Cell death and autophagy: Cytokines, drugs, and nutritional factors

Toxicology

Volumn 254, Issue 3, 2008, Pages 147-157

  Bursch, Wilfried ^a   Karwan, Anneliese ^a   Mayer, Miriam ^a   Dornetshuber, Julia ^a   Fröhwein, Ulrike ^a   Schulte Hermann, Rolf ^a   Fazi, Barbara ^b   Di Sano, Federica ^b   Piredda, Lucia ^b   Piacentini, Mauro ^b   Petrovski, Goran ^c   Fésüs, László ^c   Gerner, Christopher ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Caspase 3; Cell injury; Defense; Glucose deprivation; Hexokinase; Human breast cancer cell line (MCF 7); Human hepatoma cell line (HCC 1.2); Phagocytosis; Proteomics

Indexed keywords

CASPASE 3; DEOXYGLUCOSE; FENRETINIDE; GLUCOSE; GLUTATHIONE TRANSFERASE P1; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA1;

AGGRESOME; APOPTOSIS; AUTOPHAGY; CELL COMMUNICATION; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CYTOLYSIS; DRUG MECHANISM; HUMAN; PRIORITY JOURNAL; PROTEOMICS; REVIEW;

ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASE 3; CELL LINE, TUMOR; CYTOKINES; HOMEOSTASIS; HUMANS; NUTRITIONAL STATUS; PHAGOCYTOSIS;

EID: 56749178706     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.07.048     Document Type: Review

References (87)

