메뉴 건너뛰기




Volumn 4, Issue DEC, 2013, Pages

A replicative self-renewal model for long-lived plasma cells: Questioning irreversible cell cycle exit

Author keywords

Cell cycle; Gene expression; Lifespan; Monoclonal gammopathy; Myeloma; Plasma cell; Quiescence; Self renewal

Indexed keywords


EID: 84892164900     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00460     Document Type: Article
Times cited : (28)

References (136)
  • 1
    • 0038336729 scopus 로고    scopus 로고
    • Cell-cycle control of plasma cell differentiation and tumorigenesis
    • doi:10.1034/j.1600-065X.2003.00065.x
    • Chen-Kiang S. Cell-cycle control of plasma cell differentiation and tumorigenesis. Immunol Rev (2003) 194:39-47. doi:10.1034/j.1600-065X.2003.00065.x
    • (2003) Immunol Rev , vol.194 , pp. 39-47
    • Chen-Kiang, S.1
  • 2
    • 77953742950 scopus 로고    scopus 로고
    • Mechanisms that determine plasma cell lifespan and the duration of humoral immunity
    • doi:10.1111/j.1600-065X.2010.00912.x
    • Amanna IJ, Slifka MK. Mechanisms that determine plasma cell lifespan and the duration of humoral immunity. Immunol Rev (2010) 236:125-38. doi:10.1111/j.1600-065X.2010.00912.x
    • (2010) Immunol Rev , vol.236 , pp. 125-138
    • Amanna, I.J.1    Slifka, M.K.2
  • 5
    • 84884252950 scopus 로고    scopus 로고
    • Plasma cell homeostasis: the effects of chronic antigen stimulation and inflammation
    • doi:10.4049/jimmunol.1301163
    • Slocombe T, Brown S, Miles K, Gray M, Barr TA, Gray D. Plasma cell homeostasis: the effects of chronic antigen stimulation and inflammation. J Immunol (2013) 191:3128-38. doi:10.4049/jimmunol.1301163
    • (2013) J Immunol , vol.191 , pp. 3128-3138
    • Slocombe, T.1    Brown, S.2    Miles, K.3    Gray, M.4    Barr, T.A.5    Gray, D.6
  • 6
    • 0001112126 scopus 로고
    • An autoradiographic study of plasma cell and lymphocyte survival in rat popliteal lymph nodes
    • Miller JJ III. An autoradiographic study of plasma cell and lymphocyte survival in rat popliteal lymph nodes. J Immunol (1964) 92:673-81.
    • (1964) J Immunol , vol.92 , pp. 673-681
    • Miller I.I.I, J.J.1
  • 7
    • 0032033127 scopus 로고    scopus 로고
    • Humoral immunity due to long-lived plasma cells
    • doi:10.1016/S1074-7613(00)80541-5
    • Slifka MK, Antia R, Whitmire JK, Ahmed R. Humoral immunity due to long-lived plasma cells. Immunity (1998) 8:363-72. doi:10.1016/S1074-7613(00)80541-5
    • (1998) Immunity , vol.8 , pp. 363-372
    • Slifka, M.K.1    Antia, R.2    Whitmire, J.K.3    Ahmed, R.4
  • 8
    • 1842405362 scopus 로고    scopus 로고
    • Lifetime of plasma cells in the bone marrow
    • doi:10.1038/40540
    • Manz RA, Thiel A, Radbruch A. Lifetime of plasma cells in the bone marrow. Nature (1997) 388:133-4. doi:10.1038/40540
    • (1997) Nature , vol.388 , pp. 133-134
    • Manz, R.A.1    Thiel, A.2    Radbruch, A.3
  • 9
    • 33845949142 scopus 로고    scopus 로고
    • Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span
    • Gatto D, Martin SW, Bessa J, Pellicioli E, Saudan P, Hinton HJ, et al. Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span. J Immunol (2007) 178:67-76.
    • (2007) J Immunol , vol.178 , pp. 67-76
    • Gatto, D.1    Martin, S.W.2    Bessa, J.3    Pellicioli, E.4    Saudan, P.5    Hinton, H.J.6
  • 10
    • 79960372865 scopus 로고    scopus 로고
    • Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells
    • doi:10.1084/jem.20110040
    • Rozanski CH, Arens R, Carlson LM, Nair J, Boise LH, Chanan-Khan AA, et al. Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells. J Exp Med (2011) 208(7):1435-46. doi:10.1084/jem.20110040
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1435-1446
    • Rozanski, C.H.1    Arens, R.2    Carlson, L.M.3    Nair, J.4    Boise, L.H.5    Chanan-Khan, A.A.6
  • 11
    • 0022975140 scopus 로고
    • Distinct short-lived and long-lived antibody-producing cell populations
    • doi:10.1002/eji.1830161018
    • Ho F, Lortan JE, Maclennan IC, Khan M. Distinct short-lived and long-lived antibody-producing cell populations. Eur J Immunol (1986) 16:1297-301. doi:10.1002/eji.1830161018
    • (1986) Eur J Immunol , vol.16 , pp. 1297-1301
    • Ho, F.1    Lortan, J.E.2    Maclennan, I.C.3    Khan, M.4
  • 12
    • 0032238124 scopus 로고    scopus 로고
    • B cell responses and immune memory
    • Slifka MK, Ahmed R. B cell responses and immune memory. Dev Biol Stand (1998) 95:105-15.
    • (1998) Dev Biol Stand , vol.95 , pp. 105-115
    • Slifka, M.K.1    Ahmed, R.2
  • 13
    • 35848969753 scopus 로고    scopus 로고
    • Duration of humoral immunity to common viral and vaccine antigens
    • doi:10.1056/NEJMoa066092
    • Amanna IJ, Carlson NE, Slifka MK. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med (2007) 357:1903-15. doi:10.1056/NEJMoa066092
    • (2007) N Engl J Med , vol.357 , pp. 1903-1915
    • Amanna, I.J.1    Carlson, N.E.2    Slifka, M.K.3
  • 14
    • 84871128722 scopus 로고    scopus 로고
    • In vitro generation of long-lived human plasma cells
    • doi:10.4049/jimmunol.1103720
    • Cocco M, Stephenson S, Care MA, Newton D, Barnes NA, Davison A, et al. In vitro generation of long-lived human plasma cells. J Immunol (2012) 189(12):5773-85. doi:10.4049/jimmunol.1103720
    • (2012) J Immunol , vol.189 , Issue.12 , pp. 5773-5785
    • Cocco, M.1    Stephenson, S.2    Care, M.A.3    Newton, D.4    Barnes, N.A.5    Davison, A.6
  • 15
    • 18844383961 scopus 로고    scopus 로고
    • p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
    • Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev (2005) 19:1175-87.
