 2011; 71: 6061-72; PMID:21788346; http://dx.doi.org/10.1158/0008-5472.CAN-10-4269
-
(2011)
Cancer Res
, vol.71
, pp. 6061-6072
-
-
Zhu, T.S.1
Costello, M.A.2
Talsma, C.E.3
Flack, C.G.4
Crowley, J.G.5
Hamm, L.L.6
He, X.7
Hervey-Jumper, S.L.8
Heth, J.A.9
Muraszko, K.M.10
-
14
-
-
84861111256
-
The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: The role of the endothelial network
-
PMID:22251985
-
Gürsel DB, Berry N, Boockvar JA. The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network. Neurosurgery 2012; 70:N19-21; PMID:22251985; http://dx.doi.org/10.1227/01. neu.0000410937.38828.6f
-
(2012)
Neurosurgery
, vol.70
-
-
Gürsel, D.B.1
Berry, N.2
Boockvar, J.A.3
-
15
-
-
84877093512
-
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma
-
PMID:23444212
-
Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res 2013; 19: 1972-80; PMID:23444212; http://dx.doi.org/10.1158/1078- 0432.CCR-12-0370
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1972-1980
-
-
Hassan, K.A.1
Wang, L.2
Korkaya, H.3
Chen, G.4
Maillard, I.5
Beer, D.G.6
Kalemkerian, G.P.7
Wicha, M.S.8
-
16
-
-
84873728505
-
Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
-
PMID:23375636
-
Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell 2013; 23: 171-85; PMID:23375636; http://dx.doi.org/10.1016/j.ccr.2012.12.021
-
(2013)
Cancer Cell
, vol.23
, pp. 171-185
-
-
Lu, J.1
Ye, X.2
Fan, F.3
Xia, L.4
Bhattacharya, R.5
Bellister, S.6
Tozzi, F.7
Sceusi, E.8
Zhou, Y.9
Tachibana, I.10
-
17
-
-
77954351997
-
Synthetic lethality through combined Notchepidermal growth factor receptor pathway inhibition in basal-like breast cancer
-
PMID:20570903
-
Dong Y, Li A, Wang J, Weber JD, Michel LS. Synthetic lethality through combined Notchepidermal growth factor receptor pathway inhibition in basal-like breast cancer. Cancer Res 2010; 70: 5465-74; PMID:20570903; http://dx.doi.org/ 10.1158/0008-5472.CAN-10-0173
-
(2010)
Cancer Res
, vol.70
, pp. 5465-5474
-
-
Dong, Y.1
Li, A.2
Wang, J.3
Weber, J.D.4
Michel, L.S.5
-
18
-
-
77956294442
-
Gammasecretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence
-
PMID:20736377
-
Gilbert CA, Daou MC, Moser RP, Ross AH. Gammasecretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res 2010; 70: 6870-9; PMID:20736377; http://dx.doi.org/10.1158/0008-5472.CAN-10-1378
-
(2010)
Cancer Res
, vol.70
, pp. 6870-6879
-
-
Gilbert, C.A.1
Daou, M.C.2
Moser, R.P.3
Ross, A.H.4
-
19
-
-
84860374357
-
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
-
PMID:22351932
-
Cook N, Frese KK, Bapiro TE, Jacobetz MA, Gopinathan A, Miller JL, Rao SS, Demuth T, Howat WJ, Jodrell DI, et al. Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med 2012; 209:437-44; PMID:22351932; http://dx.doi.org/10.1084/jem.20111923
-
(2012)
J Exp Med
, vol.209
, pp. 437-444
-
-
Cook, N.1
Frese, K.K.2
Bapiro, T.E.3
Jacobetz, M.A.4
Gopinathan, A.5
Miller, J.L.6
Rao, S.S.7
Demuth, T.8
Howat, W.J.9
Jodrell, D.I.10
-
20
-
-
84866021276
-
Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch-and hedgehog-dependent tumor-initiating cells
-
PMID:22975379
-
Domingo-Domenech J, Vidal SJ, Rodriguez-Bravo V, Castillo-Martin M, Quinn SA, Rodriguez-Barrueco R, Bonal DM, Charytonowicz E, Gladoun N, de la Iglesia-Vicente J, et al. Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch-and hedgehog-dependent tumor-initiating cells. Cancer Cell 2012; 22:373-88; PMID:22975379; http://dx.doi.org/10.1016/j.ccr.2012.07.016
