메뉴 건너뛰기




Volumn 4, Issue 12, 2013, Pages

Oligomeric amyloid β induces IL-1β processing via production of ROS: Implication in Alzheimer's disease

Author keywords

IL 1 ; microglia; NLRP3; oligomer A

Indexed keywords

AMYLOID BETA PROTEIN; CRYOPYRIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OLIGOMERIC AMYLOID BETA PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

EID: 84891807547     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.503     Document Type: Article
Times cited : (179)

References (53)
  • 1
    • 84859610500 scopus 로고    scopus 로고
    • Alzheimer's disease and the amyloid beta-protein
    • Walsh DM, Teplow DB. Alzheimer's disease and the amyloid beta-protein. Prog Mol Biol Transl Sci 2012; 107: 101-124
    • (2012) Prog Mol Biol Transl Sci , vol.107 , pp. 101-124
    • Walsh, D.M.1    Teplow, D.B.2
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 2002; 297: 353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 18244389436 scopus 로고    scopus 로고
    • The role of cerebral amyloid beta accumulation in common forms of alzheimer disease
    • Gandy S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest 2005; 115: 1121-1129
    • (2005) J Clin Invest , vol.115 , pp. 1121-1129
    • Gandy, S.1
  • 6
    • 0242362596 scopus 로고    scopus 로고
    • Beta-Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH
    • Klug GM, Losic D, Subasinghe SS, Aguilar MI, Martin LL, Small DH. Beta-Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH. Eur J Biochem 2003; 270: 4282-4293
    • (2003) Eur J Biochem , vol.270 , pp. 4282-4293
    • Klug, G.M.1    Losic, D.2    Subasinghe, S.S.3    Aguilar, M.I.4    Martin, L.L.5    Small, D.H.6
  • 7
    • 33645108790 scopus 로고    scopus 로고
    • High-resolution atomic force microscopy of soluble Abeta42 oligomers
    • Mastrangelo IA, Ahmed M, Sato T, Liu W, Wang C, Hough P et al. High-resolution atomic force microscopy of soluble Abeta42 oligomers. J Mol Biol 2006; 358: 106-119
    • (2006) J Mol Biol , vol.358 , pp. 106-119
    • Mastrangelo, I.A.1    Ahmed, M.2    Sato, T.3    Liu, W.4    Wang, C.5    Hough, P.6
  • 8
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from abeta1-42 are potent central nervous system neurotoxins
    • Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 1998; 95: 6448-6453
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3    Edwards, C.4    Freed, R.5    Liosatos, M.6
  • 9
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in alzheimer's disease
    • Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999; 155: 853-862
    • (1999) Am J Pathol , vol.155 , pp. 853-862
    • Lue, L.F.1    Kuo, Y.M.2    Roher, A.E.3    Brachova, L.4    Shen, Y.5    Sue, L.6
  • 10
    • 84858120121 scopus 로고    scopus 로고
    • Amyloid-beta oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease
    • Santos AN, Ewers M, Minthon L, Simm A, Silber RE, Blennow K et al. Amyloid-beta oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease. J Alzheimers Dis 2012; 29: 171-176
    • (2012) J Alzheimers Dis , vol.29 , pp. 171-176
    • Santos, A.N.1    Ewers, M.2    Minthon, L.3    Simm, A.4    Silber, R.E.5    Blennow, K.6
  • 11
    • 75949127362 scopus 로고    scopus 로고
    • Inflammation, microglia, and alzheimer's disease
    • Cameron B, Landreth GE. Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis 2010; 37: 503-509
    • (2010) Neurobiol Dis , vol.37 , pp. 503-509
    • Cameron, B.1    Landreth, G.E.2
  • 12
    • 27644595378 scopus 로고    scopus 로고
    • Focal glial activation coincides with increased bace1 activation and precedes amyloid plaque deposition in app[v717i] transgenic mice
    • Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether T et al. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J Neuroinflammation 2005; 2: 22
    • (2005) J Neuroinflammation , vol.2 , pp. 22
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3    Dewachter, I.4    Walter, J.5    Klockgether, T.6
  • 13
    • 77949491472 scopus 로고    scopus 로고
    • Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of alzheimer's disease
    • Rodriguez JJ, Witton J, Olabarria M, Noristani HN, Verkhratsky A. Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease. Cell Death Dis 2010; 1: E1