    • (2005) Genes Dev , vol.19 , pp. 1175-1187
    • Engel, F.B.1    Schebesta, M.2    Duong, M.T.3    Lu, G.4    Ren, S.5    Madwed, J.B.6
  • 17
    • 84055199890 scopus 로고    scopus 로고
    • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
    • doi:10.1172/JCI59261
    • Malato Y, Naqvi S, Schurmann N, Ng R, Wang B, Zape J, et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest (2011) 121:4850-60. doi:10.1172/JCI59261
    • (2011) J Clin Invest , vol.121 , pp. 4850-4860
    • Malato, Y.1    Naqvi, S.2    Schurmann, N.3    Ng, R.4    Wang, B.5    Zape, J.6
  • 18
    • 84857316265 scopus 로고    scopus 로고
    • A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo
    • doi:10.1016/j.neuron.2011.11.031
    • Napoli I, Noon LA, Ribeiro S, Kerai AP, Parrinello S, Rosenberg LH, et al. A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo. Neuron (2012) 73:729-42. doi:10.1016/j.neuron.2011.11.031
    • (2012) Neuron , vol.73 , pp. 729-742
    • Napoli, I.1    Noon, L.A.2    Ribeiro, S.3    Kerai, A.P.4    Parrinello, S.5    Rosenberg, L.H.6
  • 19
    • 84872611623 scopus 로고    scopus 로고
    • Mammalian heart renewal by pre-existing cardiomyocytes
    • doi:10.1038/nature11682
    • Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature (2013) 493:433-6. doi:10.1038/nature11682
    • (2013) Nature , vol.493 , pp. 433-436
    • Senyo, S.E.1    Steinhauser, M.L.2    Pizzimenti, C.L.3    Yang, V.K.4    Cai, L.5    Wang, M.6
  • 20
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • doi:10.1038/nn2014
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci (2007) 10:1538-43. doi:10.1038/nn2014
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 21
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • doi:10.1016/j.immuni.2013.04.004
    • Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 38:792-804. doi:10.1016/j.immuni.2013.04.004
    • (2013) Immunity , vol.38 , pp. 792-804
    • Hashimoto, D.1    Chow, A.2    Noizat, C.3    Teo, P.4    Beasley, M.B.5    Leboeuf, M.6
  • 22
    • 84888063933 scopus 로고    scopus 로고
    • Beyond stem cells: self-renewal of differentiated macrophages
    • doi:10.1126/science.1242974
    • Sieweke MH, Allen JE. Beyond stem cells: self-renewal of differentiated macrophages. Science (2013) 342(6161):1242974. doi:10.1126/science.1242974
    • (2013) Science , vol.342 , Issue.6161 , pp. 1242974
    • Sieweke, M.H.1    Allen, J.E.2
  • 23
    • 0020624571 scopus 로고
    • The role of B cell proliferation in the generation of immunoglobulin-secreting cells in man
    • Jelinek DF, Lipsky PE. The role of B cell proliferation in the generation of immunoglobulin-secreting cells in man. J Immunol (1983) 130:2597-604.
    • (1983) J Immunol , vol.130 , pp. 2597-2604
    • Jelinek, D.F.1    Lipsky, P.E.2
  • 24
    • 0025732399 scopus 로고
    • Human in vivo-induced spontaneous IgG-secreting cells from tonsil, blood and bone marrow exhibit different phenotype and functional level of maturation
    • Brieva JA, Roldan E, de la Sen ML, Rodriguez C. Human in vivo-induced spontaneous IgG-secreting cells from tonsil, blood and bone marrow exhibit different phenotype and functional level of maturation. Immunology (1991) 72:580-3.
    • (1991) Immunology , vol.72 , pp. 580-583
    • Brieva, J.A.1    Roldan, E.2    de la Sen, M.L.3    Rodriguez, C.4
  • 25
    • 0025942598 scopus 로고
    • Terminal differentiation of human bone marrow cells capable of spontaneous and high-rate immunoglobulin secretion: role of bone marrow stromal cells and interleukin 6
    • doi:10.1002/eji.1830211105
    • Roldan E, Brieva JA. Terminal differentiation of human bone marrow cells capable of spontaneous and high-rate immunoglobulin secretion: role of bone marrow stromal cells and interleukin 6. Eur J Immunol (1991) 21:2671-7. doi:10.1002/eji.1830211105
    • (1991) Eur J Immunol , vol.21 , pp. 2671-2677
    • Roldan, E.1    Brieva, J.A.2
  • 26
    • 63849146905 scopus 로고    scopus 로고
    • Blood-borne human plasma cells in steady state are derived from mucosal immune responses
    • doi:10.1182/blood-2008-04-153544
    • Mei HE, Yoshida T, Sime W, Hiepe F, Thiele K, Manz RA, et al. Blood-borne human plasma cells in steady state are derived from mucosal immune responses. Blood (2009) 113:2461-9. doi:10.1182/blood-2008-04-153544
    • (2009) Blood , vol.113 , pp. 2461-2469
    • Mei, H.E.1    Yoshida, T.2    Sime, W.3    Hiepe, F.4    Thiele, K.5    Manz, R.A.6
  • 27
    • 20444400843 scopus 로고    scopus 로고
    • Phenotypic characterization of the human myeloma cell growth fraction
    • doi:10.1182/blood-2004-12-4700
    • Robillard N, Pellat-Deceunynck C, Bataille R. Phenotypic characterization of the human myeloma cell growth fraction. Blood (2005) 105:4845-8. doi:10.1182/blood-2004-12-4700
    • (2005) Blood , vol.105 , pp. 4845-4848
    • Robillard, N.1    Pellat-Deceunynck, C.2    Bataille, R.3
  • 28
    • 84871647883 scopus 로고    scopus 로고
    • Flow cytometry analysis of murine hematopoietic stem cells
    • doi:10.1002/cyto.a.22093
    • Mayle A, Luo M, Jeong M, Goodell MA. Flow cytometry analysis of murine hematopoietic stem cells. Cytometry A (2013) 83:27-37. doi:10.1002/cyto.a.22093
    • (2013) Cytometry A , vol.83 , pp. 27-37
    • Mayle, A.1    Luo, M.2    Jeong, M.3    Goodell, M.A.4
  • 29
    • 0030891628 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6
    • doi:10.1016/S1074-7613(00)80241-1
    • Morse L, Chen D, Franklin D, Xiong Y, Chen-Kiang S. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6. Immunity (1997) 6:47-56. doi:10.1016/S1074-7613(00)80241-1
    • (1997) Immunity , vol.6 , pp. 47-56
    • Morse, L.1    Chen, D.2    Franklin, D.3    Xiong, Y.4    Chen-Kiang, S.5
  • 30
    • 18644374059 scopus 로고    scopus 로고
    • CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells
    • doi:10.1016/S1074-7613(02)00364-3
    • Tourigny MR, Ursini-Siegel J, Lee H, Toellner KM, Cunningham AF, Franklin DS, et al. CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. Immunity (2002) 17:179-89. doi:10.1016/S1074-7613(02)00364-3
    • (2002) Immunity , vol.17 , pp. 179-189
    • Tourigny, M.R.1    Ursini-Siegel, J.2    Lee, H.3    Toellner, K.M.4    Cunningham, A.F.5    Franklin, D.S.6
  • 31
    • 73949109704 scopus 로고    scopus 로고
    • An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization
    • doi:10.1182/blood-2009-07-235960
    • Jourdan M, Caraux A, De Vos J, Fiol G, Larroque M, Cognot C, et al. An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization. Blood (2009) 114:5173-81. doi:10.1182/blood-2009-07-235960
    • (2009) Blood , vol.114 , pp. 5173-5181
    • Jourdan, M.1    Caraux, A.2    De Vos, J.3    Fiol, G.4    Larroque, M.5    Cognot, C.6
  • 32
    • 33646146498 scopus 로고    scopus 로고
    • Stromal niches, plasma cell differentiation and survival
    • doi:10.1016/j.coi.2006.03.004
    • Moser K, Tokoyoda K, Radbruch A, Maclennan I, Manz RA. Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol (2006) 18:265-70. doi:10.1016/j.coi.2006.03.004
    • (2006) Curr Opin Immunol , vol.18 , pp. 265-270
    • Moser, K.1    Tokoyoda, K.2    Radbruch, A.3    Maclennan, I.4    Manz, R.A.5
  • 33
    • 33749018225 scopus 로고    scopus 로고
    • Competence and competition: the challenge of becoming a long-lived plasma cell
    • doi:10.1038/nri1886
    • Radbruch A, Muehlinghaus G, Luger EO, Inamine A, Smith KG, Dorner T, et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol (2006) 6:741-50. doi:10.1038/nri1886