-
(2012)
Cancer Cell
, vol.22
, pp. 373-388
-
-
Domingo-Domenech, J.1
Vidal, S.J.2
Rodriguez-Bravo, V.3
Castillo-Martin, M.4
Quinn, S.A.5
Rodriguez-Barrueco, R.6
Bonal, D.M.7
Charytonowicz, E.8
Gladoun, N.9
De La Iglesia-Vicente, J.10
-
21
-
-
84867919330
-
Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy
-
PMID:23019585
-
McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, et al. Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc Natl Acad Sci U S A 2012; 109:E2939-48; PMID:23019585; http://dx.doi.org/10.1073/pnas. 1206400109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
McAuliffe, S.M.1
Morgan, S.L.2
Wyant, G.A.3
Tran, L.T.4
Muto, K.W.5
Chen, Y.S.6
Chin, K.T.7
Partridge, J.C.8
Poole, B.B.9
Cheng, K.H.10
-
22
-
-
84872005140
-
Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling
-
PMID:23135908
-
Liu YP, Yang CJ, Huang MS, Yeh CT, Wu AT, Lee YC, Lai TC, Lee CH, Hsiao YW, Lu J, et al. Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. Cancer Res 2013; 73: 406-16; PMID:23135908; http://dx.doi.org/10.1158/0008-5472.CAN-12-1733
-
(2013)
Cancer Res
, vol.73
, pp. 406-416
-
-
Liu, Y.P.1
Yang, C.J.2
Huang, M.S.3
Yeh, C.T.4
Wu, A.T.5
Lee, Y.C.6
Lai, T.C.7
Lee, C.H.8
Hsiao, Y.W.9
Lu, J.10
-
23
-
-
84875168492
-
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
-
PMID:23340294
-
Schott AF, Landis MD, Dontu G, Griffith KA, Layman RM, Krop I, Paskett LA, Wong H, Dobrolecki LE, Lewis MT, et al. Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res 2013; 19: 1512-24; PMID:23340294; http://dx.doi.org/10.1158/1078-0432.CCR- 11-3326
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1512-1524
-
-
Schott, A.F.1
Landis, M.D.2
Dontu, G.3
Griffith, K.A.4
Layman, R.M.5
Krop, I.6
Paskett, L.A.7
Wong, H.8
Dobrolecki, L.E.9
Lewis, M.T.10
-
24
-
-
84878459227
-
Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
-
PMID:23402814
-
Yabuuchi S, Pai SG, Campbell NR, de Wilde RF, De Oliveira E, Korangath P, Streppel MM, Rasheed ZA, Hidalgo M, Maitra A, et al. Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer. Cancer Lett 2013; 335: 41-51; PMID:23402814; http://dx.doi.org/10.1016/j.canlet.2013.01.054
-
(2013)
Cancer Lett
, vol.335
, pp. 41-51
-
-
Yabuuchi, S.1
Pai, S.G.2
Campbell, N.R.3
De Wilde, R.F.4
De Oliveira, E.5
Korangath, P.6
Streppel, M.M.7
Rasheed, Z.A.8
Hidalgo, M.9
Maitra, A.10
-
25
-
-
84875101176
-
Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models
-
PMID:23408105
-
Zhang CC, Yan Z, Zong Q, Fang DD, Painter C, Zhang Q, Chen E, Lira ME, John-Baptiste A, Christensen JG. Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models. Stem Cells Transl Med 2013; 2:233-42; PMID:23408105; http://dx.doi.org/10.5966/sctm.2012-0096
-
(2013)
Stem Cells Transl Med
, vol.2
, pp. 233-242
-
-
Zhang, C.C.1
Yan, Z.2
Zong, Q.3
Fang, D.D.4
Painter, C.5
Zhang, Q.6
Chen, E.7
Lira, M.E.8
John-Baptiste, A.9
Christensen, J.G.10
-
26
-
-
37349088615
-
Secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells
-
DOI 10.1053/j.gastro.2007.10.008, PII S0016508507018070
-
Akiyoshi T, Nakamura M, Yanai K, Nagai S, Wada J, Koga K, Nakashima H, Sato N, Tanaka M, Katano M. Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells. Gastroenterology 2008; 134: 131-44; PMID:18166351; http://dx.doi.org/10.1053/j.gastro.2007.10.008 (Pubitemid 350309314)
