Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 221-233

  Korpis, Katharina ^a   Weber, Frauke ^b   Brune, Stefanie ^a   Wünsch, Bernhard ^b   Bednarski, Patrick J ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Apoptosis; Autophagy; Cancer; Lipid peroxidation; RPMI 8226 cells; Sigma receptor

Indexed keywords

2 [1 (BIPHENYL 4 YLMETHYL) 4 (CYCLOHEXYLMETHYL)PIPERAZIN 2 YL]ETHANOL; ALPHA TOCOPHEROL; CASPASE 3; CASPASE 8; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PIPERAZINE DERIVATIVE; PROTEIN BAD; PROTEIN BAX; PROTEIN BID; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BINDING AFFINITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; IC 50; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MYELOMA CELL; RECEPTOR BINDING;

4-DIFLUORO-3,5-BIS(4-PHENYL-1,3-BUTADIENYL)-4-BORA-3A,4A-DIAZA-S-INDACENE; 2′,7′-DICHLOROFLUORESCEIN DIACETATE; 3(4,5-DIMETHYL-2-THIAZOLYL)-2,5-DIPHENYL-2H-TETRAZOLIUM BROMIDE; 3-MA; 3-METHYLADENINE; 4,6-DIAMINO-2-PHENYLINDOLE; AI; APOPTOSIS; APOPTOSIS INHIBITOR; AUTOPHAGY; B(MAX); BODIPY 665/676 C(11); CANCER; DAPI; DCFDA; DIMETHYLSULFOXIDE; DITOLYLGUANIDINE; DMSO; DTG; DULBECCOS PHOSPHATE BUFFERED SALINE; HALF MAXIMAL INHIBITORY DRUG CONCENTRATION; IC(50); INHIBITORY DISSOCIATION CONSTANT; K(D); K(I); LC3B; LIGAND DISSOCIATION CONSTANT; LIPID PEROXIDATION; LPO; MAXIMAL LIGAND BINDING SITES; MICROTUBULE-ASSOCIATED PROTEIN LIGHT CHAIN 3; MITOCHONDRIAL MEMBRANE POTENTIAL; MMP; MTT; PARP; PBS; PHOSPHATIDYLINOSITOL 3-KINASE; PI; PI3K; POLY(ADP-RIBOSE) POLYMERASE; PROPIDIUM IODIDE; REACTIVE OXYGEN SPECIES; ROS; RPMI 8226 CELLS; SD; SEM; SIGMA-RECEPTOR; STANDARD DEVIATION; STANDARD ERROR OF MEAN; TBH; TERTIARY-BUTYL-HYDROPEROXIDE; Z-VAD-FMK; Z-VAL-ALA-ASP(OME)-CH(2)F;

APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; HUMANS; LIGANDS; LIPID PEROXIDATION; MULTIPLE MYELOMA; SIGNAL TRANSDUCTION;

EID: 84891495609     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.033     Document Type: Article

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