    • (2006) Nat Rev Immunol , vol.6 , pp. 741-750
    • Radbruch, A.1    Muehlinghaus, G.2    Luger, E.O.3    Inamine, A.4    Smith, K.G.5    Dorner, T.6
  • 34
    • 2942523585 scopus 로고    scopus 로고
    • Cellular niches controlling B lymphocyte behavior within bone marrow during development
    • doi:10.1016/j.immuni.2004.05.001
    • Tokoyoda K, Egawa T, Sugiyama T, Choi BI, Nagasawa T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity (2004) 20:707-18. doi:10.1016/j.immuni.2004.05.001
    • (2004) Immunity , vol.20 , pp. 707-718
    • Tokoyoda, K.1    Egawa, T.2    Sugiyama, T.3    Choi, B.I.4    Nagasawa, T.5
  • 35
    • 44849141723 scopus 로고    scopus 로고
    • Osteoclasts support the survival of human plasma cells in vitro
    • doi:10.1093/intimm/dxn035
    • Geffroy-Luseau A, Jego G, Bataille R, Campion L, Pellat-Deceunynck C. Osteoclasts support the survival of human plasma cells in vitro. Int Immunol (2008) 20:775-82. doi:10.1093/intimm/dxn035
    • (2008) Int Immunol , vol.20 , pp. 775-782
    • Geffroy-Luseau, A.1    Jego, G.2    Bataille, R.3    Campion, L.4    Pellat-Deceunynck, C.5
  • 36
    • 77956916950 scopus 로고    scopus 로고
    • Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow
    • doi:10.1182/blood-2009-12-259457
    • Winter O, Moser K, Mohr E, Zotos D, Kaminski H, Szyska M, et al. Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow. Blood (2010) 116:1867-75. doi:10.1182/blood-2009-12-259457
    • (2010) Blood , vol.116 , pp. 1867-1875
    • Winter, O.1    Moser, K.2    Mohr, E.3    Zotos, D.4    Kaminski, H.5    Szyska, M.6
  • 37
    • 78751627318 scopus 로고    scopus 로고
    • Eosinophils are required for the maintenance of plasma cells in the bone marrow
    • doi:10.1038/ni.1981
    • Chu VT, Frohlich A, Steinhauser G, Scheel T, Roch T, Fillatreau S, et al. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nat Immunol (2011) 12:151-9. doi:10.1038/ni.1981
    • (2011) Nat Immunol , vol.12 , pp. 151-159
    • Chu, V.T.1    Frohlich, A.2    Steinhauser, G.3    Scheel, T.4    Roch, T.5    Fillatreau, S.6
  • 38
    • 84856569030 scopus 로고    scopus 로고
    • Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche
    • doi:10.4049/jimmunol.1103169
    • Belnoue E, Tougne C, Rochat AF, Lambert PH, Pinschewer DD, Siegrist CA. Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche. J Immunol (2012) 188:1283-91. doi:10.4049/jimmunol.1103169
    • (2012) J Immunol , vol.188 , pp. 1283-1291
    • Belnoue, E.1    Tougne, C.2    Rochat, A.F.3    Lambert, P.H.4    Pinschewer, D.D.5    Siegrist, C.A.6
  • 39
    • 84869745566 scopus 로고    scopus 로고
    • Pathogenic long-lived plasma cells and their survival niches in autoimmunity, malignancy, and allergy
    • doi:10.4049/jimmunol.1202317
    • Winter O, Dame C, Jundt F, Hiepe F. Pathogenic long-lived plasma cells and their survival niches in autoimmunity, malignancy, and allergy. J Immunol (2012) 189:5105-11. doi:10.4049/jimmunol.1202317
    • (2012) J Immunol , vol.189 , pp. 5105-5111
    • Winter, O.1    Dame, C.2    Jundt, F.3    Hiepe, F.4
  • 40
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • doi:10.1016/j.cell.2004.07.004
    • Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 118:149-61. doi:10.1016/j.cell.2004.07.004
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3    Sato, H.4    Matsuoka, S.5    Takubo, K.6
  • 41
    • 36749001043 scopus 로고    scopus 로고
    • Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
    • doi:10.1016/j.stem.2007.10.008
    • Qian H, Buza-Vidas N, Hyland CD, Jensen CT, Antonchuk J, Mansson R, et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell (2007) 1:671-84. doi:10.1016/j.stem.2007.10.008
    • (2007) Cell Stem Cell , vol.1 , pp. 671-684
    • Qian, H.1    Buza-Vidas, N.2    Hyland, C.D.3    Jensen, C.T.4    Antonchuk, J.5    Mansson, R.6
  • 42
    • 36748999351 scopus 로고    scopus 로고
    • Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    • doi:10.1016/j.stem.2007.10.020
    • Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 1:685-97. doi:10.1016/j.stem.2007.10.020
    • (2007) Cell Stem Cell , vol.1 , pp. 685-697
    • Yoshihara, H.1    Arai, F.2    Hosokawa, K.3    Hagiwara, T.4    Takubo, K.5    Nakamura, Y.6
  • 43
    • 39749178390 scopus 로고    scopus 로고
    • Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    • doi:10.1016/j.stem.2008.01.003
    • Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, et al. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell (2008) 2:274-83. doi:10.1016/j.stem.2008.01.003
    • (2008) Cell Stem Cell , vol.2 , pp. 274-283
    • Fleming, H.E.1    Janzen, V.2    Lo Celso, C.3    Guo, J.4    Leahy, K.M.5    Kronenberg, H.M.6
  • 44
    • 81855183667 scopus 로고    scopus 로고
    • Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
    • doi:10.1016/j.cell.2011.09.053
    • Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, et al. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 147:1146-58. doi:10.1016/j.cell.2011.09.053
    • (2011) Cell , vol.147 , pp. 1146-1158
    • Yamazaki, S.1    Ema, H.2    Karlsson, G.3    Yamaguchi, T.4    Miyoshi, H.5    Shioda, S.6
  • 45
    • 0026599838 scopus 로고
    • Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells
    • Vernino L, McAnally LM, Ramberg J, Lipsky PE. Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells. J Immunol (1992) 148:404-10.
    • (1992) J Immunol , vol.148 , pp. 404-410
    • Vernino, L.1    McAnally, L.M.2    Ramberg, J.3    Lipsky, P.E.4
  • 46
    • 0030037519 scopus 로고    scopus 로고
    • B cell differentiation and isotype switching is related to division cycle number
    • doi:10.1084/jem.184.1.277
    • Hodgkin PD, Lee JH, Lyons AB. B cell differentiation and isotype switching is related to division cycle number. J Exp Med (1996) 184:277-81. doi:10.1084/jem.184.1.277
    • (1996) J Exp Med , vol.184 , pp. 277-281
    • Hodgkin, P.D.1    Lee, J.H.2    Lyons, A.B.3
  • 47
    • 4043108358 scopus 로고    scopus 로고
    • Divide and conquer: the importance of cell division in regulating B-cell responses
    • doi:10.1111/j.1365-2567.2004.01950.x
    • Tangye SG, Hodgkin PD. Divide and conquer: the importance of cell division in regulating B-cell responses. Immunology (2004) 112:509-20. doi:10.1111/j.1365-2567.2004.01950.x
    • (2004) Immunology , vol.112 , pp. 509-520
    • Tangye, S.G.1    Hodgkin, P.D.2
  • 48
    • 84856072934 scopus 로고    scopus 로고
    • Activation-induced B cell fates are selected by intracellular stochastic competition
    • doi:10.1126/science.1213230
    • Duffy KR, Wellard CJ, Markham JF, Zhou JH, Holmberg R, Hawkins ED, et al. Activation-induced B cell fates are selected by intracellular stochastic competition. Science (2012) 335:338-41. doi:10.1126/science.1213230
    • (2012) Science , vol.335 , pp. 338-341
    • Duffy, K.R.1    Wellard, C.J.2    Markham, J.F.3    Zhou, J.H.4    Holmberg, R.5    Hawkins, E.D.6
  • 49
    • 37549000146 scopus 로고    scopus 로고
    • Interweaving the cell cycle machinery with cell differentiation
    • doi:10.4161/cc.6.23.5042
    • Miller JP, Yeh N, Vidal A, Koff A. Interweaving the cell cycle machinery with cell differentiation. Cell Cycle (2007) 6:2932-8. doi:10.4161/cc.6.23.5042
    • (2007) Cell Cycle , vol.6 , pp. 2932-2938
    • Miller, J.P.1    Yeh, N.2    Vidal, A.3    Koff, A.4
  • 50
    • 79951843773 scopus 로고    scopus 로고
    • Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors
    • doi:10.1182/blood-2010-06-288027
    • Bretz J, Garcia J, Huang X, Kang L, Zhang Y, Toellner KM, et al. Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors. Blood (2011) 117:2179-88. doi:10.1182/blood-2010-06-288027
    • (2011) Blood , vol.117 , pp. 2179-2188
    • Bretz, J.1    Garcia, J.2    Huang, X.3    Kang, L.4    Zhang, Y.5    Toellner, K.M.6
  • 51
    • 0030950523 scopus 로고    scopus 로고
    • Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation
    • doi:10.1126/science.276.5312.596
    • Lin Y, Wong K, Calame K. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science (1997) 276:596-9. doi:10.1126/science.276.5312.596
    • (1997) Science , vol.276 , pp. 596-599
    • Lin, Y.1    Wong, K.2    Calame, K.3
  • 52
    • 0034460636 scopus 로고    scopus 로고
    • Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro
    • doi:10.1128/MCB.20.23.8684-8695.2000
    • Lin KI, Lin Y, Calame K. Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro. Mol Cell Biol (2000) 20:8684-95. doi:10.1128/MCB.20.23.8684-8695.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 8684-8695
    • Lin, K.I.1    Lin, Y.2    Calame, K.3
  • 53
    • 7244231012 scopus 로고    scopus 로고
    • Plasma cell ontogeny defined by quantitative changes in blimp-1 expression
    • doi:10.1084/jem.20040973
    • Kallies A, Hasbold J, Tarlinton DM, Dietrich W, Corcoran LM, Hodgkin PD, et al. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med (2004) 200:967-77. doi:10.1084/jem.20040973
    • (2004) J Exp Med , vol.200 , pp. 967-977
    • Kallies, A.1    Hasbold, J.2    Tarlinton, D.M.3    Dietrich, W.4    Corcoran, L.M.5    Hodgkin, P.D.6
  • 54
    • 18444395232 scopus 로고    scopus 로고
    • Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    • doi:10.1016/S1074-7613(02)00335-7
    • Shaffer AL, Lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity (2002) 17:51-62. doi:10.1016/S1074-7613(02)00335-7
    • (2002) Immunity , vol.17 , pp. 51-62
    • Shaffer, A.L.1    Lin, K.I.2    Kuo, T.C.3    Yu, X.4    Hurt, E.M.5    Rosenwald, A.6
  • 55
    • 0142219442 scopus 로고    scopus 로고
    • Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
    • doi:10.1016/S1074-7613(03)00267-X
    • Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ, Liao J, McHeyzer-Williams MG, Calame K. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity (2003) 19:607-20. doi:10.1016/S1074-7613(03)00267-X
    • (2003) Immunity , vol.19 , pp. 607-620
    • Shapiro-Shelef, M.1    Lin, K.I.2    McHeyzer-Williams, L.J.3    Liao, J.4    McHeyzer-Williams, M.G.5    Calame, K.6
  • 56
    • 77956514062 scopus 로고    scopus 로고
    • An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression
    • doi:10.1093/nar/gkq268
    • Doody GM, Care MA, Burgoyne NJ, Bradford JR, Bota M, Bonifer C, et al. An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. Nucleic Acids Res (2010) 38:5336-50. doi:10.1093/nar/gkq268
    • (2010) Nucleic Acids Res , vol.38 , pp. 5336-5350
    • Doody, G.M.1    Care, M.A.2    Burgoyne, N.J.3    Bradford, J.R.4    Bota, M.5    Bonifer, C.6
  • 57
    • 0034073382 scopus 로고    scopus 로고
    • Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
    • doi:10.1128/MCB.20.7.2592-2603.2000
    • Yu J, Angelin-Duclos C, Greenwood J, Liao J, Calame K. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol Cell Biol (2000) 20:2592-603. doi:10.1128/MCB.20.7.2592-2603.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 2592-2603
    • Yu, J.1    Angelin-Duclos, C.2    Greenwood, J.3    Liao, J.4    Calame, K.5
  • 58
    • 1542347557 scopus 로고    scopus 로고
    • PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing
    • doi:10.1038/ni1046
    • Gyory I, Wu J, Fejer G, Seto E, Wright KL. PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat Immunol (2004) 5:299-308. doi:10.1038/ni1046
    • (2004) Nat Immunol , vol.5 , pp. 299-308
    • Gyory, I.1    Wu, J.2    Fejer, G.3    Seto, E.4    Wright, K.L.5
  • 59
    • 33744795753 scopus 로고    scopus 로고
    • Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
    • doi:10.1038/ncb1413
    • Ancelin K, Lange UC, Hajkova P, Schneider R, Bannister AJ, Kouzarides T, et al. Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol (2006) 8:623-30. doi:10.1038/ncb1413
    • (2006) Nat Cell Biol , vol.8 , pp. 623-630
    • Ancelin, K.1    Lange, U.C.2    Hajkova, P.3    Schneider, R.4    Bannister, A.J.5    Kouzarides, T.6
  • 60
    • 68649111205 scopus 로고    scopus 로고
    • Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties
    • doi:10.1016/j.immuni.2009.05.014
    • Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Meffre E, et al. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity (2009) 31(2):296-308. doi:10.1016/j.immuni.2009.05.014
    • (2009) Immunity , vol.31 , Issue.2 , pp. 296-308
    • Rutishauser, R.L.1    Martins, G.A.2    Kalachikov, S.3    Chandele, A.4    Parish, I.A.5    Meffre, E.6
  • 61
    • 75649136214 scopus 로고    scopus 로고
    • Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
    • doi:10.1038/ni.1837
    • Crotty S, Johnston RJ, Schoenberger SP. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol (2010) 11:114-20. doi:10.1038/ni.1837
    • (2010) Nat Immunol , vol.11 , pp. 114-120
    • Crotty, S.1    Johnston, R.J.2    Schoenberger, S.P.3
  • 62
    • 22444448587 scopus 로고    scopus 로고
    • Blimp1 is a critical determinant of the germ cell lineage in mice
    • doi:10.1038/nature03813
    • Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, et al. Blimp1 is a critical determinant of the germ cell lineage in mice. Nature (2005) 436:207-13. doi:10.1038/nature03813
    • (2005) Nature , vol.436 , pp. 207-213
    • Ohinata, Y.1    Payer, B.2    O'Carroll, D.3    Ancelin, K.4    Ono, Y.5    Sano, M.6
  • 63
    • 17244364418 scopus 로고    scopus 로고
    • The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse
    • doi:10.1242/dev.01711
    • Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, et al. The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development (2005) 132:1315-25. doi:10.1242/dev.01711
    • (2005) Development , vol.132 , pp. 1315-1325
    • Vincent, S.D.1    Dunn, N.R.2    Sciammas, R.3    Shapiro-Shalef, M.4    Davis, M.M.5    Calame, K.6
  • 64
    • 33746729815 scopus 로고    scopus 로고
    • Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    • doi:10.1016/j.cell.2006.06.048
    • Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, et al. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 126:597-609. doi:10.1016/j.cell.2006.06.048
    • (2006) Cell , vol.126 , pp. 597-609
    • Horsley, V.1    O'Carroll, D.2    Tooze, R.3    Ohinata, Y.4    Saitou, M.5    Obukhanych, T.6
  • 65
    • 38349080867 scopus 로고    scopus 로고
    • Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    • doi:10.1242/dev.012047
    • Robertson EJ, Charatsi I, Joyner CJ, Koonce CH, Morgan M, Islam A, et al. Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development (2007) 134:4335-45. doi:10.1242/dev.012047
    • (2007) Development , vol.134 , pp. 4335-4345
    • Robertson, E.J.1    Charatsi, I.2    Joyner, C.J.3    Koonce, C.H.4    Morgan, M.5    Islam, A.6
  • 66
    • 0031110468 scopus 로고    scopus 로고
    • Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype
    • Usui T, Wakatsuki Y, Matsunaga Y, Kaneko S, Koseki H, Kita T, et al. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J Immunol (1997) 158:3197-204.