    • (2010) Cell Death Dis , vol.1
    • Rodriguez, J.J.1    Witton, J.2    Olabarria, M.3    Noristani, H.N.4    Verkhratsky, A.5
  • 14
    • 84859143780 scopus 로고    scopus 로고
    • Minocycline corrects early, pre-plaque neuroinflammation and inhibits bace-1 in a transgenic model of alzheimer's disease-like amyloid pathology
    • Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC. Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation 2012; 9: 62
    • (2012) J Neuroinflammation , vol.9 , pp. 62
    • Ferretti, M.T.1    Allard, S.2    Partridge, V.3    Ducatenzeiler, A.4    Cuello, A.C.5
  • 15
    • 77952296338 scopus 로고    scopus 로고
    • Interleukin-1beta (il-1beta) processing pathway
    • Weber A, Wasiliew P, Kracht M. Interleukin-1beta (IL-1beta) processing pathway. Sci Signal 2010; 3, cm2
    • (2010) Sci Signal , vol.3
    • Weber, A.1    Wasiliew, P.2    Kracht, M.3
  • 17
    • 36849045915 scopus 로고    scopus 로고
    • The inflammasome: A danger sensing complex triggering innate immunity
    • Petrilli V, Dostert C, Muruve DA, Tschopp J. The inflammasome: A danger sensing complex triggering innate immunity. Curr Opin Immunol 2007; 19: 615-622
    • (2007) Curr Opin Immunol , vol.19 , pp. 615-622
    • Petrilli, V.1    Dostert, C.2    Muruve, D.A.3    Tschopp, J.4
  • 19
    • 34548027736 scopus 로고    scopus 로고
    • Activation of the nalp3 inflammasome is triggered by low intracellular potassium concentration
    • Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 2007; 14: 1583-1589
    • (2007) Cell Death Differ , vol.14 , pp. 1583-1589
    • Petrilli, V.1    Papin, S.2    Dostert, C.3    Mayor, A.4    Martinon, F.5    Tschopp, J.6
  • 20
    • 34548031870 scopus 로고    scopus 로고
    • The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
    • Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W et al. The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 2007; 14: 1590-1604
    • (2007) Cell Death Differ , vol.14 , pp. 1590-1604
    • Fernandes-Alnemri, T.1    Wu, J.2    Yu, J.W.3    Datta, P.4    Miller, B.5    Jankowski, W.6
  • 21
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221-225
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 23
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 9: 847-856
    • (2008) Nat Immunol , vol.9 , pp. 847-856
    • Hornung, V.1    Bauernfeind, F.2    Halle, A.3    Samstad, E.O.4    Kono, H.5    Rock, K.L.6
  • 24
    • 84873087532 scopus 로고    scopus 로고
    • Nlrp3 is activated in alzheimer's disease and contributes to pathology in app/ps1 mice
    • Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013; 493: 674-678
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3    Delekate, A.4    Schwartz, S.5    Vieira-Saecker, A.6
  • 25
    • 57149123424 scopus 로고    scopus 로고
    • Amyloid-beta oligomers set fire to inflammasomes and induce alzheimer's pathology
    • Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology. J Cell Mol Med 2008; 12: 2255-2262
    • (2008) J Cell Mol Med , vol.12 , pp. 2255-2262
    • Salminen, A.1    Ojala, J.2    Suuronen, T.3    Kaarniranta, K.4    Kauppinen, A.5
  • 26
    • 73349135899 scopus 로고    scopus 로고
    • Involvement of cathepsin b in the processing and secretion of interleukin-1beta in chromogranin a-stimulated microglia
    • Terada K, Yamada J, Hayashi Y, Wu Z, Uchiyama Y, Peters C et al. Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia 2010; 58: 114-124
    • (2010) Glia , vol.58 , pp. 114-124
    • Terada, K.1    Yamada, J.2    Hayashi, Y.3    Wu, Z.4    Uchiyama, Y.5    Peters, C.6
  • 28
  • 29
    • 79960542894 scopus 로고    scopus 로고
    • Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
    • Bauernfeind F, Bartok E, Rieger A, Franchi L, Nunez G, Hornung V. Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol 2011; 187: 613-617
    • (2011) J Immunol , vol.187 , pp. 613-617
    • Bauernfeind, F.1    Bartok, E.2    Rieger, A.3    Franchi, L.4    Nunez, G.5    Hornung, V.6
  • 30
    • 73649137143 scopus 로고    scopus 로고
    • Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease
    • Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M et al. Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. Am J Pathol 2009; 175: 2121-2132