-
(2008)
Gastroenterology
, vol.134
, Issue.1
, pp. 131-144
-
-
Akiyoshi, T.1
Nakamura, M.2
Yanai, K.3
Nagai, S.4
Wada, J.5
Koga, K.6
Nakashima, H.7
Sato, N.8
Tanaka, M.9
Katano, M.10
-
27
-
-
78751478264
-
Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes
-
PMID:21187481
-
Tasaka T, Akiyoshi T, Yamaguchi K, Tanaka M, Onishi H, Katano M. Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes. Anticancer Res 2010; 30: 4999-5010; PMID:21187481
-
(2010)
Anticancer Res
, vol.30
, pp. 4999-5010
-
-
Tasaka, T.1
Akiyoshi, T.2
Yamaguchi, K.3
Tanaka, M.4
Onishi, H.5
Katano, M.6
-
28
-
-
79959684880
-
Mitosis as an anti-cancer target
-
PMID:21339734
-
Janssen A, Medema RH. Mitosis as an anti-cancer target. Oncogene 2011; 30: 2799-809; PMID:21339734; http://dx.doi.org/10.1038/onc.2011.30
-
(2011)
Oncogene
, vol.30
, pp. 2799-2809
-
-
Janssen, A.1
Medema, R.H.2
-
29
-
-
34247333444
-
The spindle-assembly checkpoint in space and time
-
DOI 10.1038/nrm2163, PII NRM2163
-
Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007; 8: 379-93; PMID:17426725; http://dx.doi.org/ 10.1038/nrm2163 (Pubitemid 46643240)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.5
, pp. 379-393
-
-
Musacchio, A.1
Salmon, E.D.2
-
30
-
-
0026643589
-
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis
-
PMID:1506423
-
Jordan MA, Thrower D, Wilson L. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. J Cell Sci 1992; 102: 401-16; PMID:1506423
-
(1992)
J Cell Sci
, vol.102
, pp. 401-416
-
-
Jordan, M.A.1
Thrower, D.2
Wilson, L.3
-
31
-
-
0028171096
-
Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells
-
PMID:7962060
-
Andreassen PR, Margolis RL. Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells. J Cell Biol 1994; 127:789-802; PMID:7962060; http://dx.doi.org/10.1083/jcb.127.3.789
-
(1994)
J Cell Biol
, vol.127
, pp. 789-802
-
-
Andreassen, P.R.1
Margolis, R.L.2
-
32
-
-
0035836655
-
Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochoretension checkpoints
-
DOI 10.1073/pnas.081076898
-
Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc Natl Acad Sci U S A 2001; 98: 4492-7; PMID:11274370; http://dx.doi.org/10.1073/pnas.081076898 (Pubitemid 32295004)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.8
, pp. 4492-4497
-
-
Skoufias, D.A.1
Andreassen, P.R.2
Lacroix, F.B.3
Wilson, L.4
Margolis, R.L.5
-
33
-
-
0025824979
-
Mechanism of inhibition of cell proliferation by Vinca alkaloids
-
PMID:2009540
-
Jordan MA, Thrower D, Wilson L. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res 1991; 51: 2212-22; PMID:2009540
-
(1991)
Cancer Res
, vol.51
, pp. 2212-2222
-
-
Jordan, M.A.1
Thrower, D.2
Wilson, L.3
-
34
-
-
9144242386
-
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability
-
PMID:14706340
-
Shin HJ, Baek KH, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, et al. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 2003; 4: 483-97; PMID:14706340; http://dx.doi.org/10.1016/S1535-6108(03)00302-7
-
(2003)
Cancer Cell
, vol.4
, pp. 483-497
-
-
Shin, H.J.1
Baek, K.H.2
Jeon, A.H.3
Park, M.T.4
Lee, S.J.5
Kang, C.M.6
Lee, H.S.7
Yoo, S.H.8
Chung, D.H.9
Sung, Y.C.10
-
35
-
-
4444247276
-
Analysis of the spindle-assembly checkpoint in HeLa cells
-
PMID:15220532
-
Andreassen PR, Skoufias DA, Margolis RL. Analysis of the spindle-assembly checkpoint in HeLa cells. Methods Mol Biol 2004; 281: 213-25; PMID:15220532