    • (1997) J Immunol , vol.158 , pp. 3197-3204
    • Usui, T.1    Wakatsuki, Y.2    Matsunaga, Y.3    Kaneko, S.4    Koseki, H.5    Kita, T.6
  • 67
    • 0036272784 scopus 로고    scopus 로고
    • Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells
    • doi:10.1128/MCB.22.13.4771-4780.2002
    • Lin KI, Angelin-Duclos C, Kuo TC, Calame K. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol (2002) 22:4771-80. doi:10.1128/MCB.22.13.4771-4780.2002
    • (2002) Mol Cell Biol , vol.22 , pp. 4771-4780
    • Lin, K.I.1    Angelin-Duclos, C.2    Kuo, T.C.3    Calame, K.4
  • 68
    • 36148934909 scopus 로고    scopus 로고
    • Human BSAP and BLIMP1 confirm an autoregulatory feedback loop
    • doi:10.1182/blood-2007-05-092262
    • Mora-Lopez F, Reales E, Brieva JA, Campos-Caro A. Human BSAP and BLIMP1 confirm an autoregulatory feedback loop. Blood (2007) 110:3150-7. doi:10.1182/blood-2007-05-092262
    • (2007) Blood , vol.110 , pp. 3150-3157
    • Mora-Lopez, F.1    Reales, E.2    Brieva, J.A.3    Campos-Caro, A.4
  • 69
    • 52649102382 scopus 로고    scopus 로고
    • Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression
    • doi:10.1182/blood-2008-01-136440
    • Schmidlin H, Diehl SA, Nagasawa M, Scheeren FA, Schotte R, Uittenbogaart CH, et al. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. Blood (2008) 112:1804-12. doi:10.1182/blood-2008-01-136440
    • (2008) Blood , vol.112 , pp. 1804-1812
    • Schmidlin, H.1    Diehl, S.A.2    Nagasawa, M.3    Scheeren, F.A.4    Schotte, R.5    Uittenbogaart, C.H.6
  • 70
    • 0033680860 scopus 로고    scopus 로고
    • BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
    • doi:10.1016/S1074-7613(00)00020-0
    • Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity (2000) 13:199-212. doi:10.1016/S1074-7613(00)00020-0
    • (2000) Immunity , vol.13 , pp. 199-212
    • Shaffer, A.L.1    Yu, X.2    He, Y.3    Boldrick, J.4    Chan, E.P.5    Staudt, L.M.6
  • 72
    • 33846013955 scopus 로고    scopus 로고
    • Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells
    • doi:10.1074/jbc.M607592200
    • Ochiai K, Katoh Y, Ikura T, Hoshikawa Y, Noda T, Karasuyama H, et al. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem (2006) 281:38226-34. doi:10.1074/jbc.M607592200
    • (2006) J Biol Chem , vol.281 , pp. 38226-38234
    • Ochiai, K.1    Katoh, Y.2    Ikura, T.3    Hoshikawa, Y.4    Noda, T.5    Karasuyama, H.6
  • 73
    • 38449105489 scopus 로고    scopus 로고
    • Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation
    • doi:10.1093/jb/mvm106
    • Igarashi K, Ochiai K, Muto A. Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation. J Biochem (2007) 141:783-9. doi:10.1093/jb/mvm106
    • (2007) J Biochem , vol.141 , pp. 783-789
    • Igarashi, K.1    Ochiai, K.2    Muto, A.3
  • 74
    • 40049086212 scopus 로고    scopus 로고
    • Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6
    • doi:10.1093/intimm/dxn005
    • Ochiai K, Muto A, Tanaka H, Takahashi S, Igarashi K. Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. Int Immunol (2008) 20:453-60. doi:10.1093/intimm/dxn005
    • (2008) Int Immunol , vol.20 , pp. 453-460
    • Ochiai, K.1    Muto, A.2    Tanaka, H.3    Takahashi, S.4    Igarashi, K.5
  • 75
    • 78649688039 scopus 로고    scopus 로고
    • Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch
    • doi:10.1038/emboj.2010.257
    • Muto A, Ochiai K, Kimura Y, Itoh-Nakadai A, Calame KL, Ikebe D, et al. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. EMBO J (2010) 29:4048-61. doi:10.1038/emboj.2010.257
    • (2010) EMBO J , vol.29 , pp. 4048-4061
    • Muto, A.1    Ochiai, K.2    Kimura, Y.3    Itoh-Nakadai, A.4    Calame, K.L.5    Ikebe, D.6
  • 76
    • 5344280456 scopus 로고    scopus 로고
    • MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation
    • doi:10.1016/j.cell.2004.09.014
    • Fujita N, Jaye DL, Geigerman C, Akyildiz A, Mooney MR, Boss JM, et al. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell (2004) 119:75-86. doi:10.1016/j.cell.2004.09.014
    • (2004) Cell , vol.119 , pp. 75-86
    • Fujita, N.1    Jaye, D.L.2    Geigerman, C.3    Akyildiz, A.4    Mooney, M.R.5    Boss, J.M.6
  • 77
    • 77952559263 scopus 로고    scopus 로고
    • A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells
    • doi:10.1182/blood-2010-02-270082
    • Hideshima T, Mitsiades C, Ikeda H, Chauhan D, Raje N, Gorgun G, et al. A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells. Blood (2010) 115:3772-5. doi:10.1182/blood-2010-02-270082
    • (2010) Blood , vol.115 , pp. 3772-3775
    • Hideshima, T.1    Mitsiades, C.2    Ikeda, H.3    Chauhan, D.4    Raje, N.5    Gorgun, G.6
  • 78
    • 84867158927 scopus 로고    scopus 로고
    • Molecular pathogenesis of multiple myeloma and its premalignant precursor
    • doi:10.1172/JCI61188
    • Kuehl WM, Bergsagel PL. Molecular pathogenesis of multiple myeloma and its premalignant precursor. J Clin Invest (2012) 122:3456-63. doi:10.1172/JCI61188
    • (2012) J Clin Invest , vol.122 , pp. 3456-3463
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 79
    • 84860219443 scopus 로고    scopus 로고
    • The genetic architecture of multiple myeloma
    • doi:10.1038/nrc3257
    • Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer (2012) 12:335-48. doi:10.1038/nrc3257
    • (2012) Nat Rev Cancer , vol.12 , pp. 335-348
    • Morgan, G.J.1    Walker, B.A.2    Davies, F.E.3
  • 80
    • 78751508049 scopus 로고    scopus 로고
    • Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma
    • doi:10.1182/blood-2010-04-279539
    • Walker BA, Wardell CP, Chiecchio L, Smith EM, Boyd KD, Neri A, et al. Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma. Blood (2011) 117:553-62. doi:10.1182/blood-2010-04-279539
    • (2011) Blood , vol.117 , pp. 553-562
    • Walker, B.A.1    Wardell, C.P.2    Chiecchio, L.3    Smith, E.M.4    Boyd, K.D.5    Neri, A.6
  • 81
    • 84857443720 scopus 로고    scopus 로고
    • Cellular epigenetic stability and cancer
    • doi:10.1016/j.tig.2011.11.005
    • Sarkies P, Sale JE. Cellular epigenetic stability and cancer. Trends Genet (2012) 28:118-27. doi:10.1016/j.tig.2011.11.005
    • (2012) Trends Genet , vol.28 , pp. 118-127
    • Sarkies, P.1    Sale, J.E.2
  • 82
    • 84856095900 scopus 로고    scopus 로고
    • Large B-cell lymphomas with plasmablastic differentiation: a biological and therapeutic challenge
    • doi:10.3109/10428194.2011.608447
    • Montes-Moreno S, Montalban C, Piris MA. Large B-cell lymphomas with plasmablastic differentiation: a biological and therapeutic challenge. Leuk Lymphoma (2012) 53:185-94. doi:10.3109/10428194.2011.608447
    • (2012) Leuk Lymphoma , vol.53 , pp. 185-194
