Synthesis of bicyclic σ receptor ligands with cytotoxic activity

Journal of Medicinal Chemistry

Volumn 50, Issue 24, 2007, Pages 6144-6153

  Geiger, Christian ^a   Zelenka, Christel ^a   Weigl, Manuela ^a   Fröhlich, Roland ^a   Wibbeling, Birgit ^a   Lehmkuhl, Kirstin ^a   Schepmann, Dirk ^a   Grünert, Renate ^b   Bednarski, Patrick J ^b   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 6 BENZYL 2 METHOXY 8 (4 METHOXYBENZYL) 6,8 DIAZABICYCLO[3.2.2]NONANE; ALCOHOL DERIVATIVE; BICYCLO COMPOUND; CISPLATIN; DITOLYLGUANIDINE; DIZOCILPINE; ETHER DERIVATIVE; GLUTAMIC ACID DERIVATIVE; GUANIDINE DERIVATIVE; HALOPERIDOL; LITHIUM DERIVATIVE; OXALIPLATIN; PB 28; PENTAZOCINE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DIASTEREOISOMER; DIECKMANN REACTION; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; MITSUNOBU REACTION; RECEPTOR AFFINITY; REDUCTION; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; AZABICYCLO COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; GUINEA PIGS; HUMANS; LIVER; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37849012683     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070620b     Document Type: Article

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