Lysosomal membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer

Journal of Experimental and Clinical Cancer Research

Volumn 31, Issue 1, 2012, Pages

  Hornick, John R ^a   Vangveravong, Suwanna ^a   Spitzer, Dirk ^a   Abate, Carmen ^c   Berardi, Francesco ^c   Goedegebuure, Peter ^a,b   MacH, Robert H ^a   Hawkins, William G ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MO   (United States)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

caspase 3; lysosomal membrane permeablization; pancreatic cancer; sigma 2 receptor

Indexed keywords

1 CYCLOHEXYL 4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZINE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; CASPASE 3; CASPASE 3 INHIBITOR; CONCANAMYCIN A; LIGAND; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; N [9 (6 AMINOHEXYL) 9 AZABICYCLO[3.3.1]NONAN 3ALPHA YL] N (2 METHOXY 5 METHYLPHENYL)CARBAMATE; PB 28; PB 282; PB 385; PEPSTATIN; SHORT HAIRPIN RNA; SIGMA 2 OPIATE RECEPTOR; SV 119; SW 120; SW 43; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME INDUCTION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LIGAND BINDING; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; FEMALE; HUMANS; LIGANDS; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, NUDE; MICROSCOPY, CONFOCAL; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RECEPTORS, SIGMA;

EID: 84860345815     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-31-41     Document Type: Article

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