    • Montes-Moreno, S.1    Montalban, C.2    Piris, M.A.3
  • 83
    • 34047245919 scopus 로고
    • The induced development and histogenesis of plasma cells
    • doi:10.1084/jem.54.3.333
    • Miller FR. The induced development and histogenesis of plasma cells. J Exp Med (1931) 54:333-47. doi:10.1084/jem.54.3.333
    • (1931) J Exp Med , vol.54 , pp. 333-347
    • Miller, F.R.1
  • 84
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • doi:10.1016/S0092-8674(03)00401-X
    • Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 113:703-16. doi:10.1016/S0092-8674(03)00401-X
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3    Lin, A.W.4    Hearn, S.A.5    Spector, D.L.6
  • 85
    • 34147143631 scopus 로고    scopus 로고
    • Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
    • doi:10.1128/MCB.01592-06
    • Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P, et al. Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 27:2452-65. doi:10.1128/MCB.01592-06
    • (2007) Mol Cell Biol , vol.27 , pp. 2452-2465
    • Ye, X.1    Zerlanko, B.2    Zhang, R.3    Somaiah, N.4    Lipinski, M.5    Salomoni, P.6
  • 86
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • doi:10.1128/MCB.02019-06
    • Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 27:2343-58. doi:10.1128/MCB.02019-06
    • (2007) Mol Cell Biol , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 87
    • 84864297655 scopus 로고    scopus 로고
    • Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
    • doi:10.1016/j.molcel.2012.06.010
    • Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 47:203-14. doi:10.1016/j.molcel.2012.06.010
    • (2012) Mol Cell , vol.47 , pp. 203-214
    • Chandra, T.1    Kirschner, K.2    Thuret, J.Y.3    Pope, B.D.4    Ryba, T.5    Newman, S.6
  • 88
    • 0034745384 scopus 로고    scopus 로고
    • p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal
    • doi:10.1093/embo-reports/kve008
    • Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, et al. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep (2001) 2:27-34. doi:10.1093/embo-reports/kve008
    • (2001) EMBO Rep , vol.2 , pp. 27-34
    • Zezula, J.1    Casaccia-Bonnefil, P.2    Ezhevsky, S.A.3    Osterhout, D.J.4    Levine, J.M.5    Dowdy, S.F.6
  • 89
    • 84887626721 scopus 로고    scopus 로고
    • Stressing the cell cycle in senescence and aging
    • doi:10.1016/j.ceb.2013.07.005
    • Chandler H, Peters G. Stressing the cell cycle in senescence and aging. Curr Opin Cell Biol (2013) 25(6):765-71. doi:10.1016/j.ceb.2013.07.005
    • (2013) Curr Opin Cell Biol , vol.25 , Issue.6 , pp. 765-771
    • Chandler, H.1    Peters, G.2
  • 90
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: an exit from cell cycle control
    • doi:10.1038/nrc2696
    • Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 9:785-97. doi:10.1038/nrc2696
    • (2009) Nat Rev Cancer , vol.9 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 91
    • 84864011866 scopus 로고    scopus 로고
    • The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
    • doi:10.1101/gad.196238.112
    • Aksoy O, Chicas A, Zeng T, Zhao Z, McCurrach M, Wang X, et al. The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence. Genes Dev (2012) 26:1546-57. doi:10.1101/gad.196238.112
    • (2012) Genes Dev , vol.26 , pp. 1546-1557
    • Aksoy, O.1    Chicas, A.2    Zeng, T.3    Zhao, Z.4    McCurrach, M.5    Wang, X.6
  • 92
    • 35949000033 scopus 로고    scopus 로고
    • A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members
    • doi:10.1101/gr.6783507
    • Xu X, Bieda M, Jin VX, Rabinovich A, Oberley MJ, Green R, et al. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res (2007) 17:1550-61. doi:10.1101/gr.6783507
    • (2007) Genome Res , vol.17 , pp. 1550-1561
    • Xu, X.1    Bieda, M.2    Jin, V.X.3    Rabinovich, A.4    Oberley, M.J.5    Green, R.6
  • 93
    • 0037052539 scopus 로고    scopus 로고
    • A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells
    • doi:10.1126/science.1069861
    • Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells. Science (2002) 296:1132-6. doi:10.1126/science.1069861
    • (2002) Science , vol.296 , pp. 1132-1136
    • Ogawa, H.1    Ishiguro, K.2    Gaubatz, S.3    Livingston, D.M.4    Nakatani, Y.5
  • 94
    • 0035852632 scopus 로고    scopus 로고
    • The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
    • doi:10.1073/pnas.98.4.1519
    • Trimarchi JM, Fairchild B, Wen J, Lees JA. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci U S A (2001) 98:1519-24. doi:10.1073/pnas.98.4.1519
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1519-1524
    • Trimarchi, J.M.1    Fairchild, B.2    Wen, J.3    Lees, J.A.4
  • 95
    • 19944431321 scopus 로고    scopus 로고
    • A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner
    • doi:10.1074/jbc.M412509200
    • Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, et al. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2005) 280:1199-208. doi:10.1074/jbc.M412509200
    • (2005) J Biol Chem , vol.280 , pp. 1199-1208
    • Attwooll, C.1    Oddi, S.2    Cartwright, P.3    Prosperini, E.4    Agger, K.5    Steensgaard, P.6
  • 96
    • 79955972412 scopus 로고    scopus 로고
    • L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure
    • doi:10.1016/j.molcel.2011.04.004
    • Trojer P, Cao AR, Gao Z, Li Y, Zhang J, Xu X, et al. L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 42:438-50. doi:10.1016/j.molcel.2011.04.004
    • (2011) Mol Cell , vol.42 , pp. 438-450
    • Trojer, P.1    Cao, A.R.2    Gao, Z.3    Li, Y.4    Zhang, J.5    Xu, X.6
  • 97
    • 1942421702 scopus 로고    scopus 로고
    • Cyclin C/cdk3 promotes Rb-dependent G0 exit
    • doi:10.1016/S0092-8674(04)00300-9
    • Ren S, Rollins BJ. Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell (2004) 117:239-51. doi:10.1016/S0092-8674(04)00300-9
    • (2004) Cell , vol.117 , pp. 239-251
    • Ren, S.1    Rollins, B.J.2
  • 98
    • 65449179646 scopus 로고    scopus 로고
    • Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression
    • doi:10.1128/MCB.00687-08
    • Saxena UH, Powell CM, Fecko JK, Cacioppo R, Chou HS, Cooper GM, et al. Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression. Mol Cell Biol (2009) 29:2335-45. doi:10.1128/MCB.00687-08
    • (2009) Mol Cell Biol , vol.29 , pp. 2335-2345
    • Saxena, U.H.1    Powell, C.M.2    Fecko, J.K.3    Cacioppo, R.4    Chou, H.S.5    Cooper, G.M.6
  • 99
    • 0029948789 scopus 로고    scopus 로고
    • Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II
    • Rickert P, Seghezzi W, Shanahan F, Cho H, Lees E. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. Oncogene (1996) 12:2631-40.