-
(2004)
Methods Mol Biol
, vol.281
, pp. 213-225
-
-
Andreassen, P.R.1
Skoufias, D.A.2
Margolis, R.L.3
-
36
-
-
0034057320
-
Apoptosis in cancer
-
Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000; 21: 485-95; PMID:10688869; http://dx.doi.org/10.1093/carcin/21.3.485 (Pubitemid 30137934)
-
(2000)
Carcinogenesis
, vol.21
, Issue.3
, pp. 485-495
-
-
Lowe, S.W.1
Lin, A.W.2
-
37
-
-
13444301186
-
Molecular determinants of NOTCH4 transcription in vascular endothelium
-
DOI 10.1128/MCB.25.4.1458-1474.2005
-
Wu J, Iwata F, Grass JA, Osborne CS, Elnitski L, Fraser P, Ohneda O, Yamamoto M, Bresnick EH. Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol 2005; 25: 1458-74; PMID:15684396; http://dx.doi.org/10.1128/MCB.25.4.1458-1474.2005 (Pubitemid 40204922)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.4
, pp. 1458-1474
-
-
Wu, J.1
Iwata, F.2
Grass, J.A.3
Osborne, C.S.4
Elnitski, L.5
Fraser, P.6
Ohneda, O.7
Yamamoto, M.8
Bresnick, E.H.9
-
38
-
-
84881405994
-
Crosstalk between PKCα and Notch-4 in endocrineresistant breast cancer cells
-
PMID:23917222
-
Yun J, Pannuti A, Espinoza I, Zhu H, Hicks C, Zhu X, Caskey M, Rizzo P, D'Souza G, Backus K, et al. Crosstalk between PKCα and Notch-4 in endocrineresistant breast cancer cells. Oncogenesis 2013; 2:e60; PMID:23917222; http://dx.doi.org/10.1038/oncsis.2013.26
-
(2013)
Oncogenesis
, vol.2
-
-
Yun, J.1
Pannuti, A.2
Espinoza, I.3
Zhu, H.4
Hicks, C.5
Zhu, X.6
Caskey, M.7
Rizzo, P.8
D'Souza, G.9
Backus, K.10
-
39
-
-
84874556358
-
Notch activation inhibits AML growth and survival: A potential therapeutic approach
-
PMID:23359069
-
Kannan S, Sutphin RM, Hall MG, Golfman LS, Fang W, Nolo RM, Akers LJ, Hammitt RA, McMurray JS, Kornblau SM, et al. Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med 2013; 210:321-37; PMID:23359069; http://dx.doi.org/10.1084/jem.20121527
-
(2013)
J Exp Med
, vol.210
, pp. 321-337
-
-
Kannan, S.1
Sutphin, R.M.2
Hall, M.G.3
Golfman, L.S.4
Fang, W.5
Nolo, R.M.6
Akers, L.J.7
Hammitt, R.A.8
McMurray, J.S.9
Kornblau, S.M.10
-
40
-
-
10944269112
-
Centrosomal amplification and spindle multipolarity in cancer cells
-
DOI 10.1016/j.semcancer.2004.09.003, PII S1044579X0400080X
-
Saunders W. Centrosomal amplification and spindle multipolarity in cancer cells. Semin Cancer Biol 2005; 15: 25-32; PMID:15613285; http://dx.doi.org/10. 1016/j.semcancer.2004.09.003 (Pubitemid 40018525)
-
(2005)
Seminars in Cancer Biology
, vol.15
, Issue.1
, pp. 25-32
-
-
Saunders, W.1
-
41
-
-
20444407162
-
Centrosome control of the cell cycle
-
DOI 10.1016/j.tcb.2005.04.008, PII S0962892405001121
-
Doxsey S, Zimmerman W, Mikule K. Centrosome control of the cell cycle. Trends Cell Biol 2005; 15: 303-11; PMID:15953548; http://dx.doi.org/10.1016/j. tcb.2005.04.008 (Pubitemid 40805326)
-
(2005)
Trends in Cell Biology
, vol.15
, Issue.6
, pp. 303-311
-
-
Doxsey, S.1
Zimmerman, W.2
Mikule, K.3
-
42
-
-
70350771277
-
Centrioles, centrosomes, and cilia in health and disease
-
PMID:19914163
-
Nigg EA, Raff JW. Centrioles, centrosomes, and cilia in health and disease. Cell 2009; 139:663-78; PMID:19914163; http://dx.doi.org/10.1016/j.cell. 2009.10.036
-
(2009)
Cell
, vol.139
, pp. 663-678
-
-
Nigg, E.A.1
Raff, J.W.2
-
43
-
-
67649654451
-
Centrosome function in cancer: Guilty or innocent?