    • (2009) Am J Pathol , vol.175 , pp. 2121-2132
    • Doi, Y.1    Mizuno, T.2    Maki, Y.3    Jin, S.4    Mizoguchi, H.5    Ikeyama, M.6
  • 31
    • 70049102020 scopus 로고    scopus 로고
    • Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells
    • Parvathy S, Rajadas J, Ryan H, Vaziri S, Anderson L, Murphy GM Jr. Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells. Neurobiol Aging 2009; 30: 1792-1804
    • (2009) Neurobiol Aging , vol.30 , pp. 1792-1804
    • Parvathy, S.1    Rajadas, J.2    Ryan, H.3    Vaziri, S.4    Anderson, L.5    Murphy Jr., G.M.6
  • 32
    • 79952810857 scopus 로고    scopus 로고
    • Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    • Maezawa I, Zimin PI, Wulff H, Jin LW. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem 2011; 286: 3693-3706
    • (2011) J Biol Chem , vol.286 , pp. 3693-3706
    • Maezawa, I.1    Zimin, P.I.2    Wulff, H.3    Jin, L.W.4
  • 33
    • 23444455475 scopus 로고    scopus 로고
    • Beta-Amyloid protein structure determines the nature of cytokine release from rat microglia
    • Lindberg C, Selenica ML, Westlind-Danielsson A, Schultzberg M. Beta-Amyloid protein structure determines the nature of cytokine release from rat microglia. J Mol Neurosci 2005; 27: 1-12
    • (2005) J Mol Neurosci , vol.27 , pp. 1-12
    • Lindberg, C.1    Selenica, M.L.2    Westlind-Danielsson, A.3    Schultzberg, M.4
  • 34
    • 39549106246 scopus 로고    scopus 로고
    • Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein
    • Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH et al. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci USA 2008; 105: 1347-1352
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1347-1352
    • Park, L.1    Zhou, P.2    Pitstick, R.3    Capone, C.4    Anrather, J.5    Norris, E.H.6
  • 36
    • 33751192706 scopus 로고    scopus 로고
    • The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease
    • Wilkinson BL, Landreth GE. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. J Neuroinflammation 2006; 3: 30
    • (2006) J Neuroinflammation , vol.3 , pp. 30
    • Wilkinson, B.L.1    Landreth, G.E.2
  • 37
    • 1642499152 scopus 로고    scopus 로고
    • Beta-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
    • Abramov AY, Canevari L, Duchen MR. Beta-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 2004; 24: 565-575
    • (2004) J Neurosci , vol.24 , pp. 565-575
    • Abramov, A.Y.1    Canevari, L.2    Duchen, M.R.3
  • 38
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
    • Reddy PH, Beal MF. Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 2008; 14: 45-53
    • (2008) Trends Mol Med , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 39
    • 72549084916 scopus 로고    scopus 로고
    • Oxidation of potassium channels by ROS: A general mechanism of aging and neurodegeneration
    • Sesti F, Liu S, Cai SQ. Oxidation of potassium channels by ROS: A general mechanism of aging and neurodegeneratioñ Trends Cell Biol 2010; 20: 45-51
    • (2010) Trends Cell Biol , vol.20 , pp. 45-51
    • Sesti, F.1    Liu, S.2    Cai, S.Q.3
  • 41
    • 0004491134 scopus 로고    scopus 로고
    • Enhancement of outward potassium current may participate in beta-Amyloid peptide-induced cortical neuronal death
    • Yu SP, Farhangrazi ZS, Ying HS, Yeh CH, Choi DW. Enhancement of outward potassium current may participate in beta-Amyloid peptide-induced cortical neuronal death. Neurobiol Dis 1998; 5: 81-88
    • (1998) Neurobiol Dis , vol.5 , pp. 81-88
    • Yu, S.P.1    Farhangrazi, Z.S.2    Ying, H.S.3    Yeh, C.H.4    Choi, D.W.5
  • 42
    • 79959676154 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar beta-Amyloid is attenuated by oligomeric beta-Amyloid: Implications for Alzheimer's disease
    • Pan XD, Zhu YG, Lin N, Zhang J, Ye QY, Huang HP et al. Microglial phagocytosis induced by fibrillar beta-Amyloid is attenuated by oligomeric beta-Amyloid: Implications for Alzheimer's disease. Mol Neurodegener 2011; 6: 45
    • (2011) Mol Neurodegener , vol.6 , pp. 45
    • Pan, X.D.1    Zhu, Y.G.2    Lin, N.3    Zhang, J.4    Ye, Q.Y.5    Huang, H.P.6
  • 43
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 2007; 117: 1595-1604