    • (1996) Oncogene , vol.12 , pp. 2631-2640
    • Rickert, P.1    Seghezzi, W.2    Shanahan, F.3    Cho, H.4    Lees, E.5
  • 100
    • 77149132161 scopus 로고    scopus 로고
    • Cyclin C regulates human hematopoietic stem/progenitor cell quiescence
    • doi:10.1002/stem.270
    • Miyata Y, Liu Y, Jankovic V, Sashida G, Lee JM, Shieh JH, et al. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells (2010) 28:308-17. doi:10.1002/stem.270
    • (2010) Stem Cells , vol.28 , pp. 308-317
    • Miyata, Y.1    Liu, Y.2    Jankovic, V.3    Sashida, G.4    Lee, J.M.5    Shieh, J.H.6
  • 101
    • 33746938836 scopus 로고    scopus 로고
    • p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo
    • doi:10.1128/MCB.02182-05
    • Soeiro I, Mohamedali A, Romanska HM, Lea NC, Child ES, Glassford J, et al. p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo. Mol Cell Biol (2006) 26:6170-84. doi:10.1128/MCB.02182-05
    • (2006) Mol Cell Biol , vol.26 , pp. 6170-6184
    • Soeiro, I.1    Mohamedali, A.2    Romanska, H.M.3    Lea, N.C.4    Child, E.S.5    Glassford, J.6
  • 102
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • doi:10.1016/j.stem.2007.02.001
    • Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 1:101-12. doi:10.1016/j.stem.2007.02.001
    • (2007) Cell Stem Cell , vol.1 , pp. 101-112
    • Miyamoto, K.1    Araki, K.Y.2    Naka, K.3    Arai, F.4    Takubo, K.5    Yamazaki, S.6
  • 103
    • 45149123052 scopus 로고    scopus 로고
    • Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
    • doi:10.1084/jem.20080277
    • Thompson BJ, Jankovic V, Gao J, Buonamici S, Vest A, Lee JM, et al. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med (2008) 205:1395-408. doi:10.1084/jem.20080277
    • (2008) J Exp Med , vol.205 , pp. 1395-1408
    • Thompson, B.J.1    Jankovic, V.2    Gao, J.3    Buonamici, S.4    Vest, A.5    Lee, J.M.6
  • 104
    • 76949085686 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
    • doi:10.1038/ni.1839
    • Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, et al. Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 11:207-15. doi:10.1038/ni.1839
    • (2010) Nat Immunol , vol.11 , pp. 207-215
    • Reavie, L.1    Della Gatta, G.2    Crusio, K.3    Aranda-Orgilles, B.4    Buckley, S.M.5    Thompson, B.6
  • 105
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    • doi:10.1038/nrc2290
    • Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer (2008) 8:83-93. doi:10.1038/nrc2290
    • (2008) Nat Rev Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 106
    • 34548289502 scopus 로고    scopus 로고
    • Dynamic FoxO transcription factors
    • doi:10.1242/jcs.001222
    • Huang H, Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci (2007) 120:2479-87. doi:10.1242/jcs.001222
    • (2007) J Cell Sci , vol.120 , pp. 2479-2487
    • Huang, H.1    Tindall, D.J.2
  • 107
    • 0036120725 scopus 로고    scopus 로고
    • Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
    • doi:10.1128/MCB.22.7.2025-2036.2002
    • Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, et al. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol (2002) 22:2025-36. doi:10.1128/MCB.22.7.2025-2036.2002
    • (2002) Mol Cell Biol , vol.22 , pp. 2025-2036
    • Kops, G.J.1    Medema, R.H.2    Glassford, J.3    Essers, M.A.4    Dijkers, P.F.5    Coffer, P.J.6
  • 108
    • 37349025432 scopus 로고    scopus 로고
    • FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
    • doi:10.1016/j.molcel.2007.10.035
    • Bakker WJ, Harris IS, Mak TW. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell (2007) 28:941-53. doi:10.1016/j.molcel.2007.10.035
    • (2007) Mol Cell , vol.28 , pp. 941-953
    • Bakker, W.J.1    Harris, I.S.2    Mak, T.W.3
  • 109
    • 70450253358 scopus 로고    scopus 로고
    • Cited2 is an essential regulator of adult hematopoietic stem cells
    • doi:10.1016/j.stem.2009.11.001
    • Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, et al. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell (2009) 5:659-65. doi:10.1016/j.stem.2009.11.001
    • (2009) Cell Stem Cell , vol.5 , pp. 659-665
    • Kranc, K.R.1    Schepers, H.2    Rodrigues, N.P.3    Bamforth, S.4    Villadsen, E.5    Ferry, H.6
  • 110
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • doi:10.1016/S0092-8674(00)80595-4
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 96:857-68. doi:10.1016/S0092-8674(00)80595-4
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 111
    • 0035135841 scopus 로고    scopus 로고
    • Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    • doi:10.1128/MCB.21.3.952-965.2001
    • Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 21:952-65. doi:10.1128/MCB.21.3.952-965.2001
    • (2001) Mol Cell Biol , vol.21 , pp. 952-965
    • Brunet, A.1    Park, J.2    Tran, H.3    Hu, L.S.4    Hemmings, B.A.5    Greenberg, M.E.6
  • 112
    • 33749685322 scopus 로고    scopus 로고
    • Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
    • doi:10.1016/j.immuni.2006.08.015
    • Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, et al. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity (2006) 25:545-57. doi:10.1016/j.immuni.2006.08.015
    • (2006) Immunity , vol.25 , pp. 545-557
    • Omori, S.A.1    Cato, M.H.2    Anzelon-Mills, A.3    Puri, K.D.4    Shapiro-Shelef, M.5    Calame, K.6
  • 113
    • 67049162188 scopus 로고    scopus 로고
    • Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study
    • doi:10.1182/blood-2008-12-194241
    • Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood (2009) 113:5412-7. doi:10.1182/blood-2008-12-194241
    • (2009) Blood , vol.113 , pp. 5412-5417
    • Landgren, O.1    Kyle, R.A.2    Pfeiffer, R.M.3    Katzmann, J.A.4    Caporaso, N.E.5    Hayes, R.B.6
  • 114
    • 67049114114 scopus 로고    scopus 로고
    • A monoclonal gammopathy precedes multiple myeloma in most patients
    • doi:10.1182/blood-2008-12-195008
    • Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM. A monoclonal gammopathy precedes multiple myeloma in most patients. Blood (2009) 113:5418-22. doi:10.1182/blood-2008-12-195008
    • (2009) Blood , vol.113 , pp. 5418-5422
    • Weiss, B.M.1    Abadie, J.2    Verma, P.3    Howard, R.S.4    Kuehl, W.M.5
  • 115
    • 84874865836 scopus 로고    scopus 로고
    • Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease
    • doi:10.1158/1078-0432.CCR-12-2922
    • Agarwal A, Ghobrial IM. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease. Clin Cancer Res (2013) 19:985-94. doi:10.1158/1078-0432.CCR-12-2922
    • (2013) Clin Cancer Res , vol.19 , pp. 985-994
    • Agarwal, A.1    Ghobrial, I.M.2
  • 116
    • 84864561961 scopus 로고    scopus 로고
    • Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides
    • doi:10.1182/blood-2012-01-405977
    • Egan JB, Shi CX, Tembe W, Christoforides A, Kurdoglu A, Sinari S, et al. Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. Blood (2012) 120:1060-6. doi:10.1182/blood-2012-01-405977
    • (2012) Blood , vol.120 , pp. 1060-1066
    • Egan, J.B.1    Shi, C.X.2    Tembe, W.3    Christoforides, A.4    Kurdoglu, A.5    Sinari, S.6
  • 117
    • 84861532638 scopus 로고    scopus 로고
    • Clonal competition with alternating dominance in multiple myeloma
    • doi:10.1182/blood-2012-01-405985
    • Keats JJ, Chesi M, Egan JB, Garbitt VM, Palmer SE, Braggio E, et al. Clonal competition with alternating dominance in multiple myeloma. Blood (2012) 120:1067-76. doi:10.1182/blood-2012-01-405985
    • (2012) Blood , vol.120 , pp. 1067-1076
    • Keats, J.J.1    Chesi, M.2    Egan, J.B.3    Garbitt, V.M.4    Palmer, S.E.5    Braggio, E.6
  • 118
    • 84893810104 scopus 로고    scopus 로고
    • Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
    • doi:10.1038/leu.2013.199
    • Walker BA, Wardell CP, Melchor L, Brioli A, Johnson DC, Kaiser MF, et al. Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms. Leukemia (2013). doi:10.1038/leu.2013.199
    • (2013) Leukemia
    • Walker, B.A.1    Wardell, C.P.2    Melchor, L.3    Brioli, A.4    Johnson, D.C.5    Kaiser, M.F.6
  • 119
    • 0027257608 scopus 로고
    • The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell
    • doi:10.1084/jem.178.3.1023
    • Billadeau D, Ahmann G, Greipp P, Van Ness B. The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J Exp Med (1993) 178:1023-31. doi:10.1084/jem.178.3.1023
    • (1993) J Exp Med , vol.178 , pp. 1023-1031
    • Billadeau, D.1    Ahmann, G.2    Greipp, P.3    Van Ness, B.4
  • 120
    • 0036191321 scopus 로고    scopus 로고
    • Leukemic B cells clonally identical to myeloma plasma cells are myelomagenic in NOD/SCID mice
    • doi:10.1016/S0301-472X(01)00788-3
    • Pilarski LM, Seeberger K, Coupland RW, Eshpeter A, Keats JJ, Taylor BJ, et al. Leukemic B cells clonally identical to myeloma plasma cells are myelomagenic in NOD/SCID mice. Exp Hematol (2002) 30:221-8. doi:10.1016/S0301-472X(01)00788-3
    • (2002) Exp Hematol , vol.30 , pp. 221-228
    • Pilarski, L.M.1    Seeberger, K.2    Coupland, R.W.3    Eshpeter, A.4    Keats, J.J.5    Taylor, B.J.6
  • 121
    • 1542283717 scopus 로고    scopus 로고
    • Characterization of clonogenic multiple myeloma cells
    • doi:10.1182/blood-2003-09-3064
    • Matsui W, Huff CA, Wang Q, Malehorn MT, Barber J, Tanhehco Y, et al. Characterization of clonogenic multiple myeloma cells. Blood (2004) 103:2332-6. doi:10.1182/blood-2003-09-3064
    • (2004) Blood , vol.103 , pp. 2332-2336
    • Matsui, W.1    Huff, C.A.2    Wang, Q.3    Malehorn, M.T.4    Barber, J.5    Tanhehco, Y.6
  • 122
    • 45549101709 scopus 로고    scopus 로고
    • Multiple myeloma cancer stem cells
    • doi:10.1200/JCO.2007.15.8428
    • Huff CA, Matsui W. Multiple myeloma cancer stem cells. J Clin Oncol (2008) 26:2895-900. doi:10.1200/JCO.2007.15.8428
    • (2008) J Clin Oncol , vol.26 , pp. 2895-2900
    • Huff, C.A.1    Matsui, W.2
  • 123
    • 84883625365 scopus 로고    scopus 로고
    • Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma
    • doi:10.1016/j.ccr.2013.08.009
    • Leung-Hagesteijn C, Erdmann N, Cheung G, Keats JJ, Stewart AK, Reece DE, et al. Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell (2013) 24:289-304. doi:10.1016/j.ccr.2013.08.009
    • (2013) Cancer Cell , vol.24 , pp. 289-304
    • Leung-Hagesteijn, C.1    Erdmann, N.2    Cheung, G.3    Keats, J.J.4    Stewart, A.K.5    Reece, D.E.6
  • 124
    • 0035694823 scopus 로고    scopus 로고
    • The presence of circulating clonal CD19+ cells in multiple myeloma
    • Rasmussen T. The presence of circulating clonal CD19+ cells in multiple myeloma. Leuk Lymphoma (2001) 42:1359-66.