1. Aki T., Yamaguchi K., Fujimiya T., and Mizukami Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 22 52 (2003) 8529-8535
2. Baehrecke E.H. Autophagic programmed cell death in Drosophila. Cell Death Diff. 10 9 (2003) 940-945
3. Biederbick A., Kern H.F., and Elsässer H.P. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur. J. Cell Biol. 66 (1995) 3-14
4. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Diff. 8 (2001) 569-581
5. Bursch, W., Ellinger, A., Gerner, Ch., Schulte-Hermann, R., 2004. Autophagocytosis and programmed cell death. In: Autophagy, D. Klionsky (Ed.), Landes Bioscience, Georgetown, TX, USA and Eurekah.com, Austin, TX, USA, pp. 287-304.
6. Bursch W., Ellinger A., Kienzl H., Török L., Pandey S., Sikorska M., Walker R., and Schulte-Hermann R. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 17 (1996) 1595-1607
7. Bursch W., Taper H.S., Lauer B., and Schulte-Hermann R. Quantitative Histological and Histochemical Studies on the Occurrence and Stages of Apoptosis (Controlled Cell Death) during Regression of Rat Liver Hyperplasia. Vir. Arch. Abtl. B., Zellpathologie 50 (1985) 153-166
8. Bursch W., Hochegger K., Török T., Marian B., Ellinger A., and Schulte Hermann R. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J. Cell Sci. 113 7 (2000) 1189-1198
9. Buytaert E., Dewaele M., and Agostinis P. Molecular effectors of multiple cell death pathways initiated by photodynamic therapy. Biochim. Biophys. Acta 1776 1 (2007) 86-107
10. Byfield M.P., Murray J.T., and Backer J.M. hVps34 is a Nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Biochem. 280 38 (2005) 33076-33082
11. Calderwood S.K., and Ciocca D.R. Heat shock proteins: stress proteins with Janus-like properties in cancer. Int. J. Hyperthermia 24 1 (2008) 31-39
12. Chiang G.G., and Abraham R.T. Targeting the mTOR signaling network in cancer. Trends Mol. Med. 13 10 (2007) 433-442
13. Clarke P.G.H. Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol. 181 (1990) 195-213
14. Codogno, P., Meijer, A.J., 2004. Signaling pathways in mammalian autophagy. In: Autophagy, D.K. (Ed.), Landes Bioscience, Georgetown, TX, USA and Eurekah.com, Austin, TX, USA, pp. 26-47.
15. Corazzari M., Lovat P.E., Armstrong J.L., Fimia G.M., Hill D.S., Birch-Machin M., Redfern C.P., and Piacentini M. Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57. Br. J. Cancer 96 7 (2007) 1062-1071
16. Dann S.G., Selvaraj A., and Thomas G. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol. Med. 13 6 (2007) 252-259
17. Dills W.L., Schaffer-Bell L., and Onuma E.K. Inhibitory effects of substrate analogs on lactate production from fructose and glucose in bovine spermatozoa. Biol. Reprod. 25 (1981) 458-465
18. Duriez P.J., and Shah G.M. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem. Cell Biol. 75 (1997) 337-349
19. Edinger A.L., and Thompson C.B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 16 (2004) 663-669
20. England G.M., and Jordan J.C. Pure antiestrogens as a new therapy for breast cancer. Oncol. Res. 9 8 (1997) 397-402
21. Fazi B., Bursch W., Fimia G.M., Nardacci R., Piacentini M., Di Sano F., and Piredda L. Fenretinide induces autophagic cell death in caspase-defective breast cancer cells. Autophagy 4 4 (2008) 435-441
22. Fengsrud, M., Lunde Sneve, M., Overbye, A., Segeln, P.O., 2004. Structural aspects of mammalian autophagy. In: Autophagy, D.K. (Ed.), Landes Bioscience, Georgetown, TX, USA and Eurekah.com, Austin, TX, USA, pp. 11-25.
23. Festjens N., Vanden Berghe T., and Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim. Biophys. Acta 1757 9-10 (2006) 1371-1387
24. Gerner C., Frohwein U., Gotzmann J., Bayer E., Gelbmann D., Bursch W., and Schulte-Hermann R. The Fas-induced apoptosis analyzed by high throughput proteome analysis. J. Biol. Chem. 275 (2000) 39018-39026
25. Gerner C., Gotzmann J., Frohwein U., Schamberger C., Ellinger A., and Sauermann G. Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation. Cell Death Diff. 9 (2002) 671-681
26. González-Polo R.A., Niso-Santano M., Ortíz-Ortíz M.A., Gómez-Martín A., Morán J.M., García-Rubio L., Francisco-Morcillo J., Zaragoza C., Soler G., and Fuentes J.M. Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells. Toxicol. Sci. 97 2 (2007) 448-458
27. Gottlob K., Majeweski N., Kennedy E., Robey R.B., and Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 15 11 (2001) 1406-1418
