Synthesis, σ 1, σ 2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 10, 2012, Pages 3323-3331

  Riganas, Stefanos ^a,e   Papanastasiou, Ioannis ^a   Foscolos, George B ^a   Tsotinis, Andrew ^a   Bourguignon, Jean Jacques ^b   Serin, Guillaume ^c   Mirjolet, Jean François ^c   Dimas, Kostas ^d   Kourafalos, Vassilios N ^e   Eleutheriades, Andreas ^e   Moutsos, Vassilios I ^e   Khan, Humaira ^e   Georgakopoulou, Stavroula ^e   Zaniou, Angeliki ^e   Prassa, Margarita ^e   Theodoropoulou, Maria ^e   Pondiki, Stavroula ^e   Vamvakides, Alexandre ^e  

^a UNIVERSITY OF ATHENS   (Greece)

^b Laboratoire de Pharmacochimie   (France)

^c Oncodesign SA   (France)

^d Division of Pharmacology   (Greece)

^e Anavex Life Sciences   (Greece)

Author keywords

1, 2 Binding affinity; C1 substituted adamantanes; In vitro antiproliferative; In vivo anticancer activity; Synthesis

Indexed keywords

1 [4 [ALPHA (1 TRICYCLO[3.3.1.1 3,7]DECYL)PHENYLMETHYL]PHENYL]PIPERAZINE; 1 CYCLOHEXYL 4 [4 [ALPHA (1 TRICYCLO[3.3.1.1 3,7]DECYL)PHENYLMETHYL]PHENYL]PIPERAZINE; 1 ETHYL 4 [4 [ALPHA (1 TRICYCLO[3.3.1.1 3,7]DECYL)PHENYLMETHYL]PHENYL]PIPERAZINE; 1 METHYL 4 [4 [ALPHA (1 TRICYCLO[3.3.1.1 3,7]DECYL)PHENYLMETHYL]PHENYL]PIPERAZINE; 1 METHYL 4 [ALPHA,A DIPHENYL(1 TRICYCLO[3.3.1.1 3,7]DECYL)METHYL]PIPERAZINE; 1 PHENYLMETHYL 4 [4 [ALPHA (1 TRICYCLO[3.3.1.1 3,7]DECYL)PHENYLMETHYL]PHENYL]PIPERAZINE; 1 PHENYLMETHYL 4 [ALPHA,A DIPHENYL(1 TRICYCLO[3.3.1.1 3,7]DECYL)METHYL]PIPERAZINE; 4 [4 [ALPHA (1 TRICYCLO[3.3.1.1 3,7]DECYL)PHENYLMETHYL]PHENYL]MORPHOLINE; 4 [A,ALPHA DIPHENYL (1 TRICYCLO[3.3.1.1 3,7]DECYL)METHYL]MORPHOLINE; AMANTADINE DERIVATIVE; CASPASE 3; FLUOROURACIL; GABAPENTIN; GEMCITABINE; PACLITAXEL; PIPERAZINE DERIVATIVE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MULTIPLE CYCLE TREATMENT; NEUROPATHIC PAIN; NONHUMAN; PANCREAS CANCER; TUMOR XENOGRAFT;

ADAMANTANE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, NUDE; MOLECULAR STRUCTURE; PANCREATIC NEOPLASMS; RECEPTORS, SIGMA;

AGOUTI PACA;

EID: 84860466359     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.038     Document Type: Article

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