    • (2001) Leuk Lymphoma , vol.42 , pp. 1359-1366
    • Rasmussen, T.1
  • 125
    • 2542604492 scopus 로고    scopus 로고
    • In multiple myeloma clonotypic CD38-/CD19+/CD27+ memory B cells recirculate through bone marrow, peripheral blood and lymph nodes
    • Rasmussen T, Lodahl M, Hancke S, Johnsen HE. In multiple myeloma clonotypic CD38-/CD19+/CD27+ memory B cells recirculate through bone marrow, peripheral blood and lymph nodes. Leuk Lymphoma (2004) 45:1413-7.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1413-1417
    • Rasmussen, T.1    Lodahl, M.2    Hancke, S.3    Johnsen, H.E.4
  • 126
    • 84892570665 scopus 로고    scopus 로고
    • Circulating clonotypic B-cells in multiple myeloma and monoclonal gammopathy of undetermined significance
    • doi:10.3324/haematol.2013.092817
    • Thiago LS, Perez-Andres M, Balanzategui A, Sarasquete ME, Paiva B, Jara-Acevedo M, et al. Circulating clonotypic B-cells in multiple myeloma and monoclonal gammopathy of undetermined significance. Haematologica (2013). doi:10.3324/haematol.2013.092817
    • (2013) Haematologica
    • Thiago, L.S.1    Perez-Andres, M.2    Balanzategui, A.3    Sarasquete, M.E.4    Paiva, B.5    Jara-Acevedo, M.6
  • 127
    • 77957761400 scopus 로고    scopus 로고
    • Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma
    • doi:10.3324/haematol.2010.024778
    • Rasmussen T, Haaber J, Dahl IM, Knudsen LM, Kerndrup GB, Lodahl M, et al. Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma. Haematologica (2010) 95:1730-7. doi:10.3324/haematol.2010.024778
    • (2010) Haematologica , vol.95 , pp. 1730-1737
    • Rasmussen, T.1    Haaber, J.2    Dahl, I.M.3    Knudsen, L.M.4    Kerndrup, G.B.5    Lodahl, M.6
  • 128
    • 8844264524 scopus 로고    scopus 로고
    • The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells
    • doi:10.1038/sj.leu.2403513
    • Yata K, Yaccoby S. The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells. Leukemia (2004) 18:1891-7. doi:10.1038/sj.leu.2403513
    • (2004) Leukemia , vol.18 , pp. 1891-1897
    • Yata, K.1    Yaccoby, S.2
  • 129
    • 84865862858 scopus 로고    scopus 로고
    • CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients
    • doi:10.1038/leu.2012.80
    • Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, et al. CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients. Leukemia (2012) 26:2135-41. doi:10.1038/leu.2012.80
    • (2012) Leukemia , vol.26 , pp. 2135-2141
    • Hosen, N.1    Matsuoka, Y.2    Kishida, S.3    Nakata, J.4    Mizutani, Y.5    Hasegawa, K.6
  • 130
    • 84872345792 scopus 로고    scopus 로고
    • Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma
    • doi:10.1182/blood-2012-06-436220
    • Chaidos A, Barnes CP, Cowan G, May PC, Melo V, Hatjiharissi E, et al. Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma. Blood (2013) 121:318-28. doi:10.1182/blood-2012-06-436220
    • (2013) Blood , vol.121 , pp. 318-328
    • Chaidos, A.1    Barnes, C.P.2    Cowan, G.3    May, P.C.4    Melo, V.5    Hatjiharissi, E.6
  • 131
    • 84887601514 scopus 로고    scopus 로고
    • Multiple myeloma-initiating cells
    • doi:10.1007/s12185-013-1293-0
    • Hosen N. Multiple myeloma-initiating cells. Int J Hematol (2013) 97:306-12. doi:10.1007/s12185-013-1293-0
    • (2013) Int J Hematol , vol.97 , pp. 306-312
    • Hosen, N.1
  • 132
    • 22044440425 scopus 로고    scopus 로고
    • Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
    • doi:10.1182/blood-2005-01-0034
    • Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood (2005) 106:296-303. doi:10.1182/blood-2005-01-0034
    • (2005) Blood , vol.106 , pp. 296-303
    • Bergsagel, P.L.1    Kuehl, W.M.2    Zhan, F.3    Sawyer, J.4    Barlogie, B.5    Shaughnessy Jr., J.6
  • 133
    • 75149175161 scopus 로고    scopus 로고
    • Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
    • doi:10.1038/nature08684
    • Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, et al. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature (2010) 463:374-8. doi:10.1038/nature08684
    • (2010) Nature , vol.463 , pp. 374-378
    • Bienvenu, F.1    Jirawatnotai, S.2    Elias, J.E.3    Meyer, C.A.4    Mizeracka, K.5    Marson, A.6
  • 134
    • 84863256545 scopus 로고    scopus 로고
    • ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
    • doi:10.1172/JCI60256
    • Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest (2012) 122:833-43. doi:10.1172/JCI60256
    • (2012) J Clin Invest , vol.122 , pp. 833-843
    • Casimiro, M.C.1    Crosariol, M.2    Loro, E.3    Ertel, A.4    Yu, Z.5    Dampier, W.6
  • 135
    • 0035854521 scopus 로고    scopus 로고
    • Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
    • doi:10.1126/science.1062589
    • Fearon DT, Manders P, Wagner SD. Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. Science (2001) 293:248-50. doi:10.1126/science.1062589
    • (2001) Science , vol.293 , pp. 248-250
    • Fearon, D.T.1    Manders, P.2    Wagner, S.D.3
  • 136
    • 80053997259 scopus 로고    scopus 로고
    • A human memory T cell subset with stem cell-like properties
    • doi:10.1038/nm.2446
    • Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, et al. A human memory T cell subset with stem cell-like properties. Nat Med (2011) 17:1290-7. doi:10.1038/nm.2446
    • (2011) Nat Med , vol.17 , pp. 1290-1297
    • Gattinoni, L.1    Lugli, E.2    Ji, Y.3    Pos, Z.4    Paulos, C.M.5    Quigley, M.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.