Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

Molecular Systems Biology

Volumn 7, Issue , 2011, Pages

  Spitzer, Michaela ^a   Griffiths, Emma ^b,c   Blakely, Kim M ^b   Wildenhain, Jan ^a   Ejim, Linda ^b   Rossi, Laura ^b   De Pascale, Gianfranco ^b   Curak, Jasna ^b   Brown, Eric ^b   Tyers, Mike ^a   Wright, Gerard D ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

antifungal; combination; pathogen; resistance; synergism

Indexed keywords

AMPHOTERICIN B; CASPOFUNGIN; CLOFAZIMINE; CLOMIFENE; CYCLOSERINE; ERGOSTEROL; FENPROPIDINE; FLUCONAZOLE; KETOCONAZOLE; MITOXANTRONE; NAFTIFINE; PIRLINDOLE; PIVAMPICILLIN; SERTRALINE; SULOCTIDIL; TAMOXIFEN; TERBINAFINE; THIETHYLPERAZINE; TRIFLUOPERAZINE; ZUCLOPENTHIXOL; ANTIFUNGAL AGENT;

ANTIFUNGAL RESISTANCE; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS GATTII; CRYPTOCOCCUS NEOFORMANS; DRUG POTENTIATION; FUNGAL STRAIN; FUNGICIDAL ACTIVITY; GENE INTERACTION; IN VIVO STUDY; LIPOGENESIS; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES; SURVIVAL; ANIMAL; BIOLOGY; BIOSYNTHESIS; CANDIDA; CRYPTOCOCCUS; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; GROWTH, DEVELOPMENT AND AGING; INSECT; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; SPECIES DIFFERENCE;

CANDIDA; SACCHAROMYCES;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA; COMPUTATIONAL BIOLOGY; CRYPTOCOCCUS; DRUG RESISTANCE, FUNGAL; DRUG SYNERGISM; ERGOSTEROL; FLUCONAZOLE; GENE EXPRESSION PROFILING; INSECTS; MICROBIAL SENSITIVITY TESTS; SACCHAROMYCES; SPECIES SPECIFICITY;

EID: 79959580788     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2011.31     Document Type: Article

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