-
PMID:19570677
-
Zyss D, Gergely F. Centrosome function in cancer: guilty or innocent? Trends Cell Biol 2009; 19:334-46; PMID:19570677; http://dx.doi.org/10.1016/j. tcb.2009.04.001
-
(2009)
Trends Cell Biol
, vol.19
, pp. 334-346
-
-
Zyss, D.1
Gergely, F.2
-
44
-
-
33751579138
-
Origins and consequences of centrosome aberrations in human cancers
-
DOI 10.1002/ijc.22245
-
Nigg EA. Origins and consequences of centrosome aberrations in human cancers. Int J Cancer 2006; 119: 2717-23; PMID:17016823; http://dx.doi.org/10. 1002/ijc.22245 (Pubitemid 44846221)
-
(2006)
International Journal of Cancer
, vol.119
, Issue.12
, pp. 2717-2723
-
-
Nigg, E.A.1
-
45
-
-
36448987217
-
Oncogenes and tumour suppressors take on centrosomes
-
DOI 10.1038/nrc2249, PII NRC2249
-
Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007; 7:911-24; PMID:18004399; http://dx.doi.org/10.1038/nrc2249 (Pubitemid 350165854)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.12
, pp. 911-924
-
-
Fukasawa, K.1
-
46
-
-
80052153162
-
Centrosome clustering and chromosomal (in)stability: A matter of life and death
-
PMID:21646054
-
Krämer A, Maier B, Bartek J. Centrosome clustering and chromosomal (in)stability: a matter of life and death. Mol Oncol 2011; 5: 324-35; PMID:21646054; http://dx.doi.org/10.1016/j.molonc.2011.05.003
-
(2011)
Mol Oncol
, vol.5
, pp. 324-335
-
-
Krämer, A.1
Maier, B.2
Bartek, J.3
-
47
-
-
77955615631
-
Proteins required for centrosome clustering in cancer cells
-
PMID:20505215
-
Leber B, Maier B, Fuchs F, Chi J, Riffel P, Anderhub S, Wagner L, Ho AD, Salisbury JL, Boutros M, et al. Proteins required for centrosome clustering in cancer cells. Sci Transl Med 2010; 2:33ra38; PMID:20505215; http://dx.doi.org/ 10.1126/scitranslmed.3000915
-
(2010)
Sci Transl Med
, vol.2
-
-
Leber, B.1
Maier, B.2
Fuchs, F.3
Chi, J.4
Riffel, P.5
Anderhub, S.6
Wagner, L.7
Ho, A.D.8
Salisbury, J.L.9
Boutros, M.10
-
48
-
-
67349230854
-
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity
-
PMID:19427217
-
Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, et al. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol 2009; 19: 816-26; PMID:19427217; http://dx.doi.org/10.1016/j.cub.2009.04.033
-
(2009)
Curr Biol
, vol.19
, pp. 816-826
-
-
Lawo, S.1
Bashkurov, M.2
Mullin, M.3
Ferreria, M.G.4
Kittler, R.5
Habermann, B.6
Tagliaferro, A.7
Poser, I.8
Hutchins, J.R.9
Hegemann, B.10
-
49
-
-
50049085789
-
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
-
PMID:18662975
-
Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev 2008; 22:2189-203; PMID:18662975; http://dx.doi.org/10. 1101/gad.1700908
-
(2008)
Genes Dev
, vol.22
, pp. 2189-2203
-
-
Kwon, M.1
Godinho, S.A.2
Chandhok, N.S.3
Ganem, N.J.4
Azioune, A.5
Thery, M.6
Pellman, D.7
-
50
-
-
33644518971
-
Induction of centrosome amplification during arsenite-induced mitotic arrest in CGL-2 cells
-
PMID:16489010
-
Yih LH, Tseng YY, Wu YC, Lee TC. Induction of centrosome amplification during arsenite-induced mitotic arrest in CGL-2 cells. Cancer Res 2006; 66: 2098-106; PMID:16489010; http://dx.doi.org/10.1158/0008-5472.CAN-05-2308
-
(2006)
Cancer Res
, vol.66
, pp. 2098-2106
-
-
Yih, L.H.1
Tseng, Y.Y.2
Wu, Y.C.3
Lee, T.C.4
-
51
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
DOI 10.1038/34910
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998; 391: 387-90; PMID:9450754; http://dx.doi.org/10.1038/34910 (Pubitemid 28093512)