    • (2007) J Clin Invest , vol.117 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Miller, J.N.4    Johnson, R.E.5    O'Banion, M.K.6
  • 44
    • 70449518278 scopus 로고    scopus 로고
    • Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory
    • Moore AH, Wu M, Shaftel SS, Graham KA, O'Banion MK. Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory. Neuroscience 2009; 164: 1484-1495
    • (2009) Neuroscience , vol.164 , pp. 1484-1495
    • Moore, A.H.1    Wu, M.2    Shaftel, S.S.3    Graham, K.A.4    O'Banion, M.K.5
  • 45
    • 0034666435 scopus 로고    scopus 로고
    • The inhibitory effect of interleukin-1beta on long-Term potentiation is coupled with increased activity of stress-Activated protein kinases
    • Vereker E, O'Donnell E, Lynch MA. The inhibitory effect of interleukin-1beta on long-Term potentiation is coupled with increased activity of stress-Activated protein kinases. J Neurosci 2000; 20: 6811-6819
    • (2000) J Neurosci , vol.20 , pp. 6811-6819
    • Vereker, E.1    O'Donnell, E.2    Lynch, M.A.3
  • 46
    • 0032523168 scopus 로고    scopus 로고
    • Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age-And stress-induced impairments in longterm potentiation
    • Murray CA, Lynch MA. Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age-And stress-induced impairments in longterm potentiation. J Neurosci 1998; 18: 2974-2981
    • (1998) J Neurosci , vol.18 , pp. 2974-2981
    • Murray, C.A.1    Lynch, M.A.2
  • 47
    • 0037336701 scopus 로고    scopus 로고
    • Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-mapk pathway
    • Li Y, Liu L, Barger SW, Griffin WS. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J Neurosci 2003; 23: 1605-1611
    • (2003) J Neurosci , vol.23 , pp. 1605-1611
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Griffin, W.S.4
  • 48
    • 84874882726 scopus 로고    scopus 로고
    • Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model
    • Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, LaFerla FM, Olschowka JA et al. Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci 2013; 33: 5053-5064
    • (2013) J Neurosci , vol.33 , pp. 5053-5064
    • Ghosh, S.1    Wu, M.D.2    Shaftel, S.S.3    Kyrkanides, S.4    LaFerla, F.M.5    Olschowka, J.A.6
  • 49
    • 0001360461 scopus 로고
    • Brain interleukin 1 and s-100 immunoreactivity are elevated in down syndrome and alzheimer disease
    • Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 1989; 86: 7611-7615
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7611-7615
    • Griffin, W.S.1    Stanley, L.C.2    Ling, C.3    White, L.4    MacLeod, V.5    Perrot, L.J.6
  • 50
    • 27344441062 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-Amyloid
    • Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-Amyloid. J Neuroinflammation 2005; 2: 15
    • (2005) J Neuroinflammation , vol.2 , pp. 15
    • Craft, J.M.1    Watterson, D.M.2    Hirsch, E.3    Van Eldik, L.J.4
  • 51
    • 16744366716 scopus 로고    scopus 로고
    • Production of interleukin-12 and expression of its receptors by murine microglia
    • Suzumura A, Sawada M, Takayanagi T. Production of interleukin-12 and expression of its receptors by murine microglia. Brain Res 1998; 787: 139-142
    • (1998) Brain Res , vol.787 , pp. 139-142
    • Suzumura, A.1    Sawada, M.2    Takayanagi, T.3
  • 52
    • 80053281065 scopus 로고    scopus 로고
    • Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-beta neurotoxicity
    • Mizuno T, Doi Y, Mizoguchi H, Jin S, Noda M, Sonobe Y et al. Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-beta neurotoxicity. Am J Pathol 2011; 179: 2016-2027
    • (2011) Am J Pathol , vol.179 , pp. 2016-2027
    • Mizuno, T.1    Doi, Y.2    Mizoguchi, H.3    Jin, S.4    Noda, M.5    Sonobe, Y.6
  • 53
    • 84870899355 scopus 로고    scopus 로고
    • Gm-csf increases lps-induced production of proinflammatory mediators via upregulation of tlr4 and cd14 in murine microglia
    • Parajuli B, Sonobe Y, Kawanokuchi J, Doi Y, Noda M, Takeuchi H et al. GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia. J Neuroinflammation 2012; 9: 268
    • (2012) J Neuroinflammation , vol.9 , pp. 268
    • Parajuli, B.1    Sonobe, Y.2    Kawanokuchi, J.3    Doi, Y.4    Noda, M.5    Takeuchi, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.