28. Gozuacik D., and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23 (2004) 2891-2906
29. Grune T., Jung T., Merker K., and Davies K.J. Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int. J. Biochem. Cell Biol. 36 12 (2004) 2519-3250
30. Han X.I., and Liehr J.G. Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Research 52 (1992) 1360-1363
31. Hetz C.A. ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid. Redox. Signal 9 12 (2007) 2345-2355
32. Hohfeld J., Cyr D.M., and Patterson C. From the cradle to the grave: molecular chaperones that may choose between folding and degradation. EMBO Rep. 2 (2001) 885-890
33. Hu X., and Xuan Y. Bypassing cancer drug resistance by activating multiple death pathways-a proposal from the study of circumventing cancer drug resistance by induction of necroptosis. Cancer Lett. 259 2 (2008) 127-137
34. Hufnagl K., Parzefall W., Marian B., Käfer M., Bukowska K., Schulte-Hermann R., and Grasl-Kraupp B. Role of transforming growth factor alpha and prostaglandins in preferential growth of preneoplastic rat hepatocytes. Carcinogensis 22 8 (2001) 1247-1256
35. Hung C.C., Davison E.J., Robinson P.A., and Ardley H.C. The aggravating role of the ubiquitin-proteasome system in neurodegenerative disease. Biochem. Soc. Trans. 34 Pt 5 (2006) 743-745
36. Hwang S.O., and Lee G.M. Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture. Biotechnol. Bioeng. 99 3 (2008) 678-685
37. Jänicke R.U., Sprengart M.L., Wati M.R., and Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273 (1998) 9357-9360
38. Kazanci N.M., and Severcan F. Concentration dependent different action of tamoxifen on membrane fluidity. Biosci. Rep. 27 4-5 (2007) 247-255
39. Kerr J.F., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257
40. Kim I., Rodriguez-Enriquez S., and Lemasters J.J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 462 (2007) 245-253
41. Klionsky D.J., Abeliovich H., Agostinis P., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4 2 (2008) 151-175
42. Klionsky D.J., Cuervo A.M., and Seglen P.O. Methods for monitoring autophagy from yeast to human. Autophagy 3 3 (2007) 181-206
43. Kopelovich L., Fay J.R., Sigman C.C., and Crowell J.A. The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention. Cancer Epidemiol Biomarkers Prev. 16 7 (2007) 1330-1340
44. Kurokawa H., Nishio K., Fukumoto H., Tomonari A., Suzuki T., and Saijo N. Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells. Oncol. Rep. 6 1 (1999) 33-37
45. Lanneau D., Brunet M., Frisan E., Solary E., Fontenay M., and Garrido C. Heat shock proteins: essential proteins for apoptosis regulation. J. Cell Mol. Med. 12 3 (2008) 743-761
46. Lefranc F., Facchini V., and Kiss R. Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. Oncologist. 12 12 (2007) 1395-1403
47. Levenson A.S., and Jordan V.C. MCF-7: the first hormone-responsive breast cancer cell line. Cancer Res. 57 15 (1997) 3071-3078
48. Levine B., and Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 115 (2005) 2679-2688
49. Levine B., and Kroemer G. Autophagy in the pathogenesis of disease. Cell 132 1 (2008) 27-42
50. Lockshin R.A., and Zakeri Z. Apoptosis, autophagy, and more. Int. J. Biochem. Cell Biol. 36 (2004) 2405-2419
51. Lockshin R.A., and Zakeri Z. Caspase-independent cell death?. Oncogene 23 (2004) 2766-2773
52. Logue S.E., and Martin S.L. Caspase activation cascades in apoptosis. Biochem. Soc. Trans. 36 Pt 1 (2008) 1-9
53. Maiuri M.C., Zalckvar E., and Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8 9 (2007) 741-752
54. Majewski N., Nogueira V., Bhaskar P., Coy P.E., Skeen J.E., Gottlob K., Chandel N.S., Thompson C.B., Robey R.B., and Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 16 5 (2004) 819-830
55. Majewski N., Nogueira V., Robey R.B., and Hay N. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol. Cell Biol. 24 2 (2004) 730-740
56. Mayer M., Ellinger A., Karwan A., Schulte-Hermann R., and Bursch W. Cancer and nutrition: role of amino acids (AA) for the regulation of hepatocellular apoptosis. BMC Pharmacol. 7 Suppl. 2 (2007) A64
57. Mizushima N., Levine B., Cuervo A.M., and Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 451 (2008) 1069-1075
58. Moore M.N. Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress. Autophagy 4 2 (2008) 254-256
