Chiral, nonracemic (piperazin-2-yl)methanol derivatives with σ-receptor affinity

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3299-3311

  Bedürftig, Stephan ^a   Wünsch, Bernhard ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

1 receptor ligands; 2 receptor ligands; (Piperazin 2 yl)methanols; Bicyclic piperazinediones; Structure affinity relationships

Indexed keywords

(1 BENZYL 4 CYCLOHEXYLPIPERAZIN 2 YL)METHANOL; (1 BENZYL 4 METHYLPIPERAZIN 2 YL)METHANOL; (1 BENZYLPIPERAZIN 2 YL)METHANOL; [1 BENZYL 4 (2 HYDROXYETHYL)PIPERAZIN 2 YL]METHANOL; [1 BENZYL 4 (2 PHENYLETHYL)PIPERAZIN 2 YL]METHANOL; [1 BENZYL 4 (3 HYDROXYPROYL)PIPERAZIN 2 YL]METHANOL; [1 BENZYL 4 (4 METHOXYBENZYL)PIPERAZIN 2 YL]METHANOL; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; CHLOROACETAMIDE; DITOLYLGUANIDINE; ETHYL 2 [4 BENZYL 3 (HYDROXYMETHYL)PIPERAZIN 1 YL]ACETATE; GUANIDINE DERIVATIVE; HALOPERIDOL; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; PENTAZOCINE; PIPERAZINE DERIVATIVE; PIPERAZINEDIONE; SIGMA 1 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CIS TRANS ISOMERISM; DRUG DETERMINATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; RECEPTOR AFFINITY;

ANIMALS; GUINEA PIGS; LIGANDS; METHANOL; MOLECULAR STRUCTURE; PIPERAZINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; STEREOISOMERISM;

CAVIA PORCELLUS; SUS SCROFA;

EID: 2542470681     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.059     Document Type: Article

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