-
(1998)
Nature
, vol.391
, Issue.6665
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
52
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
PMID:10206644
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999; 398: 513-7; PMID:10206644; http://dx.doi.org/10.1038/19077
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
53
-
-
0033780472
-
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
-
PMID:10878808
-
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol 2000; 2: 428-34; PMID:10878808; http://dx.doi.org/10.1038/35017062
-
(2000)
Nat Cell Biol
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.Y.6
Rahmati, T.7
Xia, W.8
Selkoe, D.J.9
Wolfe, M.S.10
-
54
-
-
0034621824
-
Photoactivated γ;-secretase inhibitors directed to the active site covalently label presenilin 1
-
DOI 10.1038/35015085
-
Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, et al. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 2000; 405: 689-94; PMID:10864326; http://dx.doi.org/10.1038/35015085 (Pubitemid 30428655)
-
(2000)
Nature
, vol.405
, Issue.6787
, pp. 689-694
-
-
Li, Y.-M.1
Xu, M.2
Lai, M.-T.3
Huang, Q.4
Castro, J.L.5
DiMuzlo-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelli, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.-P.15
Yin, K.-C.16
Shafer, J.A.17
Gardell, S.J.18
-
55
-
-
0030761059
-
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
-
DOI 10.1016/S0092-8674(00)80356-6
-
Li J, Xu M, Zhou H, Ma J, Potter H. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 1997; 90: 917-27; PMID:9298903; http://dx.doi.org/10.1016/ S0092-8674(00)80356-6 (Pubitemid 27381630)
-
(1997)
Cell
, vol.90
, Issue.5
, pp. 917-927
-
-
Li, J.1
Xu, M.2
Zhou, H.3
Ma, J.4
Potter, H.5
-
56
-
-
34250304714
-
Amyloid precursor protein and presenilin1 interact with the adaptor GRB2 and modulate ERK1,2 signaling
-
DOI 10.1074/jbc.M610146200
-
Nizzari M, Venezia V, Repetto E, Caorsi V, Magrassi R, Gagliani MC, Carlo P, Florio T, Schettini G, Tacchetti C, et al. Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1, 2 signaling. J Biol Chem 2007; 282: 13833-44; PMID:17314098; http://dx.doi.org/10.1074/jbc. M610146200 (Pubitemid 47100564)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.18
, pp. 13833-13844
-
-
Nizzari, M.1
Venezia, V.2
Repetto, E.3
Caorsi, V.4
Magrassi, R.5
Gagliani, M.C.6
Carlo, P.7
Florio, T.8
Schettini, G.9
Tacchetti, C.10
Russo, T.11
Diaspro, A.12
Russo, C.13
-
57
-
-
81555234239
-
Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes
-
PMID:22112898
-
Judge M, Hornbeck L, Potter H, Padmanabhan J. Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes. Mol Neurodegener 2011; 6:80; PMID:22112898; http://dx.doi.org/10.1186/1750-1326-6-80
-
(2011)
Mol Neurodegener
, vol.6
, pp. 80
-
-
Judge, M.1
Hornbeck, L.2
Potter, H.3
Padmanabhan, J.4
-
58
-
-
38949204058
-
Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy
-
DOI 10.1016/j.neurobiolaging.2006.10.027, PII S0197458006003988
-
Boeras DI, Granic A, Padmanabhan J, Crespo NC, Rojiani AM, Potter H. Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiol Aging 2008; 29: 319-28; PMID:17169464; http://dx.doi.org/10.1016/j. neurobiolaging.2006.10.027 (Pubitemid 351215587)
-
(2008)
Neurobiology of Aging
, vol.29
, Issue.3
, pp. 319-328
-
-
Boeras, D.I.1
Granic, A.2
Padmanabhan, J.3
Crespo, N.C.4
Rojiani, A.M.5
Potter, H.6
|