59. Moretti L., Yang E.S., Kim K.W., and Lu B. Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist. Updat. 10 4-5 (2007) 135-143
60. Müllauer L., Grasl-Kraupp B., Bursch W., and Schulte-Hermann R. Transforming growth factor β1 induced cell death in preneoplastic of rat liver and senitization by the antiestrogen tamoxifen. Hepatolgy 23 (1996) 840-847
61. Nakagomi S., Barsoum M.J., Bossy-Wetzel E., Sütterlin C., Malhotra V., and Lipton S.A. A golgi fragmentation pathway in neurodegeneration. Neurobiol. Dis. 29 2 (2008) 221-231
62. Nazarewicz R.R., Zenebe W.J., Parihar A., et al. Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Cancer Res. 67 (2007) 1282-1290
63. Pandey U.B., Batlevi Y., Baehrecke E.H., and Taylor J.P. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy 3 6 (2007) 643-645
64. Pastorino J.G., Hoek J.B., and Shulga N. Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res. 65 22 (2005) 1045-1054
65. Petrovski G., Zahuczky G., Katona K., Vereb G., Martinet W., Nemes Z., Bursch W., and Fésüs L. Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes. Cell Death Diff. 14 6 (2007) 1117-1128
66. Pizzo P., and Pozzan T. Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol. 17 10 (2007) 511-517
67. Robey R.B., and Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25 34 (2006) 4683-4696
68. Rodgarkia-Dara C., Vejda S., Erlach N., Losert A., Bursch W., Berger W., Schulte-Hermann R., and Grusch M. The activin axis in liver biology and disease. Mutat. Res. 613 2-3 (2006) 123-137
69. Rubinsztein D.C., Gestwicki J.E., Murphy L.O., and Klionsky D.J. Potential therapeutic applications of autophagy. Nat. Rev. Drug. Discov. 6 4 (2007) 304-312
70. Sagmeister S., Eisenbauer M., Pirker C., Mohr T., Holzmann K., Zwickl H., Bichler C., Kandioler D., Wrba F., Mikulits W., Gerner C., Shehata M., Majidic O., Streubl B., Berger W., Micksche M., Zatloukal K., Schulte-Hermann R., and Grasl-Kraupp B. New cellular tolls reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis. Br. J. Cancer. 99 1 (2008) 151-159
71. Sargent L.M., Dragan Y., Bahnhub N., et al. Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats. Cancer Res. 4 (1994) 3357-3360
72. Savill J., and Gregory C.H. Apoptotic PS to phagocyte TIM-4: eat me. Immunity 27 (2007) 830-832
73. Scherz-Shouval R., and Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol. 17 9 (2007) 422-427
74. Schulte-Hermann, R., Bursch, W., Grasl-Kraupp, B., 1995. In: Boyer et al. (Eds.), Apoptosis in Liver Biology and Disease. Progress in Liver Disease, vol. XIII, pp. 1-35.
75. Shintani T., and Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 306 5698 (2004) 990-995
76. Stoka V., Turk V., and Turk B. Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol. Chem. 388 6 (2007) 555-560
77. Tanaka M., and Miyake Y. Apoptotic cell clearance and autoimmune disorder. Curr. Med. Chem. 14 27 (2007) 2892-2897
78. Terman A., Gustafsson B., and Brunk U.T. Autophagy, organelles and ageing. J. Pathol. 211 2 (2007) 134-143
79. Tolkovsky, A., 2004. Autophagy in Neuronal Function and Neuronal Death. In: Autophagy, D. Klionsky (ed.), Landes Bioscience, Georgetown Texas, USA and Eurekah.com, Austin Texas, USA, pp. 256-263.
80. Van der Vaart A., Mari M., and Reggiori F. A picky eater: exploring the mechansims of selective autophagy in human pathologies. Traffic 9 (2008) 281-289
81. Wakeling A.E., Nicholson R.I., and Gee J.M. Prospects for combining hormonal and nonhormonal growth factor inhibition. Clin. Cancer Res. 7 Suppl. 12 (2001) 4350s-4355s
82. Wang, C.W., Klionsky, D.L., 2004. Microautophagy. In: Autophagy, D.K. (Ed.), Landes Bioscience, Georgetown, TX, USA and Eurekah.com, Austin, TX, USA, pp. 107-125.
83. Wullschleger S., Loewith R., and Hall M. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
84. Wyllie A.H., Kerr J.F., and Currie A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68 (1980) 251-306
85. Yang X.H., Sladek T.L., Liu X., Butler B.R., Froelich C.J., and Thor A.D. Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res. 61 1 (2001) 348-354
86. Yousefi S., Perozzo R., Schmid I., Ziemecki A., Schattner T., Scapozza L., Brunner T., and Simon H.U. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell Biol. 8 10 (2006) 1124-1132
87. Zakeri Z., Bursch W., Tenniswood M., and Lockshin R.A. Cell death: programmed apoptosis, necrosis, or other?. Cell Death Diff. 2 (1995) 83-92